Is folic acid supplementation really necessary in preterm infants ≤32 weeks of gestation?

Journal of Pediatric Gastroenterology and Nutrition

Volumn 58, Issue 2, 2014, Pages 188-192

  Oncel, Mehmet Yekta ^a   Calisici, Erhan ^a   Ozdemir, Ramazan ^b   Yurttutan, Sadik ^a   Erdeve, Omer ^c   Karahan, Sevilay ^d   Dilmen, Ugur ^a  

^a Zekai Tahir Burak Maternity Teaching Hospital   (Turkey)

^b INONU UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

^c ANKARA UNIVERSITY   (Turkey)

^d HACETTEPE UNIVERSITY   (Turkey)

Author keywords

breast milk fortifiers; folic acid; preterm formula; preterm infant; supplementation

Indexed keywords

FOLIC ACID; PARENTERAL SOLUTION; VITAMIN B COMPLEX;

ARTIFICIAL MILK; BIRTH WEIGHT; BLOOD; BREAST MILK; CHEMISTRY; DIET SUPPLEMENTATION; FEMALE; FOLIC ACID DEFICIENCY; GESTATIONAL AGE; HUMAN; MALE; MATERNAL NUTRITION; NEWBORN; NUTRITIONAL REQUIREMENT; PARENTERAL NUTRITION; PREGNANCY; PREMATURITY; PRENATAL CARE; RISK FACTOR; SMOKING;

BIRTH WEIGHT; DIETARY SUPPLEMENTS; FEMALE; FOLIC ACID; FOLIC ACID DEFICIENCY; GESTATIONAL AGE; HUMANS; INFANT FORMULA; INFANT, NEWBORN; INFANT, PREMATURE; MALE; MILK, HUMAN; NUTRITIONAL REQUIREMENTS; PARENTERAL NUTRITION; PARENTERAL NUTRITION SOLUTIONS; PREGNANCY; PRENATAL CARE; PRENATAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; RISK FACTORS; SMOKING; VITAMIN B COMPLEX;

EID: 84894063912     PISSN: 02772116     EISSN: 15364801     Source Type: Journal    
DOI: 10.1097/MPG.0000000000000181     Document Type: Article

References (19)

1. Dewey KG. Nutrition, growth, and complementary feeding of the breastfed infant. Pediatr Clin North Am 2001;48:87-104.
2. Craciunescu CN, Brown EC, Mar MH, et al. Folic acid deficiency during late gestation decreases progenitor cell proliferation and increases apoptosis in fetal mouse brain. J Nutr 2004;134:162-6.
3. Moyers S, Bailey LB. Fetal malformations and folate metabolism: review of recent evidence. Nutr Rev 2001;59:215-24.
4. Craciunescu CN, Johnson AR, Zeisel SH. Dietary choline reverses some, but not all, effects of folate deficiency on neurogenesis and apoptosis in fetal mouse brain. J Nutr 2010;140:1162-6.
5. Agostoni C, Buonocore G, Carnielli VP, et al. Enteral nutrient supply for preterm infants: commentary from the European Society of Paediatric Gastroenterology, Hepatology, and Nutrition Committee on Nutrition. J Pediatr Gastroenterol Nutr 2010;50:85-91.
6. Czeizel AE, Tomcsik M. Acute toxicity offolic acid in pregnant women. Teratology 1999;60:3-4.
7. Tamura T, Yoshimura Y, Arakawa T. Human milk folate and folate status in lactating mothers and their infants. Am J Clin Nutr 1980; 33:193-7.
8. Keizer SE, Gibson RS, O'Connor DL. Postpartum folic acid supplementation of adolescents: impact on maternal folate and zinc status and milk composition. Am J Clin Nutr 1995;62:377-84.
9. Tsang RC, Lucas A, Uauy R. Nutritional Needs of the Preterm Infant: Scientific Basis and Practical Guidelines. New York: Caduceus Medical; 2005:56-65.
10. Pagan K, Hou J, Goldenberg RL, et al. Effect of smoking on serum concentrations of total homocysteine and B vitamins in mid-pregnancy. Clin Chim Acta 2001;306:103-9.
11. Ek J, Behnecke L, Halvorsen KS, et al. Plasma and red cell folate values and folate requirements in formula-fed premature infants. Eur J Pediatr 1984;142:78-82.
12. Vanier TM, Tyas JF. Folic acid status in premature infants. Arch Dis Child 1967;42:57-61.
13. Strelling MK, Blackledge DG, Goodall HB. Diagnosis and management of folate deficiency in low birthweight infants. Arch Dis Child 1979;54:271-7.
14. Hoffbrand AV. Folate deficiency in premature infants. Arch Dis Child 1970;45:441-4.
15. Orzalesi M, Colarizi P. Critical vitamins for low birthweight infants. Acta Paediatr Scand Suppl 1982;296:104-9.
16. Roberts PM, Arrowsmith DE, Lloyd AV, et al. Effect of folic acid treatment on premature infants. Arch Dis Child 1972;47:631-4.
17. Kendall AC, Jones EE, Wilson CI, et al. Folic acid in low birthweight infants. Arch Dis Child 1974;49:736-8.
18. Jyothi S, Misra I, Morris G, et al. Red cell folate and plasma homo-cysteine in preterm infants. Neonatology 2007;92:264-8.
19. Oncel MY, Ozdemir R, Erdeve O, et al. Influence of maternal cigarette smoking during pregnancy on neonatal serum folate levels. Eur J Nutr 2012;51:385-7.