Lipedema: An overview of its clinical manifestations, diagnosis and treatment of the disproportional fatty deposition syndrome - systematic review

Clinical Obesity

Volumn 2, Issue 3-4, 2012, Pages 86-95

  Forner Cordero, I ^a   Szolnoky, G ^b   Forner Cordero, A ^c   Kemeny L ^b,d  

^a HOSPITAL UNIVERSITARIO LA FE   (Spain)

^b UNIVERSITY OF SZEGED   (Hungary)

^c UNIVERSITY OF VALENCIA   (Spain)

^d INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

Decongestive lymphatic therapy; Lipedema; Liposuction; Obesity

Indexed keywords

VASCULOTROPIN;

ARTICLE; CLINICAL EXAMINATION; CLINICAL FEATURE; COMORBIDITY; COMPRESSION THERAPY; CONSERVATIVE TREATMENT; CYTOREDUCTIVE SURGERY; DIAGNOSTIC TEST; DIFFERENTIAL DIAGNOSIS; EARLY DIAGNOSIS; HUMAN; KINESIOTHERAPY; LEG EDEMA; LIPEDEMA; LIPID STORAGE; LIPOHYPERTROPHY; LIPOSUCTION; LYMPHATIC DRAINAGE; LYMPHATIC INSUFFICIENCY; LYMPHATIC SYSTEM DISEASE; LYMPHEDEMA; MEDICAL HISTORY; MOLECULAR PATHOLOGY; OBESITY; OSTEOARTHRITIS; PERIPHERAL EDEMA; PHLEBEDEMA; PREVALENCE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SEX DIFFERENCE; SKIN CARE; STREETEN TEST; SYSTEMATIC REVIEW;

EID: 84894116752     PISSN: None     EISSN: 17588111     Source Type: Journal    
DOI: 10.1111/j.1758-8111.2012.00050.x     Document Type: Article

References (61)

