Should blood donors be routinely screened for glucose-6-phosphate dehydrogenase deficiency? A systematic review of clinical studies focusing on patients transfused with glucose-6-phosphate dehydrogenase-deficient red cells

Transfusion Medicine Reviews

Volumn 28, Issue 1, 2014, Pages 7-17

  Renzaho, Andre M N ^a,b   Husser, Eliette ^a   Polonsky, Michael ^c  

^a MONASH UNIVERSITY   (Australia)

^b BURNET INSTITUTE   (Australia)

^c DEAKIN UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGE FACTORS; ANEMIA, HEMOLYTIC; BLOOD DONORS; BLOOD SAFETY; BLOOD TRANSFUSION; CHILD; DONOR SELECTION; ERYTHROCYTE TRANSFUSION; EXCHANGE TRANSFUSION, WHOLE BLOOD; FEMALE; GLUCOSEPHOSPHATE DEHYDROGENASE; GLUCOSEPHOSPHATE DEHYDROGENASE DEFICIENCY; HUMANS; HYPERBILIRUBINEMIA; INFANT, NEWBORN; INFANT, PREMATURE; LIVER; MALE; PHOTOTHERAPY; PREDICTIVE VALUE OF TESTS; PREVALENCE; RESEARCH DESIGN; WORLD HEALTH;

EID: 84893960366     PISSN: 08877963     EISSN: 15329496     Source Type: Journal    
DOI: 10.1016/j.tmrv.2013.10.003     Document Type: Review

References (42)

