Comparison of cost-effectiveness of oral rapamycin plus bare-metal stents versus first generation of drug-eluting stents (from the Randomized Oral Rapamycin in Argentina [ORAR] 3 Trial)

American Journal of Cardiology

Volumn 113, Issue 5, 2014, Pages 815-821

  Rodriguez, Alfredo E ^a,b,c   Palacios, Igor ^d   Rodriguez Granillo, Alfredo M ^a   Mieres, Juan R ^b,c   Tarragona, Sonia ^e   Fernandez Pereira, Carlos ^f   Solorzano, Leonardo ^b,f   Pauletto, Ricardo ^b,c   Serruys, Patrick W ^g   Antoniucci, David ^h  

^a Centro de Estudios en Cardiologia Intervencionista (CECI)   (Argentina)

^b Sanatorio Otamendi y Miroli   (Argentina)

^c Miembro del Consejo de Cardiometabolismo de la Sociedad Argentina de Cardiología   (Argentina)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e Argentina Association in Health and Economics   (Argentina)

^f Clinica IMA   (Argentina)

^g ERASMUS MEDICAL CENTER   (Netherlands)

^h CAREGGI UNIVERSITY HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADMINISTRATION, ORAL; AGED; CORONARY ARTERY DISEASE; COST-BENEFIT ANALYSIS; DRUG-ELUTING STENTS; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MALE; MIDDLE AGED; PACLITAXEL; PERCUTANEOUS CORONARY INTERVENTION; SIROLIMUS; STENTS; TREATMENT OUTCOME;

EID: 84893905026     PISSN: 00029149     EISSN: 18791913     Source Type: Journal    
DOI: 10.1016/j.amjcard.2013.11.033     Document Type: Article

References (29)

