Changes of microRNA profile and microRNA-mRNA regulatory network in bones of ovariectomized mice

Journal of Bone and Mineral Research

Volumn 29, Issue 3, 2014, Pages 644-656

  An, Jee Hyun ^a,b   Ohn, Jung Hun ^a   Song, Jung Ah ^a   Yang, Jae Yeon ^a   Park, Hyojung ^a   Choi, Hyung Jin ^a,c   Kim, Sang Wan ^a   Kim, Seong Yeon ^a   Park, Woog Yang ^a,d   Shin, Chan Soo ^a  

^a Seoul National University College of Medicine   (South Korea)

^b Konkuk University Hospital   (South Korea)

^c Chungbuk National University Hospital   (South Korea)

^d Samsung Medical Center   (South Korea)

Author keywords

CREB; microarray; microRNA; osteoporosis; ovariectomy; PPAR

Indexed keywords

CREB; MICROARRAY; MICRORNA; OSTEOPOROSIS; OVARIECTOMY; PPARΓ;

ANIMALS; BONE AND BONES; CELL DIFFERENTIATION; CELL LINE; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; ESTROGENS; FEMALE; MICE; MICE, INBRED C3H; MICRORNAS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OSTEOBLASTS; OVARIECTOMY; PPAR GAMMA;

EID: 84894424346     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.2060     Document Type: Article

References (51)