1. Glucose-6-phosphate dehydrogenase deficiency. Bull World Health Organ 1989, 67:601-611. World Health Organization Working Group.
2. Di Domenico G., Mottola M., Caldora M., Bevilacqua P., Meluccio E., Nocera C., et al. Characterization of glucose 6-phosphate dehydrogenase deficiency (FAVISM) in a population of blood donors in Naples. Italy. Vox Sang 2010, 99:149.
3. Minucci A., Moradkhani K., Hwang M.J., Zuppi C., Giardina B., Capoluongo E. Blood cells, molecules, and diseases. Blood Cells Mol Dis 2012, 48:154-165.
4. Pamba A., Richardson N.D., Carter N., Duparc S., Premji Z., Tiono A.B., et al. Clinical spectrum and severity of hemolytic anemia in glucose 6-phosphate dehydrogenase-deficient children receiving dapsone. Blood 2012, 120:4123-4133.
5. Cappellini M., Fiorelli G. Glucose-6-phosphate dehyrdogenase deficiency. Lancet 2008, 371:64-74.
6. Nkhoma E.T., Poole C., Vannappagari V., Hall S.A., Beutler E. The global prevalence of glucose-6-phosphate dehydrogenase deficiency: a systematic review and meta-analysis. Blood Cells Mol Dis 2009, 42:267-278.
7. Francis, R.O., J.S. Jhang, H.P. Pham, E.A. Hod, J.C. Zimring, and S.L. Spitalnik, Glucose-6-phosphate dehydrogenase deficiency in transfusion medicine: the unknown risks. Vox Sang, 2013. doi: 10.1111/vox.12068. [Epub ahead of print].
8. Alabdulaali M.K., Alayed K.M., Alshaikh A.F., Almashhadani S.A. Prevalence of glucose-6-phosphate dehydrogenase deficiency and sickle cell trait among blood donors in Riyadh. Asian J Transfus Sci 2010, 4:31-33.
9. Padilla C.D., Therrell B.L. Newborn screening in the Asia Pacific region. J Inherit Metab Dis 2007, 30:490-506.
10. World Health Organization. Blood Donor Selection: Guidelines on Assessing Donor Suitability for Blood Donation 2012. WHO: Geneva.
11. Deyhim M.R., Rostamian A.R., Abolghasemi H., Rezvan H., Maghsoudlu M., Gharabaghian A., et al. An evaluation of glucose-6-phosphatedehyrogenase (G6PD) deficiency in blood donors in Mazandaran province, in Iran by spot test and enzymatic methods. Vox Sang 2011, 101:290.
12. Riley W., Schwei M., McCullough J. The United States' potential blood donor pool: estimating the prevalence of donor-exclusion factors on the pool of potential donors. Transfusion 2007, 47:1180-1188.
13. Kaplan M., Hammerman C. Exchange transfusion for neonatal hyperbilirubinemia with glucose-6-phosphate-deficient blood. Pediatr Health 2009, 3:119-123.
14. Australian Institute of Health and Welfare Australia's Health 2012 2012, AIHW, Canberra.
15. Australian Department of Health and Ageing, Analysis of Cost Drivers and Trends in the Blood Sector Options to Manage Appropriate Use of Blood and Blood Products. Part 3: Conclusions-Key Findings and the Way Forward, 2011. Canberra: Sapere Research Group. Available at. Accessed 11/04/2013. http://www.health.gov.au/internet/main/publishing.nsf/Content/E80E195CFBCE77CBCA2578790017413B/$File/FOI%20158-1112%20document%201.pdf.
16. Brown University, Division of Biology and Medicine Blood Substitutes. Available at:, Accessed 10 September 2013. http://www.biomed.brown.edu/Courses/BI108/2006-108websites/group09artificialblood/index.htm.
17. Swerdlow P.S. Red cell exchange in sickle cell disease. Hematology Am Soc Hematol Educ Program 2006, 2006:48-53.
18. King K.E., Shirey R.S., Lankiewicz M.W., Young-Ramsaran J., Ness P.M. Delayed hemolytic transfusion reactions in sickle cell disease: simultaneous destruction of recipients' red cells. Transfusion 1997, 37:376-381.
19. Evans D. Hierarchy of evidence: a framework for ranking evidence evaluating healthcare interventions. J Clin Nurs 2003, 12:77-84.
20. Egger, M., G.D. Smith, and D.G. Altman, Systematic reviews in health care. Meta-analysis in context, 2001, London: BMJ Books.
21. Zekavat O.R., Karimi M., Rahmanian F. Is red cell from an otherwise healthy G6PD-deficient donor efficient for transfusion to fauvism patients?. Indian J Hematol Blood Transfus 2009, 25:23-26.
22. Samanta S., Kumar P., Kishore S.S., Garewal G., Narang A. Donor blood glucose 6-phosphate dehydrogenase deficiency reduces the efficacy of exchange transfusion in neonatal hyperbilirubinemia. Pediatrics 2009, 123:e96-e100.
23. Nabavizadeh S.H., Anushiravani A. The prevalence of G6PD deficiency in blood transfusion recipients. Hematology 2007, 12:85-88.
24. Pishva N., Amoozegar H. Hyperbilirubinemia following exchange transfusion with G-6-PD deficient donor blood. Ir J Med Sci 2001, 26:143-145.
25. Kumar P., Sarkar S., Narang A. Acute intravascular haemolysis following exchange transfusion with G-6-PD deficient blood. Eur J Pediatr 1994, 153:98-99.
26. Mimouni F., Shohat S., Reisner S.H. G6PD-deficient donor blood as a cause of hemolysis in two preterm infants. Isr J Med Sci 1986, 22:120-122.
27. Olowe S.A., Ransome-Kuti O. Exchange transfusion using G-6-PG deficient or Hgb-AS blood in icteric neonates. J Natl Med Assoc 1981, 73:811-819.
28. Gulati S., Singh S., Narang A., Bhakoo O. Exchange transfusion with G-6-PD deficient donor blood causes exaggeration of neonatal hyperbilirubinemia. Indian Pediatr 1989, 26:499-501.
29. Raciti P.M., Francis R.O., Spitalnik P.F., Schwartz J., Jhang J.S. Acquired hemoglobin variants and exposure to glucose-6-phosphate dehydrogenase deficient red blood cell units during exchange transfusion for sickle cell disease in a patient requiring antigen-matched blood. J Clin Apher 2013, 28:325-329.
30. Huang C.-S., Sung Y.-C., Huang M.-J., Yang C.-S., Shei W.-S., Tang T.K. Content of reduced glutathione and consequences in recipients of glucose-6-phosphate dehydrogenase deficient red blood cells. Am J Hematol 1998, 57:187-192.
31. Shalev O., Manny N., Sharon R. Posttransfusional hemolysis in recipients of glucose-6-phosphate dehydrogenase-deficient erythrocytes. Vox Sang 1993, 64:94-98.
32. De Sena, L.L. and A.S. Ramalho. Clinical evaluation of glucose-6-phosphate dehydrogenase (G-6-PD) deficiency in a Brazilian population. Rev. Bras. Genét, 8:89-96.
33. McCurdy P.R., Morse E.E. Glucose-6-phosphate dehydrogenase deficiency and blood transfusion. Vox Sang 1975, 28:230-237.
34. Kanias T., Gladwin M.T. Nitric oxide, hemolysis, and the red blood cell storage lesion: interactions between transfusion, donor, and recipient. Transfusion 2012, 52:1388-1392.
35. Beutler E. G6PD deficiency. Blood 1994, 84:3613-3636.
36. Agarwal P., Ray V.L., Choudhury N., Agarwal S., Chaudhary R.K. Effect of gamma irradiation on blood from glucose 6 phosphate dehydrogenase deficient blood donors. Hematology 2007, 12:267-270.
37. Westerman M., Wald N., Diloy-Puray M. Irradiation shortens the survival time of red cells deficient in glucose-6-phosphate dehydrogenase. Radiat Res 1980, 81:473-477.
38. Ainoon O., Alawiyah A., Yu Y., Cheong S., Hamidah N., Boo N., et al. Semiquantitative screening test for G6PD deficiency detects severe deficiency but misses a substantial proportion of partially-deficient females. Southeast Asian J Trop Med Public Health 2003, 34:405-414.
39. Peters A.L., Van Noorden C.J. Glucose-6-phosphate dehydrogenase deficiency and malaria: cytochemical detection of heterozygous G6PD deficiency in women. J Histochem Cytochem 2009, 57:1003-1011.
40. Reclos G., Hatzidakis C., Schulpis K. Glucose-6-phosphate dehydrogenase deficiency neonatal screening: preliminary evidence that a high percentage of partially deficient female neonates are missed during routine screening. J Med Screen 2000, 7:46-51.
41. Wolf B.H., Weening R.S., Schutgens R.B., van Noorden C.J., Vogels I., Nagelkerke N.J. Detection of glucose-6-phosphate dehydrogenase deficiency in erythrocytes: a spectrophotometric assay and a fluorescent spot test compared with a cytochemical method. Clin Chim Acta 1987, 168:129-136.
42. Tagarelli A., Piro A., Bastone L., Condino F., Tagarelli G. Reliability of quantitative and qualitative tests to identify heterozygotes carrying severe or mild G6PD deficiency. Clin Biochem 2006, 39:183-186.