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Volumn 343, Issue 6171, 2014, Pages

Secreting and sensing the same molecule allows cells to achieve versatile social behaviors

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR; PHEROMONE; RECEPTOR; MATING HORMONE ALPHA FACTOR RECEPTOR; MFA1 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN; STE2 PROTEIN, S CEREVISIAE;

EID: 84893690881     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1242782     Document Type: Article
Times cited : (155)

References (100)
  • 1
    • 78651448678 scopus 로고    scopus 로고
    • A biological solution to a fundamental distributed computing problem
    • doi: 10.1126/science.1193210; pmid: 21233379
    • Y. Afek et al., A biological solution to a fundamental distributed computing problem. Science 331, 183-185 (2011). doi: 10.1126/science.1193210; pmid: 21233379
    • (2011) Science , vol.331 , pp. 183-185
    • Afek, Y.1
  • 2
    • 78349313083 scopus 로고    scopus 로고
    • Approaching the molecular origins of collective dynamics in oscillating cell populations
    • doi: 10.1016/j.gde.2010.09.004; pmid: 20934869
    • P. Mehta, T. Gregor, Approaching the molecular origins of collective dynamics in oscillating cell populations. Curr. Opin. Genet. Dev. 20, 574-580 (2010). doi: 10.1016/j.gde.2010.09.004; pmid: 20934869
    • (2010) Curr. Opin. Genet. Dev. , vol.20 , pp. 574-580
    • Mehta, P.1    Gregor, T.2
  • 3
    • 80052498962 scopus 로고    scopus 로고
    • Entrainment of a population of synthetic genetic oscillators
    • doi: 10.1126/science.1205369; pmid: 21885786
    • O. Mondragón-Palomino, T. Danino, J. Selimkhanov, L. Tsimring, J. Hasty, Entrainment of a population of synthetic genetic oscillators. Science 333, 1315-1319 (2011). doi: 10.1126/science.1205369; pmid: 21885786
    • (2011) Science , vol.333 , pp. 1315-1319
    • Mondragón-Palomino, O.1    Danino, T.2    Selimkhanov, J.3    Tsimring, L.4    Hasty, J.5
  • 4
    • 77952092577 scopus 로고    scopus 로고
    • Cis-interactions between Notch and Delta generate mutually exclusive signalling states
    • doi: 10.1038/nature08959; pmid: 20418862
    • D. Sprinzak et al., Cis-interactions between Notch and Delta generate mutually exclusive signalling states. Nature 465, 86-90 (2010). doi: 10.1038/nature08959; pmid: 20418862
    • (2010) Nature , vol.465 , pp. 86-90
    • Sprinzak, D.1
  • 5
    • 0034644270 scopus 로고    scopus 로고
    • The segment polarity network is a robust developmental module
    • doi: 10.1038/35018085; pmid: 10910359
    • G. von Dassow, E. Meir, E. M. Munro, G. M. Odell, The segment polarity network is a robust developmental module. Nature 406, 188-192 (2000). doi: 10.1038/35018085; pmid: 10910359
    • (2000) Nature , vol.406 , pp. 188-192
    • Von Dassow, G.1    Meir, E.2    Munro, E.M.3    Odell, G.M.4
  • 6
    • 84861145815 scopus 로고    scopus 로고
    • Tension and robustness in multitasking cellular networks
    • doi: 10.1371/journal.pcbi.1002491; pmid: 22577355
    • J. V.Wong, B. Li, L. You, Tension and robustness in multitasking cellular networks. PLOS Comput. Biol. 8, e1002491 (2012). doi: 10.1371/journal.pcbi. 1002491; pmid: 22577355
    • (2012) PLOS Comput. Biol. , vol.8
    • Wong, J.V.1    Li, B.2    You, L.3
  • 7
    • 79961038741 scopus 로고    scopus 로고
    • Multiplexing biochemical signals
    • doi: 10.1103/PhysRevLett.107.048101; pmid: 21867046
    • W. H. de Ronde, F. Tostevin, P. R. ten Wolde, Multiplexing biochemical signals. Phys. Rev. Lett. 107, 048101 (2011). doi: 10.1103/PhysRevLett.107. 048101; pmid: 21867046
    • (2011) Phys. Rev. Lett. , vol.107 , pp. 048101
    • De Ronde, W.H.1    Tostevin, F.2    Ten Wolde, P.R.3
  • 8
    • 77955501216 scopus 로고    scopus 로고
    • Combinatorial gene regulation using auto-regulation
    • doi: 10.1371/journal.pcbi.1000813; pmid: 20548950
    • R. Hermsen, B. Ursem, P. R. ten Wolde, Combinatorial gene regulation using auto-regulation. PLOS Comput. Biol. 6, e1000813 (2010). doi: 10.1371/journal.pcbi.1000813; pmid: 20548950
    • (2010) PLOS Comput. Biol. , vol.6
    • Hermsen, R.1    Ursem, B.2    Ten Wolde, P.R.3
  • 9
    • 84856264773 scopus 로고    scopus 로고
    • A two-dimensional ERK-AKT signaling code for an NGF-triggered cell-fate decision
    • doi: 10.1016/j.molcel.2011.11.023; pmid: 22206868
    • J. Y. Chen, J. R. Lin, K. A. Cimprich, T. Meyer, A two-dimensional ERK-AKT signaling code for an NGF-triggered cell-fate decision. Mol. Cell 45, 196-209 (2012). doi: 10.1016/j.molcel.2011.11.023; pmid: 22206868
    • (2012) Mol. Cell , vol.45 , pp. 196-209
    • Chen, J.Y.1    Lin, J.R.2    Cimprich, K.A.3    Meyer, T.4
  • 10
    • 79955966186 scopus 로고    scopus 로고
    • Resolution of gene regulatory conflicts caused by combinations of antibiotics
    • doi: 10.1016/j.molcel.2011.04.016; pmid: 21596308
