Sarcopenic obesity and risk of cardiovascular disease and mortality: A population-based cohort study of older men

Journal of the American Geriatrics Society

Volumn 62, Issue 2, 2014, Pages 253-260

  Atkins, Janice L ^a   Whincup, Peter H ^b   Morris, Richard W ^a   Lennon, Lucy T ^a   Papacosta, Olia ^a   Wannamethee, S Goya ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b ST GEORGE S HOSPITAL   (United Kingdom)

Author keywords

cardiovascular disease; mortality; muscle mass; obesity; sarcopenia

Indexed keywords

CARDIOVASCULAR DISEASE; MORTALITY; MUSCLE MASS; OBESITY; SARCOPENIA;

AGED; BODY COMPOSITION; BODY MASS INDEX; CARDIOVASCULAR DISEASES; CAUSE OF DEATH; COHORT STUDIES; FORECASTING; GREAT BRITAIN; HUMANS; MALE; MIDDLE AGED; OBESITY; POPULATION SURVEILLANCE; PROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS; SARCOPENIA;

EID: 84894060559     PISSN: 00028614     EISSN: 15325415     Source Type: Journal    
DOI: 10.1111/jgs.12652     Document Type: Article

References (39)

1. Myint PK, Welch AA,. Healthier ageing. BMJ 2012; 344: e1214.
2. Baumgartner RN,. Body composition in healthy aging. Ann N Y Acad Sci 2000; 904: 437-448.
3. Zamboni M, Mazzali G, Fantin F, et al. Sarcopenic obesity: A new category of obesity in the elderly. Nutr Metab Cardiovasc Dis 2008; 18: 388-395.
4. Cruz-Jentoft AJ, Baeyens JP, Bauer JM, et al. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing 2010; 39: 412-423.
5. Janssen I, Mark AE,. Elevated body mass index and mortality risk in the elderly. Obes Rev 2007; 8: 41-59.
6. de Hollander EL, Bemelmans WJ, Boshuizen HC, et al. The association between waist circumference and risk of mortality considering body mass index in 65- to 74-year-olds: A meta-analysis of 29 cohorts involving more than 58 000 elderly persons. Int J Epidemiol 2012; 41: 805-817.
7. Wijnhoven HA, Snijder MB, van Bokhorst-de van der Schueren MA, et al. Region-specific fat mass and muscle mass and mortality in community-dwelling older men and women. Gerontology 2012; 58: 32-40.
8. Han SS, Kim KW, Kim KI, et al. Lean mass index: A better predictor of mortality than body mass index in elderly Asians. J Am Geriatr Soc 2010; 58: 312-317.
9. Landi F, Russo A, Liperoti R, et al. Midarm muscle circumference, physical performance and mortality: Results from the aging and longevity study in the Sirente geographic area (ilSIRENTE study). Clin Nutr 2010; 29: 441-447.
10. Wannamethee SG, Shaper AG, Lennon L, et al. Decreased muscle mass and increased central adiposity are independently related to mortality in older men. Am J Clin Nutr 2007; 86: 1339-1346.
11. Wijnhoven HA, van Bokhorst-de van der Schueren MA, Heymans MW, et al. Low mid-upper arm circumference, calf circumference, and body mass index and mortality in older persons. J Gerontol A Biol Sci Med Sci 2010; 65A: 1107-1114.
12. Prado CM, Wells JC, Smith SR, et al. Sarcopenic obesity: A critical appraisal of the current evidence. Clin Nutr 2012; 31: 583-601.
13. Honda H, Qureshi AR, Axelsson J, et al. Obese sarcopenia in patients with end-stage renal disease is associated with inflammation and increased mortality. Am J Clin Nutr 2007; 86: 633-638.
14. Prado CMM, Liefers JR, McCargar LJ, et al. Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: A population-based study. Lancet Oncol 2008; 9: 629-635.
15. Stephen WC, Janssen I,. Sarcopenic-obesity and cardiovascular disease risk in the elderly. J Nutr Health Aging 2009; 13: 460-466.
16. Shaper AG, Pocock SJ, Walker M, et al. British Regional Heart Study: Cardiovascular risk factors in middle-aged men in 24 towns. BMJ (Clin Res Ed) 1981; 283: 179-186.
17. Walker M, Whincup PH, Shaper AG,. The British Regional Heart Study 1975-2004. Int J Epidemiol 2004; 33: 1185-1192.
