메뉴 건너뛰기




Volumn 8, Issue 11, 2013, Pages

Novel neuroprotective function of apical-basal polarity gene Crumbs in amyloid beta 42 (Aβ42) mediated neurodegeneration

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; AXONS; DISEASE MODELS, ANIMAL; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; HUMANS; MEMBRANE PROTEINS; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84894196551     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0078717     Document Type: Article
Times cited : (24)

References (52)
  • 1
    • 67651180986 scopus 로고    scopus 로고
    • The amyloid hypothesis for Alzheimer's disease: A critical reappraisal
    • Hardy J (2009) The amyloid hypothesis for Alzheimer's disease: a critical reappraisal. J Neurochem 110: 1129-1134.
    • (2009) J Neurochem , vol.110 , pp. 1129-1134
    • Hardy, J.1
  • 2
    • 80052827024 scopus 로고    scopus 로고
    • Amyloid Precursor Protein Processing and Alzheimers Disease
    • O'Brien RJ, Wong PC (2010) Amyloid Precursor Protein Processing and Alzheimers Disease. Annu Rev Neurosci.
    • (2010) Annu Rev Neurosci
    • O'Brien, R.J.1    Wong, P.C.2
  • 3
    • 80052858465 scopus 로고    scopus 로고
    • Activation of JNK signaling mediates amyloid-ss-dependent cell death
    • Tare M, Modi RM, Nainaparampil JJ, Puli OR, Bedi S, et al. (2011) Activation of JNK signaling mediates amyloid-ss-dependent cell death. PLoS One 6: e24361.
    • (2011) PLoS One , vol.6
    • Tare, M.1    Modi, R.M.2    Nainaparampil, J.J.3    Puli, O.R.4    Bedi, S.5
  • 4
    • 49149124343 scopus 로고    scopus 로고
    • Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
    • Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, et al. (2008) Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med 14: 837-842.
    • (2008) Nat Med , vol.14 , pp. 837-842
    • Shankar, G.M.1    Li, S.2    Mehta, T.H.3    Garcia-Munoz, A.4    Shepardson, N.E.5
  • 6
    • 79955749505 scopus 로고    scopus 로고
    • Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery
    • Pandey UB, Nichols CD (2011) Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery. Pharmacol Rev 63: 411-436.
    • (2011) Pharmacol Rev , vol.63 , pp. 411-436
    • Pandey, U.B.1    Nichols, C.D.2
  • 7
    • 77954321829 scopus 로고    scopus 로고
    • Drosophila melanogaster in the study of human neurodegeneration
    • Hirth F (2010) Drosophila melanogaster in the study of human neurodegeneration. CNS Neurol Disord Drug Targets 9: 504-523.
    • (2010) CNS Neurol Disord Drug Targets , vol.9 , pp. 504-523
    • Hirth, F.1
  • 8
    • 77953892400 scopus 로고    scopus 로고
    • Molecular mechanisms of neurodegeneration in Alzheimer's disease
    • Crews L, Masliah E (2010) Molecular mechanisms of neurodegeneration in Alzheimer's disease. Hum Mol Genet 19: R12-20.
    • (2010) Hum Mol Genet , vol.19
    • Crews, L.1    Masliah, E.2
  • 9
    • 3242809725 scopus 로고    scopus 로고
    • A model for studying Alzheimer's Abeta42-induced toxicity in Drosophila melanogaster
    • DOI 10.1016/j.mcn.2004.03.001, PII S1044743104000521
    • Finelli A, Kelkar A, Song HJ, Yang H, Konsolaki M (2004) A model for studying Alzheimer's Abeta42-induced toxicity in Drosophila melanogaster. Mol Cell Neurosci 26: 365-375. (Pubitemid 38968431)
    • (2004) Molecular and Cellular Neuroscience , vol.26 , Issue.3 , pp. 365-375
    • Finelli, A.1    Kelkar, A.2    Song, H.-J.3    Yang, H.4    Konsolaki, M.5
  • 12
    • 77950458277 scopus 로고    scopus 로고
    • Transgenic Drosophila models of Alzheimer's disease and tauopathies
    • Iijima-Ando K, Iijima K (2010) Transgenic Drosophila models of Alzheimer's disease and tauopathies. Brain Struct Funct 214: 245-262.