    • T. Bollenbach, R. Kishony, Resolution of gene regulatory conflicts caused by combinations of antibiotics. Mol. Cell 42, 413-425 (2011). doi: 10.1016/j.molcel.2011.04.016; pmid: 21596308
    • (2011) Mol. Cell , vol.42 , pp. 413-425
    • Bollenbach, T.1    Kishony, R.2
  • 11
    • 84876848864 scopus 로고    scopus 로고
    • Circuit-level input integration in bacterial gene regulation
    • doi: 10.1073/pnas.1216091110; pmid: 23572583
    • L. Espinar, M. Dies, T. Cagatay, G. M. Süel, J. Garcia-Ojalvo, Circuit-level input integration in bacterial gene regulation. Proc. Natl. Acad. Sci. U.S.A. 110, 7091-7096 (2013). doi: 10.1073/pnas.1216091110; pmid: 23572583
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 7091-7096
    • Espinar, L.1    Dies, M.2    Cagatay, T.3    Süel, G.M.4    Garcia-Ojalvo, J.5
  • 12
    • 84872767054 scopus 로고    scopus 로고
    • The utility of paradoxical components in biological circuits
    • doi: 10.1016/j.molcel.2013.01.004; pmid: 23352242
    • Y. Hart, U. Alon, The utility of paradoxical components in biological circuits. Mol. Cell 49, 213-221 (2013). doi: 10.1016/j.molcel.2013.01.004; pmid: 23352242
    • (2013) Mol. Cell , vol.49 , pp. 213-221
    • Hart, Y.1    Alon, U.2
  • 13
    • 0036578795 scopus 로고    scopus 로고
    • Network motifs in the transcriptional regulation network of Escherichia coli
    • doi: 10.1038/ng881; pmid: 11967538
    • S. S. Shen-Orr, R. Milo, S. Mangan, U. Alon, Network motifs in the transcriptional regulation network of Escherichia coli. Nat. Genet. 31, 64-68 (2002). doi: 10.1038/ng881; pmid: 11967538
    • (2002) Nat. Genet. , vol.31 , pp. 64-68
    • Shen-Orr, S.S.1    Milo, R.2    Mangan, S.3    Alon, U.4
  • 14
    • 0037174670 scopus 로고    scopus 로고
    • Network motifs: Simple building blocks of complex networks
    • doi: 10.1126/science.298.5594.824; pmid: 12399590
    • R. Milo et al., Network motifs: Simple building blocks of complex networks. Science 298, 824-827 (2002). doi: 10.1126/science.298.5594.824; pmid: 12399590
    • (2002) Science , vol.298 , pp. 824-827
    • Milo, R.1
  • 15
    • 84255194232 scopus 로고    scopus 로고
    • Networks formed from interdependent networks
    • doi: 10.1038/nphys2180
    • J. Gao, S. V. Buldyrev, H. E. Stanley, S. Havlin, Networks formed from interdependent networks. Nat. Phys. 8, 40-48 (2012). doi: 10.1038/nphys2180
    • (2012) Nat. Phys. , vol.8 , pp. 40-48
    • Gao, J.1    Buldyrev, S.V.2    Stanley, H.E.3    Havlin, S.4
  • 16
    • 78650362376 scopus 로고    scopus 로고
    • Emerging properties of animal gene regulatory networks
    • doi: 10.1038/nature09645; pmid: 21164479
    • E. H. Davidson, Emerging properties of animal gene regulatory networks. Nature 468, 911-920 (2010). doi: 10.1038/nature09645; pmid: 21164479
    • (2010) Nature , vol.468 , pp. 911-920
    • Davidson, E.H.1
  • 17
    • 84874765320 scopus 로고    scopus 로고
    • Encoding and decoding cellular information through signaling dynamics
    • doi: 10.1016/j.cell.2013.02.005; pmid: 23452846
    • J. E. Purvis, G. Lahav, Encoding and decoding cellular information through signaling dynamics. Cell 152, 945-956 (2013). doi: 10.1016/j.cell.2013. 02.005; pmid: 23452846
    • (2013) Cell , vol.152 , pp. 945-956
    • Purvis, J.E.1    Lahav, G.2
  • 18
    • 0037687416 scopus 로고    scopus 로고
    • Reverse engineering gene networks: Integrating genetic perturbations with dynamical modeling
    • doi: 10.1073/pnas.0933416100; pmid: 12730377
    • J. Tegner, M. K. S. Yeung, J. Hasty, J. J. Collins, Reverse engineering gene networks: Integrating genetic perturbations with dynamical modeling. Proc. Natl. Acad. Sci. U.S.A. 100, 5944-5949 (2003). doi: 10.1073/pnas.0933416100; pmid: 12730377
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 5944-5949
    • Tegner, J.1    Yeung, M.K.S.2    Hasty, J.3    Collins, J.J.4
  • 19
    • 71149116163 scopus 로고    scopus 로고
    • Simple, realistic models of complex biological processes: Positive feedback and bistability in a cell fate switch and a cell cycle oscillator
    • doi: 10.1016/j.febslet.2009.10.068; pmid: 19878681
    • J. E. Ferrell Jr. et al., Simple, realistic models of complex biological processes: Positive feedback and bistability in a cell fate switch and a cell cycle oscillator. FEBS Lett. 583, 3999-4005 (2009). doi: 10.1016/j.febslet.2009. 10.068; pmid: 19878681
    • (2009) FEBS Lett. , vol.583 , pp. 3999-4005
    • Ferrell Jr., J.E.1
  • 20
    • 77953080728 scopus 로고    scopus 로고
    • The onset of collective behavior in social amoebae
    • doi: 10.1126/science.1183415; pmid: 20413456
    • T. Gregor, K. Fujimoto, N. Masaki, S. Sawai, The onset of collective behavior in social amoebae. Science 328, 1021-1025 (2010). doi: 10.1126/science.1183415; pmid: 20413456
    • (2010) Science , vol.328 , pp. 1021-1025