1. Allen EV, Hines EAJ. Lipedema of the legs: a syndrome characterised by fat legs and orthostatic edema. Proc Staff Meet Mayo Clin 1940; 15: 184-187.
2. Schmeller W, Meier-Vollrath I. Lipödem: Ein update. [Lipedema: an update] Lymphol Forsch Prax 2005; 9: 10-20.
3. Tiwari A, Myint F, Hamilton G. Management of lower limb lymphoedema in the United Kingdom. Eur J Vasc Endovasc Surg 2006; 31: 311-315.
4. World Health Organization. 2010. International Statistical Classification of Diseases and Related Health Problems 10th Revision. [WWW document]. URL http://apps.who.int/classifications/ icd10/browse/2010/en (accessed October 2011).
5. Clearinghouse National Guidelines. Rockville (MD): National Guideline Clearinghouse. c1998- [updated 2010 March 29]. [WWW document]. URL http://www.guideline.gov/ (accessed March 2010).
6. Sheffield Evidence for Effectiveness and Knowledge. Sheffield (UK): National electronic Library for Health. c2000-[updated 2010 March 29]. [WWW document]. URL http://www.library.nhs.uk/ GUIDELINESFINDER/ (accessed March 2010).
7. CMA Infobase. 2010. Ontario (Canada): Canadian Medical Association. [WWW document]. URL http://mdm.ca/cpgsnew/ cpgs/index.asp (accessed March 2010).
8. CDR databases. York (UK): Centre for Reviews and Dissemination. c1994- [updated 2010 March 29]. [WWW document]. URL http://www.york.ac.uk/inst/crd/crddatabases.htm (accessed March 2010).
9. ACP Journal Club. Philadelphia (PA): American College of Physicians. C1994- [updated 2010 March 16]. [WWW document]. URL http://www.acponline.org/journals/acpjc/jcmenu.htm (accessed March 2010).
10. Cochrane Library. Oxford (UK): Update Software Ltd. c2001- [updated 2010 March 29]. [WWW document]. URL http:// www.thecochranelibrary.com/view/0/index.html (accessed March 2010).
11. Clinical Queries PubMed. Bethesda (MD): National Library of Medicine (US). c1993- [updated 2011 May 11].[WWWdocument]. URL http://www.ncbi.nlm.nih.gov/entrez/query/static/clinical.html (accessed May 2011).
12. EMBASE. Amsterdam (The Netherlands): Elsevier. [updated 2010 March 29]. [WWW document]. URL http://www.embase. com/ (accessed March 2010).
13. Web of Knowledge. New York: Thomson Reuters. [updated 2011 May 11]. [WWW document]. URL http://www.accesowok. fecyt.es/ (accessed May 2011).
14. Scopus. Amsterdam (The Netherlands): Elsevier B.V. [updated 2010 March 29]. [WWW document]. URL http://scopees.elsevier. com/ees_login.asp (accessed March 2010).
15. Herpertz U. Krankheitsspektrum des lipodems an einer lymphologischen fachklinik - erscheinungsformen, mischbilder und behandlungsmoglichkeiten. [Range of lipedema at a special clinic for lymphological diseases: Manifestations, combinations and treatment possibilities]. Vasomed 1997; 9: 301-307.
16. Schook CC, Mulliken JB, Fishman SJ et al. Differential diagnosis of lower extremity enlargement in pediatric patients referred with a diagnosis of lymphedema. Plast Reconstr Surg 2011; 127: 1571-1581.
17. Wienert V, Foldi E, JungerMet al. Lipoedema guidelines of the German society for phlebology. Phlebologie 2009; 38: 164-167.
18. Van Geest AJ, Esten SC, Cambier JP et al. Lymphatic disturbances in lipoedema. Phlebologie 2003; 32: 138-142.
19. Harwood CA, Bull RH, Evans J, Mortimer PS. Lymphatic and venous function in lipoedema. Br J Dermatol 1996; 134: 1-6.
20. Kröger K. Lymphoedema and lipoedema of the extremities. Vasa 2008; 37: 39-51.
21. Langendoen SI, Habbema L, Nijsten TE, Neumann HA. Lipoedema: from clinical presentation to therapy. A review of the literature. Br J Dermatol 2009; 161: 980-986.
22. Child AH, Gordon KD, Sharpe P et al. Lipedema: an inherited condition. Am J Med Genet A 2010; 152A: 970-976.
23. Fries R. Ursachensuche bei generalisierten und lokalisierten odemen. [Differential diagnosis of leg edema]. MMW Fortschr Med 2004; 146: 39-41.
24. Herpertz U. Der missbrauch des lipödems. [The misuse of lipedema]. Lymphol Forsch Prax 2003; 7: 90-93.
25. Schmeller W, Meier-Vollrath I. Moderne therapie des lipödems: kombination von konservativen und operativen maßnahmen. [Modern therapy in lipedema: Combination of conservative and surgical methods]. Lymphol Forsch Prax 2004; 8: 22-26.
26. Fife CE, Maus EA, Carter MJ. Lipedema: a frequently misdiagnosed and misunderstood fatty deposition syndrome. Adv Skin Wound Care 2010; 23: 81-92.
27. Roux J, Vitaut M. Maladie de Dercum. [Adiposis dolorosa]. Revue Neurol (Paris) 1901; 9: 881-888.
28. Herbst KL, Asare-Berdiako S. Adiposis dolorosa is more than painful fat. Endocrinologist 2007; 17: 326-334.
29. Brodovsky S,Westreich M, Leibowitz A, Schwartz Y. Adiposis dolorosa (Dercum's disease): 10-year follow-up. Ann Plast Surg 1994; 33: 664-668.
30. Müssig K, Gallwitz B. Lipohypertrophy. Dtsch Med Wochenschr 2006; 131: 1807-1808.
31. Herpertz U. Das Lipödem. Z Lymphol 1995; 19: 1-11.
32. Schingale FJ. Lipoedema. In: Schingale FJ (ed.). Lymphoedema, Lipoedema: A Guide for Those Effected. Hannover: Schlütersche, 2003, pp. 64-71.
