메뉴 건너뛰기




Volumn 91, Issue 6, 2013, Pages 419-427

Comparative in vitro evaluation of transportability and toxicity of capecitabine and its metabolites in cells derived from normal human kidney and renal cancers

Author keywords

membrane transport; nucleobases and cytotoxicity; nucleosides; renal cancer

Indexed keywords

ANTIMETABOLITES, ANTINEOPLASTIC; BIOLOGICAL TRANSPORT; BIOTRANSFORMATION; CELL LINE, TUMOR; DEOXYCYTIDINE; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1; EQUILIBRATIVE-NUCLEOSIDE TRANSPORTER 2; FLOXURIDINE; FLUOROURACIL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYDROGEN-ION CONCENTRATION; INTERFERON-ALPHA; KIDNEY TUBULES, PROXIMAL; KINETICS; NUCLEOSIDES; SIGNAL TRANSDUCTION; THYMIDINE PHOSPHORYLASE;

EID: 84894225793     PISSN: 08298211     EISSN: 12086002     Source Type: Journal    
DOI: 10.1139/bcb-2013-0041     Document Type: Article
Times cited : (8)

References (40)
  • 1
    • 18144403118 scopus 로고    scopus 로고
    • Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes
    • 10.1074/jbc.M414337200. 15701636.
    • Baldwin S.A. Yao S.Y. Hyde R.J. Ng A.M. Foppolo S. Barnes K. et al 2005. Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes. J. Biol. Chem. 280: 15880-15887. 10.1074/jbc.M414337200. 15701636.
    • (2005) J. Biol. Chem. , vol.280 , pp. 15880-15887
    • Baldwin, S.A.1    Yao, S.Y.2    Hyde, R.J.3    Ng, A.M.4    Foppolo, S.5    Barnes, K.6
  • 2
    • 33748337923 scopus 로고    scopus 로고
    • Distribution and functional characterization of equilibrative nucleoside transporter-4, a novel cardiac adenosine transporter activated at acidic pH
    • 10.1161/01.RES.0000238359.18495.42. 16873718.
    • Barnes K. Dobrzynski H. Foppolo S. Beal P.R. Ismat F. Scullion E.R. et al 2006. Distribution and functional characterization of equilibrative nucleoside transporter-4, a novel cardiac adenosine transporter activated at acidic pH. Circ. Res. 99: 510-519. 10.1161/01.RES.0000238359.18495.42. 16873718.
    • (2006) Circ. Res. , vol.99 , pp. 510-519
    • Barnes, K.1    Dobrzynski, H.2    Foppolo, S.3    Beal, P.R.4    Ismat, F.5    Scullion, E.R.6
  • 3
    • 0023854182 scopus 로고
    • Electrophysiology and ultrastructure of cultured human proximal tubule cells
    • 10.1038/ki.1988.27. 3361752.
    • Blackburn J.G. Hazen-Martin D.J. Detrisac C.J. Sens D.A. 1988. Electrophysiology and ultrastructure of cultured human proximal tubule cells. Kidney Int. 33: 508-516. 10.1038/ki.1988.27. 3361752.
    • (1988) Kidney Int. , vol.33 , pp. 508-516
    • Blackburn, J.G.1    Hazen-Martin, D.J.2    Detrisac, C.J.3    Sens, D.A.4
  • 4
    • 0030694506 scopus 로고    scopus 로고
    • Molecular identification of the equilibrative NBMPR-sensitive (es) nucleoside transporter and demonstration of an equilibrative NBMPR-insensitive (ei) transport activity in human erythroleukemia (K562) cells
    • 10.1016/S0028-3908(97)00136-6. 9364472.
    • Boleti H. Coe I.R. Baldwin S.A. Young J.D. Cass C.E. 1997. Molecular identification of the equilibrative NBMPR-sensitive (es) nucleoside transporter and demonstration of an equilibrative NBMPR-insensitive (ei) transport activity in human erythroleukemia (K562) cells. Neuropharmacology, 36: 1167-1179. 10.1016/S0028-3908(97)00136-6. 9364472.
