A higher d-dimer threshold safely rules-out pulmonary embolism in very elderly emergency department patients

Thrombosis Research

Volumn 133, Issue 3, 2014, Pages 380-383

  Polo Friz, Hernan ^a   Pasciuti, Lorenzo ^a   Meloni, Dario Francesco ^a   Crippa, Matteo ^a   Villa, Giulia ^a   Molteni, Mauro ^a   Primitz, Laura ^a   Del Sorbo, Davide ^a   Delgrossi, Giovanni ^a   Cimminiello, Claudio ^a  

^a DESIO HOSPITAL   (Italy)

Author keywords

Cutoff values; D dimer; Pulmonary computed tomography angiography; Pulmonary embolism; Very elderly

Indexed keywords

FIBRIN DEGRADATION PRODUCT; FIBRIN FRAGMENT D;

AGE; AGED; ANGIOGRAPHY; BLOOD; COHORT ANALYSIS; EMERGENCY HEALTH SERVICE; FEMALE; HUMAN; MALE; METABOLISM; PROCEDURES; PULMONARY EMBOLISM; RADIOGRAPHY; RETROSPECTIVE STUDY; VERY ELDERLY;

AGE FACTORS; AGED; AGED, 80 AND OVER; ANGIOGRAPHY; COHORT STUDIES; EMERGENCY SERVICE, HOSPITAL; FEMALE; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; HUMANS; MALE; PULMONARY EMBOLISM; RETROSPECTIVE STUDIES;

EID: 84893963547     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2013.12.045     Document Type: Article

References (17)

1. A. Torbicki, A. Perrier, S. Konstantinides, G. Agnelli, N. Gali e', and P. Pruszczyk et al. Guidelines on the diagnosis and management of acute pulmonary embolism: the Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC) Eur Heart J 29 2008 2276 2315
2. J. Hirsh, G. Guyatt, G.W. Albers, R. Harrington, H.J. Schunemann, and American College of Chest Physicians Executive summary: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition) Chest 133 2008 71S 109S
3. P.S. Wells, D.R. Anderson, M. Rodger, J.S. Ginsberg, C. Kearon, and M. Gent et al. Derivation of a simple clinical model to categorize patients probability of pulmonary embolism: increasing the models utility with the SimpliRED D-dimer Thromb Haemost 83 2000 416 420
4. J. Wicki, T.V. Perneger, A.F. Junod, H. Bounameaux, and A. Perrier Assessing clinical probability of pulmonary embolism in the emergency ward: a simple score Arch Intern Med 161 2001 92 97
5. E. Ceriani, C. Combescure, G. Le Gal, M. Nendaz, T. Perneger, and H. Bounameaux et al. Clinical prediction rules for pulmonary embolism: a systematic review and meta-analysis J Thromb Haemost 8 5 2010 May 957 970
6. A. Penaloza, F. Verschuren, G. Meyer, S. Quentin-Georget, C. Soulie, and F. Thys et al. Comparison of the unstructured clinician gestalt, the wells score, and the revised Geneva score to estimate pretest probability for suspected pulmonary embolism Ann Emerg Med 62 2 2013 117 124
7. G. Le Gal, and H. Bounameaux Diagnosing pulmonary embolism: running after the decreasing prevalence of cases among suspected patients J Thromb Haemost 2 8 2004 1244 1246
8. P.L. Harper, E. Theakston, J. Ahmed, and P. Ockelford D-dimer concentration increases with age reducing the clinical value of the D-dimer assay in the elderly Intern Med J 37 9 2007 607 613
9. R.A. Douma, G. le Gal, M. Söhne, M. Righini, P.W. Kamphuisen, and A. Perrier et al. Potential of an age adjusted D-dimer cutoff value to improve the exclusion of pulmonary embolism in older patients: a retrospective analysis of three large cohorts BMJ 340 2010 c1475
10. M. Jaffrelot, F. Le Ven, and P.Y. Le Roux et al. External validation of a D-dimer age adjusted cutoff for the exclusion of pulmonary embolism Thromb Haemost 107 5 2012 1005 1007
11. A. Penaloza, P.M. Roy, and J. Kline et al. Performance of age-adjusted D-dimer cutoff to rule out pulmonary embolism J Thromb Haemost 10 7 2012 1291 1296
12. H.J. Schouten, H.L. Koek, and R. Oudega et al. Validation of two age dependent D-dimer cutoff values for exclusion of deep vein thrombosis in suspected elderly patients in primary care: retrospective, cross sectional, diagnostic analysis BMJ 344 2012 e2985
13. F.J. Haas, R.E. Schutgens, and D.H. Biesma An age-adapted approach for the use of D-dimers in the exclusion of deep venous thrombosis Am J Hematol 84 8 2009 488 491
14. D. Coen Herak, M. Milos, and R. Zadro Evaluation of the Innovance D-DIMER analytical performance Clin Chem Lab Med 47 8 2009 945 951
15. R.S. Wiener, L.M. Schwartz, and S. Woloshin When a test is too good: how CT pulmonary angiograms find pulmonary emboli that do not need to be found BMJ 347 Jul 2 2013 f3368
16. A.C. Ng, T. Chung, A.S. Yong, H.S. Wong, V. Chow, and D.S. Celermajer et al. Long-term cardiovascular and noncardiovascular mortality of 1023 patients with confirmed acute pulmonary embolism Circ Cardiovasc Qual Outcomes 4 1 2011 122 128
17. F. Pomero, L. Fenoglio, R. Melchio, C. Serraino, W. Ageno, and F. Dentali Incidence and diagnosis of pulmonary embolism in Northern Italy: A population-based study Eur J Intern Med S0953-6205 13 2013 00012 00015