Reduced subcutaneous tissue distribution of cefazolin in morbidly obese versus non-obese patients determined using clinical microdialysis

Journal of Antimicrobial Chemotherapy

Volumn 69, Issue 3, 2014, Pages 715-723

  Brill, Margreke J E ^a,b   Houwink, Aletta P I ^b   Schmidt, Stephan ^c   Van dongen, Eric P A ^b   Hazebroek, Eric J ^b   Van ramshorst, Bert ^b   Deneer, Vera H ^b   Mouton, Johan W ^d   Knibbe, Catherijne A J ^a,b  

^a LEIDEN UNIVERSITY   (Netherlands)

^b ST ANTONIUS HOSPITAL   (Netherlands)

^c UNIVERSITY OF FLORIDA HEALTH   (United States)

^d RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Monte carlo simulations; Population pharmacokinetics; Subcutaneous ISF; Surgical prophylaxis

Indexed keywords

ANTIINFECTIVE AGENT; CEFAZOLIN;

ADULT; CHEMISTRY; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; MICRODIALYSIS; MIDDLE AGED; MORBID OBESITY; PLASMA; PROSPECTIVE STUDY; STATISTICAL MODEL; SUBCUTANEOUS TISSUE;

ADMINISTRATION, INTRAVENOUS; ADULT; ANTI-BACTERIAL AGENTS; CEFAZOLIN; FEMALE; HUMANS; MALE; MICRODIALYSIS; MIDDLE AGED; MODELS, STATISTICAL; OBESITY, MORBID; PLASMA; PROSPECTIVE STUDIES; SUBCUTANEOUS TISSUE;

EID: 84894051169     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkt444     Document Type: Article

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