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Volumn 37, Issue 2, 2014, Pages 105-114

Wilms tumor gene (WT1) peptide-based cancer vaccine combined with gemcitabine for patients with advanced pancreatic cancer

(32)  Nishida, Sumiyuki a,b   Koido, Shigeo f   Takeda, Yutaka a   Homma, Sadamu g   Komita, Hideo f   Takahara, Akitaka f   Morita, Satoshi i   Ito, Toshinori a   Morimoto, Soyoko b   Hara, Kazuma c   Tsuboi, Akihiro a   Oka, Yoshihiro b,e   Yanagisawa, Satoru h   Toyama, Yoichi i   Ikegami, Masahiro h   Kitagawa, Toru a   Eguchi, Hidetoshi a   Wada, Hiroshi a   Nagano, Hiroaki a   Nakata, Jun b   more..


Author keywords

cancer immunotherapy; gemcitabine; pancreatic cancer; Wilms tumor gene (WT1); WT1 peptide vaccine

Indexed keywords

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADENOCARCINOMA; ADULT; AGED; CANCER VACCINES; CELLS, CULTURED; DEOXYCYTIDINE; DRUG THERAPY, COMBINATION; FEASIBILITY STUDIES; FEMALE; HLA-A24 ANTIGEN; HUMANS; HYPERSENSITIVITY, DELAYED; IMMUNOLOGIC MEMORY; MALE; MANNITOL; MIDDLE AGED; NEOPLASM METASTASIS; NEOPLASM STAGING; OLEIC ACIDS; PANCREATIC NEOPLASMS; PEPTIDE FRAGMENTS; SURVIVAL ANALYSIS; T-LYMPHOCYTES, CYTOTOXIC; TUMOR SUPPRESSOR PROTEINS; VACCINES, SUBUNIT;

EID: 84894412309     PISSN: 15249557     EISSN: 15374513     Source Type: Journal    
DOI: 10.1097/CJI.0000000000000020     Document Type: Article
Times cited : (78)

References (42)
  • 1
    • 77949264996 scopus 로고    scopus 로고
    • Advanced pancreatic carcinoma: Current treatment and future challenges
    • Stathis A, Moore MJ. Advanced pancreatic carcinoma: current treatment and future challenges. Nat Rev Clin Oncol. 2010;7: 163-172.
    • (2010) Nat Rev Clin Oncol. , vol.7 , pp. 163-172
    • Stathis, A.1    Moore, M.J.2
  • 2
    • 8244254377 scopus 로고    scopus 로고
    • Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial
    • Burris HA III, Moore MJ, Andersen J, et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol. 1997;15:2403-2413.
    • (1997) J Clin Oncol , vol.15 , pp. 2403-2413
    • Burris III, H.A.1    Moore, M.J.2    Andersen, J.3
  • 3
    • 34249933404 scopus 로고    scopus 로고
    • Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group
    • Moore MJ, Goldstein D, Hamm J, et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol. 2007;25:1960-1966.
    • (2007) J Clin Oncol , vol.25 , pp. 1960-1966
    • Moore, M.J.1    Goldstein, D.2    Hamm, J.3
  • 4
    • 60249091474 scopus 로고    scopus 로고
    • Use of tumour-responsive T cells as cancer treatment
    • Disis ML, Bernhard H, Jaffee EM. Use of tumour-responsive T cells as cancer treatment. Lancet. 2009;373:673-683.
    • (2009) Lancet , vol.373 , pp. 673-683
    • Disis, M.L.1    Bernhard, H.2    Jaffee, E.M.3
  • 5
    • 84255197842 scopus 로고    scopus 로고
    • Cancer immunotherapy comes of age
    • Mellman I, Coukos G, Dranoff G. Cancer immunotherapy comes of age. Nature. 2011;480:480-489.
