Interactions between nutrition and immune function: Using inflammation biomarkers to interpret micronutrient status

Proceedings of the Nutrition Society

Volumn 73, Issue 1, 2014, Pages 1-8

  Thurnham, David I ^a  

^a UNIVERSITY OF ULSTER   (United Kingdom)

Author keywords

1 acid glycoprotein; C reactive protein; Ferritin; Immune response; Vitamin A; Zinc

Indexed keywords

ACUTE-PHASE PROTEINS; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; FERRITINS; HIV INFECTIONS; HUMANS; INFLAMMATION; MICRONUTRIENTS; NUTRITIONAL STATUS; VITAMIN A; ZINC;

ACUTE PHASE PROTEIN; C REACTIVE PROTEIN; FERRITIN; GLYCOPROTEIN; IRON; OROSOMUCOID; RETINOL; TRACE ELEMENT; ZINC;

ACUTE PHASE RESPONSE; CONFERENCE PAPER; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; INFLAMMATION; INTERVENTION STUDY; META ANALYSIS (TOPIC); METABOLISM; NUTRIENT; NUTRITIONAL STATUS; VITAMIN SUPPLEMENTATION;

EID: 84893899193     PISSN: 00296651     EISSN: 14752719     Source Type: Journal    
DOI: 10.1017/S0029665113003662     Document Type: Article

References (38)

