Global long interspersed nuclear element 1 DNA methylation in a Colombian sample of patients with late-onset Alzheimer's disease

American Journal of Alzheimer's Disease and other Dementias

Volumn 29, Issue 1, 2014, Pages 50-53

  Hernández, Hernán G ^a,b   Mahecha, María F ^b   Mejía, Adriana ^b   Arboleda, Humberto ^b   Forero, Diego A ^a  

^a CENTRO DE INVESTIGACIONES   (Colombia)

^b UNIVERSIDAD NACIONAL DE COLOMBIA   (Colombia)

Author keywords

DNA methylation; epigenetics; late onset Alzheimer's disease; Latin America; LINE 1; MS HRM; repetitive sequences

Indexed keywords

APOLIPOPROTEIN E4; BISULFITE; GENOMIC DNA;

AGED; ALZHEIMER DISEASE; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; COLOMBIA; CONTROLLED STUDY; DNA EXTRACTION; DNA METHYLATION; DNA METHYLATION ASSAY; FEMALE; HUMAN; LONG INTERSPERSED REPEAT; MALE;

DNA METHYLATION; EPIGENETICS; LATE-ONSET ALZHEIMER'S DISEASE; LATIN AMERICA; LINE-1; MS-HRM; REPETITIVE SEQUENCES;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; CASE-CONTROL STUDIES; COLOMBIA; DNA METHYLATION; FEMALE; HUMANS; LINEAR MODELS; LONG INTERSPERSED NUCLEOTIDE ELEMENTS; MALE;

EID: 84894448587     PISSN: 15333175     EISSN: 19382731     Source Type: Journal    
DOI: 10.1177/1533317513505132     Document Type: Article

References (18)

1. Marques SC, Oliveira CR, Outeiro TF, Pereira CM. Alzheimer's disease: the quest to understand complexity. J Alzheimers Dis. 2010 ; 21 (2). 373-383
2. Maestre GE. Dementia in Latin America and the Caribbean: an overlooked epidemic. Neuroepidemiology. 2008 ; 31 (4). 252-253
3. Wimo A, Winblad B, Jonsson L. The worldwide societal costs of dementia: estimates for 2009. Alzheimers Dement. 2010 ; 6 (2). 98-103
4. Arboleda GH, Yunis JJ, Pardo R, et al. Apolipoprotein E genotyping in a sample of Colombian patients with Alzheimer's disease. Neurosci Lett. 2001 ; 305 (2). 135-138
5. Rao JS, Keleshian VL, Klein S, Rapoport SI. Epigenetic modifications in frontal cortex from Alzheimer's disease and bipolar disorder patients. Transl Psychiatry. 2012 ; 2: e132
6. Weisenberger DJ, Campan M, Long TI, et al. Analysis of repetitive element DNA methylation by methylight. Nucleic Acids Res. 2005 ; 33 (21). 6823-6836
7. Tse MY, Ashbury JE, Zwingerman N, King WD, Taylor SA, Pang SC. A refined, rapid and reproducible high resolution melt (HRM)-based method suitable for quantification of global LINE-1 repetitive element methylation. BMC Res Notes. 2011 ; 4: 565
8. Bollati V, Galimberti D, Pergoli L, et al. DNA methylation in repetitive elements and Alzheimer disease. Brain Behav Immun. 2011 ; 25 (6). 1078-1083
9. Wojdacz TK, Dobrovic A. Methylation-sensitive high resolution melting (MS-HRM): a new approach for sensitive and high-throughput assessment of methylation. Nucleic Acids Res. 2007 ; 35 (6). e41
10. Hernandez HG, Tse MY, Pang SC, Arboleda H, Forero DA. Optimizing methodologies for PCR-based DNA methylation analysis. Biotechniques. 2013 ; 55 (4). 181-197
11. Forero DA, Benítez B, Arboleda G, Yunis JJ, Pardo R, Arboleda H.. Analysis of functional polymorphisms in three synaptic plasticity-related genes (BDNF, COMT AND UCHL1) in Alzheimer's disease in Colombia. Neurosci Res. 2006 ; 55 (3). 334-341
12. Booij BB, Lindahl T, Wetterberg P, et al. A gene expression pattern in blood for the early detection of Alzheimer's disease. J Alzheimers Dis. 2011 ; 23 (1). 109-119
13. Pellicano C, Buttarelli FR, Circella A, et al. Dopamine transporter immunoreactivity in peripheral blood lymphocytes discriminates Parkinson's disease from essential tremor. J Neural Transm. 2007 ; 114 (7). 935-938
14. Terry MB, Delgado-Cruzata L, Vin-Raviv N, Wu HC, Santella RM. DNA methylation in white blood cells: association with risk factors in epidemiologic studies. Epigenetics. 2011 ; 6 (7). 828-837
15. Wang SC, Oelze B, Schumacher A. Age-specific epigenetic drift in late-onset Alzheimer's disease. PLoS ONE. 2008 ; 3 (7). e2698
16. Wojdacz TK, Dobrovic A, Hansen LL. Methylation-sensitive high-resolution melting. Nat Protoc. 2008 ; 3 (12). 1903-1908
17. Bakulski KM, Dolinoy DC, Sartor MA, et al. Genome-wide DNA methylation differences between late-onset Alzheimer's disease and cognitively normal controls in human frontal cortex. J Alzheimers Dis. 2012 ; 29 (3). 571-588
18. Forero DA, Casadesus G, Perry G, Arboleda H. Synaptic dysfunction and oxidative stress in Alzheimer's disease: emerging mechanisms. J Cell Mol Med. 2006 ; 10 (3). 796-805