Age and sex differences in the incorporation of EPA and DHA into plasma fractions, cells and adipose tissue in humans

British Journal of Nutrition

Volumn 111, Issue 4, 2014, Pages 679-689

  Walker, Celia G ^a   Browning, Lucy M ^a   Mander, Adrian P ^b   Madden, Jackie ^c   West, Annette L ^c   Calder, Philip C ^c,d   Jebb, Susan A ^e  

^a MRC HUMAN NUTRITION RESEARCH   (United Kingdom)

^b MRC BIOSTATISTICS UNIT   (United Kingdom)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^d UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

DHA; EPA; Fish oil; n 3 PUFA

Indexed keywords

CHOLESTEROL ESTER; DOCOSAHEXAENOIC ACID; FATTY ACID; ICOSAPENTAENOIC ACID; MONOUNSATURATED FATTY ACID; PHOSPHATIDYLCHOLINE; TRIACYLGLYCEROL;

ADIPOSE TISSUE; ADULT; AGE; AGED; ARTICLE; CHEEK; CONTROLLED STUDY; DIET SUPPLEMENTATION; DIETARY INTAKE; DOSE RESPONSE; ERYTHROCYTE MEMBRANE; FATTY ACID BLOOD LEVEL; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; LIPID COMPOSITION; MALE; MIDDLE AGED; MONONUCLEAR CELL; PLASMA; SEX DIFFERENCE; THROMBOCYTE; TREATMENT DURATION; TRIACYLGLYCEROL BLOOD LEVEL; YOUNG ADULT;

ADIPOSE TISSUE; ADULT; AGE FACTORS; AGED; BLOOD PLATELETS; DIETARY SUPPLEMENTS; DOCOSAHEXAENOIC ACIDS; DOUBLE-BLIND METHOD; EICOSAPENTAENOIC ACID; ERYTHROCYTE MEMBRANE; FEMALE; FISH OILS; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; MOUTH MUCOSA; SEAFOOD; SEX FACTORS; TRIGLYCERIDES; YOUNG ADULT;

EID: 84894191415     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114513002985     Document Type: Article

References (34)