1. Albright F, Smith PH, Richardson AM., Postmenopausal osteoporosis. JAMA. 1941; 116: 2465-74.
2. Riggs BL, Wahner HW, Seeman E, et al. Changes in bone mineral density of the proximal femur and spine with aging. Differences between the postmenopausal and senile osteoporosis syndromes. J Clin Invest. 1982; 70: 716-23.
3. Richelson LS, Wahner HW, Melton LJ 3rd, Riggs BL., Relative contributions of aging and estrogen deficiency to postmenopausal bone loss. N Engl J Med. 1984; 311: 1273-5.
4. Effects of hormone therapy on bone mineral density: results from the postmenopausal estrogen/progestin interventions (PEPI) trial. The Writing Group for the PEPI. JAMA. 1996; 276: 1389-96.
5. Anderson GL, Limacher M, Assaf AR, et al. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial. JAMA. 2004; 291: 1701-12.
6. Bartel DP., MicroRNAs: target recognition and regulatory functions. Cell. 2009; 136: 215-33.
7. Berezikov E, Guryev V, van de Belt J, Wienholds E, Plasterk RH, Cuppen E., Phylogenetic shadowing and computational identification of human microRNA genes. Cell. 2005; 120: 21-4.
8. Esau C, Davis S, Murray SF, et al. miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting. Cell Metab. 2006; 3: 87-98.
9. Leung AK, Sharp PA., microRNAs: a safeguard against turmoil ? Cell. 2007; 130: 581-5.
10. Osman A., MicroRNAs in health and disease-basic science and clinical applications. Clin Lab. 2012; 58: 393-402.
11. Sayed D, Abdellatif M., MicroRNAs in development and disease. Physiol Rev. 2011; 91: 827-87.
12. Ajit SK., Circulating microRNAs as biomarkers, therapeutic targets, and signaling molecules. Sensors (Basel). 2012; 12: 3359-69.
13. Kobayashi T, Lu J, Cobb BS, et al. Dicer-dependent pathways regulate chondrocyte proliferation,differentiation. Proc Natl Acad Sci USA. 2008; 105: 1949-54.
14. Wienholds E, Kloosterman WP, Miska E, et al. MicroRNA expression in zebrafish embryonic development. Science. 2005; 309: 310-1.
15. Li Z, Hassan MQ, Volinia S, et al. A microRNA signature for a BMP2-induced osteoblast lineage commitment program. Proc Natl Acad Sci USA. 2008; 105: 13906-11.
16. Inose H, Ochi H, Kimura A, et al. A microRNA regulatory mechanism of osteoblast differentiation. Proc Natl Acad Sci USA. 2009; 106: 20794-9.
17. Huang J, Zhao L, Xing L, Chen D., MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation. Stem Cells. 2010; 28: 357-64.
18. Li H, Xie H, Liu W, et al. A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans. J Clin Invest. 2009; 119: 3666-77.
19. Kim KM, Park SJ, Jung SH, et al. miR-182 is a negative regulator of osteoblast proliferation, differentiation, and skeletogenesis through targeting FoxO1. J Bone Miner Res. 2012; 27: 1669-79.
20. Sugatani T, Hruska KA., MicroRNA-223 is a key factor in osteoclast differentiation. J Cell Biochem. 2007; 101: 996-9.
21. Sugatani T, Hruska KA., Impaired micro-RNA pathways diminish osteoclast differentiation and function. J Biol Chem. 2009; 284: 4667-78.
22. Sugatani T, Vacher J, Hruska KA., A microRNA expression signature of osteoclastogenesis. Blood. 2011; 117: 3648-57.
23. Bellino FL., Nonprimate animal models of menopause: workshop report. Menopause. 2000; 7: 14-24.
24. Kim D, Cho SW, Her SJ, et al. Retrovirus-mediated gene transfer of receptor activator of nuclear factor-kappaB-Fc prevents bone loss in ovariectomized mice. Stem Cells. 2006; 24: 1798-805.
25. Irizarry RA, Hobbs B, Collin F, et al. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics. 2003; 4: 249-64.
26. Smyth GK., Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol. 2004; 3: Article 3.
27. Lopez-Romero P, Gonzalez MA, Callejas S, Dopazo A, Irizarry RA., Processing of Agilent microRNA array data. BMC Res Notes. 2010; 3: 18.
28. Lewis BP, Burge CB, Bartel DP., Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell. 2005; 120: 15-20.
29. Krek A, Grun D, Poy MN, et al. Combinatorial microRNA target predictions. Nat Genet. 2005; 37: 495-500.
30. Huang da W, Sherman BT, Lempicki RA., Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 2009; 4: 44-57.
31. Subramanian A, Tamayo P, Mootha VK, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA. 2005; 102: 15545-50.
32. Cho SW, Yang JY, Her SJ, et al. Osteoblast-targeted overexpression of PPARgamma inhibited bone mass gain in male mice and accelerated ovariectomy-induced bone loss in female mice. J Bone Miner Res. 2011; 26: 1939-52.
33. An JH, Yang JY, Ahn BY, et al. Enhanced mitochondrial biogenesis contributes to Wnt induced osteoblastic differentiation of C3H10T1/2 cells. Bone. 2010; 47: 140-50.
34. Sato MM, Nashimoto M, Katagiri T, Yawaka Y, Tamura M., Bone morphogenetic protein-2 down-regulates miR-206 expression by blocking its maturation process. Biochem Biophys Res Commun. 2009; 383: 125-9.
35. Zhang Y, Xie RL, Croce CM, et al. A program of microRNAs controls osteogenic lineage progression by targeting transcription factor Runx2. Proc Natl Acad Sci USA. 2011; 108: 9863-8.
36. Kahai S, Lee SC, Lee DY, et al. MicroRNA miR-378 regulates nephronectin expression modulating osteoblast differentiation by targeting GalNT-7. PLoS One. 2009; 4: e7535.
37. Seitz H, Youngson N, Lin SP, et al. Imprinted microRNA genes transcribed antisense to a reciprocally imprinted retrotransposon-like gene. Nat Genet. 2003; 34: 261-2.
38. Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T., Identification of tissue-specific microRNAs from mouse. Curr Biol. 2002; 12: 735-9.
39. Li G, Luna C, Qiu J, Epstein DL, Gonzalez P., Role of miR-204 in the regulation of apoptosis, endoplasmic reticulum stress response, and inflammation in human trabecular meshwork cells. Invest Ophthalmol Vis Sci. 2011; 52: 2999-3007.
40. Xiao J, Zhu X, He B, et al. MiR-204 regulates cardiomyocyte autophagy induced by ischemia-reperfusion through LC3-II. J Biomed Sci. 2011; 18: 35.
41. Shan ZX, Lin QX, Deng CY, et al. miR-1/miR-206 regulate Hsp60 expression contributing to glucose-mediated apoptosis in cardiomyocytes. FEBS Lett. 2010; 584: 3592-600.
42. Shan ZX, Lin QX, Fu YH, et al. Upregulated expression of miR-1/miR-206 in a rat model of myocardial infarction. Biochem Biophys Res Commun. 2009; 381: 597-601.
43. Manolagas SC., Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr Rev. 2000; 21: 115-37.
44. Psarra AM, Solakidi S, Sekeris CE., The mitochondrion as a primary site of action of steroid and thyroid hormones: presence and action of steroid and thyroid hormone receptors in mitochondria of animal cells. Mol Cell Endocrinol. 2006; 246: 21-33.
45. Chen JQ, Brown TR, Yager JD., Mechanisms of hormone carcinogenesis: evolution of views, role of mitochondria. Adv Exp Med Biol. 2008; 630: 1-18.
46. Gigli I, Bussmann LE., Exercise and ovarian steroid hormones: their effects on mitochondrial respiration. Life Sci. 2001; 68: 1505-14.
47. Kliewer SA, Forman BM, Blumberg B, et al. Differential expression,activation of a family of murine peroxisome proliferator-activated receptors. Proc Natl Acad Sci USA. 1994; 91: 7355-9.
48. Tontonoz P, Hu E, Spiegelman BM., Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor [published erratum appears in Cell 1995 Mar 24;80(6):following 957]. Cell. 1994; 79: 1147-56.
49. Lecka-Czernik B, Gubrij I, Moerman EJ, et al. Inhibition of Osf2/Cbfa1 expression and terminal osteoblast differentiation by PPARgamma2. J Cell Biochem. 1999; 74: 357-71.
50. Rodriguez JP, Montecinos L, Rios S, Reyes P, Martinez J., Mesenchymal stem cells from osteoporotic patients produce a type I collagen-deficient extracellular matrix favoring adipogenic differentiation. J Cell Biochem. 2000; 79: 557-65.
51. Rosen CJ, Ackert-Bicknell C, Rodriguez JP, Pino AM., Marrow fat and the bone microenvironment: developmental, functional, and pathological implications. Crit Rev Eukaryot Gene Expr. 2009; 19: 109-24.