Pneumocystis jiroveci pneumonia in immunocompromised patients: Delayed diagnosis and poor outcomes in non-HIV-infected individuals

Journal of Microbiology, Immunology and Infection

Volumn 47, Issue 1, 2014, Pages 42-47

  Li, Ming Chi ^a   Lee, Nan Yao ^a   Lee, Ching Chi ^a   Lee, Hsin Chun ^a   Chang, Chia Ming ^a   Ko, Wen Chien ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

Human immunodeficiency virus; Immunocompromised; Pneumocystis jiroveci; Treatment

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS; IMMUNOCOMPROMISED; PNEUMOCYSTIS JIROVECI; TREATMENT;

ADULT; AGED; AGED, 80 AND OVER; DELAYED DIAGNOSIS; FEMALE; HUMANS; IMMUNOCOMPROMISED HOST; MALE; MIDDLE AGED; PNEUMOCYSTIS JIROVECII; PNEUMONIA, PNEUMOCYSTIS; PROGNOSIS; RISK FACTORS; SURVIVAL ANALYSIS; TAIWAN; TREATMENT OUTCOME;

EID: 84894415614     PISSN: 16841182     EISSN: 19959133     Source Type: Journal    
DOI: 10.1016/j.jmii.2012.08.024     Document Type: Article

References (31)

