Forelimb locomotor rating scale for behavioral assessment of recovery after unilateral cervical spinal cord injury in rats

Journal of Neuroscience Methods

Volumn 226, Issue , 2014, Pages 124-131

  Singh, Anita ^a   Krisa, Laura ^b,d   Frederick, Kelly L ^b   Sandrow Feinberg, Harra ^b   Balasubramanian, Sriram ^c   Stackhouse, Scott K ^b   Murray, Marion ^b   Shumsky, Jed S ^b  

^a UNIVERSITY OF DELAWARE   (United States)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^c DREXEL UNIVERSITY   (United States)

^d THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Behavioral test; Forelimb; Locomotion; Rat; Recovery of function; Spinal cord injury

Indexed keywords

ANIMAL; CERVICAL SPINE; CONVALESCENCE; DISABILITY; DISEASE MODEL; FEMALE; FORELIMB; HEMISPHERIC DOMINANCE; MOTOR ACTIVITY; PATHOLOGY; RAT; REPRODUCIBILITY; SEVERITY OF ILLNESS INDEX; SEX DIFFERENCE; SPINAL CORD; SPINAL CORD INJURIES; SPRAGUE DAWLEY RAT; TIME; VALIDATION STUDY;

ANIMALS; CERVICAL VERTEBRAE; DISABILITY EVALUATION; DISEASE MODELS, ANIMAL; FEMALE; FORELIMB; FUNCTIONAL LATERALITY; MOTOR ACTIVITY; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; REPRODUCIBILITY OF RESULTS; SEVERITY OF ILLNESS INDEX; SEX FACTORS; SPINAL CORD; SPINAL CORD INJURIES; TIME FACTORS;

EID: 84894458036     PISSN: 01650270     EISSN: 1872678X     Source Type: Journal    
DOI: 10.1016/j.jneumeth.2014.01.001     Document Type: Article

References (26)

