Bactericidal effect of colistin on planktonic Pseudomonas aeruginosa is independent of hydroxyl radical formation

International Journal of Antimicrobial Agents

Volumn 43, Issue 2, 2014, Pages 140-147

  Brochmann, Rikke Prejh ^a   Toft, Anders ^b   Ciofu, Oana ^b   Briales, Alejandra ^a,c   Kolpen, Mette ^a   Hempel, Casper ^a   Bjarnsholt, Thomas ^a,b   Høiby, Niels ^a,b   Jensen, Peter Østrup ^a  

^a Rigshospitalet   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c UNIVERSITY OF SEVILLE   (Spain)

Author keywords

Ciprofloxacin; Colistin; Oxidative stress; Pseudomonas aeruginosa

Indexed keywords

CIPROFLOXACIN; COLISTIN; OXIDATIVE STRESS; PSEUDOMONAS AERUGINOSA;

ANTI-BACTERIAL AGENTS; COLISTIN; HUMANS; HYDROXYL RADICAL; MICROBIAL VIABILITY; OXIDATIVE STRESS; PSEUDOMONAS AERUGINOSA;

EID: 84893699182     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2013.10.015     Document Type: Article

References (34)

1. R.E. Hancock Peptide antibiotics Lancet 349 1997 418 422
2. M.E. Falagas, and P.I. Rafailidis Re-emergence of colistin in today's world of multidrug-resistant organisms: personal perspectives Expert Opin Investig Drugs 17 2008 973 981
3. M.A. Kohanski, D.J. Dwyer, B. Hayete, C.A. Lawrence, and J.J. Collins A common mechanism of cellular death induced by bactericidal antibiotics Cell 130 2007 797 810
4. J.A. Imlay Pathways of oxidative damage Annu Rev Microbiol 57 2003 395 418
5. V. Lorian The mode of action of antibiotics on Gram-negative bacilli Arch Intern Med 128 1971 623 632
6. S.J. Pamp, M. Gjermansen, H.K. Johansen, and T. Tolker-Nielsen Tolerance to the antimicrobial peptide colistin in Pseudomonas aeruginosa biofilms is linked to metabolically active cells, and depends on the pmr and mexAB-oprM genes Mol Microbiol 68 2008 223 240
7. D. Worlitzsch, R. Tarran, M. Ulrich, U. Schwab, A. Cekici, and K.C. Meyer et al. Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients J Clin Invest 109 2002 317 325
8. M. Kolpen, C.R. Hansen, T. Bjarnsholt, C. Moser, L.D. Christensen, and M.V. Gennip et al. Polymorphonuclear leucocytes consume oxygen in sputum from chronic Pseudomonas aeruginosa pneumonia in cystic fibrosis Thorax 65 2010 57 62
9. K. Aanaes, L.F. Rickelt, H.K. Johansen, C.V. Buchwald, T. Pressler, and N. Høiby et al. Decreased mucosal oxygen tension in the maxillary sinuses in patients with cystic fibrosis J Cyst Fibros 10 2011 114 120
10. A. Novogrodsky, A. Ravid, A.L. Rubin, and K.H. Stenzel Hydroxyl radical scavengers inhibit lymphocyte mitogenesis Proc Natl Acad Sci USA 79 1982 1171 1174
11. J.A. Imlay, S.M. Chin, and S. Linn Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro Science 240 1988 640 642
12. I. Galani, F. Kontopidou, M. Souli, P.D. Rekatsina, E. Koratzanis, and J. Deliolanis et al. Colistin susceptibility testing by Etest and disk diffusion methods Int J Antimicrob Agents 31 2008 434 439
13. R.H. Eng, F.T. Padberg, S.M. Smith, E.N. Tan, and C.E. Cherubin Bactericidal effects of antibiotics on slowly growing and nongrowing bacteria Antimicrob Agents Chemother 35 1991 1824 1828
14. E. Gradelski, L. Valera, B. Kolek, D. Bonner, and J. Fung-Tomc Comparative killing kinetics of the novel des-fluoro(6) quinolone BMS-284756, fluoroquinolones, vancomycin and β-lactams Int J Antimicrob Agents 18 2001 43 48
15. K.R. Allison, M.P. Brynildsen, and J.J. Collins Metabolite-enabled eradication of bacterial persisters by aminoglycosides Nature 473 2011 216 220