    • (2010) Brain Struct Funct , vol.214 , pp. 245-262
    • Iijima-Ando, K.1    Iijima, K.2
  • 13
    • 58149380019 scopus 로고    scopus 로고
    • Drosophila models of Alzheimer's amyloidosis: The challenge of dissecting the complex mechanisms of toxicity of amyloid-beta 42
    • Iijima K, Iijima-Ando K (2008) Drosophila models of Alzheimer's amyloidosis: the challenge of dissecting the complex mechanisms of toxicity of amyloid-beta 42. J Alzheimers Dis 15: 523-540.
    • (2008) J Alzheimers Dis , vol.15 , pp. 523-540
    • Iijima, K.1    Iijima-Ando, K.2
  • 14
    • 77955945605 scopus 로고    scopus 로고
    • Insights from Drosophila models of Alzheimer's disease
    • Cowan CM, Shepherd D, Mudher A (2010) Insights from Drosophila models of Alzheimer's disease. Biochem Soc Trans 38: 988-992.
    • (2010) Biochem Soc Trans , vol.38 , pp. 988-992
    • Cowan, C.M.1    Shepherd, D.2    Mudher, A.3
  • 15
    • 45149093564 scopus 로고    scopus 로고
    • Identification of novel genes that modify phenotypes induced by Alzheimer's beta-amyloid overexpression in Drosophila
    • Cao W, Song HJ, Gangi T, Kelkar A, Antani I, et al. (2008) Identification of novel genes that modify phenotypes induced by Alzheimer's beta-amyloid overexpression in Drosophila. Genetics 178: 1457-1471.
    • (2008) Genetics , vol.178 , pp. 1457-1471
    • Cao, W.1    Song, H.J.2    Gangi, T.3    Kelkar, A.4    Antani, I.5
  • 16
    • 10644276290 scopus 로고    scopus 로고
    • Drosophila, the golden bug, emerges as a tool for human genetics
    • Bier E (2005) Drosophila, the golden bug, emerges as a tool for human genetics. Nat Rev Genet 6: 9-23.
    • (2005) Nat Rev Genet , vol.6 , pp. 9-23
    • Bier, E.1
  • 17
    • 77957918269 scopus 로고    scopus 로고
    • Retinal determination the beginning of eye development
    • Kumar JP (2010) Retinal determination the beginning of eye development. Curr Top Dev Biol 93: 1-28.
    • (2010) Curr Top Dev Biol , vol.93 , pp. 1-28
    • Kumar, J.P.1
  • 18
    • 0017110220 scopus 로고
    • Development of the Drosophila retina, a neurocrystalline lattice
    • Ready DF, Hanson TE, Benzer S (1976) Development of the Drosophila retina, a neurocrystalline lattice. Dev Biol 53: 217-240.
    • (1976) Dev Biol , vol.53 , pp. 217-240
    • Ready, D.F.1    Hanson, T.E.2    Benzer, S.3
  • 19
    • 0037302522 scopus 로고    scopus 로고
    • Patterning the fly eye: The role of apoptosis
    • DOI 10.1016/S0168-9525(02)00041-0, PII S0168952502000410
    • Brachmann CB, Cagan RL (2003) Patterning the fly eye: the role of apoptosis. Trends Genet 19: 91-96. (Pubitemid 36120666)
    • (2003) Trends in Genetics , vol.19 , Issue.2 , pp. 91-96
    • Brachmann, C.B.1    Cagan, R.L.2
  • 20
    • 23444458441 scopus 로고    scopus 로고
    • Morphogens and cell survival during development
    • DOI 10.1002/neu.20167
    • Mehlen P, Mille F, Thibert C (2005) Morphogens and cell survival during development. J Neurobiol 64: 357-366. (Pubitemid 41114045)
    • (2005) Journal of Neurobiology , vol.64 , Issue.4 , pp. 357-366
    • Mehlen, P.1    Mille, F.2    Thibert, C.3
  • 21
    • 0027160708 scopus 로고
    • Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
    • Brand AH, Perrimon N (1993) Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118: 401-415. (Pubitemid 23214028)
    • (1993) Development , vol.118 , Issue.2 , pp. 401-415
    • Brand, A.H.1    Perrimon, N.2
  • 22
    • 0025898443 scopus 로고
    • Glass encodes a site-specific DNA-binding protein that is regulated in response to positional signals in the developing Drosophila eye
    • Moses K, Rubin GM (1991) Glass encodes a site-specific DNA-binding protein that is regulated in response to positional signals in the developing Drosophila eye. Genes Dev 5: 583-593. (Pubitemid 21905979)
    • (1991) Genes and Development , vol.5 , Issue.4 , pp. 583-593
    • Moses, K.1    Rubin, G.M.2
  • 23
    • 0025285657 scopus 로고
    • crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia
    • Tepass U, Theres C, Knust E (1990) crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia. Cell 61: 787-799.