1. Allred R.P., Adkins D.L., Woodlee M.T., Husbands L.C., Maldonado M.A., Kane J.R., et al. The vermicelli handling test: a simple quantitative measure of dexterous forepaw function in rats. J Neurosci Methods 2008, 170:229-244.
2. Anderson K.D., Gunawan A., Steward O. Quantitative assessment of forelimb motor function after cervical spinal cord injury in rats: relationship to the corticospinal tract. Exp Neurol 2005, 194:161-174.
3. Anderson K.D., Sharp K.G., Hofstadter M., Irvine K.A., Murray M., Steward O. Forelimb locomotor assessment scale (FLAS): novel assessment of forelimb dysfunction after cervical spinal cord injury. Exp Neurol 2009, 220(1):23-33.
4. Basso D.M., Beattie M.S., Bresnahan J.C. A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 1995, 12:1-21.
5. Basso D.M., Fisher L.C., Anderson A.J., Jakeman L.B., McTigue D.M., Popovich P.G. Basso Mouse Scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains. J Neurotrauma 2006, 23:635-659.
6. Bertelli J.A., Mira J.C. Behavioral evaluating methods in the objective clinical assessment of motor function after experimental brachial plexus reconstruction in the rat. J Neurosci Methods 1993, 46:203-208.
7. Cao Y., Shumsky J.S., Sabol M.A., Kushner R.A., Strittmatter S., Hamers F.P., et al. Nogo-66 receptor antagonist peptide (NEP1-40) administration promotes functional recovery and axonal growth after lateral funiculus injury in the adult rat. Neurorehabil Neural Repair 2008, 22:262-278.
8. Grill R., Murai K., Blesch A., Gage F.H., Tuszynski M.H. Cellular delivery of neurotrophin-3 promotes corticospinal axonal growth and partial functional recovery after spinal cord injury. J Neurosci 1997, 17:5560-5572.
9. Hamers F.P.T., Lankhorst A.J., Van Laar T.J., Veldhuis W.B., Gispen W.H. Automated quantitative gait analysis during overground locomotion in the rat: its application to spinal cord contusion and transaction injuries. J Neurotrauma 2001, 18:187-201.
10. Heiderstadt K.M., McLaughlin R.M., Wright D.C., Walker S.E., Gomez-Sanchez C.E. The effect of chronic food and water restriction on open-field behaviour and serum corticosterone levels in rats. Lab Anim 2000, 34(1):20-28.
11. Jang E.H., Ahn S.H., Lee Y.S., Lee H.R., Kaang B.K. Effect of food deprivation on a delayed nonmatch-to-place T-maze task. Exp Neurobiol 2013, 22(2):124-127.
12. Khaing Z.Z., Geissler A.S., Jiang S., Milman D.B., Aguilar V.S., Schmidt E.C., et al. Assessing forelimb function after unilateral cervical spinal cord injury: novel forelimb tasks predict lesion severity and recovery. J Neurotrauma 2012, 29(3):488-498.
13. Krisa L., Frederick K.L., Canver J., Stackhouse S.K., Shumsky J.S., Murray M. Amphetamine enhanced motor training following cervical contusion injury. J. Neurotrauma 2011, [Epub 2011, June 8].
14. Martinez M., Brezun J.M., Bonnier L., Xerri C. A new rating scale for openfield evaluation of behavioral recovery after cervical spinal cord injury in rats. J Neurotrauma 2009, 26:1043-1053.
15. McKenna J.E., Whishaw I.Q. Complete compensation in skilled reaching success with associated impairments in limb synergies after dorsal column lesion in the rat. J Neurosci 1999, 19:1885-1894.
16. Metz G.A., Dietz V., Schwab M.E., Van de Meent H. The effects of unilateral pyramidal tract section on hindlimb motor performance in the rat. Behav Brain Res 1998, 96:37-46.
17. National Spinal Cord Injury Statistical Center Spinal cord injury facts and figures at a glance. J Spinal Cord Med 2008, 31:357-358.
18. Onifer S.M., Zhang Y.P., Burke D.A., Brooks D.L., Decker J.A., McClure N.J., et al. Adult rat forelimb dysfunction after dorsal cervical spinal cord injury. Exp Neurol 2005, 192:25-38.
19. Rasband W.S. ImageJ 1997-2011, U.S. National Institutes of Health, Bethesda, Maryland, USA. http://imagej.nih.gov/ij/.
20. Sandrow-Feinberg H.R., Izzi J., Shumsky J.S., Zhukareva V., Houle J.D. Forced exercise as a rehabilitation strategy after unilateral cervical spinal cord contusion injury. J Neurotrauma 2009, 26:721-731.
21. Shumsky J.S., Tobias C.A., Tumolo M., Long W.D., Giszter S.F., Murray M. Delayed transplantation of fibroblasts genetically modified to secrete BDNF and NT-3 into a spinal cord injury site is associated with limited recovery of function. Exp Neurol 2003, 184:114-130.
22. Soblosky J.S., Colgin L.L., Chorney-Lane D., Davidson J.F., Carey M.E. Ladder beam and camera video recording system for evaluating forelimb and hindlimb deficits after sensorimotor cortex injury in rats. J Neurosci Methods 1997, 78:75-83.
23. Soblosky J.S., Song J.H., Dinh D.H. Graded unilateral cervical spinal cord injury in the rat: evaluation of forelimb recovery and histological effects. Behav Brain Res 2001, 119:1-13.
24. Stackhouse S.K., Murray M., Shumsky J.S. The effect of cervical dorsolateral funiculotemy on reach-to-grasp function in the rat. J Neurotrauma 2008, 25:1039-1047.
25. Tucci V., Hardy A., Nolan P.M. A comparison of physiological and behavioural parameters in C57BL/6J mice undergoing food or water restriction regimes. Behav Brain Res 2006, 2(1731):22-29.
26. Yanai S., Okaichi Y., Okaichi H. Long-term dietary restriction causes negative effects on cognitive functions in rats. Neurobiol Aging 2004, 25(3):325-332.