Small intestinal bacterial overgrowth: What it is and what it is not

Current Opinion in Gastroenterology

Volumn 30, Issue 2, 2014, Pages 141-146

  Quigley, Eamonn M M ^a  

^a HOUSTON METHODIST HOSPITAL   (United States)

Author keywords

Diarrhea; Hydrogen breath test; Jejunal culture; Malabsorption; Small intestinal bacterial overgrowth

Indexed keywords

BLIND LOOP SYNDROME; BREATH TESTS; HUMANS; INTESTINE, SMALL; MICROBIOTA; RISK FACTORS;

EID: 84894069075     PISSN: 02671379     EISSN: 15317056     Source Type: Journal    
DOI: 10.1097/MOG.0000000000000040     Document Type: Review

References (62)

1. Quigley EMM, Quera R. Small intestinal bacterial overgrowth: Roles of antibiotics, prebiotics and probiotics. Gastroenterology 2006; 130 (2 Suppl): 304-311
2. Ford AC, Spiegel BM, Talley NJ, Moayyedi P. Small intestinal bacterial overgrowth in irritable bowel syndrome: Systematic review and meta-Analysis. Clin Gastroenterol Hepatol 2009; 7:1279-1286
3. Leimena MM, Ramiro-Garcia J, Davids M, et al. A comprehensive metatranscriptome analysis pipeline and its validation using human small intestine microbiota datasets. BMC Genomics 2013; 14:530
4. Wang ZK, Yang YS. Upper gastrointestinal microbiota and digestive diseases. World J Gastroenterol 2013; 19:1541-1550
5. Hartman AL, Lough DM, Barupal DK, et al. Human gut microbiome adopts an alternative state following small bowel transplantation. PNAS 2009; 106:17187-17192
6. Booijink CCGM, El-Aidy S, Rajilic-Stojanovic M, et al. High temporal and interindividual variation detected in the human ileal microbiota. Environ Microbiol 2010; 12:3213-3227
7. Van Den Bogert B, De Vos WM, Zoetendal EG, Kleerebezem M. Microarray analysis and barcoded pyrosequencing provide consistent microbial profiles depending on the source of human intestinal samples. Appl Environ Microbiol 2011; 77:2071-2080
8. Oh PL, Martinez I, Sun Y, et al. Characterization of the ileal microbiota in rejecting and nonrejecting recipients of small bowel transplants. Am J Transplantation 2012; 12:753-762
9. Zoetendal EG, Raes J, van Den Bogert B, et al. The human small intestinal microbiota is driven by rapid uptake and conversion of simple carbohydrates. ISME J 2012; 6:1415-1426
10. Dave M, Johnson AL, Walk ST, et al. A randomized trial of sheathed versus standard forceps for obtaining uncontaminated biopsy specimens from the terminal ileum. Gut 2011; 60:1043-1049
11. Di Cagno R, De Angelis M, De Pasquale I, et al. Duodenal and faecal microbiota of celiac children: Molecular, phenotype and metabolome characterization. BMC Microbiol 2011; 11:219
12. Steed H, Macfarlane GT, Blackett KL, et al. Bacterial translocation in cirrhosis is not caused by an abnormal small bowel gut microbiota. FEMS Immunol Med Microbiol 2011; 63:346-354
13. Sanchez E, Donat E, Ribes-Koninckx C, et al. Duodenal-mucosal bacteria associated with celiac disease in children. Appl Environ Microbiol 2013; 79:5472-5479
14. Wacklin P, Kaukinen K, Tuovinen E, et al. The duodenal microbiota composition of adult celiac disease patients is associated with the clinical manifestations of the disease. Inflamm Bowel Dis 2013; 19:934-941
15. Kalliomaki M, Satokari R, Laheenoja H, et al. Expression of microbiota, Toll-like receptors, and their regulators in the small intestinal mucosa in celiac disease. J Pediatr Gastroenterol Nutr 2012; 54:727-732
16. Nisatl E, Caminero A, Herran AR, et al. Differences of small intestinal bacteria populations in adults and children with/without celiac disease: Effect of age, gluten diet and disease. Inflamm Bowel Dis 2012; 18:649-656
17. Schippa S, Iebba V, Barbato M, et al. A distinctive 'microbial signature' in celiac pediatric patients. BMC Microbiol 2010; 10:175
18. Ou G, Hedberg M, Horstedt P, et al. Proximal small intestinal microbiota and identification of rod-shaped bacteria associated with childhood celiac disease. Am J Gastroenterol 2009; 104:3058-3067
19. Nadal I, Donat E, Ribes-Koninckz C, et al. Imbalance in the composition of the duodenal microbiota of children with celiac disease. J Med Microbiol 2007; 56:1669-1674