    • (1997) Neuropharmacology , vol.36 , pp. 1167-1179
    • Boleti, H.1    Coe, I.R.2    Baldwin, S.A.3    Young, J.D.4    Cass, C.E.5
  • 5
    • 36849010349 scopus 로고    scopus 로고
    • Nucleoside and nucleobase transporters of primary human cardiac microvascular endothelial cells: Characterization of a novel nucleobase transporter
    • 10.1152/ajpheart.01006.2007. 17921321.
    • Bone D.B. Hammond J.R. 2007. Nucleoside and nucleobase transporters of primary human cardiac microvascular endothelial cells: characterization of a novel nucleobase transporter. Am. J. Physiol. Heart Circ. Physiol. 293: H3325-H3332. 10.1152/ajpheart.01006.2007. 17921321.
    • (2007) Am. J. Physiol. Heart Circ. Physiol. , vol.293
    • Bone, D.B.1    Hammond, J.R.2
  • 6
    • 0030049056 scopus 로고    scopus 로고
    • Gemcitabine: A phase II study in patients with advanced renal cancer
    • 10.1007/s002800050417. 8599874.
    • De Mulder P.H. Weissbach L. Jakse G. Osieka R. Blatter J. 1996. Gemcitabine: a phase II study in patients with advanced renal cancer. Cancer Chemother. Pharmacol. 37: 491-495. 10.1007/s002800050417. 8599874.
    • (1996) Cancer Chemother. Pharmacol. , vol.37 , pp. 491-495
    • De Mulder, P.H.1    Weissbach, L.2    Jakse, G.3    Osieka, R.4    Blatter, J.5
  • 7
    • 57149136129 scopus 로고    scopus 로고
    • Human concentrative nucleoside transporter 3 is a determinant of fludarabine transportability and cytotoxicity in human renal proximal tubule cell cultures
    • 10.1007/s00280-008-0739-1. 18500522.
    • Elwi A.N. Damaraju V.L. Kuzma M.L. Baldwin S.A. Young J.D. Sawyer M.B. et al 2009. Human concentrative nucleoside transporter 3 is a determinant of fludarabine transportability and cytotoxicity in human renal proximal tubule cell cultures. Cancer Chemother. Pharmacol. 63: 289-301. 10.1007/s00280-008- 0739-1. 18500522.
    • (2009) Cancer Chemother. Pharmacol. , vol.63 , pp. 289-301
    • Elwi, A.N.1    Damaraju, V.L.2    Kuzma, M.L.3    Baldwin, S.A.4    Young, J.D.5    Sawyer, M.B.6
  • 8
    • 0026526266 scopus 로고
    • Nucleobase transporter-mediated permeation of 2′,3′- dideoxyguanosine in human erythrocytes and human T-lymphoblastoid CCRF-CEM cells
    • 1429579.
    • Gati W.P. Paterson A.R. Tyrrell D.L. Cass C.E. Moravek J. Robins M.J. 1992. Nucleobase transporter-mediated permeation of 2′,3′- dideoxyguanosine in human erythrocytes and human T-lymphoblastoid CCRF-CEM cells. J. Biol. Chem. 267: 22272-22276. 1429579.
    • (1992) J. Biol. Chem. , vol.267 , pp. 22272-22276
    • Gati, W.P.1    Paterson, A.R.2    Tyrrell, D.L.3    Cass, C.E.4    Moravek, J.5    Robins, M.J.6
  • 9
    • 2442628251 scopus 로고    scopus 로고
    • The role of systemic chemotherapy in the treatment of kidney cancer
    • 10.1007/978-1-4615-0451-1-10. 14650832.
    • George C.M. Stadler W.M. 2003. The role of systemic chemotherapy in the treatment of kidney cancer. Cancer Treat. Res. 116: 173-182. 10.1007/978-1-4615-0451-1-10. 14650832.
    • (2003) Cancer Treat. Res. , vol.116 , pp. 173-182
    • George, C.M.1    Stadler, W.M.2
  • 10
    • 0027182514 scopus 로고
    • High affinity sodium-dependent nucleobase transport in cultured renal epithelial cells (LLC-PK1)
    • 8376366.
    • Griffith D.A. Jarvis S.M. 1993. High affinity sodium-dependent nucleobase transport in cultured renal epithelial cells (LLC-PK1). J. Biol. Chem. 268: 20085-20090. 8376366.
