The effect of estradiol, progesterone, and melatonin on estrous cycling and ovarian aromatase expression in intact female mice

European Journal of Obstetrics and Gynecology and Reproductive Biology

Volumn 174, Issue 1, 2014, Pages 80-85

  Bondi, C D ^a   Alonso Gonzalez, C ^b   Clafshenkel, W P ^a   Kotlarczyk, M P ^a   Dodda, B R ^a   Sanchez Barcelo, E ^b   Davis, V L ^a,c   Witt Enderby, P A ^a  

^a DUQUESNE UNIVERSITY   (United States)

^b UNIVERSITY OF CANTABRIA   (Spain)

^c CLARION UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Aromatase; Estrogen; Hormone replacement therapy; Melatonin; Progesterone; Selective estrogen enzyme modulator (SEEM)

Indexed keywords

AROMATASE; DRINKING WATER; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; MELATONIN; MESSENGER RNA; PROGESTERONE; PROGESTERONE RECEPTOR A;

ARTICLE; CLIMACTERIUM; CONTROLLED STUDY; DIET; DRUG EFFECT; ESTROGEN BLOOD LEVEL; ESTROGEN SYNTHESIS; ESTRUS CYCLE; FEMALE; FEMALE GENITAL SYSTEM; HORMONE SUBSTITUTION; MOUSE; NONHUMAN; OVARY; PRIORITY JOURNAL; PROGESTERONE BLOOD LEVEL; PROTEIN EXPRESSION; TREATMENT DURATION; UTERUS WEIGHT;

AROMATASE; ESTROGEN; HORMONE REPLACEMENT THERAPY; MELATONIN; PROGESTERONE; SELECTIVE ESTROGEN ENZYME MODULATOR (SEEM);

ANIMALS; AROMATASE; DRUG INTERACTIONS; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROUS CYCLE; FEMALE; GENE EXPRESSION; MELATONIN; MENOPAUSE; MICE; ORGAN SIZE; OVARY; PROGESTERONE; RECEPTORS, PROGESTERONE; RNA, MESSENGER; UTERUS;

EID: 84894276778     PISSN: 03012115     EISSN: 18727654     Source Type: Journal    
DOI: 10.1016/j.ejogrb.2013.11.027     Document Type: Article

References (46)