20. Kerckhoffs AP, Samsom M, van Der Rest ME, et al. Lower Bifidobacterial counts in both duodenal mucosa-Associated and fecal microbiota in irritable bowel syndrome patients. World J Gastroenterol 2009; 15:2887-2892
21. Hayashi H, Takahashi R, Nishi T, et al. Molecular analysis of jejunal, ileal, caecal and rectosigmoidal human colonic microbiota using 16S rRNA gene libraries and terminal restriction fragment length polymorphism. J Med Microbiol 2005; 54:1093-1101
22. Larsson E, Tremaroli V, Lee YS, et al. Analysis of gut microbial regulation of host gene expression along the length of the gut and regulation of gut microbial ecology through MyD88. Gut 2012; 61:1124-1131
23. Zilberstein B, Quintanilha AG, Santos MA, et al. Digestive tract microbiota in healthy volunteers. Clinics 2007; 62:47-54
24. Quintanilha AG, Zilberstein B, Santos MA, et al. A novel sampling method for the investigation of gut microbiota. World J Gastroenterol 2007; 13:3990-3995
25. Sachdev AH, Pimentel M. Gastrointestinal bacterial overgrowth: Pathogenesis and clinical significance. Ther Adv Chronic Dis 2013; 4:223-231
26. Grace E, Shaw C, Whelan K, Andreyev HJ. Review article: Small intestinal bacterial overgrowth -prevalence, clinical features, current and developing diagnostic tests and treatment. Aliment Phramacol Ther 2013; 38:674-688
27. Rana SV, Sharma S, Kaur J, et al. Comparison of lactulose and glucose breath test for diagnosis of small intestinal bacterial overgrowth in patients with irritable bowel syndrome. Digestion 2012; 85:243-247
28. Yu D, Cheesman F, Vanner S. Combined oro-cecal scintigraphy and lactulose hydrogen breath testing demonstrate that breath testing detects oro-cecal transit, not small intestinal bacterial overgrowth in patients with IBS. Gut 2011; 60:334-340
29. Pyleris E, Giamarellos-Bourboulis EJ, Tzivras D, et al. The prevalence of overgrowth by aerobic bacteria in the small intestine by small bowel culture: Relationship with irritable bowel syndrome. Dig Dis Sci 2012; 57:1321-1329
30. Furnari M, Savarino E, Bruzzone L, et al. Reassessment of the role of methane production between irritable bowel syndrome and functional constipation. J Gastrointest Liver Dis 2012; 21:157-163
31. Scarpellini E, Giorgio V, Gabrielli M, et al. Rifaximin treatment for small intestinal bacterial overgrowth in children with irritable bowel syndrome. Eur Rev Med Pharmacol Sci 2013; 17:1314-1320
32. Spiegel BM. Questioning the bacterial overgrowth hypothesis of irritable bowel syndrome: An epidemiologic and evolutionary perspective. Clin Gastroenterol Hepatol 2011; 9:461-469
33. Deloose E, Janssen P, Depoortere I, Tack J. The migrating motor complex: Control mechanisms and its role in health and disease. Nat Rev Gastroenterol Hepatol 2012; 9:271-285
34. Choung RS, Ruff KC, Malhotra A, et al. Clinical predictors of small intestinal bacterial overgrowth by duodenal aspirate culture. Aliment Pharmacol Ther 2011; 33:1059-1067
35. Gutierrez IM, Kang KH, Calvert CE, et al. Risk factors for small bowel bacterial overgrowth and diagnostic yield of duodenal aspirates in children with intestinal failure: A retrospective review. J Pediatr Surg 2012; 47:1150-1154
36. Savarino E, Mei F, Parodi A, et al. Gastrointestinal motility disorder assessment in systemic sclerosis. Rheumatology 2013; 52:1095-1100
37. Bablir-Gurman A, Brook OR, Chermesh I, Braun-Moscovici Y. Pneumatosis cystoides intestinalis in scleroderma-related conditions. Intern Med J 2012; 42:323-329
38. Faria M, Pavin EJ, Parisi MC, et al. Delayed small intestinal transit in patients with long-standing type 1 diabetes mellitus: Investigation of the relationships with clinical features, gastric emptying, psychological distress, and nutritional parameters. Diabetes Technol Ther 2013; 15:32-38
39. Rana S, Bhansali A, Bhadada S, et al. Orocecal transit time and small intestinal bacterial overgrowth in type 2 diabetes patients from North India. Diabetes Technol Ther 2011; 13:115-120
40. George NS, Sankineni A, Parkman HP. Small intestinal bacterial overgrowth in gastroparesis. Dig Dis Sci 2012; Epub ahead of print