    • (2011) Nature , vol.480 , pp. 480-489
    • Mellman, I.1    Coukos, G.2    Dranoff, G.3
  • 6
    • 4644324025 scopus 로고    scopus 로고
    • Cancer immunotherapy: Moving beyond current vaccines
    • Rosenberg SA, Yang JC, Restifo NP. Cancer immunotherapy: moving beyond current vaccines. Nat Med. 2004;10:909-915.
    • (2004) Nat Med , vol.10 , pp. 909-915
    • Rosenberg, S.A.1    Yang, J.C.2    Restifo, N.P.3
  • 7
    • 58149307496 scopus 로고    scopus 로고
    • Combinatorial treatments including vaccines, chemotherapy and monoclonal antibodies for cancer therapy
    • Baxevanis CN, Perez SA, Papamichail M. Combinatorial treatments including vaccines, chemotherapy and monoclonal antibodies for cancer therapy. Cancer Immunol Immunother. 2009;58:317-324.
    • (2009) Cancer Immunol Immunother , vol.58 , pp. 317-324
    • Baxevanis, C.N.1    Perez, S.A.2    Papamichail, M.3
  • 8
    • 33751209215 scopus 로고    scopus 로고
    • Combined chemoimmunotherapy of solid tumours: Improving vaccines?
    • Nowak AK, Lake RA, Robinson BWS. Combined chemoimmunotherapy of solid tumours: improving vaccines? Adv Drug Deliv Rev. 2006;58:975-990.
    • (2006) Adv Drug Deliv Rev. , vol.58 , pp. 975-990
    • Nowak, A.K.1    Lake, R.A.2    Bws, R.3
  • 10
    • 77951178310 scopus 로고    scopus 로고
    • Chemotherapy enhances tumor cell susceptibility to CTL-mediated killing during cancer immunotherapy in mice
    • Ramakrishnan R, Assudani D, Nagaraj S, et al. Chemotherapy enhances tumor cell susceptibility to CTL-mediated killing during cancer immunotherapy in mice. J Clin Invest. 2010;120:1111-1124.
    • (2010) J Clin Invest , vol.120 , pp. 1111-1124
    • Ramakrishnan, R.1    Assudani, D.2    Nagaraj, S.3
  • 11
    • 80054691705 scopus 로고    scopus 로고
    • Gemcitabine enhances Wilms' tumor gene WT1 expression and sensitizes human pancreatic cancer cells with WT1-specific T-cell-mediated antitumor immune response
    • Takahara A, Koido S, Ito M, et al. Gemcitabine enhances Wilms' tumor gene WT1 expression and sensitizes human pancreatic cancer cells with WT1-specific T-cell-mediated antitumor immune response. Cancer Immunol Immunother. 2011;60:1289-1297.
    • (2011) Cancer Immunol Immunother , vol.60 , pp. 1289-1297
    • Takahara, A.1    Koido, S.2    Ito, M.3
  • 12
    • 79151472081 scopus 로고    scopus 로고
    • Wilms' tumours: About tumour suppressor genes, an oncogene and a chameleon gene
    • Huff V. Wilms' tumours: about tumour suppressor genes, an oncogene and a chameleon gene. Nature Rev Cancer. 2011;11:111-121.
    • (2011) Nature Rev Cancer , vol.11 , pp. 111-121
    • Huff, V.1
  • 13
    • 77952566271 scopus 로고    scopus 로고
    • WT1 (Wilms' tumor gene 1): Biology and cancer immunotherapy
    • Sugiyama H. WT1 (Wilms' tumor gene 1): biology and cancer immunotherapy. Jpn J Clin Oncol. 2010;40:377-387.
    • (2010) Jpn J Clin Oncol , vol.40 , pp. 377-387
    • Sugiyama, H.1
  • 14
    • 0036566202 scopus 로고    scopus 로고
    • Humoral immune responses against Wilms' tumor gene WT1 product in patients with hematopoietic malignancies
    • Elisseeva OA, Oka Y, Tsuboi A, et al. Humoral immune responses against Wilms' tumor gene WT1 product in patients with hematopoietic malignancies. Blood. 2002;99:3272-3279.