    • (1993) J. Biol. Chem. , vol.268 , pp. 20085-20090
    • Griffith, D.A.1    Jarvis, S.M.2
  • 11
    • 0030606020 scopus 로고    scopus 로고
    • Nucleoside and nucleobase transport systems of mammalian cells
    • 10.1016/S0304-4157(96)00008-1. 8982282.
    • Griffith D.A. Jarvis S.M. 1996. Nucleoside and nucleobase transport systems of mammalian cells. Biochim. Biophys. Acta, 1286: 153-181. 10.1016/S0304-4157(96)00008-1. 8982282.
    • (1996) Biochim. Biophys. Acta , vol.1286 , pp. 153-181
    • Griffith, D.A.1    Jarvis, S.M.2
  • 12
    • 0031439882 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a nitrobenzylthioinosine- insensitive (ei) equilibrative nucleoside transporter from human placenta
    • 9396714.
    • Griffiths M. Yao S.Y. Abidi F. Phillips S.E. Cass C.E. Young J.D. et al 1997. Molecular cloning and characterization of a nitrobenzylthioinosine- insensitive (ei) equilibrative nucleoside transporter from human placenta. Biochem. J. 328 (3): 739-743. 9396714.
    • (1997) Biochem. J. , vol.328 , Issue.3 , pp. 739-743
    • Griffiths, M.1    Yao, S.Y.2    Abidi, F.3    Phillips, S.E.4    Cass, C.E.5    Young, J.D.6
  • 13
    • 79952253825 scopus 로고    scopus 로고
    • Treatment of metastatic renal carcinoma patients with the combination of gemcitabine, capecitabine and bevacizumab at a tertiary cancer centre
    • 10.1111/j.1464-410X.2010.09626.x. 21355978.
    • Jonasch E. Lal L.S. Atkinson B.J. Byfield S.D. Miller L.A. Pagliaro L.C. et al 2011. Treatment of metastatic renal carcinoma patients with the combination of gemcitabine, capecitabine and bevacizumab at a tertiary cancer centre. BJU Int. 107: 741-747. 10.1111/j.1464-410X.2010.09626.x. 21355978.
    • (2011) BJU Int. , vol.107 , pp. 741-747
    • Jonasch, E.1    Lal, L.S.2    Atkinson, B.J.3    Byfield, S.D.4    Miller, L.A.5    Pagliaro, L.C.6
  • 14
    • 0032874167 scopus 로고    scopus 로고
    • A human capecitabine excretion balance and pharmacokinetic study after administration of a single oral dose of 14C-labelled drug
    • 10.1023/A:1006263400888. 10555122.
    • Judson I.R. Beale P.J. Trigo J.M. Aherne W. Crompton T. Jones D. et al 1999. A human capecitabine excretion balance and pharmacokinetic study after administration of a single oral dose of 14C-labelled drug. Invest. New Drugs, 17: 49-56. 10.1023/A:1006263400888. 10555122.
    • (1999) Invest. New Drugs , vol.17 , pp. 49-56
    • Judson, I.R.1    Beale, P.J.2    Trigo, J.M.3    Aherne, W.4    Crompton, T.5    Jones, D.6
  • 15
    • 33646400259 scopus 로고    scopus 로고
    • Characterization of novel Na+-dependent nucleobase transport systems at the blood-testis barrier
    • 10.1152/ajpendo.00160.2005. 16368787.
    • Kato R. Maeda T. Akaike T. Tamai I. 2006. Characterization of novel Na+-dependent nucleobase transport systems at the blood-testis barrier. Am. J. Physiol. Endocrinol. Metab. 290: E968-E975. 10.1152/ajpendo.00160.2005. 16368787.
    • (2006) Am. J. Physiol. Endocrinol. Metab. , vol.290
    • Kato, R.1    Maeda, T.2    Akaike, T.3    Tamai, I.4
  • 16
    • 0028049867 scopus 로고
    • Evaluation of low dose continuous infusion 5-fluorouracil in patients with advanced and recurrent renal cell carcinoma
    • 10.1002/1097-0142(19940801)74:3<916: AID-CNCR2820740319>3.0.CO;2-Z. 8039119.
    • Kish J.A. Wolf M. Crawford E.D. Leimert J.T. Bueschen A. Neefe J.R. et al 1994. Evaluation of low dose continuous infusion 5-fluorouracil in patients with advanced and recurrent renal cell carcinoma. A Southwest Oncology Group Study. Cancer, 74: 916-919. 10.1002/1097-0142(19940801)74:3<916::AID- CNCR2820740319>3.0.CO;2-Z. 8039119.