    • Gregor, T.1    Fujimoto, K.2    Masaki, N.3    Sawai, S.4
  • 21
    • 36749071584 scopus 로고    scopus 로고
    • Dynamical quorum sensing: Population density encoded in cellular dynamics
    • doi: 10.1073/pnas.0706089104; pmid: 18003917
    • S. De Monte, F. d'Ovidio, S. Danø, P. Graae Sørensen, Dynamical quorum sensing: Population density encoded in cellular dynamics. Proc. Natl. Acad. Sci. U.S.A. 104, 18377-18381 (2007). doi: 10.1073/pnas.0706089104; pmid: 18003917
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 18377-18381
    • De Monte, S.1    D'Ovidio, F.2    Danø, S.3    Graae Sørensen, P.4
  • 22
    • 84866734314 scopus 로고    scopus 로고
    • Dynamical quorum-sensing in oscillators coupled through an external medium
    • doi: 10.1016/j.physd.2012.08.005; pmid: 23087494
    • D. J. Schwab, A. Baetica, P. Mehta, Dynamical quorum-sensing in oscillators coupled through an external medium. Physica D 241, 1782-1788 (2012). doi: 10.1016/j.physd.2012.08.005; pmid: 23087494
    • (2012) Physica D , vol.241 , pp. 1782-1788
    • Schwab, D.J.1    Baetica, A.2    Mehta, P.3
  • 23
    • 12744280743 scopus 로고    scopus 로고
    • An autoregulatory circuit for long-range self-organization in Dictyostelium cell populations
    • doi: 10.1038/nature03228; pmid: 15662425
    • S. Sawai, P. A. Thomason, E. C. Cox, An autoregulatory circuit for long-range self-organization in Dictyostelium cell populations. Nature 433, 323-326 (2005). doi: 10.1038/nature03228; pmid: 15662425
    • (2005) Nature , vol.433 , pp. 323-326
    • Sawai, S.1    Thomason, P.A.2    Cox, E.C.3
  • 24
    • 79961108799 scopus 로고    scopus 로고
    • 'Dicty dynamics': Dictyostelium motility as persistent random motion
    • doi: 10.1088/1478-3975/8/4/046006; pmid: 21610290
    • L. Li, E. C. Cox, H. Flyvbjerg, 'Dicty dynamics': Dictyostelium motility as persistent random motion. Phys. Biol. 8, 046006 (2011). doi: 10.1088/1478-3975/8/4/046006; pmid: 21610290
    • (2011) Phys. Biol. , vol.8 , pp. 046006
    • Li, L.1    Cox, E.C.2    Flyvbjerg, H.3
  • 25
    • 0344120665 scopus 로고    scopus 로고
    • Cell sorting by differential cell motility: A model for pattern formation in Dictyostelium
    • doi: 10.1016/j.jtbi.2003.08.016; pmid: 14643191
    • T. Umeda, K. Inouye, Cell sorting by differential cell motility: A model for pattern formation in Dictyostelium. J. Theor. Biol. 226, 215-224 (2004). doi: 10.1016/j.jtbi.2003.08.016; pmid: 14643191
    • (2004) J. Theor. Biol. , vol.226 , pp. 215-224
    • Umeda, T.1    Inouye, K.2
  • 26
    • 73349114916 scopus 로고    scopus 로고
    • Bacterial quorum-sensing network architectures
    • doi: 10.1146/annurev-genet-102108-134304; pmid: 19686078
    • W. L. Ng, B. L. Bassler, Bacterial quorum-sensing network architectures. Annu. Rev. Genet. 43, 197-222 (2009). doi: 10.1146/annurev-genet-102108-134304; pmid: 19686078
    • (2009) Annu. Rev. Genet. , vol.43 , pp. 197-222
    • Ng, W.L.1    Bassler, B.L.2
  • 27
    • 76849115266 scopus 로고    scopus 로고
    • Negative feedback loops involving small regulatory RNAs precisely control the Vibrio harveyi quorum-sensing response
    • doi: 10.1016/j.molcel.2010.01.022; pmid: 20188674
    • K. C. Tu, T. Long, S. L. Svenningsen, N. S. Wingreen, B. L. Bassler, Negative feedback loops involving small regulatory RNAs precisely control the Vibrio harveyi quorum-sensing response. Mol. Cell 37, 567-579 (2010). doi: 10.1016/j.molcel.2010.01.022; pmid: 20188674
    • (2010) Mol. Cell , vol.37 , pp. 567-579
    • Tu, K.C.1    Long, T.2    Svenningsen, S.L.3    Wingreen, N.S.4    Bassler, B.L.5
  • 28
    • 1942467023 scopus 로고    scopus 로고
    • Programmed population control by cell-cell communication and regulated killing
    • doi: 10.1038/nature02491; pmid: 15064770
    • L. You, R. S. Cox III, R. Weiss, F. H. Arnold, Programmed population control by cell-cell communication and regulated killing. Nature 428, 868-871 (2004). doi: 10.1038/nature02491; pmid: 15064770
    • (2004) Nature , vol.428 , pp. 868-871
    • You, L.1    Cox III, R.S.2    Weiss, R.3    Arnold, F.H.4
  • 29
    • 66149121458 scopus 로고    scopus 로고
    • Complexity in bacterial cell-cell communication: Quorum signal integration and subpopulation signaling in the Bacillus subtilis phosphorelay
    • doi: 10.1073/pnas.0810878106; pmid: 19380751
    • I. B. Bischofs, J. A. Hug, A. W. Liu, D. M. Wolf, A. P. Arkin, Complexity in bacterial cell-cell communication: Quorum signal integration and subpopulation signaling in the Bacillus subtilis phosphorelay. Proc. Natl. Acad. Sci. U.S.A. 106, 6459-6464 (2009). doi: 10.1073/pnas.0810878106; pmid: 19380751
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 6459-6464
    • Bischofs, I.B.1    Hug, J.A.2    Liu, A.W.3    Wolf, D.M.4    Arkin, A.P.5
  • 30
    • 71449101586 scopus 로고    scopus 로고