    • (2002) Blood , vol.99 , pp. 3272-3279
    • Elisseeva, O.A.1    Oka, Y.2    Tsuboi, A.3
  • 15
    • 0035287994 scopus 로고    scopus 로고
    • WT1-specific serum antibodies in patients with leukemia
    • Gaiger A, Carter L, Greinix H, et al. WT1-specific serum antibodies in patients with leukemia. Clin Cancer Res. 2001; 7:761s-765s.
    • (2001) Clin Cancer Res , vol.7
    • Gaiger, A.1    Carter, L.2    Greinix, H.3
  • 16
    • 67449088945 scopus 로고    scopus 로고
    • WT1 IgG antibody for early detection of nonsmall cell lung cancer and as its prognostic factor
    • Oji Y, Kitamura Y, Kamino E, et al. WT1 IgG antibody for early detection of nonsmall cell lung cancer and as its prognostic factor. Int J Cancer. 2009;125:381-387.
    • (2009) Int J Cancer , vol.125 , pp. 381-387
    • Oji, Y.1    Kitamura, Y.2    Kamino, E.3
  • 17
    • 0034112824 scopus 로고    scopus 로고
    • Human cytotoxic Tlymphocyte responses specific for peptides of the wild-type Wilms' tumor gene (WT1) product
    • Oka Y, Elisseeva OA, Tsuboi A, et al. Human cytotoxic Tlymphocyte responses specific for peptides of the wild-type Wilms' tumor gene (WT1) product. Immunogenetics. 2000; 51:99-107.
    • (2000) Immunogenetics , vol.51 , pp. 99-107
    • Oka, Y.1    Elisseeva, O.A.2    Tsuboi, A.3
  • 18
    • 29344436442 scopus 로고    scopus 로고
    • T-cell responses directed against multiple HLA-A*0201-restricted epitopes derived from Wilms' tumor 1 protein in patients with leukemia and healthy donors: Identification, quantification, and characterization
    • Rezvani K, Brenchley JM, Price DA, et al. T-cell responses directed against multiple HLA-A*0201-restricted epitopes derived from Wilms' tumor 1 protein in patients with leukemia and healthy donors: identification, quantification, and characterization. Clin Cancer Res. 2005;11:8799-8807.
    • (2005) Clin Cancer Res , vol.11 , pp. 8799-8807
    • Rezvani, K.1    Brenchley, J.M.2    Price, D.A.3
  • 19
    • 4644289323 scopus 로고    scopus 로고
    • Induction of WT1 (Wilms' tumor gene)-specific cytotoxic T lymphocytes by WT1 peptide vaccine and the resultant cancer regression
    • Oka Y, Tsuboi A, Taguchi T, et al. Induction of WT1 (Wilms' tumor gene)-specific cytotoxic T lymphocytes by WT1 peptide vaccine and the resultant cancer regression. Proc Natl Acad Sci USA. 2004;101:13885-13890.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 13885-13890
    • Oka, Y.1    Tsuboi, A.2    Taguchi, T.3
  • 20
    • 33745686444 scopus 로고    scopus 로고
    • A phase I/II trial of a WT1 (Wilms' tumor gene) peptide vaccine in patients with solid malignancy: Safety assessment based on the phase i data
    • Morita S, Oka Y, Tsuboi A, et al. A phase I/II trial of a WT1 (Wilms' tumor gene) peptide vaccine in patients with solid malignancy: safety assessment based on the phase I data. Jpn J Clin Oncol. 2006;36:231-236.
    • (2006) Jpn J Clin Oncol. , vol.36 , pp. 231-236
    • Morita, S.1    Oka, Y.2    Tsuboi, A.3
  • 21
    • 43249090418 scopus 로고    scopus 로고
    • Phase II clinical trial of Wilms tumor 1 peptide vaccination for patients with recurrent glioblastoma multiforme
    • Izumoto S, Tsuboi A, Oka Y, et al. Phase II clinical trial of Wilms tumor 1 peptide vaccination for patients with recurrent glioblastoma multiforme. J Neurosurg. 2008;108:963-971.
