Identification of a methoxynaphthalene scaffold as a core replacement in quinolizidinone amide M1 positive allosteric modulators

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 5, 2014, Pages 1417-1420

  Kuduk, Scott D ^a   Di Marco, Christina N ^a   Saffold, Jonathan R ^a   Ray, William J ^a   Ma, Lei ^a   Wittmann, Marion ^a   Koeplinger, Kenneth A ^b   Thompson, Charles D ^b   Hartman, George D ^a   Bilodeau, Mark T ^a   Beshore, Douglas C ^a  

^a Department of Medicinal Chemistry ^*  (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Allosteric modulator; Alzheimer's disease; M1; Muscarinic; P glycoprotein

Indexed keywords

ALLOSTERIC MODULATOR; ALZHEIMER'S DISEASE; M(1); MUSCARINIC; P-GLYCOPROTEIN;

ALLOSTERIC REGULATION; AMIDES; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; MICE; NAPHTHALENES; PROTEIN BINDING; QUINOLIZIDINES; RECEPTOR, MUSCARINIC M1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84894556086     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.01.012     Document Type: Article

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