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Volumn 33, Issue 8, 2014, Pages 1066-1072

MYC activity is negatively regulated by a C-terminal lysine cluster

Author keywords

Apoptosis; Cellular transformation; Lysine; Myc; Transcription

Indexed keywords

ANIMALS; CELL DIVISION; GENE EXPRESSION REGULATION; GENES, MYC; HETEROGRAFTS; HUMANS; LYSINE; NEOPLASMS; PHOSPHORYLATION; PROTEIN STABILITY; RATS;

EID: 84894535205     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.36     Document Type: Article
Times cited : (14)

References (28)
  • 1
    • 33748138585 scopus 로고    scopus 로고
    • Role of post-Translational modifications in regulating c-Myc proteolysis, transcriptional activity and biological function
    • Hann SR. Role of post-Translational modifications in regulating c-Myc proteolysis, transcriptional activity and biological function. Semin Cancer Biol 2006; 16: 288-302
    • (2006) Semin Cancer Biol , vol.16 , pp. 288-302
    • Hann, S.R.1
  • 2
    • 13944252067 scopus 로고    scopus 로고
    • The life cycle of C-myc: From synthesis to degradation
    • Sears RC. The life cycle of C-myc: From synthesis to degradation. Cell Cycle 2004; 3: 1133-1137
    • (2004) Cell Cycle , vol.3 , pp. 1133-1137
    • Sears, R.C.1
  • 4
    • 0027275755 scopus 로고
    • Point mutations in the c-Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas
    • Bhatia K, Huppi K, Spangler G, Siwarski D, Iyer R, Magrath I. Point mutations in the c-Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas. Nat Genet 1993; 5: 56-61
    • (1993) Nat Genet , vol.5 , pp. 56-61
    • Bhatia, K.1    Huppi, K.2    Spangler, G.3    Siwarski, D.4    Iyer, R.5    Magrath, I.6
  • 5
    • 0021088187 scopus 로고
    • Altered nucleotide sequences of a translocated c-myc gene in Burkitt lymphoma
    • Rabbitts TH, Hamlyn PH, Baer R. Altered nucleotide sequences of a translocated c-myc gene in Burkitt lymphoma. Nature 1984; 306: 760-765
    • (1984) Nature , vol.306 , pp. 760-765
    • Rabbitts, T.H.1    Hamlyn, P.H.2    Baer, R.3
  • 6
    • 0034037132 scopus 로고    scopus 로고
    • The c-Myc transactivation domain is a direct modulator of apoptotic versus proliferative signals
    • Chang DW, Claassen GF, Hann SR, Cole MD. The c-Myc transactivation domain is a direct modulator of apoptotic versus proliferative signals. Mol Cell Biol 2000; 20: 4309-4319
    • (2000) Mol Cell Biol , vol.20 , pp. 4309-4319
    • Chang, D.W.1    Claassen, G.F.2    Hann, S.R.3    Cole, M.D.4
  • 7
  • 8
    • 79551552058 scopus 로고    scopus 로고
    • Phosphorylation regulates c-Myc's oncogenic activity in the mammary gland
    • Wang X, Cunningham M, Zhang X, Tokarz S, Laraway B, Troxell M et al. Phosphorylation regulates c-Myc's oncogenic activity in the mammary gland. Cancer Res 2011; 71: 925-936
    • (2010) Cancer Res , vol.71 , pp. 925-936
    • Wang, X.1    Cunningham, M.2    Zhang, X.3    Tokarz, S.4    Laraway, B.5    Troxell, M.6
  • 9
    • 0033861775 scopus 로고    scopus 로고
    • Induction of cell cycle progression and acceleration of apoptosis are two separable functions of c-Myc: Transrepression correlates with acceleration of apoptosis
    • Conzen SD, Gottlob K, Kandel ES, Khanduri P, Wagner AJ, O'Leary M et al. Induction of cell cycle progression and acceleration of apoptosis are two separable functions of c-Myc: Transrepression correlates with acceleration of apoptosis. Mol Cell Biol 2000; 20: 6008-6018
    • (2000) Mol Cell Biol , vol.20 , pp. 6008-6018
    • Conzen, S.D.1    Gottlob, K.2    Kandel, E.S.3    Khanduri, P.4    Wagner, A.J.5    O'Leary, M.6
  • 11
    • 27544473311 scopus 로고    scopus 로고
    • The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation
    • Adhikary S, Marinoni F, Hock A, Hulleman E, Popov N, Beier R et al. The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation. Cell 2005; 123: 409-421
    • (2005) Cell , vol.123 , pp. 409-421
    • Adhikary, S.1    Marinoni, F.2    Hock, A.3    Hulleman, E.4    Popov, N.5    Beier, R.6
  • 12
    • 82455179484 scopus 로고    scopus 로고
    • Systematic and quantitative assessment of the ubiquitin-modified proteome
    • Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A et al. Systematic and quantitative assessment of the ubiquitin-modified proteome. Mol Cell 2011; 44: 325-340
    • (2010) Mol Cell , vol.44 , pp. 325-340
    • Kim, W.1    Bennett, E.J.2    Huttlin, E.L.3    Guo, A.4    Li, J.5    Possemato, A.6
  • 13
    • 10044262126 scopus 로고    scopus 로고
    • The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60
    • Patel JH, Du Y, Ard PG, Phillips C, Carella B, Chen CJ et al. The c-MYC oncoprotein is a substrate of the acetyltransferases hGCN5/PCAF and TIP60. Mol Cell Biol 2004; 24: 10826-10834