1. Hodson L, Skeaff CM & Fielding BA (2008) Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake. Prog Lipid Res 47, 348-380.
2. Childs CE, Romeu-Nadal M, Burdge GC, et al. (2008) Gender differences in the n-3 fatty acid content of tissues. Proc Nutr Soc 67, 19-27.
3. Crowe FL, Skeaff CM, Green TJ, et al. (2008) Serum n-3 longchain PUFA differ by sex and age in a population-based survey of New Zealand adolescents and adults. Br J Nutr 99, 168-174.
4. Bakewell L, Burdge GC & Calder PC (2006) Polyunsaturated fatty acid concentrations in young men and women consuming their habitual diets. Br J Nutr 96, 93-99.
5. Garneau V, Rudkowska I, Paradis AM, et al. (2012) Omega-3 fatty acids status in human subjects estimated using a food frequency questionnaire and plasma phospholipids levels. Nutr J 11, 46.
6. Pawlosky RJ, Hibbeln JR, Novotny JA, et al. (2001) Physiological compartmental analysis of alpha-linolenic acid metabolism in adult humans. J Lipid Res 42, 1257-1265.
7. Burdge GC, Jones AE & Wootton SA (2002) Eicosapentaenoic and docosapentaenoic acids are the principal products of alpha-linolenic acid metabolism in young men. Br J Nutr 88, 355-363.
8. Burdge GC & Wootton SA (2002) Conversion of alphalinolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women. Br J Nutr 88, 411-420.
9. Bolton-Smith C, Woodward M & Tavendale R (1997) Evidence for age-related differences in the fatty acid composition of human adipose tissue, independent of diet. Eur J Clin Nutr 51, 619-624.
10. Rees D, Miles EA, Banerjee T, et al. (2006) Dose-related effects of eicosapentaenoic acid on innate immune function in healthy humans: a comparison of young and older men. Am J Clin Nutr 83, 331-342.
11. Caslake MJ, Miles EA, Kofler BM, et al. (2008) Effect of sex and genotype on cardiovascular biomarker response to fish oils: the FINGEN Study. Am J Clin Nutr 88, 618-629.
12. Calder PC (2012) Mechanisms of action of (n-3) fatty acids. J Nutr 142, 592S-599S.
13. Browning LM, Walker CG, Mander AP, et al. (2012) Incorporation of eicosapentaenoic and docosahexaenoic acids into lipid pools when given as supplements providing doses equivalent to typical intakes of oily fish. Am J Clin Nutr 96, 748-758.
14. Scientific Advisory Committee on Nutrition (SACN) and Committee on Toxicity (COT) Combined Report (2004) Advice on Fish Consumption: Benefits & Risks. London: TSO.
15. Nikkari T, Luukkainen P, Pietinen P, et al. (1995) Fatty acid composition of serum lipid fractions in relation to gender and quality of dietary fat. Ann Med 27, 491-498.
16. Giltay EJ, Gooren LJ, Toorians AW, et al. (2004) Docosahexaenoic acid concentrations are higher in women than in men because of estrogenic effects. Am J Clin Nutr 80, 1167-1174.
17. Tavendale R, Lee AJ, Smith WC, et al. (1992) Adipose tissue fatty acids in Scottish men and women: results from the Scottish Heart Health Study. Atherosclerosis 94, 161-169.
18. Welch AA, Bingham SA, Ive J, et al. (2006) Dietary fish intake and plasma phospholipid n-3 polyunsaturated fatty acid concentrations in men and women in the European Prospective Investigation into Cancer-Norfolk United Kingdom Cohort. Am J Clin Nutr 84, 1330-1339.
19. Dewailly E, Blanchet C, Lemieux S, et al. (2001) n-3 Fatty acids and cardiovascular disease risk factors among the Inuit of Nunavik. Am J Clin Nutr 74, 464-473.
20. Dewailly EE, Blanchet C, Gingras S, et al. (2001) Relations between n-3 fatty acid status and cardiovascular disease risk factors among Quebecers. Am J Clin Nutr 74, 603-611.
21. Brossard N, Croset M, Pachiaudi C, et al. (1996) Retroconversion and metabolism of [13C]22:6n-3 in humans and rats after intake of a single dose of [13C]22:6n-3-triacylglycerols. Am J Clin Nutr 64, 577-586.
22. Sumino H, Ichikawa S, Murakami M, et al. (2003) Effects of hormone replacement therapy on circulating docosahexaenoic acid and eicosapentaenoic acid levels in postmenopausal women. Endocr J 50, 51-59.
23. Stark KD & Holub BJ (2004) Differential eicosapentaenoic acid elevations and altered cardiovascular disease risk factor responses after supplementation with docosahexaenoic acid in postmenopausal women receiving and not receiving hormone replacement therapy. Am J Clin Nutr 79, 765-773.
24. Giltay EJ, Duschek EJ, Katan MB, et al. (2004) Raloxifene and hormone replacement therapy increase arachidonic acid and docosahexaenoic acid levels in postmenopausal women. J Endocrinol 182, 399-408.
25. Calder PC, Harvey DJ, Pond CM, et al. (1992) Site-specific differences in the fatty acid composition of human adipose tissue. Lipids 27, 716-720.
26. Babin F, Abderrazik M, Favier F, et al. (1999) Differences between polyunsaturated fatty acid status of non-institutionalised elderly women and younger controls: a bioconversion defect can be suspected. Eur J Clin Nutr 53, 591-596.
27. Sands SA, Reid KJ, Windsor SL, et al. (2005) The impact of age, body mass index, and fish intake on the EPA and DHA content of human erythrocytes. Lipids 40, 343-347.
28. Sala-Vila A, Harris WS, Cofan M, et al. (2011) Determinants of the omega-3 index in a Mediterranean population at increased risk for CHD. Br J Nutr 106, 425-431.
29. Ogura T, Takada H, Okuno M, et al. (2010) Fatty acid composition of plasma, erythrocytes and adipose: their correlations and effects of age and sex. Lipids 45, 137-144.
30. Itomura M, Fujioka S, Hamazaki K, et al. (2008) Factors influencing EPA \+ DHA levels in red blood cells in Japan. In Vivo 22, 131-135.
31. de Groot RH, van Boxtel MP, Schiepers OJ, et al. (2009) Age dependence of plasma phospholipid fatty acid levels: potential role of linoleic acid in the age-associated increase in docosahexaenoic acid and eicosapentaenoic acid concentrations. Br J Nutr 102, 1058-1064.
32. Harris WS, Pottala JV, Lacey SM, et al. (2012) Clinical correlates and heritability of erythrocyte eicosapentaenoic and docosahexaenoic acid content in the Framingham Heart Study. Atherosclerosis 225, 425-431.
33. Calder PC (2004) n-3 Fatty acids and cardiovascular disease: evidence explained and mechanisms explored. Clin Sci (Lond) 107, 1-11.
34. Calder PC & Yaqoob P (2012) Marine omega-3 fatty acids and coronary heart disease. Curr Opin Cardiol 27, 412-419.