    • (1994) A Southwest Oncology Group Study. Cancer , vol.74 , pp. 916-919
    • Kish, J.A.1    Wolf, M.2    Crawford, E.D.3    Leimert, J.T.4    Bueschen, A.5    Neefe, J.R.6
  • 17
    • 50949105874 scopus 로고    scopus 로고
    • Efficacy of the oral fluorouracil pro-drug capecitabine in cancer treatment: A review
    • 10.3390/molecules13081897. 18794792.
    • Koukourakis G.V. Kouloulias V. Koukourakis M.J. Zacharias G.A. Zabatis H. Kouvaris J. 2008. Efficacy of the oral fluorouracil pro-drug capecitabine in cancer treatment: a review. Molecules, 13: 1897-1922. 10.3390/molecules13081897. 18794792.
    • (2008) Molecules , vol.13 , pp. 1897-1922
    • Koukourakis, G.V.1    Kouloulias, V.2    Koukourakis, M.J.3    Zacharias, G.A.4    Zabatis, H.5    Kouvaris, J.6
  • 18
    • 0028823826 scopus 로고
    • Nucleobase and nucleoside transport in mammalian cells
    • 8533427.
    • Kraupp M. Marz R. 1995. Nucleobase and nucleoside transport in mammalian cells. Wien. Klin. Wochenschr. 107: 677-680. 8533427.
    • (1995) Wien. Klin. Wochenschr. , vol.107 , pp. 677-680
    • Kraupp, M.1    Marz, R.2
  • 19
    • 55449102594 scopus 로고    scopus 로고
    • Functional differences in nucleoside and nucleobase transporters expressed on the rabbit corneal epithelial cell line (SIRC) and isolated rabbit cornea
    • 12866942.
    • Majumdar S. Tirucherai G.S. Pal D. Mitra A.K. 2003. Functional differences in nucleoside and nucleobase transporters expressed on the rabbit corneal epithelial cell line (SIRC) and isolated rabbit cornea. AAPS PharmSci. 5: E15. 12866942.
    • (2003) AAPS PharmSci. , vol.5 , pp. 15
    • Majumdar, S.1    Tirucherai, G.S.2    Pal, D.3    Mitra, A.K.4
  • 20
    • 0027231510 scopus 로고
    • Gemcitabine in advanced renal cell carcinoma. A phase II study of the National Cancer Institute of Canada Clinical Trials Group
    • 8518225.
    • Mertens W.C. Eisenhauer E.A. Moore M. Venner P. Stewart D. Muldal A. et al 1993. Gemcitabine in advanced renal cell carcinoma. A phase II study of the National Cancer Institute of Canada Clinical Trials Group. Ann. Oncol. 4: 331-332. 8518225.
    • (1993) Ann. Oncol. , vol.4 , pp. 331-332
    • Mertens, W.C.1    Eisenhauer, E.A.2    Moore, M.3    Venner, P.4    Stewart, D.5    Muldal, A.6
  • 21
    • 0032127244 scopus 로고    scopus 로고
    • Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue
    • 10.1016/S0959-8049(98)00058-6. 9849491.
    • Miwa M. Ura M. Nishida M. Sawada N. Ishikawa T. Mori K. et al 1998. Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue. Eur. J. Cancer, 34: 1274-1281. 10.1016/S0959-8049(98)00058-6. 9849491.
    • (1998) Eur. J. Cancer , vol.34 , pp. 1274-1281
    • Miwa, M.1    Ura, M.2    Nishida, M.3    Sawada, N.4    Ishikawa, T.5    Mori, K.6
  • 22
    • 0033030892 scopus 로고    scopus 로고
    • Biomodulation of 5-fluorouracil by interferon-alpha in human renal carcinoma cells: Relationship to the expression of thymidine phosphorylase
    • 10.1007/s002800050951. 10412941.
    • Morita T. Tokue A. 1999. Biomodulation of 5-fluorouracil by interferon-alpha in human renal carcinoma cells: relationship to the expression of thymidine phosphorylase. Cancer Chemother. Pharmacol. 44: 91-96. 10.1007/s002800050951. 10412941.
