Modulation of an ectodomain motif in the influenza A virus neuraminidase alters tetherin sensitivity and results in virus attenuation in vivo

Journal of Molecular Biology

Volumn 426, Issue 6, 2014, Pages 1308-1321

  Leyva Grado, Victor H ^a   Hai, Rong ^a   Fernandes, Fiona ^b   Belicha Villanueva, Alan ^a   Carter, Carol ^b   Yondola, Mark A ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

budding; ectodomain; influenza; neuraminidase; tetherin

Indexed keywords

ASPARTIC ACID; HOST FACTOR; PROTEIN; TETHERIN; UNCLASSIFIED DRUG; VIRUS SIALIDASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MEMBRANE; CELLULAR DISTRIBUTION; CHEMOSENSITIVITY; CONTROLLED STUDY; DEATH; ENDOPLASMIC RETICULUM; FEMALE; GAIN OF FUNCTION MUTATION; GENE SILENCING; GROWTH; HUMAN; HUMAN CELL; IMMUNOGOLD ELECTRON MICROSCOPY; IMMUNOPRECIPITATION; INFLUENZA A; INFLUENZA VIRUS; INFLUENZA VIRUS A; LD 50; LOSS OF FUNCTION MUTATION; MOUSE; MOUSE MODEL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN MOTIF; SURVIVAL TIME; VIRUS ATTENUATION; VIRUS INHIBITION; VIRUS LIKE AGENT; VIRUS MUTANT; VIRUS MUTATION; VIRUS RELEASE;

HUMAN IMMUNODEFICIENCY VIRUS 1; INFLUENZA A VIRUS; ORTHOMYXOVIRIDAE;

BUDDING; ECTODOMAIN; INFLUENZA; NEURAMINIDASE; TETHERIN;

AMINO ACID MOTIFS; ANIMALS; ANTIGENS, CD; CERCOPITHECUS AETHIOPS; COS CELLS; FEMALE; GPI-LINKED PROTEINS; HELA CELLS; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNOPRECIPITATION; INFLUENZA A VIRUS; MICE; MICE, INBRED BALB C; NEURAMINIDASE; ORTHOMYXOVIRIDAE INFECTIONS; PROTEIN STRUCTURE, TERTIARY; VIRAL PROTEINS; VIRION;

EID: 84894557021     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2013.12.023     Document Type: Article

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