Genetics, epigenetics, and regulation of drug-metabolizing cytochrome P450 enzymes

Clinical Pharmacology and Therapeutics

Volumn 95, Issue 3, 2014, Pages 258-261

  Zanger, U M ^a,b   Klein, K ^a,b   Thomas, M ^a,b   Rieger, J K ^a,b   Tremmel, R ^a,b   Kandel, B A ^a,b   Klein, M ^a,b   Magdy, T ^a,b  

^a DR MARGARETE FISCHER BOSCH INSTITUTE OF CLINICAL PHARMACOLOGY   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P-450 ENZYME SYSTEM; DRUG DISCOVERY; EPIGENOMICS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENETIC VARIATION; GENETICS; HUMANS; ISOENZYMES; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84894437046     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2013.220     Document Type: Article

References (6)

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3. Thomas, M. et al. Direct transcriptional regulation of human hepatic cytochrome P450 3A4 (CYP3A4) by peroxisome proliferator-activated receptor alpha (PPARa). Mol. Pharmacol. 83, 709-718 (2013).
4. Ivanov, M., Kacevska, M. & Ingelman-Sundberg, M. Epigenomics and interindividual differences in drug response. Clin. Pharmacol. Ther. 92, 727-736 (2012).
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6. Zanger U.M., & Schwab M. Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacol. Ther. 138, 103-141 (2013). Clinica