16. T. Bjarnsholt, P.O. Jensen, M. Burmølle, M. Hentzer, J.A. Haagensen, and H.P. Hougen et al. Pseudomonas aeruginosa tolerance to tobramycin, hydrogen peroxide and polymorphonuclear leukocytes is quorum-sensing dependent Microbiology 151 2005 373 383
17. T.R. Sampson, X. Liu, M.R. Schroeder, C.S. Kraft, E.M. Burd, and D.S. Weiss Rapid killing of Acinetobacter baumannii by polymyxins is mediated by a hydroxyl radical death pathway Antimicrob Agents Chemother 56 2012 5642 5649
18. Y. Liu, X. Liu, Y. Qu, X. Wang, L. Li, and X. Zhao Inhibitors of reactive oxygen species accumulation delay and/or reduce the lethality of several antistaphylococcal agents Antimicrob Agents Chemother 56 2012 6048 6050
19. S. Renggli, W. Keck, U. Jenal, and D. Ritz Role of autofluorescence in flow cytometric analysis of Escherichia coli treated with bactericidal antibiotics J Bacteriol 195 2013 4067 4073
20. Y. Liu, and J.A. Imlay Cell death from antibiotics without the involvement of reactive oxygen species Science 339 2013 1210 1213
21. I. Keren, Y. Wu, J. Inocencio, L.R. Mulcahy, and K. Lewis Killing by bactericidal antibiotics does not depend on reactive oxygen species Science 339 2013 1213 1216
22. M. Malik, S. Hussain, and K. Drlica Effect of anaerobic growth on quinolone lethality with Escherichia coli Antimicrob Agents Chemother 5 2007 28 34
23. X. Wang, X. Zhao, M. Malik, and K. Drlica Contribution of reactive oxygen species to pathways of quinolone-mediated bacterial cell death J Antimicrob Chemother 65 2010 520 524
24. J.G. Hurdle, A.J. O'Neill, I. Chopra, and R.E. Lee Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections Nat Rev Microbiol 9 2011 62 75
25. F. Ratjen, E. Rietschel, D. Kasel, R. Schwiertz, K. Starke, and H. Beier et al. Pharmacokinetics of inhaled colistin in patients with cystic fibrosis J Antimicrob Chemother 57 2006 306 311
26. J. Li, J. Turnidge, R. Milne, R.L. Nation, and K. Coulthard In vitro pharmacodynamic properties of colistin and colistin methanesulfonate against Pseudomonas aeruginosa isolates from patients with cystic fibrosis Antimicrob Agents Chemother 45 2001 781 785
27. T.D. Thi, E. López, A. Rodríguez-Rojas, J. Rodríguez-Beltrán, A. Couce, and J.R. Guelfo et al. Effect of recA inactivation on mutagenesis of Escherichia coli exposed to sublethal concentrations of antimicrobials J Antimicrob Chemother 66 2011 531 538
28. J. Blázquez, A. Couce, J. Rodríguez-Beltrán, and A. Rodríguez-Rojas Antimicrobials as promoters of genetic variation Curr Opin Microbiol 15 2012 561 569
29. 2, pH, and redox potential of experimental abscesses Proc Soc Exp Biol Med 147 1974 29 30
30. K.D. Xu, P.S. Stewart, F. Xia, C. Huang, and G.A. McFeters Spatial physiological heterogeneity in Pseudomonas aeruginosa biofilm is determined by oxygen availability Appl Environ Microbiol 64 1998 4035 4039
31. N. Høiby, T. Bjarnsholt, M. Givskov, S. Molin, and O. Ciofu Antibiotic resistance of bacterial biofilms Int J Antimicrob Agents 35 2010 322 332
32. A.G. Oglesby, J.M. Farrow 3rd, J.H. Lee, A.P. Tomaras, E.P. Greenberg, and E.C. Pesci et al. The influence of iron on Pseudomonas aeruginosa physiology: a regulatory link between iron and quorum sensing J Biol Chem 283 2008 15558 15567
33. T. Jensen, S.S. Pedersen, S. Garne, C. Heilmann, N. Høiby, and C. Koch Colistin inhalation therapy in cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infection J Antimicrob Chemother 19 1987 831 838
34. G. Herrmann, L. Yang, H. Wu, S. Zhijun, W. Hengzhuang, and N. Høiby et al. Colistin-tobramycin combinations are superior to monotherapy concerning the killing of biofilm Pseudomonas aeruginosa J Infect Dis 202 2010 1585 1592