    • (1990) Cell , vol.61 , pp. 787-799
    • Tepass, U.1    Theres, C.2    Knust, E.3
  • 24
    • 69549098043 scopus 로고    scopus 로고
    • Crumbs stabilises epithelial polarity during tissue remodelling
    • Campbell K, Knust E, Skaer H (2009) Crumbs stabilises epithelial polarity during tissue remodelling. J Cell Sci 122: 2604-2612.
    • (2009) J Cell Sci , vol.122 , pp. 2604-2612
    • Campbell, K.1    Knust, E.2    Skaer, H.3
  • 25
    • 0035818984 scopus 로고    scopus 로고
    • Drosophila stardust is a partner of Crumbs in the control of epithelial cell polarity
    • DOI 10.1038/414638a
    • Bachmann A, Schneider M, Theilenberg E, Grawe F, Knust E (2001) Drosophila Stardust is a partner of Crumbs in the control of epithelial cell polarity. Nature 414: 638-643. (Pubitemid 33151259)
    • (2001) Nature , vol.414 , Issue.6864 , pp. 638-643
    • Bachmann, A.1    Schneider, M.2    Theilenberg, E.3    Grawe, F.4    Knust, E.5
  • 26
    • 0033582916 scopus 로고    scopus 로고
    • Discs lost, a novel multi-PDZ domain protein, establishes and maintains epithelial polarity
    • Bhat MA, Izaddoost S, Lu Y, Cho KO, Choi KW, et al. (1999) Discs Lost, a novel multi-PDZ domain protein, establishes and maintains epithelial polarity. Cell 96: 833-845. (Pubitemid 29165086)
    • (1999) Cell , vol.96 , Issue.6 , pp. 833-845
    • Bhat, M.A.1    Izaddoost, S.2    Lu, Y.3    Cho, K.-O.4    Choi, K.-W.5    Bellen, H.J.6
  • 27
    • 39149138983 scopus 로고    scopus 로고
    • Drosophila Lin-7 is a component of the Crumbs complex in epithelia and photoreceptor cells and prevents light-induced retinal degeneration
    • Bachmann A, Grawe F, Johnson K, Knust E (2008) Drosophila Lin-7 is a component of the Crumbs complex in epithelia and photoreceptor cells and prevents light-induced retinal degeneration. Eur J Cell Biol 87: 123-136.
    • (2008) Eur J Cell Biol , vol.87 , pp. 123-136
    • Bachmann, A.1    Grawe, F.2    Johnson, K.3    Knust, E.4
  • 28
    • 0033953429 scopus 로고    scopus 로고
    • A conserved motif in crumbs is required for E-cadherin localisation and zonula adherens formation in Drosophila
    • Klebes A, Knust E (2000) A conserved motif in Crumbs is required for E-cadherin localisation and zonula adherens formation in Drosophila. Curr Biol 10: 76-85. (Pubitemid 30079192)
    • (2000) Current Biology , vol.10 , Issue.2 , pp. 76-85
    • Klebes, A.1    Knust, E.2
  • 29
    • 0036745540 scopus 로고    scopus 로고
    • Eye suppression, a novel function of teashirt, requires Wingless signaling
    • Singh A, Kango-Singh M, Sun YH (2002) Eye suppression, a novel function of teashirt, requires Wingless signaling. Development 129: 4271-4280.
    • (2002) Development , vol.129 , pp. 4271-4280
    • Singh, A.1    Kango-Singh, M.2    Sun, Y.H.3
  • 30
    • 79959211894 scopus 로고    scopus 로고
    • Role of kinesin heavy chain in Crumbs localization along the rhabdomere elongation in Drosophila photoreceptor
    • League GP, Nam SC (2011) Role of kinesin heavy chain in Crumbs localization along the rhabdomere elongation in Drosophila photoreceptor. PLoS One 6: e21218.
