Acidified nitrite: A host defence against colonization with C. difficile spores?

Journal of Hospital Infection

Volumn 86, Issue 2, 2014, Pages 155-157

  Cunningham, R ^a   Mustoe, E ^a   Spiller, L ^a   Lewis, S ^a   Benjamin, N ^b  

^a PLYMOUTH HOSPITALS NHS TRUST   (United Kingdom)

^b UNIVERSITY OF EXETER   (United Kingdom)

Author keywords

Acidified nitrite; Clostridium difficile infection; Proton pump inhibitor; Spore

Indexed keywords

NITRITE; NITROGEN OXIDE;

ACIDIFICATION; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL COUNT; BACTERIAL SPORE; CLOSTRIDIUM DIFFICILE; NONHUMAN; STOMACH ACID; STOMACH PH;

ACIDIFIED NITRITE; CLOSTRIDIUM DIFFICILE INFECTION; PROTON PUMP INHIBITOR; SPORE;

ANTI-BACTERIAL AGENTS; CLOSTRIDIUM DIFFICILE; HUMANS; HYDROGEN-ION CONCENTRATION; MICROBIAL VIABILITY; NITRITES; NITROGEN OXIDES; SPORES, BACTERIAL; TIME FACTORS;

EID: 84893695079     PISSN: 01956701     EISSN: 15322939     Source Type: Journal    
DOI: 10.1016/j.jhin.2013.12.003     Document Type: Article

References (10)

1. Gurian L., Ward T.T., Katon R.M. Possible foodborne transmission in a case of pseudomembranous colitis due to Clostridium difficile: influence of gastrointestinal secretions on Clostridium difficile infection. Gastroenterology 1982, 83:465-469.
2. Cunningham R., Dale B., Gaunt N. Proton pump inhibitors as a risk factor for Clostridium difficile diarrhoea. J Hosp Infect 2003, 54:243-245.
3. Tleyjeh I.M., Bin Abdulhak A.A., Riaz M., et al. The association between Histamine 2 receptor antagonist use and Clostridium difficile infection: a systematic review and meta-analysis. PLoS One 2013, 8:e56498.
4. Jump R.L., Pultz M.J., Donskey C.J. Vegetative Clostridium difficile survives in room air on moist surfaces and in gastric contents with reduced acidity: a potential mechanism to explain the association between proton pump inhibitors and C. difficile-associated diarrheaα. Antimicrob Agents Chemother 2007, 51:2883-2887.
5. Lundberg J.O., Weitzberg E., Cole J.A., Benjamin N. Nitrate, bacteria and human health. Nat Rev Microbiol 2004, 2:593-602.
6. Xia D., Liu Y., Zhang C., et al. Antimicrobial effect of acidified nitrate and nitrite on six common oral pathogens in vitro. Chin Med J 2006, 119:1904-1909.
7. Dykhuizen R.S., Frazer R., Duncan C., et al. Antimicrobial effect of acidified nitrite on gut pathogens: importance of dietary nitrate in host defense. Antimicrob Agents Chemother 1996, 40:1422-1425.
8. Wulit M., Odenholt I., Walder M. Activity of three disinfectants and acidified nitrite against Clostridium difficile spores. Infect Control Hosp Epidemiol 2003, 24:765-768.
9. Rao A., Jump R.L., Pultz N.J., Pultz M.J., Donskey C.J. In vitro killing of nosocomial pathogens by acid and acidified nitrite. Antimicrob Agents Chemother 2006, 50:3901-3904.
10. Hamish T., Smith L., Duncan C., Benjamin N. The effect of amoxicillin on salivary nitrite concentrations: an important mechanism of adverse reactionsα. Br J Clin Pharmacol 1995, 39:460-462.