    • (2008) J Neurosurg. , vol.108 , pp. 963-971
    • Izumoto, S.1    Tsuboi, A.2    Oka, Y.3
  • 22
    • 84876307846 scopus 로고    scopus 로고
    • WT1 peptide immunotherapy for gynecologic malignancies resistant to conventional therapies: A phase II trial
    • Miyatake T, Ueda Y, Morimoto A, et al. WT1 peptide immunotherapy for gynecologic malignancies resistant to conventional therapies: a phase II trial. J Cancer Res Clin Oncol. 2013;139:457-463.
    • (2013) J Cancer Res Clin Oncol , vol.139 , pp. 457-463
    • Miyatake, T.1    Ueda, Y.2    Morimoto, A.3
  • 23
    • 84861999235 scopus 로고    scopus 로고
    • Long-term WT1 peptide vaccination for patients with acute myeloid leukemia with minimal residual disease
    • Tsuboi A, Oka Y, Kyo T, et al. Long-term WT1 peptide vaccination for patients with acute myeloid leukemia with minimal residual disease. Leukemia. 2012;26:1410-1413.
    • (2012) Leukemia , vol.26 , pp. 1410-1413
    • Tsuboi, A.1    Oka, Y.2    Kyo, T.3
  • 24
    • 84858002036 scopus 로고    scopus 로고
    • WT1 peptide vaccination following allogeneic stem cell transplantation in pediatric leukemic patients with high risk for relapse: Successful maintenance of durable remission
    • Hashii Y, Sato-Miyashita E, Matsumura R, et al. WT1 peptide vaccination following allogeneic stem cell transplantation in pediatric leukemic patients with high risk for relapse: successful maintenance of durable remission. Leukemia. 2012; 26:530-532.
    • (2012) Leukemia , vol.26 , pp. 530-532
    • Hashii, Y.1    Sato-Miyashita, E.2    Matsumura, R.3
  • 25
    • 69249220181 scopus 로고    scopus 로고
    • A clinical and immunologic phase 2 trial of Wilms tumor gene product 1 (WT1) peptide vaccination in patients with AML and MDS
    • Keilholz U, Letsch A, Busse A, et al. A clinical and immunologic phase 2 trial of Wilms tumor gene product 1 (WT1) peptide vaccination in patients with AML and MDS. Blood. 2009;113:6541-6548.
    • (2009) Blood. , vol.113 , pp. 6541-6548
    • Keilholz, U.1    Letsch, A.2    Busse, A.3
  • 26
    • 38049188363 scopus 로고    scopus 로고
    • Leukemia-associated antigen-specific T-cell responses following combined PR1 and WT1 peptide vaccination in patients with myeloid malignancies
    • Rezvani K, Yong AS, Mielke S, et al. Leukemia-associated antigen-specific T-cell responses following combined PR1 and WT1 peptide vaccination in patients with myeloid malignancies. Blood. 2008;111:236-242.
    • (2008) Blood , vol.111 , pp. 236-242
    • Rezvani, K.1    Yong, A.S.2    Mielke, S.3
  • 27
    • 0027407786 scopus 로고
    • The functional assessment of cancer therapy scale: Development and validation of the general measure
    • Cella DF, Tulsky DS, Gray G, et al. The functional assessment of cancer therapy scale: development and validation of the general measure. J Clin Oncol. 1993;11:570-579.
    • (1993) J Clin Oncol , vol.11 , pp. 570-579
    • Cella, D.F.1    Tulsky, D.S.2    Gray, G.3
  • 28
    • 13944260238 scopus 로고    scopus 로고
    • Pancreatic cancer and thromboembolic disease
    • Khorana AA, Fine RL. Pancreatic cancer and thromboembolic disease. Lancet Oncol. 2004;5:655-663.