    • (1999) Cancer Chemother. Pharmacol. , vol.44 , pp. 91-96
    • Morita, T.1    Tokue, A.2
  • 23
    • 78751477225 scopus 로고    scopus 로고
    • More than 4 years of progression-free survival in a patient with metastatic renal cell carcinoma treated sequentially with sunitinib, everolimus, sorafenib, and temsirolimus
    • 21187517.
    • Oudard S. 2010. More than 4 years of progression-free survival in a patient with metastatic renal cell carcinoma treated sequentially with sunitinib, everolimus, sorafenib, and temsirolimus. Anticancer Res. 30: 5223-5225. 21187517.
    • (2010) Anticancer Res. , vol.30 , pp. 5223-5225
    • Oudard, S.1
  • 24
    • 48749096696 scopus 로고    scopus 로고
    • SLC28 genes and concentrative nucleoside transporter (CNT) proteins
    • 10.1080/00498250802069096. 18668436.
    • Pastor-Anglada M. Cano-Soldado P. Errasti-Murugarren E. Casado F.J. 2008. SLC28 genes and concentrative nucleoside transporter (CNT) proteins. Xenobiotica, 38: 972-994. 10.1080/00498250802069096. 18668436.
    • (2008) Xenobiotica , vol.38 , pp. 972-994
    • Pastor-Anglada, M.1    Cano-Soldado, P.2    Errasti-Murugarren, E.3    Casado, F.J.4
  • 25
    • 79952258599 scopus 로고    scopus 로고
    • Treatment of metastatic renal carcinoma patients with the combination of gemcitabine, capecitabine and bevacizumab at a tertiary cancer centre
    • 10.1111/j.1464-410X.2011.10154.x. 21355979.
    • Porta C. Paglino C. 2011. Treatment of metastatic renal carcinoma patients with the combination of gemcitabine, capecitabine and bevacizumab at a tertiary cancer centre. BJU Int. 107: 747-748. 10.1111/j.1464-410X.2011.10154.x. 21355979.
    • (2011) BJU Int. , vol.107 , pp. 747-748
    • Porta, C.1    Paglino, C.2
  • 26
    • 77249113329 scopus 로고    scopus 로고
    • Uptake of purines in Plasmodium falciparum-infected human erythrocytes is mostly mediated by the human equilibrative nucleoside transporter and the human facilitative nucleobase transporter
    • 10.1186/1475-2875-9-36. 20113503.
    • Quashie N.B. Ranford-Cartwright L.C. de Koning H.P. 2010. Uptake of purines in Plasmodium falciparum-infected human erythrocytes is mostly mediated by the human equilibrative nucleoside transporter and the human facilitative nucleobase transporter. Malar. J. 9: 36. 10.1186/1475-2875-9-36. 20113503.
    • (2010) Malar. J. , vol.9 , pp. 36
    • Quashie, N.B.1    Ranford-Cartwright, L.C.2    De Koning, H.P.3
  • 27
    • 0035076059 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of capecitabine
    • 10.2165/00003088-200140020-00002. 11286326.
    • Reigner B. Blesch K. Weidekamm E. 2001. Clinical pharmacokinetics of capecitabine. Clin. Pharmacokinet. 40: 85-104. 10.2165/00003088-200140020-00002. 11286326.
    • (2001) Clin. Pharmacokinet. , vol.40 , pp. 85-104
    • Reigner, B.1    Blesch, K.2    Weidekamm, E.3
  • 28
    • 0034046892 scopus 로고    scopus 로고
    • Phase II trial of weekly intravenous gemcitabine with continuous infusion fluorouracil in patients with metastatic renal cell cancer
    • 10856102.
    • Rini B.I. Vogelzang N.J. Dumas M.C. Wade J.L. III Taber D.A. Stadler W.M. 2000. Phase II trial of weekly intravenous gemcitabine with continuous infusion fluorouracil in patients with metastatic renal cell cancer. J. Clin. Oncol. 18: 2419-2426. 10856102.
    • (2000) J. Clin. Oncol. , vol.18 , pp. 2419-2426
    • Rini, B.I.1    Vogelzang, N.J.2    Dumas, M.C.3    Wade III, J.L.4    Taber, D.A.5    Stadler, W.M.6
  • 29
    • 0030938889 scopus 로고    scopus 로고
    • Molecular cloning and functional expression of cDNAs encoding a human Na+-nucleoside cotransporter (hCNT1)
    • 9124315.