41. Kim KM, Kim BT, Lee DJ, et al. Erosive esophagitis may be related to small intestinal bacterial overgrowth. Scand J Gastroenterol 2012; 47:493-498
42. Wiest R, Lawson M, Geuking M. Pathological bacterial translocation in liver cirrhosis. J Hepatol 2014; 60:197-209
43. Bellot P, Frances R, Such J. Pathological bacterial translocation in cirrhosis: Pathophysiology, diagnosis and clinical implications. Liver Int 2013; 33:31-39
44. Chander Roland B, Garcia-Tsao G, Ciarleglio MM, et al. Decompensated cirrhotics have slower intestinal transit times as compared with compensated cirrhotics and healthy controls. J Clin Gastroenterol 2013; 47:888-893
45. Fasano A, Bove F, Gabrielli M, et al. The role of small intestinal bacterial overgrowth in Parkinson's disease. Mov Disord 2013; 28:1241-1249
46. Dobbs RJ, Charlett A, Dobbs SM, et al. Leukocyte-subset counts in idiopathic parkinsonism provide clues to a pathogenic pathway involving small intestinal bacterial overgrowth. A prevalence study. Gut Pathogens 2012; 4:12
47. Gabrielli M, Bonazzi P, Scarpellini E, et al. Prevalence of small intestinal bacterial overgrowth in Parkinson's disease. Mov Disord 2011; 26:889-892
48. Dobbs SM, Charlett A, Dobbs RJ, et al. Antimicrobial surveillance in idiopathic parkinsonism: Indication-specific improvement in hypokinesia following Helicobacter pylori eradication and nonspecific effect of antimicrobials for other indications in worsening rigidity. Helicobacter 2013; 18:187-196
49. Rana SV, Sharma S, Malik A, et al. Small intestinal bacterial overgrowth and orocecal transit time in patients of inflammatory bowel disease. Dig Dis Sci 2013; 58:2594-2598
50. Jacobs C, Coss Adams E, Attaluri A, et al. Dysmotility and proton pump inhibitor use are independent risk factors for small intestinal bacterial and/or fungal overgrowth. Aliment Pharmacol Ther 2013; 37:1103-1111
51. Ratuapli SK, Ellington TG, O'Neill MT, et al. Proton pump inhibitor therapy use does not predispose to small intestinal bacterial overgrowth. Am J Gastroenterol 2012; 107:730-735
52. Van Vlerken LG, Huisman EJ, van Hoek B, et al. Bacterial infections in cirrhosis: Role of proton pump inhibitors and intestinal permeability. Eur J Clin Invest 2012; 42:760-767
53. Lo WK, Chan WW. Proton pump inhibitor use and the risk of small intestinal bacterial overgrowth: A meta-Analysis. Clin Gastroenterol Hepatol 2013; 11:483-490
54. Miller LS, Vegesna AK, Sampath AM, et al. Ileocecal valve dysfunction in small intestinal bacterial overgrowth: A pilot study. World J Gastroenterol 2012; 18:6801-6808
55. Sung YK, Gwak GY, Choi MS, et al. A case of nonalcoholic steatohepatitis and small intestinal bacterial overgrowth with peripheral edema caused by intestinal bypass surgery and relived by repair. Gut Liver 2012; 6:520-523
56. Lisowska A, Pogorzelski A, Oracz G, et al. Oral antibiotic therapy improves fat absorption in cystic fibrosis patients with small intestine bacterial overgrowth. J Cyst Fibrosis 2011; 10:418-421
57. Campanati A, Gesuita R, Giannoni M, et al. Role of small intestinal bacterial overgrowth and Helicobacter pylori infection in chronic spontaneous urticarial: A prospective analysis. Acta Derm Venereol 2013; 93:161-164
58. Basu PP, Shah NJ, Krishnaswamy N, Pacana T. Prevalence of restless legs syndrome in patients with irritable bowel syndrome. World J Gastroenterol 2011; 17:4404-4407
59. Bohm M, Siwiec RM, Wo JM. Diagnosis and management of small intestinal bacterial overgrowth. Nutr Clin Pract 2013; 28:289-299
60. Shah SC, Day LW, Somsouk M, Sewell JL. Meta-Analysis: Antibiotic therapy for small intestinal bacterial overgrowth. Aliment Pharmacol Ther 2013; 38:925-934
61. Kerckhoffs AP, Visser MR, Samsom M, et al. Critical evaluation of diagnosing bacterial overgrowth in the proximal small intestine. J Clin Gastroenterol 2008; 42:1095-1102
62. Rosania R, Giorgio F, Principi M, et al. Effect of probiotic or prebiotic supplementation on antibiotic therapy in the small intestinal bacterial overgrowth: A comparative evaluation. Curr Clin Pharmacol 2013; 8:169-172