The electroretinogram as a biomarker of central dopamine and serotonin: Potential relevance to psychiatric disorders

Biological Psychiatry

Volumn 75, Issue 6, 2014, Pages 479-486

  Lavoie, Joëlle ^a,b,c   Illiano, Placido ^d   Sotnikova, Tatyana D ^d   Gainetdinov, Raul R ^d   Beaulieu, Jean Martin ^a,c   Hébert, Marc ^b,c  

^a Department of Psychiatry and Neurosciences ^*  (Canada)

^b UNIVERSITÉ LAVAL   (Canada)

^c CENTRE DE RECHERCHE DE L INSTITUT UNIVERSITAIRE EN SANTÉ MENTALE DE QUÉBEC   (Canada)

^d ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

Author keywords

Biomarker; dopamine; dopamine transporter; electroretinogram; psychiatric disorders; serotonin

Indexed keywords

BIOLOGICAL MARKER; DOPAMINE; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; DOPAMINE TRANSPORTER; SEROTONIN; TPH2 PROTEIN, MOUSE; TRYPTOPHAN HYDROXYLASE;

ANIMAL; CORPUS STRIATUM; DOPAMINERGIC NERVE CELL; ELECTRORETINOGRAPHY; FEMALE; GENE TARGETING; GENETICS; KNOCKOUT MOUSE; MALE; MENTAL DISEASE; METABOLISM; MOUSE; PATHOPHYSIOLOGY; PHYSIOLOGY; RETINA; SEROTONINERGIC NERVE CELL; SYNAPTIC TRANSMISSION;

ANIMALS; BIOLOGICAL MARKERS; CORPUS STRIATUM; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DOPAMINERGIC NEURONS; ELECTRORETINOGRAPHY; FEMALE; GENE KNOCK-IN TECHNIQUES; MALE; MENTAL DISORDERS; MICE; MICE, KNOCKOUT; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D2; RETINA; SEROTONERGIC NEURONS; SEROTONIN; SYNAPTIC TRANSMISSION; TRYPTOPHAN HYDROXYLASE;

EID: 84894492918     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2012.11.024     Document Type: Article

References (54)