33. Warren AG, Janz BA, Borud LJ, Slavin SA. Evaluation and management of the fat leg syndrome. Plast Reconstr Surg 2007; 119: 9e-15e.
34. Földi E. Facts about lipoedema and lymph/lipoedema. In: 1st Jobst® Scientific Symposium, 2008 (ed.). Lymph/Lipoedema Treatment in Its Different Approaches. Wounds UK: Aberdeen (UK), 2009, pp. 36-40.
35. Streeten DH. Idiopathic edema. Pathogenesis, clinical features, and treatment. Endocrinol Metab Clin North Am 1995; 24: 531- 547.
36. Naouri M, Samimi M, Atlan M et al. High-resolution cutaneous ultrasonography to differentiate lipoedema from lymphoedema. Br J Dermatol 2010; 163: 296-301.
37. Breu FX, Marshall M. Neue ergebnisse der duplexsonographischen diagnostik des lip- und lymphodems: kompressionssonographie mit einer neven 13-mhz-linearsonde. [New results of the duplex-sonographic diagnosis of the lip- and lymphedema: compression sonography with a new 13 MHz linear array]. Phlebologie 2000; 29: 124-128.
38. Monnin-Delhom ED, Gallix BP, Achard C, Bruel JM, Janbon C. High resolution unenhanced computed tomography in patients with swollen legs. Lymphology 2002; 35: 121-128.
39. Dimakakos PB, Stefanopoulos T, Antoniades P et al. MRI and ultrasonographic findings in the investigation of lymphedema and lipedema. Int Surg 1997; 82: 411-416.
40. Duewell S, Hagspiel KD, Zuber J et al. Swollen lower extremity: role of MR imaging. Radiology 1992; 184: 227-231.
41. Lohrmann C, Foeldi E, Langer M. MR imaging of the lymphatic system in patients with lipedema and lipo-lymphedema. Microvasc Res 2009; 77: 335-339.
42. Pecking AP, Desprez-Curely JP, Cluzan RV. Explorations et imagerie du système lymphatique. [Tests and imaging of the lymphatic system]. Rev Med Interne 2002; 23: S391-S397.
43. Bräutigam P, Földi E, Schaiper I et al. Analysis of lymphatic drainage in various forms of leg edema using two compartment lymphoscintigraphy. Lymphology 1998; 31: 43-55.
44. Tiwari A, Cheng KS, Button M, Myint F, Hamilton G. Differential diagnosis, investigation, and current treatment of lower limb lymphedema. Arch Surg 2003; 138: 152-161.
45. Boursier V, Pecking A, Analyse VS. comparative de la lymphoscintigraphie au cours des lipooedèmes et des lymphooedèmes primitifs des membres infe'rieurs. [Comparative analysis of lymphoscintigraphy between lipedema and lower limb lymphedema]. J Mal Vasc 2004; 29: 257-261.
46. Siems W, Grune T, Voss P, Brenke R. Anti-fibrosclerotic effects of shock wave therapy in lipedema and cellulite. Biofactors 2005; 24: 275-282.
47. Bano G, Mansour S, Brice G et al. Pit-1 mutation and lipoedema in a family. Exp Clin Endocrinol Diabetes 2010; 118: 377-380.
48. Suga H, Araki J, Aoi N et al. Adipose tissue remodeling in lipedema: adipocyte death and concurrent regeneration. J Cutan Pathol 2009; 36: 1293-1298.
49. Williams A. Manual lymphatic drainage: exploring the history and evidence base. Br J Community Nurs 2010; 15: S18-S24.
50. Partsch H, Flour M, Smith PC, International Compression Club. Indications for compression therapy in venous and lymphatic disease consensus based on experimental data and scientific evidence. Under the auspices of the IUP. Int Angiol 2008; 27: 193-219.
51. Deri G, Weissleder H. Vergleichende prä- und posttherapeutische Volumenmessungen in Beinsegmenten beim Lipödem. [Comparative pre-and post-therapeutic volume measurements in leg segments in Lipedema]. Lymph Forsch 1997; 1: 35-37.
52. Szolnoky G, Nagy N, Kovács RK et al. Complex decongestive physiotherapy decreases capillary fragility in lipedema. Lymphology 2008; 41: 161-166.
53. Szolnoky G, Borsos B, Bársony K, Balogh M, Kemény L. Complete decongestive physiotherapy with and without pneumatic compression for treatment of lipedema: a pilot study. Lymphology 2008; 41: 40-44.
54. Szolnoky G, Kemény L. Lipoedema: from clinical presentation to therapy: further aspects. Br J Dermatol 2010; 162: 889.
55. Pereira de Godoy JM, De Fatima Guerreiro Godoy M, Hayashida M. Lipoedema and varicose vein surgery: a worse prognosis? Acta Angiol 2005; 11: 186-187.
56. Stiefelhagen P. No lymphedema, no obesity. How can lipedema be treated? MMW Fortschr Med 2001; 143: 15.
57. Stutz JJ, Krahl D. Water jet-assisted liposuction for patients with lipoedema: histologic and immunohistologic analysis of the aspirates of 30 lipoedema patients. Aesthtetic Plast Surg 2009; 33: 153-162.
58. Schmeller W, Meier-Vollrath I. Erfolgreiche operative Therapie des Lipödems mittels Liposuktion. [Successful surgical therapy of lipedema by liposuction]. Phlebologie 2004; 33: 23-29.
59. Rapprich S, Loehnert M, Hagedorn M. Therapy of lipoedema syndrome by liposuction under tumescent local anaesthesia. Ann Dermatol Venereol 2002; 129: S711.
60. Schmeller W, Hueppe M, Meier-Vollrath I. Tumescent liposuction in lipoedema yields good long-term results. Br J Dermatol 2012; 166: 161-168.
61. Peled AW, Slavin SA, Brorson H. Long-term outcome after surgical treatment of lipedema. Ann Plast Surg 2012; 68: 303-307.