Damage-associated molecular patterns derived from mitochondria may contribute to the hemodialysis-associated inflammation

International Urology and Nephrology

Volumn 46, Issue 1, 2014, Pages 107-112

  Eleftheriadis, Theodoros ^a   Pissas, Georgios ^a   Antoniadi, Georgia ^a   Liakopoulos, Vassilios ^a   Stefanidis, Ioannis ^a  

^a UNIVERSITY OF THESSALY   (Greece)

Author keywords

Cytochrome c; DAMP; Hemodialysis; IL 6; Inflammation; Mitochondrion

Indexed keywords

AGED; APOPTOSIS; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CYTOCHROMES C; FEMALE; HUMANS; INFLAMMATION; INTERLEUKIN-6; KIDNEY FAILURE, CHRONIC; MALE; MIDDLE AGED; MITOCHONDRIAL PROTEINS; RENAL DIALYSIS;

EID: 84893819313     PISSN: 03011623     EISSN: 15732584     Source Type: Journal    
DOI: 10.1007/s11255-013-0417-z     Document Type: Article

References (35)

1. Stenvinkel P, Heimburger O, Lindholm B, Kaysen GA, Bergstrom J (2000) Are there two types of malnutrition in chronic renal failure? Evidence for relationships between malnutrition, inflammation and atherosclerosis (MIA syndrome). Nephrol Dial Transplant 15(7):953-960 (Pubitemid 30410364)
2. Eleftheriadis T, Antoniadi G, Liakopoulos V, Kartsios C, Stefanidis I (2007) Disturbances of acquired immunity in hemodialysis patients. Semin Dial 20(5):440-451. doi: 10.1111/j.1525-139X.2007.00283.x
3. Eleftheriadis T, Liakopoulos V, Leivaditis K, Antoniadi G, Stefanidis I (2011) Infections in hemodialysis: a concise review. Part 1: bacteremia and respiratory infections. Hippokratia 15(1):12-17
4. Eleftheriadis T, Liakopoulos V, Leivaditis K, Antoniadi G, Stefanidis I (2011) Infections in hemodialysis: a concise review. Part II: blood transmitted viral infections. Hippokratia 15(2):120-126
5. Eleftheriadis T, Liakopoulos V, Antoniadi G, Kartsios C, Stefanidis I (2009) The role of hepcidin in iron homeostasis and anemia in hemodialysis patients. Semin Dial 22(1):70-77. doi: 10.1111/j.1525-139X.2008.00532.x
6. Janeway CA Jr (1992) The immune system evolved to discriminate infectious nonself from noninfectious self. Immunol Today 13(1):11-16. doi: 10.1016/0167-5699(92)90198-G
7. Matzinger P (2002) The danger model: a renewed sense of self. Science 296(5566):301-305. doi: 10.1126/science.1071059 (Pubitemid 34303674)
8. Baccala R, Gonzalez-Quintial R, Lawson BR, Stern ME, Kono DH, Beutler B, Theofilopoulos AN (2009) Sensors of the innate immune system: their mode of action. Nat Rev Rheumatol 5(8):448-456. doi: 10.1038/nrrheum.2009.136
9. Eleftheriadis T, Pissas G, Liakopoulos V, Stefanidis I, Lawson BR (2012) Toll-like receptors and their role in renal pathologies. Inflamm Allergy Drug Targets 11(6):464-477
10. Bossola M, Sanguinetti M, Scribano D, Zuppi C, Giungi S, Luciani G, Torelli R, Posteraro B, Fadda G, Tazza L (2009) Circulating bacterial-derived DNA fragments and markers of inflammation in chronic hemodialysis patients. Clin J Am Soc Nephrol 4(2):379-385. doi: 10.2215/CJN.03490708
11. Atamaniuk J, Kopecky C, Skoupy S, Saemann MD, Weichhart T (2012) Apoptotic cell-free DNA promotes inflammation in haemodialysis patients. Nephrol Dial Transplant 27(3):902-905. doi: 10.1093/ndt/gfr695
12. Dyall SD, Brown MT, Johnson PJ (2004) Ancient invasions: from endosymbionts to organelles. Science 304(5668):253-257. doi: 10.1126/science.1094884 (Pubitemid 38452171)
13. Krysko DV, Agostinis P, Krysko O, Garg AD, Bachert C, Lambrecht BN, Vandenabeele P (2011) Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation. Trends Immunol 32(4):157-164. doi: 10.1016/j.it.2011.01.005
14. Jemmerson R, LaPlante B, Treeful A (2002) Release of intact, monomeric cytochrome c from apoptotic and necrotic cells. Cell Death Differ 9(5):538-548. doi: 10.1038/sj/cdd/4400981 (Pubitemid 34521181)
15. Renz A, Berdel WE, Kreuter M, Belka C, Schulze-Osthoff K, Los M (2001) Rapid extracellular release of cytochrome c is specific for apoptosis and marks cell death in vivo. Blood 98(5):1542-1548
16. Raj DS, Boivin MA, Dominic EA, Boyd A, Roy PK, Rihani T, Tzamaloukas AH, Shah VO, Moseley P (2007) Haemodialysis induces mitochondrial dysfunction and apoptosis. Eur J Clin Invest 37(12):971-977. doi: 10.1111/j.1365-2362.2007. 01886.x (Pubitemid 350151187)
17. Friedrich B, Janessa A, Schmieder R, Risler T, Alexander D (2008) Acute effects of haemodialysis on pro-/anti- apoptotic genes in peripheral blood leukocytes. Cell Physiol Biochem 22(5-6):423-430. doi: 10.1159/000185486