18. Expert Panel on the Identification, Evaluation, and Treatment of Overweight in Adults. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: Executive summary. Am J Clin Nutr 1998; 68: 899-917.
19. Heymsfield SB, McManus C, Smith J, et al. Anthropometric measurement of muscle mass: Revised equations for calculating bone-free arm muscle area. Am J Clin Nutr 1982; 36: 680-690.
20. Noori N, Kopple JD, Kovesdy CP, et al. Mid-arm muscle circumference and quality of life and survival in maintenance hemodialysis patients. Clin J Am Soc Nephrol 2010; 5: 2258-2268.
21. Deurenberg P, van der Kooij K, Evers P, et al. Assessment of body composition by bioelectrical impedance in a population aged greater than 60 y. Am J Clin Nutr 1990; 51: 3-6.
22. Ramsay SE, Whincup PH, Shaper AG, et al. The relations of body composition and adiposity measures to ill health and physical disability in elderly men. Am J Epidemiol 2006; 164: 459-469.
23. Wannamethee SG, Lowe GD, Whincup PH, et al. Physical activity and hemostatic and inflammatory variables in elderly men. Circulation 2002; 105: 1785-1790.
24. Shaper AG, Wannamethee G, Walker M,. Alcohol and mortality in British men: Explaining the U-shaped curve. Lancet 1988; 2: 1267-1273.
25. Wannamethee SG, Whincup PH, Rumley A, et al. Inter-relationships of interleukin-6, cardiovascular risk factors and the metabolic syndrome among older men. J Thromb Haemost 2007; 5: 1637-1643.
26. Walker M, Shaper AG, Lennon L, et al. Twenty year follow-up of a cohort based in general practices in 24 British towns. J Public Health Med 2000; 22: 479-485.
27. Rose GA BH, Gillum RF, Prineas RJ,. Cardiovascular Survey Methods. Geneva, Switzerland: World Health Organization, 1982.
28. Sattar N, Murray HM, Welsh P, et al. Are markers of inflammation more strongly associated with risk for fatal than for nonfatal vascular events? PLoS Med 2009; 6: e1000099.
29. Lim S, Kim JH, Yoon JW, et al. Sarcopenic obesity: Prevalence and association with metabolic syndrome in the Korean Longitudinal Study on Health and Aging (KLoSHA). Diabetes Care 2010; 33: 1652-1654.
30. Lu CW, Yang KC, Chang HH, et al. Sarcopenic obesity is closely associated with metabolic syndrome. Obes Res Clin Pract 2012; 7: e301-e307.
31. Jensen GL,. Inflammation: Roles in aging and sarcopenia. JPEN J Parenter Enteral Nutr 2008; 32: 656-659.
32. Kaptoge S, Di Angelantonio E, Lowe G, et al. C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: An individual participant meta-analysis. Lancet 2010; 375: 132-140.
33. Grabowski DC, Ellis JE,. High body mass index does not predict mortality in older people: Analysis of the longitudinal study of aging. J Am Geriatr Soc 2001; 49: 968-979.
34. Dolan CM, Kraemer H, Browner W, et al. Associations between body composition, anthropometry, and mortality in women aged 65 years and older. Am J Public Health 2007; 97: 913-918.
35. Zamboni M, Mazzali G, Zoico E, et al. Health consequences of obesity in the elderly: A review of four unresolved questions. Int J Obes (Lond) 2005; 29: 1011-1029.
36. Rantanen T, Harris T, Leveille SG, et al. Muscle strength and body mass index as long-term predictors of mortality in initially healthy men. J Gerontol A Biol Sci Med Sci 2000; 55A: M168-M173.
37. Roubenoff R, Baumgartner RN, Harris TB, et al. Application of bioelectrical impedance analysis to elderly populations. J Gerontol A Biol Sci Med Sci 1997; 52A: M129-M136.
38. Bussolotto M, Ceccon A, Sergi G, et al. Assessment of body composition in elderly: Accuracy of bioelectrical impedance analysis. Gerontology 1999; 45: 39-43.
39. Thomas EL, Parkinson JR, Frost GS, et al. The missing risk: MRI and MRS phenotyping of abdominal adiposity and ectopic fat. Obesity 2012; 20: 76-87.