1. Radhi S., Alexander T., Ukwu M., Saleh S., Morris A. Outcome of HIV-associated Pneumocystis pneumonia in hospitalized patients from 2000 through 2003. BMC Infect Dis 2008, 8:118.
2. Enomoto T., Azuma A., Kohno A., Kaneko K., Saito H., Kametaka M., et al. Differences in the clinical characteristics of Pneumocystis jirovecii pneumonia in immunocompromized patients with and without HIV infection. Respirology 2010, 15:126-131.
3. Su Y.S., Lu J.J., Perng C.L., Chang F.Y. Pneumocystis jirovecii pneumonia in patients with and without human immunodeficiency virus infection. J Microbiol Immuno Infect 2008, 41:478-482.
4. Monnet X., Vidal-Petiot E., Osman D., Hamzaoui O., Durrbach A., Goujard C., et al. Critical care management and outcome of severe Pneumocystis pneumonia in patients with and without HIV infection. Crit Care 2008, 12. R28.
5. Pinlaor S., Mootsikapun P., Pinlaor P., Phunmanee A., Pipitgool V., Sithithaworn P., et al. PCR diagnosis of Pneumocystis carinii on sputum and bronchoalveolar lavage samples in immunocompromised patients. Parasitol Res 2004, 94:213-218.
6. Kaplan J.E., Hanson D., Dworkin M.S., Toni F., Jeanne B., Mary L.L., et al. Epidemiology of human immunodeficiency virus-associated opportunistic infections in the United States in the era of highly active antiretroviral therapy. Clin Infect Dis 2000, 30:S5-14.
7. Stephanie H.M., Rebecca C., Patricia K. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. N Engl J Med 1998, 339:405-406.
8. Mansharamani N.G. Management and outcome patterns for adult Pneumocystis carinii pneumonia, 1985 to 1995: comparison of HIV-associated cases to other immunocompromised states. Chest 2000, 118:704-711.
9. Tsai M.J., Chou C.W., Lin F.C., Chang S.C. Pneumocystis jiroveci pneumonia in patients with systemic lupus erythematosus after rituximab therapy. Lupus 2012, 21:914-918.
10. Hugle B., Solomon M., Harvey E., James A., Wadhwa A., Amin R., et al. Pneumocystis jiroveci pneumonia following rituximab treatment in Wegener's granulomatosis. Arthritis Care Res (Hoboken) 2010, 62:1661-1664.
11. Le Gal S., Damiani C., Rouille A., Grall A., Treguer L., Virmaux M., et al. A cluster of Pneumocystis infections among renal transplant recipients: molecular evidence of colonized patients as potential infectious sources of Pneumocystis jirovecii. Clin Infect Dis 2012, 54:e62-e71.
12. Phipps L.M., Chen S.C., Kable K., Halliday C.L., Firacative C., Meyer W., et al. Nosocomial Pneumocystis jirovecii pneumonia: lessons from a cluster in kidney transplant recipients. Transplantation 2011, 92:1327-1334.
13. Ainoda Y, Hirai Y, Fujita T, Isoda N, Totsuka K. Analysis of clinical features of non-HIV Pneumocystis jirovecii pneumonia. J Infect Chemother 2012 Mar 30. [Epub ahead ofprint].
14. Wakefield A.E. DNA sequences identical to Pneumocystis carinii f. sp. carinii and Pneumocystis carinii f. sp. hominis in samples of air spora. J Clin Microbiol 1996, 34:1754-1759.
15. Fine M.J., Singer D.E., Hanusa B.H., Lave J.R., Kapoor W.N. Validation of a pneumonia prognostic index using the MedisGroups Comparative Hospital Database. Am J Med 1993, 94:153-159.
16. Moon S.M., Kim T., Sung H., Kim S.H., Choi S.H., Jeong J.Y., et al. Outcomes of moderate-to-severe Pneumocystis pneumonia treated with adjunctive steroid in non-HIV-infected patients. Antimicrob Agents Chemother 2011, 55:4613-4618.
17. Sepkowitz K.A. Pneumocystis carinii pneumonia among patients with neoplastic disease. Semin Respir Infect 1992, 7:114-121.
18. Roblot F., Godet C., Le Moal G., Garo B., Faouzi Souala M., Dary M., et al. Analysis of underlying diseases and prognosis factors associated with Pneumocystis carinii pneumonia in immunocompromised HIV-negative patients. Eur J Clin Microbiol Infect Dis 2002, 21:523-531.
19. Azoulay E., Bergeron A., Chevret S., Bele N., Schlemmer B., Menotti J. Polymerase chain reaction for diagnosing Pneumocystis pneumonia in non-HIV immunocompromised patients with pulmonary infiltrates. Chest 2009, 135:655-661.
20. Morris A. Is there anything new in Pneumocystis jirovecii pneumonia? Changes in P. jirovecii pneumonia over the course of the AIDS epidemic. Clin Infect Dis 2008, 46:634-636.
21. Lee N.Y., Chang C.M., Lee C.C., Lee H.C., Li M.C., Ko W.C. Improved outcome of Pneumocystis pneumonia by early treatment. JMicrobiol Immunol Infect 2012, 45:163-164.
22. Tasaka S., Tokuda H., Sakai F., Fujii T., Tateda K., Johkoh T., et al. Comparison of clinical and radiological features of Pneumocystis pneumonia between malignancy cases and acquired immunodeficiency syndrome cases: a multicenter study. Intern Med 2010, 49:273-281.
23. Bollee G., Sarfati C., Thiery G., Bergeron A., de Miranda S., Menotti J., et al. Clinical picture of Pneumocystis jiroveci pneumonia in cancer patients. Chest 2007, 132:1305-1310.
24. Gordin F.M., Simon G.L., Wofsy C.B., Mills J. Adverse reactions to trimethoprim-sulfamethoxazole in patients with the acquired immunodeficiency syndrome. Ann Intern Med 1984, 100:495-499.
25. Lipschik G.Y., Gill V.J., Lundgren J.D., Andrawis V.A., Nelson N.A., Nielsen J.O., et al. Improved diagnosis of Pneumocystis carinii infection by polymerase chain reaction on induced sputum and blood. Lancet 1992, 340:203-206.
26. Wang H.W., Lin C.C., Kuo C.F., Liu C.P., Lee C.M. Mortality predictors of Pneumocystis jirovecii pneumonia in human immunodeficiency virus-infected patients at presentation: experience in a tertiary care hospital of northern Taiwan. J Microbiol Immunol Infect 2011, 44:274-281.
27. Matsumura Y., Shindo Y., linuma Y., Yamamoto M., Shirano M., Matsushima A., et al. Clinical characteristics of Pneumocystis pneumonia in non-HIV patients and prognostic factors including microbiological genotypes. BMC Infect Dis 2011, 11:76.
28. Ewig S., Bauer T., Schneider C., Pickenhain A., Pizzulli L., Loos U., et al. Clinical characteristics and outcome of Pneumocystis carinii pneumonia in HIV-infected and otherwise immunosuppressed patients. Eur Respir J 1995, 8:1548-1553.
29. Morris A., Kingsley L.A., Groner G., Lebedeva I.P., Beard C.B., Norris K.A. Prevalence and clinical predictors of Pneumocystis colonization among HIV-infected men. AIDS 2004, 18:793-798.
30. Davis J.L., Welsh D.A., Beard C.B., Jones J.L., Lawrence G.G., Fox M.R., et al. Pneumocystis colonisation is common among hospitalised HIV infected patients with non-Pneumocystis pneumonia. Thorax 2008, 63:329-334.
31. Limper A.H., Offord K.P., Smith T.F., Martin W.J. Pneumocystis carinii pneumonia. Differences in lung parasite number and inflammation in patients with and without AIDS. Am Rev Respir Dis 1989, 140:1204-1209.