    • (2011) PLoS One , vol.6
    • League, G.P.1    Nam, S.C.2
  • 32
    • 33846084612 scopus 로고    scopus 로고
    • Lobe and Serrate are required for cell survival during early eye development in Drosophila
    • DOI 10.1242/dev.02686
    • Singh A, Shi X, Choi KW (2006) Lobe and Serrate are required for cell survival during early eye development in Drosophila. Development 133: 4771-4781. (Pubitemid 46063089)
    • (2006) Development , vol.133 , Issue.23 , pp. 4771-4781
    • Singh, A.1    Shi, X.2    Choi, K.-W.3
  • 33
    • 0036795371 scopus 로고    scopus 로고
    • Drosophila crumbs is required to inhibit light-induced photoreceptor degeneration
    • DOI 10.1016/S0960-9822(02)01180-6, PII S0960982202011806
    • Johnson K, Grawe F, Grzeschik N, Knust E (2002) Drosophila crumbs is required to inhibit light-induced photoreceptor degeneration. Curr Biol 12: 1675-1680. (Pubitemid 35161922)
    • (2002) Current Biology , vol.12 , Issue.19 , pp. 1675-1680
    • Johnson, K.1    Grawe, F.2    Grzeschik, N.3    Knust, E.4
  • 34
    • 0021346195 scopus 로고
    • Neuronal development in the drosophila retina: Monoclonal antibodies as molecular probes
    • Zipursky SL, Venkatesh TR, Teplow DB, Benzer S (1984) Neuronal development in the Drosophila retina: monoclonal antibodies as molecular probes. Cell 36: 15-26. (Pubitemid 14155366)
    • (1984) Cell , vol.36 , Issue.1 , pp. 15-26
    • Zipursky, S.L.1    Venkatesh, T.R.2    Teplow, D.B.3    Benzer, S.4
  • 35
    • 0035829720 scopus 로고    scopus 로고
    • Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila
    • DOI 10.1016/S0896-6273(01)00496-2
    • Gunawardena S, Goldstein LS (2001) Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila. Neuron 32: 389-401. (Pubitemid 33082041)
    • (2001) Neuron , vol.32 , Issue.3 , pp. 389-401
    • Gunawardena, S.1    Goldstein, L.S.B.2
  • 37
    • 0033119536 scopus 로고    scopus 로고
    • Retinal axon target selection in Drosophila is regulated by a receptor protein tyrosine phosphatase
    • DOI 10.1016/S0896-6273(00)80730-8
    • Garrity PA, Lee CH, Salecker I, Robertson HC, Desai CJ, et al. (1999) Retinal axon target selection in Drosophila is regulated by a receptor protein tyrosine phosphatase. Neuron 22: 707-717. (Pubitemid 29203494)
    • (1999) Neuron , vol.22 , Issue.4 , pp. 707-717
    • Garrity, P.A.1    Lee, C.-H.2    Salecker, I.3    Robertson, H.C.4    Desai, C.J.5    Zinn, K.6    Zipursky, S.L.7
  • 38
    • 33747834891 scopus 로고    scopus 로고
    • The FERM Protein Yurt Is a Negative Regulatory Component of the Crumbs Complex that Controls Epithelial Polarity and Apical Membrane Size
    • DOI 10.1016/j.devcel.2006.06.001, PII S1534580706002577
    • Laprise P, Beronja S, Silva-Gagliardi NF, Pellikka M, Jensen AM, et al. (2006) The FERM protein Yurt is a negative regulatory component of the Crumbs complex that controls epithelial polarity and apical membrane size. Dev Cell 11: 363-374. (Pubitemid 44283938)
    • (2006) Developmental Cell , vol.11 , Issue.3 , pp. 363-374
    • Laprise, P.1    Beronja, S.2    Silva-Gagliardi, N.F.3    Pellikka, M.4    Jensen, A.M.5    McGlade, C.J.6    Tepass, U.7
  • 39
    • 0141502071 scopus 로고    scopus 로고
    • Interaction of Par-6 and Crumbs complexes is essential for photoreceptor morphogenesis in Drosophila
    • Nam SC, Choi KW (2003) Interaction of Par-6 and Crumbs complexes is essential for photoreceptor morphogenesis in Drosophila. Development 130: 4363-4372.
