Meclizine inhibits mitochondrial respiration through direct targeting of cytosolic phosphoethanolamine metabolism

Journal of Biological Chemistry

Volumn 288, Issue 49, 2013, Pages 35489-35499

  Gohil, Vishal M ^a,b,c,d   Zhu, Lin ^e   Baker, Charli D ^d   Cracan, Valentin ^a,b,c   Yaseen, Abbas ^a   Jain, Mohit ^a,b,c   Clish, Clary B ^b   Brookes, Paul S ^f   Bakovic, Marica ^e   Mootha, Vamsi K ^a,b,c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d TEXAS A AND M UNIVERSITY   (United States)

^e UNIVERSITY OF GUELPH   (Canada)

^f UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY;

CLINICAL APPLICATION; CYTIDYLYLTRANSFERASE; KENNEDY PATHWAYS; MITOCHONDRIAL RESPIRATION; MOLECULAR TARGETS; OVER THE COUNTERS; PHOSPHATIDYLETHANOLAMINE; PHOSPHOETHANOLAMINE;

MITOCHONDRIA;

CHOLINE PHOSPHATE CYTIDYLYLTRANSFERASE; MECLOZINE; PHOSPHOETHANOLAMINE; ANTIEMETIC AGENT; ENZYME INHIBITOR; ETHANOLAMINE DERIVATIVE; ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE; RNA POLYMERASE;

ARTICLE; BIOACCUMULATION; BIOSYNTHESIS; CELL LEVEL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSOL; DRUG MECHANISM; DRUG TARGETING; ENZYME INHIBITION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; IN VITRO STUDY; KENNEDY PATHWAY; MITOCHONDRIAL RESPIRATION; PRIORITY JOURNAL; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CELL RESPIRATION; DRUG EFFECTS; GENE SILENCING; GENETICS; METABOLISM; MITOCHONDRION; MOUSE;

ANIMALS; ANTIEMETICS; CELL LINE; CELL RESPIRATION; CYTOSOL; ENZYME INHIBITORS; ETHANOLAMINES; GENE KNOCKDOWN TECHNIQUES; HUMANS; MECLIZINE; METABOLIC NETWORKS AND PATHWAYS; MICE; MITOCHONDRIA; RNA NUCLEOTIDYLTRANSFERASES;

EID: 84894372000     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.489237     Document Type: Article

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