    • Information processing and signal integration in bacteria quorum sensing
    • doi: 10.1038/msb.2009.79; pmid: 19920810
    • P. Mehta, S. Goyal, T. Long, B. L. Bassler, N. S. Wingreen, Information processing and signal integration in bacteria quorum sensing. Mol. Syst. Biol. 5, 325 (2009). doi: 10.1038/msb.2009.79; pmid: 19920810
    • (2009) Mol. Syst. Biol. , vol.5 , pp. 325
    • Mehta, P.1    Goyal, S.2    Long, T.3    Bassler, B.L.4    Wingreen, N.S.5
  • 31
    • 80051958792 scopus 로고    scopus 로고
    • Social conflict drives the evolutionary divergence of quorum sensing
    • doi: 10.1073/pnas.1102923108; pmid: 21807995
    • A. Eldar, Social conflict drives the evolutionary divergence of quorum sensing. Proc. Natl. Acad. Sci. U.S.A. 108, 13635-13640 (2011). doi: 10.1073/pnas.1102923108; pmid: 21807995
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 13635-13640
    • Eldar, A.1
  • 32
    • 84870372913 scopus 로고    scopus 로고
    • Optimality and robustness in quorum sensing (QS)-mediated regulation of a costly public good enzyme
    • doi: 10.1073/pnas.1211072109; pmid: 23144221
    • A. Pai, Y. Tanouchi, L. You, Optimality and robustness in quorum sensing (QS)-mediated regulation of a costly public good enzyme. Proc. Natl. Acad. Sci. U.S.A. 109, 19810-19815 (2012). doi: 10.1073/pnas.1211072109; pmid: 23144221
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 19810-19815
    • Pai, A.1    Tanouchi, Y.2    You, L.3
  • 33
    • 84875138991 scopus 로고    scopus 로고
    • Engineered quorum sensing using pheromone-mediated cell-to-cell communication in Saccharomyces cerevisiae
    • doi: 10.1021/sb300110b; pmid: 23656437
    • T. C. Williams, L. K. Nielsen, C. E. Vickers, Engineered quorum sensing using pheromone-mediated cell-to-cell communication in Saccharomyces cerevisiae. ACS Synth. Biol. 2, 136-149 (2013). doi: 10.1021/sb300110b; pmid: 23656437
    • (2013) ACS Synth. Biol. , vol.2 , pp. 136-149
    • Williams, T.C.1    Nielsen, L.K.2    Vickers, C.E.3
  • 34
    • 75149191906 scopus 로고    scopus 로고
    • A synchronized quorum of genetic clocks
    • doi: 10.1038/nature08753; pmid: 20090747
    • T. Danino, O. Mondragón-Palomino, L. Tsimring, J. Hasty, A synchronized quorum of genetic clocks. Nature 463, 326-330 (2010). doi: 10.1038/nature08753; pmid: 20090747
    • (2010) Nature , vol.463 , pp. 326-330
    • Danino, T.1    Mondragón-Palomino, O.2    Tsimring, L.3    Hasty, J.4
  • 35
    • 79957570531 scopus 로고    scopus 로고
    • Active regulation of receptor ratios controls integration of quorum-sensing signals in Vibrio harveyi
    • doi: 10.1038/msb.2011.30; pmid: 21613980
    • S. W. Teng et al., Active regulation of receptor ratios controls integration of quorum-sensing signals in Vibrio harveyi. Mol. Syst. Biol. 7, 491 (2011). doi: 10.1038/msb.2011.30; pmid: 21613980
    • (2011) Mol. Syst. Biol. , vol.7 , pp. 491
    • Teng, S.W.1
  • 36
    • 84876828969 scopus 로고    scopus 로고
    • Antagonistic self-sensing and mate-sensing signaling controls antibiotic-resistance transfer
    • doi: 10.1073/pnas.1212256110; pmid: 23569272
    • A. Chatterjee et al., Antagonistic self-sensing and mate-sensing signaling controls antibiotic-resistance transfer. Proc. Natl. Acad. Sci. U.S.A. 110, 7086-7090 (2013). doi: 10.1073/pnas.1212256110; pmid: 23569272
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 7086-7090
    • Chatterjee, A.1
  • 37
    • 28644440579 scopus 로고    scopus 로고
    • Artificial cell-cell communication in yeast Saccharomyces cerevisiae using signaling elements from Arabidopsis thaliana
    • doi: 10.1038/nbt1162; pmid: 16299520
    • M. T. Chen, R. Weiss, Artificial cell-cell communication in yeast Saccharomyces cerevisiae using signaling elements from Arabidopsis thaliana. Nat. Biotechnol. 23, 1551-1555 (2005). doi: 10.1038/nbt1162; pmid: 16299520
    • (2005) Nat. Biotechnol. , vol.23 , pp. 1551-1555
    • Chen, M.T.1    Weiss, R.2
  • 38
    • 50949088540 scopus 로고    scopus 로고
    • Insulin signaling in the pancreatic b-cell
    • doi: 10.1146/annurev.nutr.28.061807. 155530; pmid: 18481923
    • I. B. Leibiger, B. Leibiger, P. O. Berggren, Insulin signaling in the pancreatic b-cell. Annu. Rev. Nutr. 28, 233-251 (2008). doi: 10.1146/annurev.nutr.28.061807. 155530; pmid: 18481923
    • (2008) Annu. Rev. Nutr. , vol.28 , pp. 233-251
    • Leibiger, I.B.1    Leibiger, B.2    Berggren, P.O.3
  • 39
    • 0033525754 scopus 로고    scopus 로고
    • Insulin-stimulated insulin secretion in single pancreatic beta cells
    • doi: 10.1074/jbc.274.10.6360; pmid: 10037726
    • C. A. Aspinwall, J. R. T. Lakey, R. T. Kennedy, Insulin-stimulated insulin secretion in single pancreatic beta cells. J. Biol. Chem. 274, 6360-6365 (1999). doi: 10.1074/jbc.274.10.6360; pmid: 10037726
    • (1999) J. Biol. Chem. , vol.274 , pp. 6360-6365