    • (2003) Development , vol.130 , pp. 4363-4372
    • Nam, S.C.1    Choi, K.W.2
  • 40
    • 4143119015 scopus 로고    scopus 로고
    • DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila
    • DOI 10.1083/jcb.200311031
    • Sotillos S, Diaz-Meco MT, Caminero E, Moscat J, Campuzano S (2004) DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila. J Cell Biol 166: 549-557. (Pubitemid 39097174)
    • (2004) Journal of Cell Biology , vol.166 , Issue.4 , pp. 549-557
    • Sotillos, S.1    Diaz-Meco, M.T.2    Caminero, E.3    Moscat, J.4    Campuzano, S.5
  • 42
    • 76449098074 scopus 로고    scopus 로고
    • Crumbs is required to achieve proper organ size control during Drosophila head development
    • Richardson EC, Pichaud F (2010) Crumbs is required to achieve proper organ size control during Drosophila head development. Development 137: 641-650.
    • (2010) Development , vol.137 , pp. 641-650
    • Richardson, E.C.1    Pichaud, F.2
  • 43
    • 33645777828 scopus 로고    scopus 로고
    • Self-refinement of Notch activity through the transmembrane protein Crumbs: Modulation of gammasecretase activity
    • Herranz H, Stamataki E, Feiguin F, Milan M (2006) Self-refinement of Notch activity through the transmembrane protein Crumbs: modulation of gammasecretase activity. EMBO Rep 7: 297-302.
    • (2006) EMBO Rep , vol.7 , pp. 297-302
    • Herranz, H.1    Stamataki, E.2    Feiguin, F.3    Milan, M.4
  • 46
    • 77953738883 scopus 로고    scopus 로고
    • The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded
    • Ling C, Zheng Y, Yin F, Yu J, Huang J, et al. (2010) The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded. Proc Natl Acad Sci U S A 107: 10532-10537.
    • (2010) Proc Natl Acad Sci U S a , vol.107 , pp. 10532-10537
    • Ling, C.1    Zheng, Y.2    Yin, F.3    Yu, J.4    Huang, J.5
  • 47
    • 77950478873 scopus 로고    scopus 로고
    • Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded
    • Robinson BS, Huang J, Hong Y, Moberg KH (2010) Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded. Curr Biol 20: 582-590.
    • (2010) Curr Biol , vol.20 , pp. 582-590
    • Robinson, B.S.1    Huang, J.2    Hong, Y.3    Moberg, K.H.4
  • 48
    • 70350050887 scopus 로고    scopus 로고
    • A role for the extracellular domain of Crumbs in morphogenesis of Drosophila photoreceptor cells
    • Richard M, Muschalik N, Grawe F, Ozuyaman S, Knust E (2009) A role for the extracellular domain of Crumbs in morphogenesis of Drosophila photoreceptor cells. Eur J Cell Biol 88: 765-777.
    • (2009) Eur J Cell Biol , vol.88 , pp. 765-777
    • Richard, M.1    Muschalik, N.2    Grawe, F.3    Ozuyaman, S.4    Knust, E.5
  • 49
    • 69549101766 scopus 로고    scopus 로고
    • The Crumbs complex: From epithelial-cell polarity to retinal degeneration
    • Bulgakova NA, Knust E (2009) The Crumbs complex: from epithelial-cell polarity to retinal degeneration. J Cell Sci 122: 2587-2596.
    • (2009) J Cell Sci , vol.122 , pp. 2587-2596
    • Bulgakova, N.A.1    Knust, E.2
  • 51
    • 0030578406 scopus 로고    scopus 로고
    • Crumbs, a component of the apical membrane, is required for zonula adherens formation in primary epithelia of Drosophila
    • Tepass U (1996) Crumbs, a component of the apical membrane, is required for zonula adherens formation in primary epithelia of Drosophila. Dev Biol 177: 217-225.
    • (1996) Dev Biol , vol.177 , pp. 217-225
    • Tepass, U.1
  • 52
    • 54249119561 scopus 로고    scopus 로고
    • JNK signaling in apoptosis
    • Dhanasekaran DN, Reddy EP (2008) JNK signaling in apoptosis. Oncogene 27: 6245-6251.
    • (2008) Oncogene , vol.27 , pp. 6245-6251
    • Dhanasekaran, D.N.1    Reddy, E.P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.