1. A.E. Rodríguez, A. Maree, S. Tarragona, C. Fernández- Pereira, O. Santaera, A.M. Rodriguez Granillo, G.A. Rodríguez-Granillo, M. Russo-Felssen, N. Kukreja, D. Antoniucci, I. Palacios, and P.W. Serruys Percutaneous coronary intervention with oral sirolimus and bare metal stents has comparable safety and efficacy to treatment with drug eluting stents, but with significant cost saving: long-term follow-up results from the randomized, controlled ORAR III (Oral Rapamycin in ARgentina) study Euro Intervention 5 2009 255 264
2. A.E. Rodriguez, A.M. Rodriguez-Granillo, D. Antoniucci, J. Mieres, C. Fernandez-Pereira, G.A. Rodriguez-Granillo, O. Santaera, B. Rubilar, I.F. Palacios, and P.W. Serruys Randomized comparison of cost-saving and effectiveness of oral rapamycin plus bare-metal stents with drug-eluting stents: three-year outcome from the randomized oral rapamycin in Argentina (ORAR) III trial Catheter Cardiovasc Interv 80 2012 385 394
3. A.E. Rodriguez, L. Grinfeld, C. Fernandez-Pereira, J. Mieres, M. Rodriguez Alemparte, D. Berrocal, A.M. Rodriguez-Granillo, C.F. Vigo, M. Russo Felsen, W. O'Neill, and I. Palacios Revascularization strategies of coronary multiple vessel disease in the drug eluting stent era: one year follow-up results of the ERACI III trial Euro Intervention 2 2006 53 60
4. A.E. Rodriguez, J. Mieres, C. Fernandez-Pereira, C.F. Vigo, M. Rodriguez-Alemparte, D. Berrocal, L. Grinfeld, and I. Palacios Coronary stent thrombosis in the current drug eluting stent era: insights from the ERACI III trial J Am Coll Cardiol 47 2006 205 207
5. P. Vranckx, P.-P. Kint, M.-A. Morel, G.-A. Van Es, P.W. Serruys, and D. Cutlip Identifying stent thrombosis, a critical appraisal of the Academic Research Consortium (ARC) consensus definitions: a lighthouse and as a toe in the water Euro Intervention 4 Suppl. C 2008 C39 C44
6. M.R. Gold, J.E. Siegel, L.B. Russell, and M.C. Weinstein Cost-Effectiveness in Health and Medicine 1996 Oxford University Press
7. J.W. Moses, M.B. Leon, J.J. Popma, P.J. Fitzgerald, D.R. Holmes, C. O'Shaughnessy, R.P. Caputo, D.J. Kereiakes, D.O. Williams, P.S. Teirstein, J.L. Jaeger, and R.E. Kuntz Sirolimus-eluting stents versus standard stents in patients with stenosis in a native coronary artery N Engl J Med 349 2003 1315 1323
8. G.W. Stone, S.G. Ellis, L. Cannon, J.T. Mann, J.D. Greenberg, D. Spriggs, C.D. O'Shaughnessy, S. De Mario, P. Hall, J.J. Popma, J. Koglin, and M.E. Russell Comparison of a polymer based paclitaxel-eluting stent with a bare metal stent in patients with complex coronary artery disease: a randomized controlled trial JAMA 294 2005 1215 1223
9. A. Caixeta, M.B. Leon, A.J. Lansky, E. Nikolsky, J. Aoki, J.W. Moses, J. Schofer, M.C. Morice, E. Schampaert, A.J. Kirtane, J.J. Popma, H. Parise, M. Fahy, and R. Mehran 5-Year clinical outcomes after sirolimus eluting stent implantation: insights from a patient-level pooled analysis of 4 randomized trials comparing sirolimus-eluting stents with bare-metal stents J Am Coll Cardiol 54 2009 894 902
10. G.W. Stone, S.G. Ellis, A. Colombo, E. Grube, J.J. Popma, T. Uchida, J.S. Bleuit, K.D. Dawkins, and M.E. Russell Long term safety and efficacy of paclitaxel eluting stents J Am Coll Cardiol Intv 4 2011 530 542
11. T. Kimura, T. Morimoto, Y. Nakagawa, K. Kawai, S. Miyazaki, T. Muramatsu, N. Shiode, M. Namura, T. Sone, S. Oshima, H. Nishi kawa, Y. Hiasa, Y. Hayashi, M. Nobuyoshi, K. Mitudo j-Cypher Registry Investigators Very late stent thrombosis and late target lesion revascularization after sirolimus-eluting stent implantation: five-year outcome of the j-Cypher Registry Circulation 125 2012 584 591
12. G. Nakazawa, F. Otsuka, M. Nakano, M. Vorpahl, S.K. Yazdani, E. Ladich, F.D. Kolodgie, A.V. Finn, and R. Virmani The pathology of neoatherosclerosis in human coronary implants bare-metal and drug-eluting stents J Am Coll Cardiol 57 2011 1314 1322
13. L. Raber, L. Wohlwend, M. Wigger, M. Togni, S. Wandel, P. Wenaweser, S. Cook, A. Mos chovitis, R. Vogel, B. Kalesan, C. Seiler, F. Eberli, T.F. Luscher, B. Meier, P. Juni, and S. Windecker Five-year clinical and angiographic outcomes of a randomized comparison of sirolimus-eluting and paclitaxel-eluting stent: results of the Sirolimus-Eluting Versus Paclitaxel-Eluting Stents for Coronary Revascularization LATE trail Circulation 123 2011 2819 2828
14. W.S. Weintraub, M.V. Grau-Sepulveda, J.M. Weiss, S.M. O'Brien, E.D. Peterson, P. Kolm, Z. Zhang, L.W. Klein, R.E. Shaw, C. McKay, L.L. Ritzenthaler, J.J. Popma, J.C. Messenger, D.M. Shahian, F.L. Grover, J.E. Mayer, C.M. Shewan, K.N. Garratt, I.D. Moussa, G.D. Dangas, and F.H. Edwards Comparative effectiveness of revascularization strategies N Eng J Med 366 2012 1467 1476
15. F.W. Mohr, M.C. Morice, A.P. Kappetein, T.E. Feldman, E. Ståhle, A. Colombo, M.J. Mack, D.R. Holmes Jr., M.A. Morel, N. Van Dyck, V.M. Houle, K.D. Dawkins, and P.W. Serruys Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial Lancet 381 2013 629 638