1. Z. Balogh, G. Benedek, and S. Keri Retinal dysfunctions in schizophrenia Prog Neuropsychopharmacol Biol Psychiatry 32 2008 297 300
2. R. Warner, J. Laugharne, M. Peet, L. Brown, and N. Rogers Retinal function as a marker for cell membrane omega-3 fatty acid depletion in schizophrenia: A pilot study Biol Psychiatry 45 1999 1138 1142
3. M. Hébert, M. Dumont, and P. Lachapelle Electrophysiological evidence suggesting a seasonal modulation of retinal sensitivity in subsyndromal winter depression J Affect Disord 68 2002 191 202
4. M. Hébert, C.W. Beattie, E.M. Tam, L.N. Yatham, and R.W. Lam Electroretinography in patients with winter seasonal affective disorder Psychiatry Res 127 2004 27 34
5. M.P. Lavoie, R.W. Lam, G. Bouchard, A. Sasseville, M.C. Charron, and A.M. Gagne Evidence of a biological effect of light therapy on the retina of patients with seasonal affective disorder Biol Psychiatry 66 2009 253 258
6. R.W. Lam, C.W. Beattie, A. Buchanan, and J.A. Mador Electroretinography in seasonal affective disorder Psychiatry Res 43 1992 55 63
7. E.R. Ritvo, D. Creel, G. Realmuto, A.S. Crandall, B.J. Freeman, and J.B. Bateman Electroretinograms in autism: A pilot study of b-wave amplitudes Am J Psychiatry 145 1988 229 232
8. M.J. Jaffe, G. Bruno, G. Campbell, R.A. Lavine, C.N. Karson, and D.R. Weinberger Ganzfeld electroretinographic findings in parkinsonism: Untreated patients and the effect of levodopa intravenous infusion J Neurol Neurosurg Psychiatry 50 1987 847 852
9. M. Hebert, A.M. Gagne, M.E. Paradis, V. Jomphe, M.A. Roy, and C. Merette Retinal response to light in young nonaffected offspring at high genetic risk of neuropsychiatric brain disorders Biol Psychiatry 67 2010 270 274
10. R.A. Reis, A.L. Ventura, R.C. Kubrusly, M.C. de Mello, and F.G. de Mello Dopaminergic signaling in the developing retina Brain Res Rev 54 2007 181 188
11. P. Witkovsky Dopamine and retinal function Doc Ophthalmol 108 2004 17 40
12. J.M. Beaulieu, and R.R. Gainetdinov The physiology, signaling, and pharmacology of dopamine receptors Pharmacol Rev 63 2011 182 217
13. J. Nguyen-Legros, A. Simon, I. Caille, and B. Bloch Immunocytochemical localization of dopamine D1 receptors in the retina of mammals Vis Neurosci 14 1997 545 551
14. M. Doi, I. Yujnovsky, J. Hirayama, M. Malerba, E. Tirotta, and P. Sassone-Corsi Impaired light masking in dopamine D2 receptor-null mice Nat Neurosci 9 2006 732 734
15. M.J. Kuhar, P.M. Sanchez-Roa, D.F. Wong, R.F. Dannals, D.E. Grigoriadis, and R. Lew Dopamine transporter: biochemistry, pharmacology and imaging Eur Neurol 30 suppl 1 1990 15 20
16. R.R. Gainetdinov, S.R. Jones, and M.G. Caron Functional hyperdopaminergia in dopamine transporter knock-out mice Biol Psychiatry 46 1999 303 311
17. S.R. Jones, R.R. Gainetdinov, M. Jaber, B. Giros, R.M. Wightman, and M.G. Caron Profound neuronal plasticity in response to inactivation of the dopamine transporter Proc Natl Acad Sci U S A 95 1998 4029 4034
18. M.J. Gastinger, N. Tian, T. Horvath, and D.W. Marshak Retinopetal axons in mammals: Emphasis on histamine and serotonin Curr Eye Res 31 2006 655 667
19. X. Zhang, J.M. Beaulieu, T.D. Sotnikova, R.R. Gainetdinov, and M.G. Caron Tryptophan hydroxylase-2 controls brain serotonin synthesis Science 305 2004 217
20. D.J. Walther, J.U. Peter, S. Bashammakh, H. Hortnagl, M. Voits, and H. Fink Synthesis of serotonin by a second tryptophan hydroxylase isoform Science 299 2003 76
21. J. Liang, J.H. Wessel 3rd, P.M. Iuvone, G. Tosini, and C. Fukuhara Diurnal rhythms of tryptophan hydroxylase 1 and 2 mRNA expression in the rat retina Neuroreport 15 2004 1497 1500
22. X. Zhang, R.R. Gainetdinov, J.M. Beaulieu, T.D. Sotnikova, L.H. Burch, and R.B. Williams Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression Neuron 45 2005 11 16
23. J.M. Beaulieu, X. Zhang, R.M. Rodriguiz, T.D. Sotnikova, M.J. Cools, and W.C. Wetsel Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiency Proc Natl Acad Sci U S A 105 2008 1333 1338
24. J.P. Jacobsen, W.B. Siesser, B.D. Sachs, S. Peterson, M.J. Cools, and V. Setola Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice Mol Psychiatry 17 2012 694 704
25. F. Huppe-Gourgues, G. Coude, P. Lachapelle, and C. Casanova Effects of the intravitreal administration of dopaminergic ligands on the b-wave amplitude of the rabbit electroretinogram Vision Res 45 2005 137 145
26. V. Porciatti, R. Alesci, P. Bagnoli, G. Signorini, and A. Raffaelli Serotonin depletion modifies the pigeon electroretinogram Doc Ophthalmol 72 1989 93 100
27. K. Nakatsuka, and D.I. Hamasaki Destruction of the indoleamine- accumulating amacrine cells alters the ERG of rabbits Invest Ophthalmol Vis Sci 26 1985 1109 1116
28. W. Skrandies, and H. Wassle Dopamine and serotonin in cat retina: Electroretinography and histology Exp Brain Res 71 1988 231 240
