Elevated platelets enhance cancer cell migration, promote hematogenous metastasis and associate with a poor prognosis in advanced non-small cell lung cancer cases

Asian Pacific Journal of Cancer Prevention

Volumn 15, Issue 1, 2014, Pages 139-143

  Li, Yan ^a   Miao, Li Yun ^a   Xiao, Yong Long ^a   Cai, Hou Rong ^a   Zhang, De Ping ^a  

^a THE AFFILIATED DRUM TOWER HOSPITAL OF NANJING UNIVERSITY MEDICAL SCHOOL   (China)

Author keywords

Metastasis; Non small cell lung carcinoma; Platelets; Prognosis; Survival

Indexed keywords

AGED; ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BLOOD; CELL MOTION; DISEASE FREE SURVIVAL; FEMALE; HUMAN; KAPLAN MEIER METHOD; LUNG NON SMALL CELL CANCER; LUNG TUMOR; MALE; METASTASIS; MIDDLE AGED; MOUSE; NUDE MOUSE; PATHOLOGY; RETROSPECTIVE STUDY; THROMBOCYTE; THROMBOCYTE COUNT; TUMOR CELL CULTURE; TUMOR EMBOLISM;

AGED; ANIMALS; BLOOD PLATELETS; CARCINOMA, NON-SMALL-CELL LUNG; CELL MOVEMENT; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; LUNG NEOPLASMS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; MIDDLE AGED; NEOPLASTIC CELLS, CIRCULATING; PLATELET COUNT; RETROSPECTIVE STUDIES; TUMOR CELLS, CULTURED;

EID: 84894050565     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: 10.7314/APJCP.2014.15.1.139     Document Type: Article

References (22)

1. Ayhan A, Bozdag G, Taskiran C, et al (2006). The value of preoperative platelet count in the prediction of cervical involvement and poor prognostic variables in patients with endometrial carcinoma. Gynecol Oncol, 103, 902-5.
2. Cho MS, Bottsford-Miller J, Vasquez HG, et al (2012). Platelets increase the proliferation of ovarian cancer cells. Blood, 120, 4869-72.
3. Costantini V, Zacharski LR, Moritz TE, Edwards RL (1990). The platelet count in carcinoma of the lung and colon. Thromb Haemost, 64, 501-5.
4. Davì G, Patrono C (2007). Platelet activation and atherothrombosis. N Engl J Med, 357, 2482-94.
5. Engan T, Hannisdal E (1990). Blood analyses as prognostic factors in primary lung cancer. Acta Oncol, 29, 151-4.
6. Gay LJ, Felding-Habermann B (2011). Contribution of platelets to tumour metastasis. Nat Rev Cancer, 11, 123-34.
7. Herbst RS, Heymach JV, Lippman SM (2008). Lung cancer. N Engl J Med, 359, 1367-80.
8. Hernandez E, Lavine M, Dunton CJ, et al (1992). Poor prognosis associated with thrombocytosis in patients with cervical cancer. Cancer, 69, 2975-7.
9. Ho-Tin-Noé B, Goerge T, Wagner DD (2009). Platelets: guardians of tumor vasculature. Cancer Res, 69, 5623-6.
10. Ikeda M, Furukawa H, Imamura H, et al (2002). Poor prognosis associated with thrombocytosis in patients with gastric cancer. Ann Surg Oncol, 9, 287-91.
11. Italiano JE Jr, Richardson JL, Patel-Hett S, et al (2008). Angiogenesis is regulated by a novel mechanism: pro-and antiangiogenic proteins are organized into separateplatelet alpha granules and differentially released. Blood, 111, 1227-33.
12. Nieswandt B, Hafner M, Echtenacher B, Mannel DN (1999). Lysis of tumor cells by natural killer cells in mice is impeded by platelets. Cancer Res, 59, 1295-300.
13. Palumbo JS, Talmage KE, Massari JV, et al (2005). Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells. Blood, 105, 178-85.
14. Pedersen LM, Milman N (1996). Prognostic significance of thrombocytosis in patients with primary lung cancer. Eur Respir J, 9, 1826-30.
15. Ruggeri ZM, Mendolicchio GL (2007). Adhesion mechanisms in platelet function. Circ Res, 100, 1673-85.
16. Scholz HS, Petru E, Gucer F, et al (2000). Preoperative thrombocytosis is an independent prognostic factor in stage III and IV endometrial cancer. Anticancer Res, 20, 3983-5.
17. Shimada H, Oohira G, Okazumi S, et al (2004). Thrombocytosis associated with poor prognosis in patients with esophageal carcinoma. J Am Coll Surg, 198, 737-41.
18. Siegel R, Naishadham D, Jemal A (2012). Cancer statistics, 2012. CA Cancer J Clin, 62, 10-29.
19. Takagi S, Sato S, Oh-Hara T, et al (2013). Platelets Promote Tumor Growth and Metastasis via Direct Interaction between Aggrus/Podoplanin and CLEC-2. PLoS One, 8, e73609.
20. Tomita M, Shimizu T, Hara M, et al (2008). Prognostic impact of thrombocytosis in resectable non-small cell lung cancer. Interact Cardiovasc Thorac Surg, 7, 613-5.
21. Yu D, Liu B, Zhang L, Du K (2013). Platelet count predicts prognosis in operable non-small cell lung cancer. Exp Ther Med, 5, 1351-4.
22. Zeimet AG, Marth C, Muller-Holzner E, et al (1994). Significance of thrombocytosis in patients with epithelial ovarian cancer. Am J Obstet Gynecol, 170, 549-54.