    • Aspinwall, C.A.1    Lakey, J.R.T.2    Kennedy, R.T.3
  • 40
    • 79953768697 scopus 로고    scopus 로고
    • Quantitative variation in autocrine signaling and pathway crosstalk in the Caenorhabditis vulval network
    • doi: 10.1016/j.cub.2011.02.040; pmid: 21458263
    • E. Hoyos et al., Quantitative variation in autocrine signaling and pathway crosstalk in the Caenorhabditis vulval network. Curr. Biol. 21, 527-538 (2011). doi: 10.1016/j.cub.2011.02.040; pmid: 21458263
    • (2011) Curr. Biol. , vol.21 , pp. 527-538
    • Hoyos, E.1
  • 41
    • 0442294193 scopus 로고    scopus 로고
    • The lateral signal for LIN-12/Notch in C. Elegans vulval development comprises redundant secreted and transmembrane DSL proteins
    • doi: 10.1016/S1534-5807(04)00021-8; pmid: 14960273
    • N. Chen, I. Greenwald, The lateral signal for LIN-12/Notch in C. elegans vulval development comprises redundant secreted and transmembrane DSL proteins. Dev. Cell 6, 183-192 (2004). doi: 10.1016/S1534-5807(04)00021-8; pmid: 14960273
    • (2004) Dev. Cell , vol.6 , pp. 183-192
    • Chen, N.1    Greenwald, I.2
  • 42
    • 0024345778 scopus 로고
    • Cell autonomy of lin-12 function in a cell fate decision in C. Elegans
    • doi: 10.1016/0092-8674(89)90060-3; pmid: 2736627
    • G. Seydoux, I. Greenwald, Cell autonomy of lin-12 function in a cell fate decision in C. elegans . Cell 57, 1237-1245 (1989). doi: 10.1016/0092-8674(89) 90060-3; pmid: 2736627
    • (1989) Cell , vol.57 , pp. 1237-1245
    • Seydoux, G.1    Greenwald, I.2
  • 43
    • 0024309272 scopus 로고
    • The combined action of two intercellular signaling pathways specifies three cell fates during vulval induction in C. Elegans
    • doi: 10.1016/0092-8674(89)90103-7; pmid: 2548732
    • P. W. Sternberg, H. R. Horvitz, The combined action of two intercellular signaling pathways specifies three cell fates during vulval induction in C. elegans. Cell 58, 679-693 (1989). doi: 10.1016/0092-8674(89)90103-7; pmid: 2548732
    • (1989) Cell , vol.58 , pp. 679-693
    • Sternberg, P.W.1    Horvitz, H.R.2
  • 44
    • 84859581036 scopus 로고    scopus 로고
    • Geometry, epistasis, and developmental patterning
    • doi: 10.1073/pnas.1201505109; pmid: 22434912
    • F. Corson, E. D. Siggia, Geometry, epistasis, and developmental patterning. Proc. Natl. Acad. Sci. U.S.A. 109, 5568-5575 (2012). doi: 10.1073/pnas.1201505109; pmid: 22434912
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 5568-5575
    • Corson, F.1    Siggia, E.D.2
  • 45
    • 0021271862 scopus 로고
    • The interleukin-2 T-cell system: A new cell growth model
    • doi: 10.1126/science.6427923; pmid: 6427923
    • D. A. Cantrell, K. A. Smith, The interleukin-2 T-cell system: A new cell growth model. Science 224, 312-1316 (1984). doi: 10.1126/science.6427923; pmid: 6427923
    • (1984) Science , vol.224 , pp. 312-1316
    • Cantrell, D.A.1    Smith, K.A.2
  • 46
    • 33746547247 scopus 로고    scopus 로고
    • The biology of interleukin-2 and interleukin-15: Implications for cancer therapy and vaccine design
    • doi: 10.1038/nri1901; pmid: 16868550
    • T. A. Waldmann, The biology of interleukin-2 and interleukin-15: Implications for cancer therapy and vaccine design. Nat. Rev. Immunol. 6, 595-601 (2006). doi: 10.1038/nri1901; pmid: 16868550
    • (2006) Nat. Rev. Immunol. , vol.6 , pp. 595-601
    • Waldmann, T.A.1
  • 47
    • 84865339322 scopus 로고    scopus 로고
    • Balancing speed and accuracy of polyclonal T cell activation: A role for extracellular feedback
    • doi: 10.1186/1752-0509-6-111; pmid: 22925037
    • Y. Savir, N. Waysbort, Y. E. Antebi, T. Tlusty, N. Friedman, Balancing speed and accuracy of polyclonal T cell activation: A role for extracellular feedback. BMC Syst. Biol. 6, 111 (2012). doi: 10.1186/1752-0509-6-111; pmid: 22925037
    • (2012) BMC Syst. Biol. , vol.6 , pp. 111
    • Savir, Y.1    Waysbort, N.2    Antebi, Y.E.3    Tlusty, T.4    Friedman, N.5
  • 48
    • 78649875958 scopus 로고    scopus 로고
    • Single-cell quantification of IL-2 response by effector and regulatory T cells reveals critical plasticity in immune response
    • doi: 10.1038/msb.2010.90; pmid: 21119631
    • O. Feinerman et al., Single-cell quantification of IL-2 response by effector and regulatory T cells reveals critical plasticity in immune response. Mol. Syst. Biol. 6, 437 (2010). doi: 10.1038/msb.2010.90; pmid: 21119631
    • (2010) Mol. Syst. Biol. , vol.6 , pp. 437
    • Feinerman, O.1
  • 49
    • 0034281442 scopus 로고    scopus 로고
    • Computational model for effects of ligand/receptor binding properties on interleukin-2 trafficking dynamics and T cell proliferation response
    • doi: 10.1021/bp000097t; pmid: 11027188