    • (2004) Lancet Oncol , vol.5 , pp. 655-663
    • Khorana, A.A.1    Fine, R.L.2
  • 29
    • 0942265619 scopus 로고    scopus 로고
    • Symptomatic venous thromboembolism in cancer patients treated with chemotherapy: An underestimated phenomenon
    • Otten HM, Mathijssen J, ten Cate H, et al. Symptomatic venous thromboembolism in cancer patients treated with chemotherapy: an underestimated phenomenon. Arch Intern Med. 2004;164:190-194.
    • (2004) Arch Intern Med , vol.164 , pp. 190-194
    • Otten, H.M.1    Mathijssen, J.2    Ten Cate, H.3
  • 30
    • 0035082324 scopus 로고    scopus 로고
    • Phase i trial of gemcitabine in patients with advanced pancreatic cancer
    • Okada S, Ueno H, Okusaka T, et al. Phase I trial of gemcitabine in patients with advanced pancreatic cancer. Jpn J Clin Oncol. 2001;31:7-12.
    • (2001) Jpn J Clin Oncol. , vol.31 , pp. 7-12
    • Okada, S.1    Ueno, H.2    Okusaka, T.3
  • 31
    • 0034663331 scopus 로고    scopus 로고
    • Immunity to WT1 in the animal model and in patients with acute myeloid leukemia
    • Gaiger A, Reese V, Disis ML, et al. Immunity to WT1 in the animal model and in patients with acute myeloid leukemia. Blood. 2000;96:1480-1489.
    • (2000) Blood , vol.96 , pp. 1480-1489
    • Gaiger, A.1    Reese, V.2    Disis, M.L.3
  • 32
    • 0034176750 scopus 로고    scopus 로고
    • Selective elimination of leukemic CD34+ progenitor cells by cytotoxic T lymphocytes specific for WT1
    • Gao L, Bellantuono I, Elsasser A, et al. Selective elimination of leukemic CD34+ progenitor cells by cytotoxic T lymphocytes specific for WT1. Blood. 2000;95:2198-2203.
    • (2000) Blood , vol.95 , pp. 2198-2203
    • Gao, L.1    Bellantuono, I.2    Elsasser, A.3
  • 33
    • 84880047829 scopus 로고    scopus 로고
    • Randomized phase III study of gemcitabine plus S-1, S-1 alone, or gemcitabine alone in patients with locally advanced and metastatic pancreatic cancer in Japan and Taiwan: GEST study
    • Ueno H, Ioka T, Ikeda M, et al. Randomized phase III study of gemcitabine plus S-1, S-1 alone, or gemcitabine alone in patients with locally advanced and metastatic pancreatic cancer in Japan and Taiwan: GEST study. J Clin Oncol. 2013; 31:1640-1648.
    • (2013) J Clin Oncol. , vol.31 , pp. 1640-1648
    • Ueno, H.1    Ioka, T.2    Ikeda, M.3
  • 34
    • 79955921754 scopus 로고    scopus 로고
    • FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer
    • Conroy T, Desseigne F, Ychou M, et al. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med. 2011;364:1817-1825.
    • (2011) N Engl J Med , vol.364 , pp. 1817-1825
    • Conroy, T.1    Desseigne, F.2    Ychou, M.3
  • 35
    • 84871723767 scopus 로고    scopus 로고
    • Impact of FOLFIRINOX compared with gemcitabine on quality of life in patients with metastatic pancreatic cancer: Results from the PRODIGE 4/ACCORD 11 randomized trial
    • Gourgou-Bourgade S, Bascoul-Mollevi C, Desseigne F, et al. Impact of FOLFIRINOX compared with gemcitabine on quality of life in patients with metastatic pancreatic cancer: results from the PRODIGE 4/ACCORD 11 randomized trial. J Clin Oncol. 2013;31:23-29.