    • (2004) Mol Cell Biol , vol.24 , pp. 10826-10834
    • Patel, J.H.1    Du, Y.2    Ard, P.G.3    Phillips, C.4    Carella, B.5    Chen, C.J.6
  • 14
    • 24344451246 scopus 로고    scopus 로고
    • Six lysine residues on c-Myc are direct substrates for acetylation by p300
    • Zhang K, Faiola F, Martinez E. Six lysine residues on c-Myc are direct substrates for acetylation by p300. Biochem Biophys Res Commun 2005; 336: 274-280
    • (2005) Biochem Biophys Res Commun , vol.336 , pp. 274-280
    • Zhang, K.1    Faiola, F.2    Martinez, E.3
  • 16
    • 0030849451 scopus 로고    scopus 로고
    • Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination
    • Mateyak MK, Obaya AJ, Adachi S, Sedivy JM. Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination. Cell Growth Differ 1997; 8: 1039-1048
    • (1997) Cell Growth Differ , vol.8 , pp. 1039-1048
    • Mateyak, M.K.1    Obaya, A.J.2    Adachi, S.3    Sedivy, J.M.4
  • 17
    • 27944448727 scopus 로고    scopus 로고
    • Dual regulation of c-Myc by p300 via acetylation-dependent control of Myc protein turnover and coactivation of Myc-induced transcription
    • Faiola F, Liu X, Lo S, Pan S, Zhang K, Lymar E et al. Dual regulation of c-Myc by p300 via acetylation-dependent control of Myc protein turnover and coactivation of Myc-induced transcription. Mol Cell Biol 2005; 25: 10220-10234
    • (2005) Mol Cell Biol , vol.25 , pp. 10220-10234
    • Faiola, F.1    Liu, X.2    Lo, S.3    Pan, S.4    Zhang, K.5    Lymar, E.6
  • 18
    • 0034612593 scopus 로고    scopus 로고
    • A genetic screen to identify genes that rescue the slow growth phenotype of c-myc null fibroblasts
    • Berns K, Hijmans EM, Koh E, Daley GQ, Bernards R. A genetic screen to identify genes that rescue the slow growth phenotype of c-myc null fibroblasts. Oncogene 2000; 19: 3330-3334
    • (2000) Oncogene , vol.19 , pp. 3330-3334
    • Berns, K.1    Hijmans, E.M.2    Koh, E.3    Daley, G.Q.4    Bernards, R.5
  • 20
    • 84867010006 scopus 로고    scopus 로고
    • C-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells
    • Nie Z, Hu G, Wei G, Cui K, Yamane A, Resch W et al. c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells. Cell 2012; 151: 68-79
    • (2013) Cell , vol.151 , pp. 68-79
    • Nie, Z.1    Hu, G.2    Wei, G.3    Cui, K.4    Yamane, A.5    Resch, W.6
  • 22
    • 0023116071 scopus 로고
    • Definition of regions in human c-myc that are involved in transformation and nuclear localization
    • Stone J, de Lange T, Ramsay G, Jakobovits E, Bishop JM, Varmus H et al. Definition of regions in human c-myc that are involved in transformation and nuclear localization. Mol Cell Biol 1987; 7: 1697-1709
    • (1987) Mol Cell Biol , vol.7 , pp. 1697-1709
    • Stone, J.1    De Lange, T.2    Ramsay, G.3    Jakobovits, E.4    Bishop, J.M.5    Varmus, H.6
  • 23
    • 78149431906 scopus 로고    scopus 로고
    • Point mutations in c-Myc uncouple neoplastic transformation from multiple other phenotypes in rat fibroblasts
    • Graves JA, Rothermund K, Wang T, Qian W, Van Houten B, Prochownik EV. Point mutations in c-Myc uncouple neoplastic transformation from multiple other phenotypes in rat fibroblasts. PLoS One 5: E13717
    • PLoS One , vol.5
    • Graves, J.A.1    Rothermund, K.2    Wang, T.3    Qian, W.4    Van Houten, B.5    Prochownik, E.V.6
  • 24
    • 0034036779 scopus 로고    scopus 로고
    • An in vivo function for the transforming Myc protein: Elicitation of the angiogenic phenotype
    • Ngo CV, Gee M, Akhtar N, Yu D, Volpert O, Auerbach R et al. An in vivo function for the transforming Myc protein: Elicitation of the angiogenic phenotype. Cell Growth Differ 2000; 11: 201-210
    • (2000) Cell Growth Differ , vol.11 , pp. 201-210
    • Ngo, C.V.1    Gee, M.2    Akhtar, N.3    Yu, D.4    Volpert, O.5    Auerbach, R.6
  • 27
    • 0037417130 scopus 로고    scopus 로고
    • Functional analysis of the N-Terminal domain of the Myc oncoprotein
    • Oster SK, Mao DY, Kennedy J, Penn LZ. Functional analysis of the N-Terminal domain of the Myc oncoprotein. Oncogene 2003; 22: 1998-2010
    • (2003) Oncogene , vol.22 , pp. 1998-2010
    • Oster, S.K.1    Mao, D.Y.2    Kennedy, J.3    Penn, L.Z.4
  • 28
    • 0037603113 scopus 로고    scopus 로고
    • Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures
    • Debnath J, Muthuswamy SK, Brugge JS. Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods 2003; 30: 256-268.
    • (2003) Methods , vol.30 , pp. 256-268
    • Debnath, J.1    Muthuswamy, S.K.2    Brugge, J.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.