    • E. M. Fallon, D. A. Lauffenburger, Computational model for effects of ligand/receptor binding properties on interleukin-2 trafficking dynamics and T cell proliferation response. Biotechnol. Prog. 16, 905-916 (2000). doi: 10.1021/bp000097t; pmid: 11027188
    • (2000) Biotechnol. Prog. , vol.16 , pp. 905-916
    • Fallon, E.M.1    Lauffenburger, D.A.2
  • 50
    • 4544300880 scopus 로고    scopus 로고
    • A walk-through of the yeast mating pheromone response pathway
    • doi: 10.1016/j.peptides.2003.10.022;pmid: 15374648
    • L. Bardwell, A walk-through of the yeast mating pheromone response pathway. Peptides 25, 1465-1476 (2004). doi: 10.1016/j.peptides.2003.10. 022;pmid: 15374648
    • (2004) Peptides , vol.25 , pp. 1465-1476
    • Bardwell, L.1
  • 51
    • 40849100220 scopus 로고    scopus 로고
    • Using engineered scaffold interactions to reshape MAP kinase pathway signaling dynamics
    • doi: 10.1126/science.1151153; pmid: 18339942
    • C. J. Bashor, N. C. Helman, S. Yan, W. A. Lim, Using engineered scaffold interactions to reshape MAP kinase pathway signaling dynamics. Science 319, 1539-1543 (2008). doi: 10.1126/science.1151153; pmid: 18339942
    • (2008) Science , vol.319 , pp. 1539-1543
    • Bashor, C.J.1    Helman, N.C.2    Yan, S.3    Lim, W.A.4
  • 52
    • 0032480978 scopus 로고    scopus 로고
    • Protease helps yeast find mating partners
    • doi: 10.1038/24760; pmid: 9853747
    • N. Barkai, M. Rose, N. Wingreen, Protease helps yeast find mating partners. Nature 396, 422-423 (1998). doi: 10.1038/24760; pmid: 9853747
    • (1998) Nature , vol.396 , pp. 422-423
    • Barkai, N.1    Rose, M.2    Wingreen, N.3
  • 53
    • 84863870994 scopus 로고    scopus 로고
    • Disentangling signaling gradients generated by equivalent sources
    • doi: 10.1007/s10867-011-9240-x; pmid: 23450187
    • N. Rappaport, N. Barkai, Disentangling signaling gradients generated by equivalent sources. J. Biol. Phys. 38, 267-278 (2012). doi: 10.1007/s10867-011- 9240-x; pmid: 23450187
    • (2012) J. Biol. Phys. , vol.38 , pp. 267-278
    • Rappaport, N.1    Barkai, N.2
  • 54
    • 80051857711 scopus 로고    scopus 로고
    • Yeast dynamically modify their environment to achieve better mating efficiency
    • doi: 10.1126/scisignal.2001763; pmid: 21868361
    • M. Jin et al., Yeast dynamically modify their environment to achieve better mating efficiency. Sci. Signal. 4, ra54 (2011). doi: 10.1126/scisignal. 2001763; pmid: 21868361
    • (2011) Sci. Signal. , vol.4
    • Jin, M.1
  • 55
    • 80052005118 scopus 로고    scopus 로고
    • Asymmetry in sexual pheromones is not required for ascomycete mating
    • doi: 10.1016/j.cub.2011.06.054; pmid: 21835624
    • J. Gonçalves-Sá, A. Murray, Asymmetry in sexual pheromones is not required for ascomycete mating. Curr. Biol. 21, 1337-1346 (2011). doi: 10.1016/j.cub.2011.06.054; pmid: 21835624
    • (2011) Curr. Biol. , vol.21 , pp. 1337-1346
    • Gonçalves-Sá, J.1    Murray, A.2
  • 56
    • 44449091966 scopus 로고    scopus 로고
    • Regulation of cell signaling dynamics by the protein kinase-scaffold Ste5
    • doi: 10.1016/j.molcel.2008.04.016; pmid: 18538663
    • N. Hao et al., Regulation of cell signaling dynamics by the protein kinase-scaffold Ste5. Mol. Cell 30, 649-656 (2008). doi: 10.1016/j.molcel.2008. 04.016; pmid: 18538663
    • (2008) Mol. Cell , vol.30 , pp. 649-656
    • Hao, N.1
  • 57
    • 34047258309 scopus 로고    scopus 로고
    • Positive-feedback loops as a flexible biological module
    • doi: 10.1016/j.cub.2007.03.016; pmid: 17398098
    • N. T. Ingolia, A. W. Murray, Positive-feedback loops as a flexible biological module. Curr. Biol. 17, 668-677 (2007). doi: 10.1016/j.cub.2007.03. 016; pmid: 17398098
    • (2007) Curr. Biol. , vol.17 , pp. 668-677
    • Ingolia, N.T.1    Murray, A.W.2
  • 58
    • 57649130757 scopus 로고    scopus 로고
    • Negative feedback that improves information transmission in yeast signalling
    • doi: 10.1038/nature07513; pmid: 19079053
    • R. C. Yu et al., Negative feedback that improves information transmission in yeast signalling. Nature 456, 755-761 (2008). doi: 10.1038/nature07513; pmid: 19079053
    • (2008) Nature , vol.456 , pp. 755-761
    • Yu, R.C.1
  • 60
    • 77957579883 scopus 로고    scopus 로고
    • Coordinate control of gene expression noise and interchromosomal interactions in a MAP kinase pathway
    • doi: 10.1038/ncb2097; pmid: 20852627
    • E. McCullagh, A. Seshan, H. El-Samad, H. D. Madhani, Coordinate control of gene expression noise and interchromosomal interactions in a MAP kinase pathway. Nat. Cell Biol. 12, 954-962 (2010). doi: 10.1038/ncb2097; pmid: 20852627
    • (2010) Nat. Cell Biol. , vol.12 , pp. 954-962
    • McCullagh, E.1    Seshan, A.2    El-Samad, H.3    Madhani, H.D.4
  • 61
    • 84855502585 scopus 로고    scopus 로고
    • Full details are available as supplementary materials on
    • Full details are available as supplementary materials on Science Online.