1. Keusch GT (1993) Infection, fever and nutrition. In Encyclopaedia of Food Science, Food Technology and Nutrition, pp. 2522-2526 [R Macrae, RK Robinson and MJ Sadler, editors]. New York: Academic Press.
2. Louw JA, Werbeck A, Louw MEJ et al. (1992) Blood vitamin concentrations during the acute-phase response. Crit Care Med 20, 934-941.
3. Baumann H & Gauldie J (1994) The acute phase response. Immunol Today 15, 74-80.
4. Steel DM & Whitehead AS (1994) The major acute phase reactants: C-reactive protein, serum amyloid P component and serum amyloid A protein. Immunol Today 15, 81-88.
5. Whicher JT (1990) Acute phase proteins, physiology and clinical uses. Clin Biochem Rev 11, 4-9.
6. Fleck A & Myers MA (1985) Diagnostic and prognostic significance of acute phase proteins. In The Acute Phase Response to Injury and Infection, pp. 249-271 [AH Gordon and AKoj, editors]. Amsterdam: Elsevier Scientific Publishers.
7. Rowland MGM, Cole TJ & Whitehead RG (1977) A quantitative study into the role of infection in determining nutritional status in Gambian village children. Brit J Nutr 37, 441-450.
8. Shankar AH, Genton B, Semba RA et al. (1999) Effect of vitamin A supplementation on morbidity due to Plasmodium falciparum in young children in Papua New Guinea: a randomised trial. Lancet 354, 203-209.
9. Calvin J, Neale G, Fotherby KJ et al. (1988) The relative merits of acute phase proteins in the recognition of inflammatory conditions. Ann Clin Biochem 25, 60-66.
10. Stuart J & Whicher JT (1988) Tests for detecting and monitoring the acute phase response. Arch Dis Child 63, 115-117.
11. Thurnham DI, Mburu ASW, Mwaniki DL et al. (2008) Using plasma acute-phase protein concentrations to interpret nutritional biomarkers in apparently healthy HIV-1- seropositive Kenyan adults. Br J Nutr 100, 174-182.
12. Ramsden DB, Prince HP, Burr WA et al. (1978) The interrelationship of thyroid hormones, vitamin A and their binding proteins following acute stress. Clin Endocrinol (Oxf) 8, 109-122.
13. Feelders RA, Vreugdenhil G, Eggermont AMM et al. (1998) Regulation of iron metabolism in the acute-phase response: interferon-γ and tumor necrosis factor-α induce hypoferraemia, ferritin production and a decrease in circulating transferrin receptors in cancer patients. Eur J Clin Invest 28, 520-527.
14. Beesley R, Filteau SM, Tomkins A et al. (2000) Impact of acute malaria on plasma concentrations of transferrin receptors. Trans R Soc Trop Med Hyg 94, 295-298.
15. Beisel WR (1976) Trace elements in infectious processes. Med Clin North Am 60, 831-849.
16. Mburu ASW, Thurnham DI, Mwaniki DL et al. (2010) The influence of inflammation on plasma zinc concentration in apparently-healthy, HIV+ Kenyan adults and zinc responses after a multi-micronutrient supplement. Eur J Clin Nutr 64, 510-517.
17. Miller M, Humphrey JH, Johnson EJ et al. (2002) Why do children become vitamin A deficient' J Nutr 132, 2867S-2880S.
18. Hume EM & Krebs HA (1949) Vitamin A Requirements of Human Adults. A Report of the Vitamin A Sub-Committee of the Accessory Food Factors Committee no. 264. London: His Majesty's Stationery Office.
19. Paracha PI, Jamil A, Northrop-Clewes CA et al. (2000) Interpretation of vitamin A status in apparently-healthy Pakistani children using markers of sub-clinical infection. Am J Clin Nutr 72, 1164-1169.
20. Thurnham DI, Northrop-Clewes CA, McCullough FSW et al. (2000) Innate immunity, gut integrity and vitamin A in Gambian and Indian infants. J Inf Dis 182, S23-S28.
21. UNICEF, UNU & WHO (2001) Iron Deficiency Anaemia. Assessment, Prevention and Control. A Guide for Programme Managers no. WHO/NHD/01'3. Geneva, Switzerland: World Health Organisation.
22. Mei Z, Cogswell ME, Parvanta I et al. (2005) Hemoglobin and ferritin are currently the most efficient indicators of population response to iron interventions: an analysis of nine randomized controlled trials. J Nutr 135, 1974-1980.
23. World Health Organization & CDC (2004) Assessing the Iron Status of Populations. Geneva: WHO Press.
24. World Health Organisation & Centres for Disease Control and Prevention (2007) Assessing the Iron Status of Populations, 2nd ed., Geneva: WHO Press.
25. Beard JL, Murray-Kolb LE, Rosales FJ et al. (2006) Interpretation of serum ferritin concentrations as indicators of total-body iron stores in survey populations: the role of biomarkers for the acute phase response. Am J Clin Nutr 84, 1498-1505.
26. Witte DL (1991) Can ferritin be effectively interpreted in the presence of the acute-phase response' Clin Chem 37, 484-485.
27. Thurnham DI, McCabe LD, Haldar S et al. (2010) Adjusting plasma ferritin concentrations to remove the effects of subclinical inflammation in the assessment of iron deficiency: a meta-analysis. Am J Clin Nutr 92, 546-555.
28. Darboe MK, Thurnham DI, Morgan G et al. (2007) Effectiveness of the new IVACG early high-dose vitamin A supplementation scheme compared to the standard WHO protocol: a randomised controlled trial in Gambian mothers and infants. Lancet 369, 2088-2096.
29. Thurnham DI, Mburu ASW, Mwaniki DL et al. (2005) Micronutrients in childhood and the influence of subclinical inflammation. Proc Nutr Soc 64, 502-509.
30. Thurnham DI, McCabe GP, Northrop-Clewes CA et al. (2003) Effect of subclinical infection on plasma retinol concentrations and assessment of prevalence of vitamin A deficiency: meta-analysis. Lancet 362, 2052-2058.
31. Mburu ASW, Thurnham DI, Mwaniki DL et al. (2008) The influence and benefits of controlling for inflammation on plasma ferritin and hemoglobin responses following a multi-micronutrient supplement in apparently-healthy, HIV+ Kenyan adults. J Nutr 138, 613-619.
32. Gibson RS & Fergusson EL (1998) Assessment of dietary zinc in a population. Am J Clin Nutr 68, 430S-434S.
33. Hotz C & Brown KH (editors) (2004) International Zinc Nutrition Consultative Group (IZiNCG). Assessment of the risk of zinc deficiency in populations and options for its control. Food Nutr Bull 25, S94-S204.
34. Wieringa FT, Dijkhuizen MA, West CE et al. (2002) Estimation of the effect of the acute phase response on indicators of micronutrient status in Indonesian infants. J Nutr 132, 3061-3066.
35. Doherty JF, Golden MHN, Raynes JG et al. (1993) Acute-phase protein response is impaired in severely malnourished children. Clin Sci 84, 169-175.
36. Van Leeuwen MA & Van Rijswijk MH (1994) Acute phase proteins in the monitoring of inflammatory disorders. Bailliere's Clin Rheum 8, 531-554.
37. Northrop-Clewes CA, Lunn PG & Downes RM (1994) Seasonal fluctuations in vitamin A status and health indicators in Gambian infants. Proc Nutr Soc 53, 144A.
38. Papathakis PC, Rollins NC, Chantry CJ et al. (2007) Micronutrient status during lactation in HIV-infected and HIV-uninfected South African women during the first 6 mo after delivery. Am J Clin Nutr 85, 182-192.