1. R.J. Santen, D.C. Allred, and S.P. Ardoin et al. Postmenopausal hormone therapy: an Endocrine Society scientific statement J Clin Endocrinol Metab 95 7 Suppl. 1 2010 s1 s66
2. G.A. Wood, J.E. Fata, K.L. Watson, and R. Khokha Circulating hormones and estrous stage predict cellular and stromal remodeling in murine uterus Reproduction 133 2007 1035 1044
3. J.C. Prior, and C.L. Hitchcock The endocrinology of perimenopause: need for a paradigm shift Front Biosci 3 2011 474 486
4. J.C. Prior Ovarian aging and the perimenopausal transition: the paradox of endogenous ovarian hyperstimulation Endocrine 26 2005 297 300
5. E.J. Sanchez-Barcelo, S. Cos, D. Mediavilla, C. Martinez-Campa, A. Gonzalez, and C. Alonso-Gonzalez Melatonin-estrogen interactions in breast cancer J Pineal Res 38 2005 217 222
6. S.G. Grant, M.A. Melan, J.J. Latimer, and P.A. Witt-Enderby Melatonin and breast cancer: cellular mechanisms, clinical studies and future perspectives Expert Rev Mol Med 11 2009 e5
7. H. Iguichi, K.I. Kato, and H. Ibayashi Age-dependent reduction in serum melatonin concentrations in healthy human subjects J Clin Endocrinol Metab 55 1982 27 29
8. O. Vakkuri, A. Kivela, J. Leppaluoto, M. Valtonen, and A. Kauppila Decrease in melatonin precedes follicle-stimulating hormone increase during perimenopause Eur J Endocrinol 135 1996 188 192
9. G. Bellipanni, P. Bianchi, W. Pierpaoli, D. Bulian, and E. Ilyia Effects of melatonin in perimenopausal and menopausal women: a randomized and placebo controlled study Exp Gerontol 36 2001 297 310
10. N. Schlabritz-Loutsevitch, N. Hellner, R. Middendorf, D. Muller, and J. Olcese The human myometrium as a target for melatonin J Clin Endocrinol Metab 88 2003 908 913
11. H. Zhao, S.F. Pang, and A.M. Poon Variations of mt1 melatonin receptor density in the rat uterus during decidualization, the estrous cycle and in response to exogenous steroid treatment J Pineal Res 33 2002 140 145
12. C. Stocco Aromatase expression in the ovary: hormonal and molecular regulation Steroids 73 2008 473 487
13. S. Cos, C. Martinez-Campa, M.D. Mediavilla, and E.J. Sanchez-Barcelo Melatonin modulates aromatase activity in MCF-7 human breast cancer cells J Pineal Res 38 2005 136 142
14. C. Martinez-Campa, A. Gonzalez, M.D. Mediavilla, C. Alonso-Gonzalez, E.J. Sanchez-Barcelo, and S. Cos Melatonin enhances the inhibitory effect of aminoglutethimide on aromatase activity in MCF-7 human breast cancer cells Breast Cancer Res Treat 94 2005 249 254
15. C. Martinez-Campa, A. Gonzalez, and M.D. Mediavilla et al. Melatonin inhibits aromatase promoter expression by regulating cyclooxygenases expression and activity in breast cancer cells Br J Cancer 101 2009 1613 1619
16. P.E. Lonning, M. Dowsett, and T.J. Powles Postmenopausal estrogen synthesis and metabolism: alterations caused by aromatase inhibitors used for the treatment of breast cancer J Steroid Biochem 35 1990 355 366
17. T. Suzuki, Y. Miki, N. Ohuchi, and H. Sasano Intratumoral estrogen production in breast carcinoma: significance of aromatase Breast Cancer 15 2008 270 277
18. E. Simpson, G. Rubin, and C. Clyne et al. Local estrogen biosynthesis in males and females Endocr Relat Cancer 6 1999 131 137
19. S. Cos, A. Gonzalez, and A. Guezmes et al. Melatonin inhibits the growth of DMBA-induced mammary tumors by decreasing the local biosynthesis of estrogens through the modulation of aromatase activity Int J Cancer 118 2006 274 278
20. V.S. Tanavde, and A. Maitra In vitro modulation of steroidogenesis and gene expression by melatonin: a study with porcine antral follicles Endocr Res 29 2003 399 410
21. G.E. Webley, and M.R. Luck Melatonin directly stimulates the secretion of progesterone by human and bovine granulosa cells in vitro J Reprod Fertil 78 1986 711 717
22. I. Adrians, P. Jacuet, R. Corturindt, K. Janssen, J. Smitz, and B. Voordauw Melatonin has dose-dependent effects on folliculogenesis, oocyte maturation capacity and steroidogenesis Toxicology 228 2006 333 343
23. H. Tamura, Y. Nakamura, and S. Takiguchi et al. Melatonin directly suppresses steroid production by preovulatory follicles in the cyclic hamster J Pineal Res 25 1998 135 141
24. P.A. Witt-Enderby, J.P. Slater, and N.A. Johnson et al. Effects on bone by the light/dark cycle and chronic treatment with melatonin and/or hormone replacement therapy in intact female mice J Pineal Res 53 2012 374 384