    • Science Online
  • 62
    • 84861434996 scopus 로고    scopus 로고
    • Design principles of cell circuits with paradoxical components
    • doi: 10.1073/pnas.1117475109; pmid: 22562798
    • Y. Hart, Y. E. Antebi, A. E. Mayo, N. Friedman, U. Alon, Design principles of cell circuits with paradoxical components. Proc. Natl. Acad. Sci. U.S.A. 109, 8346-8351 (2012). doi: 10.1073/pnas.1117475109; pmid: 22562798
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 8346-8351
    • Hart, Y.1    Antebi, Y.E.2    Mayo, A.E.3    Friedman, N.4    Alon, U.5
  • 63
    • 40749085952 scopus 로고    scopus 로고
    • Feedback regulation of opposing enzymes generates robust, all-or-none bistable responses
    • doi: 10.1016/j.cub.2008.02.035; pmid: 18364225
    • J. E. Ferrell Jr., Feedback regulation of opposing enzymes generates robust, all-or-none bistable responses. Curr. Biol. 18, R244-R245 (2008). doi: 10.1016/j.cub.2008.02.035; pmid: 18364225
    • (2008) Curr. Biol. , vol.18
    • Ferrell Jr., J.E.1
  • 64
    • 38949194331 scopus 로고    scopus 로고
    • Noise propagation and signaling sensitivity in biological networks: A role for positive feedback
    • doi: 10.1371/journal.pcbi.0040008; pmid: 18179281
    • G. Hornung, N. Barkai, Noise propagation and signaling sensitivity in biological networks: A role for positive feedback. PLOS Comp. Biol. 4, e8 (2008). doi: 10.1371/journal.pcbi.0040008; pmid: 18179281
    • (2008) PLOS Comp. Biol. , vol.4
    • Hornung, G.1    Barkai, N.2
  • 65
    • 0034050722 scopus 로고    scopus 로고
    • Noise-based switches and amplifiers for gene expression
    • doi: 10.1073/pnas.040411297; pmid: 10681449
    • J. Hasty, J. Pradines, M. Dolnik, J. J. Collins, Noise-based switches and amplifiers for gene expression. Proc. Natl. Acad. Sci. U.S.A. 97, 2075-2080 (2000). doi: 10.1073/pnas.040411297; pmid: 10681449
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 2075-2080
    • Hasty, J.1    Pradines, J.2    Dolnik, M.3    Collins, J.J.4
  • 66
    • 81355150962 scopus 로고    scopus 로고
    • Speed, sensitivity, and bistability in auto-activating signaling circuits
    • doi: 10.1371/journal.pcbi.1002265; pmid: 22125482
    • R. Hermsen, D. Erickson, T. Hwa, Speed, sensitivity, and bistability in auto-activating signaling circuits. PLOS Comput. Biol. 7, e1002265 (2011). doi: 10.1371/journal.pcbi.1002265; pmid: 22125482
    • (2011) PLOS Comput. Biol. , vol.7
    • Hermsen, R.1    Erickson, D.2    Hwa, T.3
  • 67
    • 50149090966 scopus 로고    scopus 로고
    • Variability and robustness in T cell activation from regulated heterogeneity in protein levels
    • doi: 10.1126/science.1158013; pmid: 18719282
    • O. Feinerman, J. Veiga, J. R. Dorfman, R. N. Germain, G. Altan-Bonnet, Variability and robustness in T cell activation from regulated heterogeneity in protein levels. Science 321, 1081-1084 (2008). doi: 10.1126/science.1158013; pmid: 18719282
    • (2008) Science , vol.321 , pp. 1081-1084
    • Feinerman, O.1    Veiga, J.2    Dorfman, J.R.3    Germain, R.N.4    Altan-Bonnet, G.5
  • 68
    • 36849039660 scopus 로고    scopus 로고
    • IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland
    • doi: 10.1172/JCI32533; pmid: 18060036
    • P. Sansone et al., IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland. J. Clin. Invest. 117, 3988-4002 (2007). doi: 10.1172/JCI32533; pmid: 18060036
    • (2007) J. Clin. Invest. , vol.117 , pp. 3988-4002
    • Sansone, P.1
  • 69
    • 66049146558 scopus 로고    scopus 로고
    • Quantifying the integration of quorum-sensing signals with single-cell resolution
    • doi: 10.1371/journal.pbio.1000068; pmid: 19320539
    • T. Long et al., Quantifying the integration of quorum-sensing signals with single-cell resolution. PLOS Biol. 7, e68 (2009). doi: 10.1371/journal. pbio.1000068; pmid: 19320539
    • (2009) PLOS Biol. , vol.7
    • Long, T.1
  • 70
    • 0019320348 scopus 로고
    • Autocrine secretion and malignant transformation of cells
    • doi: 10.1056/NEJM198010093031511; pmid: 7412807
    • M. B. Sporn, G. J. Todaro, Autocrine secretion and malignant transformation of cells. N. Engl. J. Med. 303, 878-880 (1980). doi: 10.1056/NEJM198010093031511; pmid: 7412807
    • (1980) N. Engl. J. Med. , vol.303 , pp. 878-880
    • Sporn, M.B.1    Todaro, G.J.2
  • 71
    • 34548739659 scopus 로고    scopus 로고
    • Time and length scales of autocrine signals in three dimensions
    • doi: 10.1529/biophysj.107.109736; pmid: 17720734
    • M. Coppey, A. M. Berezhkovskii, S. C. Sealfon, S. Y. Shvartsman, Time and length scales of autocrine signals in three dimensions. Biophys. J. 93, 1917-1922 (2007). doi: 10.1529/biophysj.107.109736; pmid: 17720734
    • (2007) Biophys. J. , vol.93 , pp. 1917-1922
    • Coppey, M.1    Berezhkovskii, A.M.2    Sealfon, S.C.3    Shvartsman, S.Y.4
  • 72
    • 0034805462 scopus 로고    scopus 로고
    • Spatial range of autocrine signaling: Modeling and computational analysis
    • doi: 10.1016/S0006-3495(01)75837-7; pmid: 11566760