29. K. Holopigian, L. Clewner, W. Seiple, and M.J. Kupersmith The effects of dopamine blockade on the human flash electroretinogram Doc Ophthalmol 86 1994 1 10
30. T. Schneider, and E. Zrenner Effects of D-1 and D-2 dopamine antagonists on ERG and optic nerve response of the cat Exp Eye Res 52 1991 425 430
31. B. Giros, M. Jaber, S.R. Jones, R.M. Wightman, and M.G. Caron Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter Nature 379 1996 606 612
32. J. Drago, C.R. Gerfen, J.E. Lachowicz, H. Steiner, T.R. Hollon, and P.E. Love Altered striatal function in a mutant mouse lacking D1A dopamine receptors Proc Natl Acad Sci U S A 91 1994 12564 12568
33. M.A. Kelly, M. Rubinstein, S.L. Asa, G. Zhang, C. Saez, and J.R. Bunzow Pituitary lactotroph hyperplasia and chronic hyperprolactinemia in dopamine D2 receptor-deficient mice Neuron 19 1997 103 113
34. L. Wachtmeister Oscillatory potentials in the retina: What do they reveal Prog Retin Eye Res 17 1998 485 521
35. M. Hébert, P. Lachapelle, and M. Dumont Reproducibility of electroretinograms recorded with DTL electrodes Doc Ophthalmol 91 1995 333 342
36. R.R. Gainetdinov, W.C. Wetsel, S.R. Jones, E.D. Levin, M. Jaber, and M.G. Caron Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity Science 283 1999 397 401
37. G. Schechter, P. Hock, K. Rodgers, A. Pfefferbaum, M.F. Marmor, and P.A. Berger Electroretinographic assessment in schizophrenia Electroencephalogr Clin Neurophysiol Suppl 40 1987 746 751
38. M.F. Marmor, P. Hock, G. Schechter, A. Pfefferbaum, P.A. Berger, and R. Maurice Oscillatory potentials as a marker for dopaminergic disease Doc Ophthalmol 69 1988 255 261
39. A. Westrin, and R.W. Lam Seasonal affective disorder: A clinical update Ann Clin Psychiatry 19 2007 239 246
40. N. Praschak-Rieder, M. Willeit, A.A. Wilson, S. Houle, and J.H. Meyer Seasonal variation in human brain serotonin transporter binding Arch Gen Psychiatry 65 2008 1072 1078
41. M. Willeit, H.H. Sitte, N. Thierry, K. Michalek, N. Praschak-Rieder, and P. Zill Enhanced serotonin transporter function during depression in seasonal affective disorder Neuropsychopharmacology 33 2008 1503 1513
42. A. Neumeister, M. Willeit, N. Praschak-Rieder, S. Asenbaum, J. Stastny, and E. Hilger Dopamine transporter availability in symptomatic depressed patients with seasonal affective disorder and healthy controls Psychol Med 31 2001 1467 1473
43. A.M. Gagne, G. Bouchard, P. Tremblay, A. Sasseville, and M. Hebert [When a season means depression] Med Sci (Paris) 26 2010 79 82
44. D.A. Oren, A.A. Levendosky, S. Kasper, C.C. Duncan, and N.E. Rosenthal Circadian profiles of cortisol, prolactin, and thyrotropin in seasonal affective disorder Biol Psychiatry 39 1996 157 170
45. R.A. Depue, P. Arbisi, S. Krauss, W.G. Iacono, A. Leon, and R. Muir Seasonal independence of low prolactin concentration and high spontaneous eye blink rates in unipolar and bipolar II seasonal affective disorder Arch Gen Psychiatry 47 1990 356 364
46. C.N. Karson Spontaneous eye-blink rates and dopaminergic systems Brain 106 Pt 3 1983 643 653
47. R.A. Depue, P. Arbisi, M.R. Spoont, S. Krauss, A. Leon, and B. Ainsworth Seasonal and mood independence of low basal prolactin secretion in premenopausal women with seasonal affective disorder Am J Psychiatry 146 1989 989 995
48. R. Herrmann, S.J. Heflin, T. Hammond, B. Lee, J. Wang, and R.R. Gainetdinov Rod vision is controlled by dopamine-dependent sensitization of rod bipolar cells by GABA Neuron 72 2011 101 110
49. P.S. Goldman-Rakic, S.A. Castner, T.H. Svensson, L.J. Siever, and G.V. Williams Targeting the dopamine D1 receptor in schizophrenia: Insights for cognitive dysfunction Psychopharmacology (Berl) 174 2004 3 16
50. M. Maziade, N. Rouleau, C. Merette, C. Cellard, M. Battaglia, and C. Marino Verbal and visual memory impairments among young offspring and healthy adult relatives of patients with schizophrenia and bipolar disorder: Selective generational patterns indicate different developmental trajectories Schizophr Bull 37 2011 1218 1228
51. M.C. Citron, L. Erinoff, D.W. Rickman, and N.C. Brecha Modification of electroretinograms in dopamine-depleted retinas Brain Res 345 1985 186 191
52. B.L. Roth, D.J. Sheffler, and W.K. Kroeze Magic shotguns versus magic bullets: Selectively non-selective drugs for mood disorders and schizophrenia Nat Rev Drug Discov 3 2004 353 359
53. J.B. Eells The control of dopamine neuron development, function and survival: Insights from transgenic mice and the relevance to human disease Curr Med Chem 10 2003 857 870
54. R. Bosse, F. Fumagalli, M. Jaber, B. Giros, R.R. Gainetdinov, and W.C. Wetsel Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter Neuron 19 1997 127 138