25. C.T. Guy, M.A. Webster, M. Schaller, T.J. Parsons, R.D. Cardiff, and W.J. Muller Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease Proc Natl Acad Sci USA 89 1992 10578 10582
26. V.L. Davis, M.J. Jayo, and A. Ho et al. Black cohosh increases metastatic mammary cancer in transgenic mice expressing c-erbB2 Cancer Res 68 2008 8377 8383
27. U.S. Department of Health and Human Services National Health and Nutrition Examination Survey: intake of calories and selected nutrients for the United States population, 1999-2000 2000
28. Caligioni CS. Assessing reproductive status/stages in mice. Current protocols in neuroscience/editorial board, Jacqueline N Crawley, et al. 2009; Appendix 4: Appendix 4I.
29. R.V. Mettus, and S.G. Rane Characterization of the abnormal pancreatic development, reduced growth and infertility in Cdk4 mutant mice Oncogene 22 2003 8413 8421
30. K.J. Livak, and T.D. Schmittgen Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method Methods 25 2001 402 408
31. M.P. Steinkampf, C.R. Mendelson, and E.R. Simpson Effects of epidermal growth factor and insulin-like growth factor I on the levels of mRNA encoding aromatase cytochrome P-450 of human ovarian granulosa cells Mol Cell Endocrinol 59 1988 93 99
32. P.A. Witt-Enderby, and M.L. Dubocovich Characterization and regulation of the human ML1A melatonin receptor stably expressed in Chinese hamster ovary cells Mol Pharmacol 50 1996 166 174
33. M.J. Jarzynka, D.K. Passey, and P.F. Ignatius et al. Modulation of melatonin receptors and G-protein function by microtubules J Pineal Res 41 2006 324 336
34. C.D. Bondi, R.M. McKeon, and J.M. Bennett et al. MT1 melatonin receptor internalization underlies melatonin-induced morphologic changes in Chinese hamster ovary cells and these processes are dependent on Gi proteins, MEK 1/2 and microtubule modulation J Pineal Res 44 2008 288 298
35. L.G. Chuffa, F.R. Seiva, and W.J. Favaro et al. Melatonin reduces LH, 17 beta-estradiol and induces differential regulation of sex steroid receptors in reproductive tissues during rat ovulation Reprod Biol Endocrinol 9 2011 108
36. J.W. Clemens, M.J. Jarzynka, and P.A. Witt-Enderby Down-regulation of mt1 melatonin receptors in rat ovary following estrogen exposure Life Sci 69 2001 27 35
37. M.P. Kotlarczyk, H.C. Lassila, and C.K. O'Neil et al. Melatonin osteoporosis prevention study (MOPS): a randomized, double-blind, placebo-controlled study examining the effects of melatonin on bone health and quality of life in perimenopausal women J Pineal Res 52 2012 414 426
38. A.R. Abd-Allah, S.M. El-Sayed el, M.H. Abdel-Wahab, and F.M. Hamada Effect of melatonin on estrogen and progesterone receptors in relation to uterine contraction in rats Pharmacol Res 47 2003 349 354
39. T. Kurita, K. Lee, and P.T. Saunders et al. Regulation of progesterone receptors and decidualization in uterine stroma of the estrogen receptor-alpha knockout mouse Biol Reprod 64 2001 272 283
40. W.L. Kraus, and B.S. Katzenellenbogen Regulation of progesterone receptor gene expression and growth in the rat uterus: modulation of estrogen actions by progesterone and sex steroid hormone antagonists Endocrinology 132 1993 2371 2379
41. T.A. Tibbetts, M. Mendoza-Meneses, B.W. O'Malley, and O.M. Conneely Mutual and intercompartmental regulation of estrogen receptor and progesterone receptor expression in the mouse uterus Biol Reprod 59 1998 1143 1152
42. W. Schneider, C. Ramachandran, P.G. Satyaswaroop, and G. Shyamala Murine progesterone receptor exists predominantly as the 83-kilodalton 'A' form J Steroid Biochem Mol Biol 38 1991 285 291
43. O.M. Conneely, B. Mulac-Jericevic, and J.P. Lydon Progesterone-dependent regulation of female reproductive activity by two distinct progesterone receptor isoforms Steroids 68 2003 771 778
44. P. Witt-Enderby, W.P. Clafshenkel, M. Kotlarczyk, and S. Sethi Melatonin in bone health R.R. Watson, Melatonin in the promotion of health 2nd ed. 2011 CRC Press Boca Raton 261 270
45. V.L. Davis, B.R. Dodda, and P.A. Witt-Enderby Prevention and treatment of breast cancer using melatonin R.R. Watson, Melatonin in the promotion of health 2nd ed. 2012 CRC Press Boca Raton 271 285
46. B. Kos-Kudla, Z. Ostrowska, and B. Marek et al. Circadian rhythm of melatonin in postmenopausal asthmatic women with hormone replacement therapy Neuro Endocrinol Lett 23 2002 243 248