    • Ritzel M.W. Yao S.Y. Huang M.Y. Elliott J.F. Cass C.E. Young J.D. 1997. Molecular cloning and functional expression of cDNAs encoding a human Na+-nucleoside cotransporter (hCNT1). Am. J. Physiol. 272: C707-C714. 9124315.
    • (1997) Am. J. Physiol. , vol.272
    • Ritzel, M.W.1    Yao, S.Y.2    Huang, M.Y.3    Elliott, J.F.4    Cass, C.E.5    Young, J.D.6
  • 30
    • 0032467105 scopus 로고    scopus 로고
    • Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine
    • 10.3109/09687689709044322. 10087507.
    • Ritzel M.W. Yao S.Y. Ng A.M. Mackey J.R. Cass C.E. Young J.D. 1998. Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine. Mol. Membr. Biol. 15: 203-211. 10.3109/ 09687689709044322. 10087507.
    • (1998) Mol. Membr. Biol. , vol.15 , pp. 203-211
    • Ritzel, M.W.1    Yao, S.Y.2    Ng, A.M.3    Mackey, J.R.4    Cass, C.E.5    Young, J.D.6
  • 31
    • 0035951808 scopus 로고    scopus 로고
    • Molecular identification and characterization of novel human and mouse concentrative Na+-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib)
    • 10.1074/jbc.M007746200. 11032837.
    • Ritzel M.W. Ng A.M. Yao S.Y. Graham K. Loewen S.K. Smith K.M. et al 2001. Molecular identification and characterization of novel human and mouse concentrative Na+-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib). J. Biol. Chem. 276: 2914-2927. 10.1074/jbc.M007746200. 11032837.
    • (2001) J. Biol. Chem. , vol.276 , pp. 2914-2927
    • Ritzel, M.W.1    Ng, A.M.2    Yao, S.Y.3    Graham, K.4    Loewen, S.K.5    Smith, K.M.6
  • 32
    • 0015962412 scopus 로고
    • Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate
    • 10.1021/bi00700a012. 4203910.
    • Santi D.V. McHenry C.S. Sommer H. 1974. Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate. Biochemistry, 13: 471-481. 10.1021/bi00700a012. 4203910.
    • (1974) Biochemistry , vol.13 , pp. 471-481
    • Santi, D.V.1    McHenry, C.S.2    Sommer, H.3
  • 33
    • 0032922413 scopus 로고    scopus 로고
    • Nucleobase transport in opossum kidney epithelial cells and Xenopus laevis oocytes: The characterisation, structure-activity relationship of uracil analogues and oocyte expression studies of sodium-dependent and-independent hypoxanthine uptake
    • 10.1016/S0005-2736(98)00213-2. 9889340.
    • Shayeghi M. Akerman R. Jarvis S.M. 1999. Nucleobase transport in opossum kidney epithelial cells and Xenopus laevis oocytes: the characterisation, structure-activity relationship of uracil analogues and oocyte expression studies of sodium-dependent and-independent hypoxanthine uptake. Biochim. Biophys. Acta, 1416: 109-118. 10.1016/S0005-2736(98)00213-2. 9889340.
    • (1999) Biochim. Biophys. Acta , vol.1416 , pp. 109-118
    • Shayeghi, M.1    Akerman, R.2    Jarvis, S.M.3
  • 34
    • 0015011371 scopus 로고
    • Purification and kinetic studies of adenine phosphoribosyltransferase from human erythrocytes
    • 10.1016/0003-9861(71)90506-6. 4323725.
    • Srivastava S.K. Beutler E. 1971. Purification and kinetic studies of adenine phosphoribosyltransferase from human erythrocytes. Arch. Biochem. Biophys. 142: 426-434. 10.1016/0003-9861(71)90506-6. 4323725.
    • (1971) Arch. Biochem. Biophys. , vol.142 , pp. 426-434
    • Srivastava, S.K.1    Beutler, E.2
  • 35
    • 0038546638 scopus 로고    scopus 로고
    • Na+ gradient-dependent transport of hypoxanthine by calf intestinal brush border membrane vesicles
    • 10.1007/s00360-002-0324-6. 12624654.