18. Dounousi E, Koliousi E, Papagianni A, Ioannou K, Zikou X, Katopodis K, Kelesidis A, Tsakiris D, Siamopoulos KC (2012) Mononuclear leukocyte apoptosis and inflammatory markers in patients with chronic kidney disease. Am J Nephrol 36(6):531-536. doi: 10.1159/000345352
19. Soriano S, Martin-Malo A, Carracedo J, Ramirez R, Rodriguez M, Aljama P (2005) Lymphocyte apoptosis: role of uremia and permeability of dialysis membrane. Nephron Clin Pract 100(3):c71-c77. doi: 10.1159/000085051 (Pubitemid 40868988)
20. Ranjan R, Shah H, Siu J, Varghese E, Bhaskaran M, Reddy K, Kapasi AA, Wagner JD, Singhal PC (2002) Monocyte apoptosis in dialysis patients is Fas ligand-mediated. Clin Nephrol 58(6):423-430 (Pubitemid 35446913)
21. Koller H, Hochegger K, Zlabinger GJ, Lhotta K, Mayer G, Rosenkranz AR (2004) Apoptosis of human polymorphonuclear neutrophils accelerated by dialysis membranes via the activation of the complement system. Nephrol Dial Transplant 19(12):3104-3111. doi: 10.1093/ndt/gfh500 (Pubitemid 40057635)
22. Nahar N, Shah H, Siu J, Colvin R, Bhaskaran M, Ranjan R, Wagner JD, Singhal PC (2001) Dialysis membrane-induced neutrophil apoptosis is mediated through free radicals. Clin Nephrol 56(1):52-59 (Pubitemid 32621829)
23. Sardenberg C, Suassuna P, Andreoli MC, Watanabe R, Dalboni MA, Manfredi SR, dos Santos OP, Kallas EG, Draibe SA, Cendoroglo M (2006) Effects of uraemia and dialysis modality on polymorphonuclear cell apoptosis and function. Nephrol Dial Transplant 21(1):160-165. doi: 10.1093/ndt/gfi095 (Pubitemid 43057125)
24. Eleftheriadis T, Kartsios C, Yiannaki E, Kazila P, Antoniadi G, Liakopoulos V, Markala D (2008) Chronic inflammation and CD16+ natural killer cell zeta-chain downregulation in hemodialysis patients. Blood Purif 26(4):317-321. doi: 10.1159/000130068
25. Eleftheriadis T, Kartsios C, Yiannaki E, Kazila P, Antoniadi G, Liakopoulos V, Markala D (2008) Chronic inflammation and T cell zeta-chain downregulation in hemodialysis patients. Am J Nephrol 28(1):152-157. doi: 10.1159/000110020 (Pubitemid 350126506)
26. Eleftheriadis T, Liakopoulos V, Antoniadi G, Stefanidis I, Galaktidou G (2011) Arginase type I as a marker of coronary heart disease in hemodialysis patients. Int Urol Nephrol 43(4):1187-1194. doi: 10.1007/s11255-010-9842-4
27. Zhang Q, Raoof M, Chen Y, Sumi Y, Sursal T, Junger W, Brohi K, Itagaki K, Hauser CJ (2010) Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature 464(7285):104-107. doi: 10.1038/nature08780
28. Oka T, Hikoso S, Yamaguchi O, Taneike M, Takeda T, Tamai T, Oyabu J, Murakawa T, Nakayama H, Nishida K, Akira S, Yamamoto A, Komuro I, Otsu K (2012) Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure. Nature 485(7397):251-255. doi: 10.1038/nature10992
29. Collins LV, Hajizadeh S, Holme E, Jonsson IM, Tarkowski A (2004) Endogenously oxidized mitochondrial DNA induces in vivo and in vitro inflammatory responses. J Leukoc Biol 75(6):995-1000. doi: 10.1189/jlb.0703328 (Pubitemid 38720639)
30. Pullerits R, Bokarewa M, Jonsson IM, Verdrengh M, Tarkowski A (2005) Extracellular cytochrome c, a mitochondrial apoptosis-related protein, induces arthritis. Rheumatology (Oxford) 44(1):32-39. doi: 10.1093/rheumatology/keh406 (Pubitemid 40124329)
31. Adachi N, Hirota M, Hamaguchi M, Okamoto K, Watanabe K, Endo F (2004) Serum cytochrome c level as a prognostic indicator in patients with systemic inflammatory response syndrome. Clin Chim Acta 342(1-2):127-136. doi: 10.1016/j.cccn.2003.12.011 (Pubitemid 38352921)
32. Hosoya M, Kawasaki Y, Katayose M, Sakuma H, Watanabe M, Igarashi E, Aoyama M, Nunoi H, Suzuki H (2006) Prognostic predictive values of serum cytochrome c, cytokines, and other laboratory measurements in acute encephalopathy with multiple organ failure. Arch Dis Child 91(6):469-472. doi: 10.1136/adc.2005.078436 (Pubitemid 43836094)
33. Herrman J, Simmons RE, Frank BH, Rabkin R (1988) Differences in renal metabolism of insulin and cytochrome c. Am J Physiol 254(4 Pt 1):E419-E428
34. Orlando RA, Rader K, Authier F, Yamazaki H, Posner BI, Bergeron JJ, Farquhar MG (1998) Megalin is an endocytic receptor for insulin. J Am Soc Nephrol 9(10):1759-1766 (Pubitemid 28443472)
35. Krieter DH, Morgenroth A, Barasinski A, Lemke HD, Schuster O, von Harten B, Wanner C (2007) Effects of a polyelectrolyte additive on the selective dialysis membrane permeability for low-molecular-weight proteins. Nephrol Dial Transplant 22(2):491-499. doi: 10.1093/ndt/gfl610 (Pubitemid 46189894)