16. M.E. Farkouh, M. Domanski, L.A. Sleeper, F.S. Siami, G. Dangas, M. Mack, M. Yang, D.J. Cohen, Y. Rosenberg, S.D. Solomon, A.S. Desai, B.J. Gersh, E.A. Magnuson, A. Lansky, R. Boineau, J. Weinberger, K. Ramanathan, J.E. Sousa, J. Rankin, B. Bhargava, J. Buse, W. Hueb, C.R. Smith, V. Muratov, S. Bansilal, S. King 3rd, M. Bertrand, and V. Fuster Strategies for multivessel revascularization in patients with diabetes N Engl J Med 367 2012 2375 2384
17. M. Flather, J. Wha Rhee, D. Boothroyd, E. Boersma, M. Mori Brooks, D. Carrié, T. Clayton, N. Danchin, C. Hamm, W. Hueb, S.B. King, S.P. Pocock, A.E. Rodriguez, P.W. Serruys, U. Sigwart, R. Stables, and M.A. Hlatky The effect of age on outcomes of coronary artery bypass surgery compared with balloon angioplasty or bare-metal stent implantation among patients with multivessel coronary disease. A collaborative analysis of individual patient data from 10 randomized trials J Am Coll Cardiol 60 2012 2150 2157
18. P.W. Groeneveld, M.A. Matta, A.P. Greenhut, and F. Yang Drug-eluting compared with bare-metal coronary stents among elderly J Am Coll Cardiol 51 2008 2017 2024
19. A.E. Rodriguez, M.R. Alemparte, C.F. Vigo, C.F. Pereira, C. Llaurado, M. Russo, R. Virmani, and J.A. Ambrose Pilot study of oral rapamycin to prevent restenosis in patients undergoing Coronary stent therapy: Argentina Single-Center Study (ORAR Trial) J Invasive Cardiol 15 2003 581 584
20. R. Waksman, A.E. Ajani, A.D. Pichard, R. Torguson, E. Pinnow, D. Canos, L.F. Satler, K.M. Kent, P. Kuchulakanti, C. Pappas, L. Gambone, N. Weissman, M.C. Abbott, and J. Lindsay Oral rapamycin to inhibit restenosis after stenting of de novo coronary lesions: the Oral Rapamune to Inhibit Restenosis (ORBIT) study J Am Coll Cardiol 44 2004 1386 1392
21. A.E. Rodriguez, J.F. Granada, M. Rodriguez-Alemparte, C.F. Vigo, J. Delgado, C. Fernandez- Pereira, A. Pocovi, A.M. Rodriguez-Granillo, D. Schulz, A.E. Raizner, I. Palacios, W. O'Neill, G.L. Kaluza, and G. Stone Oral rapamycin after coronary bare-metal stent implantation to prevent restenosis: the Prospective, Randomized Oral Rapamycin in Argentina (ORAR II) Study J Am Coll Cardiol 47 2006 1522 1529
22. J. Hausleiter, A. Kastrati, J. Mehilli, M. Vogeser, D. Zohlnhöfer, H. Schühlen, C. Goos, J. Pache, F. Dotzer, G. Pogatsa Murray, J. Dirschinger, U. Heemann, and A. Schömig Randomized, double-blind, placebo-controlled trial of oral sirolimus for restenosis prevention in patients with in-stent restenosis: the Oral Sirolimus to Inhibit Recurrent In-stent Stenosis (OSIRIS) trial Circulation 110 2004 790 795
23. S. Stojkovic, M. Ostojic, M. Nedeljkovic, G. Stankovic, B. Beleslin, V. Vukcevic, D. Orlic, A. Arandjelovic, J. Kostic, M. Dikic, and M. Tomasevic Systemic rapamycin without loading dose for restenosis prevention after coronary bare metal stent implantation Catheter Cardiovasc Interv 75 2010 317 325
24. F. Versaci, A. Gaspardone, F. Tomai, F. Ribichini, P. Russo, I. Proietti, A.S. Ghini, V. Ferrero, L. Chiariello, P.A. Gioffre', F. Romeo, and F. Crea Immunosuppressive therapy for the prevention of restenosis after coronary artery stent implantation (IMPRESS Study) J Am Coll Cardiol 40 2002 1935 1942
25. F. Ribichini, F. Tomai, G. Pesarini, A. Zivelonghi C,Rognoni, G. De Luca, G. Boccuzzi, P. Presbitero, V. Ferrero, A. Ghini, P. Marino, and C. Vassanelli Long-term clinical follow-up of the multicenter, randomized study to test immunosuppressive therapy with oral prednisone for the prevention of restenosis after percutaneous coronary interventions: Cortisone plus BMS or DES veRsus BMS alone to EliminAte Restenosis (CEREA DES) Eur Heart J 34 2013 Jun 1740 1748
26. C. Cernigliaro, M. Sansa, G. Vitrella, A. Verde, A.S. Bongo, L. Giuliani, and E. Novelli Preventing restenosis after implantation of bare stents with oral rapamycin: a randomized angiographic and intravascular ultrasound study with a 5-year clinical follow-up Cardiology 115 2010 77 86
27. S. Deftereos, G. Giannopoulos, K. Raisakis, C. Kossyvakis, A. Kaoukis, V. Panagopoulou, M. Driva, G. Hahalis, V. Pyrgakis, D. Alexopoulos, A.S. Manolis, C. Stefanadis, and M.W. Cleman Colchicine treatment for the prevention of bare-metal stent restenosis in diabetic patients J Am Coll Cardiol 61 2013 1679 1685
28. B.E. Claessen, G.W. Stone, P.C. Smits, E. Kedhi, W.J. Kikkert, J.J. Piek, and J.P. Henriques Would SYNTAX have been a positive trial if XIENCE V have been used instead TAXUS? A meta-analysis of a first-generation vs a second generation drug-eluting system Neth Heart J 18 2010 451 453
29. M. Bischof, M. Briel, A. Bucher, and A. Nordmann Cost effectiveness of DES in US Medicare system: a cost utility analysis of 3 years clinical follow up data Value. Health 12 2009 649 656