    • Theisinger A. Grenacher B. Scharrer E. 2003. Na+ gradient-dependent transport of hypoxanthine by calf intestinal brush border membrane vesicles. J. Comp. Physiol. B, 173: 165-170. 10.1007/s00360-002-0324-6. 12624654.
    • (2003) J. Comp. Physiol. B , vol.173 , pp. 165-170
    • Theisinger, A.1    Grenacher, B.2    Scharrer, E.3
  • 36
    • 84861530844 scopus 로고    scopus 로고
    • Phase II, Multicenter, Uncontrolled Trial of Single-agent Capecitabine in Patients with Non-clear Cell Metastatic Renal Cell Carcinoma
    • 10.1097/COC.0b013e31820dbc17. 21358295.
    • Tsimafeyeu I. Demidov L. Kharkevich G. Petenko N. Galchenko V. Sinelnikov I. et al 2012. Phase II, Multicenter, Uncontrolled Trial of Single-agent Capecitabine in Patients With Non-clear Cell Metastatic Renal Cell Carcinoma. Am. J. Clin. Oncol. 35: 251-254. 10.1097/COC.0b013e31820dbc17. 21358295.
    • (2012) Am. J. Clin. Oncol. , vol.35 , pp. 251-254
    • Tsimafeyeu, I.1    Demidov, L.2    Kharkevich, G.3    Petenko, N.4    Galchenko, V.5    Sinelnikov, I.6
  • 37
    • 0023064189 scopus 로고
    • Expression of the high-affinity purine nucleobase transporter in mutant mouse S49 cells does not require a functional wild-type nucleoside-nucleobase transporter
    • 3561404.
    • Ullman B. Patrick J. McCartan K. 1987. Expression of the high-affinity purine nucleobase transporter in mutant mouse S49 cells does not require a functional wild-type nucleoside-nucleobase transporter. Mol. Cell. Biol. 7: 97-103. 3561404.
    • (1987) Mol. Cell. Biol. , vol.7 , pp. 97-103
    • Ullman, B.1    Patrick, J.2    McCartan, K.3
  • 38
    • 84861369048 scopus 로고    scopus 로고
    • Sunitinib malate for the treatment of renal cell carcinoma
    • 10.1517/14656566.2012.689130. 22607009.
    • Wood L. 2012. Sunitinib malate for the treatment of renal cell carcinoma. Expert Opin. Pharmacother. 13: 1323-1336. 10.1517/14656566.2012.689130. 22607009.
    • (2012) Expert Opin. Pharmacother. , vol.13 , pp. 1323-1336
    • Wood, L.1
  • 39
    • 0037067704 scopus 로고    scopus 로고
    • Functional and molecular characterization of nucleobase transport by recombinant human and rat equilibrative nucleoside transporters 1 and 2. Chimeric constructs reveal a role for the ENT2 helix 5-6 region in nucleobase translocation
    • 10.1074/jbc.M200966200. 12006583.
    • Yao S.Y. Ng A.M. Vickers M.F. Sundaram M. Cass C.E. Baldwin S.A. et al 2002. Functional and molecular characterization of nucleobase transport by recombinant human and rat equilibrative nucleoside transporters 1 and 2. Chimeric constructs reveal a role for the ENT2 helix 5-6 region in nucleobase translocation. J. Biol. Chem. 277: 24938-24948. 10.1074/jbc.M200966200. 12006583.
    • (2002) J. Biol. Chem. , vol.277 , pp. 24938-24948
    • Yao, S.Y.1    Ng, A.M.2    Vickers, M.F.3    Sundaram, M.4    Cass, C.E.5    Baldwin, S.A.6
  • 40
    • 48749085061 scopus 로고    scopus 로고
    • Human equilibrative nucleoside transporter (ENT) family of nucleoside and nucleobase transporter proteins
    • 10.1080/00498250801927427. 18668437.
    • Young J.D. Yao S.Y. Sun L. Cass C.E. Baldwin S.A. 2008. Human equilibrative nucleoside transporter (ENT) family of nucleoside and nucleobase transporter proteins. Xenobiotica, 38: 995-1021. 10.1080/00498250801927427. 18668437.
    • (2008) Xenobiotica , vol.38 , pp. 995-1021
    • Young, J.D.1    Yao, S.Y.2    Sun, L.3    Cass, C.E.4    Baldwin, S.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.