    • (2013) J Clin Oncol , vol.31 , pp. 23-29
    • Gourgou-Bourgade, S.1    Bascoul-Mollevi, C.2    Desseigne, F.3
  • 36
    • 79953816808 scopus 로고    scopus 로고
    • Immunologic biomarkers as correlates of clinical response to cancer immunotherapy
    • Disis ML. Immunologic biomarkers as correlates of clinical response to cancer immunotherapy. Cancer Immunol Immunother. 2011;60:433-442.
    • (2011) Cancer Immunol Immunother , vol.60 , pp. 433-442
    • Disis, M.L.1
  • 37
    • 78650743475 scopus 로고    scopus 로고
    • Long-term follow-up of patients with resected pancreatic cancer following vaccination against mutant K-ras
    • Weden S, Klemp M, Gladhaug IP, et al. Long-term follow-up of patients with resected pancreatic cancer following vaccination against mutant K-ras. Int J Cancer. 2011;128:1120-1128.
    • (2011) Int J Cancer , vol.128 , pp. 1120-1128
    • Weden, S.1    Klemp, M.2    Gladhaug, I.P.3
  • 38
    • 0038326676 scopus 로고    scopus 로고
    • Induction of tumor cell apoptosis in vivo increases tumor antigen cross-presentation, cross-priming rather than cross-tolerizing host tumorspecific CD8 T cells
    • Nowak AK, Lake RA, Marzo AL, et al. Induction of tumor cell apoptosis in vivo increases tumor antigen cross-presentation, cross-priming rather than cross-tolerizing host tumorspecific CD8 T cells. J Immunol. 2003;170:4905-4913.
    • (2003) J Immunol , vol.170 , pp. 4905-4913
    • Nowak, A.K.1    Lake, R.A.2    Marzo, A.L.3
  • 39
    • 0037089545 scopus 로고    scopus 로고
    • Gemcitabine exerts a selective effect on the humoral immune response: Implications for combination chemo-immunotherapy
    • Nowak AK, Robinson BWS, Lake RA. Gemcitabine exerts a selective effect on the humoral immune response: implications for combination chemo-immunotherapy. Cancer Res. 2002;62:2353-2358.
    • (2002) Cancer Res. , vol.62 , pp. 2353-2358
    • Nowak, A.K.1    Bws, R.2    Lake, R.A.3
  • 40
    • 25144466458 scopus 로고    scopus 로고
    • Gemcitabine selectively eliminates splenic Gr-1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity
    • Suzuki E, Kapoor V, Jassar AS, et al. Gemcitabine selectively eliminates splenic Gr-1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity. Clin Cancer Res. 2005;11:6713-6721.
    • (2005) Clin Cancer Res , vol.11 , pp. 6713-6721
    • Suzuki, E.1    Kapoor, V.2    Jassar, A.S.3
  • 41
    • 79959733137 scopus 로고    scopus 로고
    • Gemcitabine depletes regulatory T-cells in human and mice and enhances triggering of vaccine-specific cytotoxic T-cells
    • Rettig L, Seidenberg S, Parvanova I, et al. Gemcitabine depletes regulatory T-cells in human and mice and enhances triggering of vaccine-specific cytotoxic T-cells. Int J Cancer. 2010;129:832-838.
    • (2010) Int J Cancer , vol.129 , pp. 832-838
    • Rettig, L.1    Seidenberg, S.2    Parvanova, I.3
  • 42
    • 79959518670 scopus 로고    scopus 로고
    • Specificity for the tumorassociated self-antigen WT1 drives the development of fully functional memory T cells in the absence of vaccination
    • Pospori C, Xue SA, Holler A, et al. Specificity for the tumorassociated self-antigen WT1 drives the development of fully functional memory T cells in the absence of vaccination. Blood. 2011;117:6813-6824.
    • (2011) Blood , vol.117 , pp. 6813-6824
    • Pospori, C.1    Xue, S.A.2    Holler, A.3


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