    • S. Y. Shvartsman, H. S. Wiley, W. M. Deen, D. A. Lauffenburger, Spatial range of autocrine signaling: Modeling and computational analysis. Biophys. J. 81, 1854-1867 (2001). doi: 10.1016/S0006-3495(01)75837-7; pmid: 11566760
    • (2001) Biophys. J. , vol.81 , pp. 1854-1867
    • Shvartsman, S.Y.1    Wiley, H.S.2    Deen, W.M.3    Lauffenburger, D.A.4
  • 73
    • 0034942833 scopus 로고    scopus 로고
    • Quantitative analysis of the EGF receptor autocrine system reveals cryptic regulation of cell response by ligand capture
    • pmid: 11493669
    • A. E. DeWitt, J. Y. Dong, H. S. Wiley, D. A. Lauffenburger, Quantitative analysis of the EGF receptor autocrine system reveals cryptic regulation of cell response by ligand capture. J. Cell Sci. 114, 2301-2313 (2001). pmid: 11493669
    • (2001) J. Cell Sci. , vol.114 , pp. 2301-2313
    • DeWitt, A.E.1    Dong, J.Y.2    Wiley, H.S.3    Lauffenburger, D.A.4
  • 74
    • 0036080555 scopus 로고    scopus 로고
    • Autocrine loops with positive feedback enable context-dependent cell signaling
    • doi: 10.1152/ajpcell.00260.2001; pmid: 11832340
    • S. Y. Shvartsman et al., Autocrine loops with positive feedback enable context-dependent cell signaling. Am. J. Physiol. Cell Physiol. 282, C545-C559 (2002). doi: 10.1152/ajpcell.00260.2001; pmid: 11832340
    • (2002) Am. J. Physiol. Cell Physiol. , vol.282
    • Shvartsman, S.Y.1
  • 75
    • 84880940410 scopus 로고    scopus 로고
    • Mapping differentiation under mixed culture conditions reveals a tunable continuum of T cell fates
    • doi: 10.1371/journal.pbio.1001616; pmid: 23935451
    • Y. E. Antebi et al., Mapping differentiation under mixed culture conditions reveals a tunable continuum of T cell fates. PLOS Biol. 11, e1001616 (2013). doi: 10.1371/journal.pbio.1001616; pmid: 23935451
    • (2013) PLOS Biol. , vol.11
    • Antebi, Y.E.1
  • 76
    • 84880953116 scopus 로고    scopus 로고
    • Stochastic cytokine expression induces mixed T helper cell states
    • doi: 10.1371/journal.pbio.1001618; pmid: 23935453
    • M. Fang, H. Xie, S. K. Dougan, H. Ploegh, A. van Oudenaarden, Stochastic cytokine expression induces mixed T helper cell states. PLOS Biol. 11, e1001618 (2013). doi: 10.1371/journal.pbio.1001618; pmid: 23935453
    • (2013) PLOS Biol. , vol.11
    • Fang, M.1    Xie, H.2    Dougan, S.K.3    Ploegh, H.4    Van Oudenaarden, A.5
  • 77
    • 2942738996 scopus 로고    scopus 로고
    • The Hedgehog response network: Sensors, switches, and routers
    • doi: 10.1126/science.1098020; pmid: 15205520
    • L. Lum, P. A. Beachy, The Hedgehog response network: Sensors, switches, and routers. Science 304, 1755-1759 (2004). doi: 10.1126/science.1098020; pmid: 15205520
    • (2004) Science , vol.304 , pp. 1755-1759
    • Lum, L.1    Beachy, P.A.2
  • 78
    • 34447099234 scopus 로고    scopus 로고
    • Probing the limits to positional information
    • doi: 10.1016/j.cell.2007.05.025; pmid: 17632062
    • T. Gregor, D. W. Tank, E. F. Wieschaus, W. Bialek, Probing the limits to positional information. Cell 130, 153-164 (2007). doi: 10.1016/j.cell.2007.05. 025; pmid: 17632062
    • (2007) Cell , vol.130 , pp. 153-164
    • Gregor, T.1    Tank, D.W.2    Wieschaus, E.F.3    Bialek, W.4
  • 79
    • 84876840287 scopus 로고    scopus 로고
    • Dynamic interpretation of maternal inputs by the Drosophila segmentation gene network
    • doi: 10.1073/pnas.1220912110; pmid: 23580621
    • F. Liu, A. H. Morrison, T. Gregor, Dynamic interpretation of maternal inputs by the Drosophila segmentation gene network. Proc. Natl. Acad. Sci. U.S.A. 110, 6724-6729 (2013). doi: 10.1073/pnas.1220912110; pmid: 23580621
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 6724-6729
    • Liu, F.1    Morrison, A.H.2    Gregor, T.3
  • 80
    • 85027931386 scopus 로고    scopus 로고
    • Quantitative imaging of transcription in living Drosophila embryos links polymerase activity to patterning
    • doi: 10.1016/j.cub.2013.08.054; pmid: 24139738
    • H. G. Garcia, M. Tikhonov, A. Lin, T. Gregor, Quantitative imaging of transcription in living Drosophila embryos links polymerase activity to patterning. Curr. Biol. 23, 2140-2145 (2013). doi: 10.1016/j.cub.2013.08.054; pmid: 24139738
    • (2013) Curr. Biol. , vol.23 , pp. 2140-2145
    • Garcia, H.G.1    Tikhonov, M.2    Lin, A.3    Gregor, T.4
  • 81
    • 84873861213 scopus 로고    scopus 로고
    • Accurate measurements of dynamics and reproducibility in small genetic networks
    • doi: 10.1038/msb.2012.72; pmid: 23340845
    • J. O. Dubuis, R. Samanta, T. Gregor, Accurate measurements of dynamics and reproducibility in small genetic networks. Mol. Syst. Biol. 9, 639 (2013). doi: 10.1038/msb.2012.72; pmid: 23340845
    • (2013) Mol. Syst. Biol. , vol.9 , pp. 639
    • Dubuis, J.O.1    Samanta, R.2    Gregor, T.3
  • 82
    • 84865682920 scopus 로고    scopus 로고
    • Self-organized shuttling: Generating sharp dorsoventral polarity in the early Drosophila embryo
    • doi: 10.1016/j.cell.2012.06.044; pmid: 22939625
    • M. Haskel-Ittah et al., Self-organized shuttling: Generating sharp dorsoventral polarity in the early Drosophila embryo. Cell 150, 1016-1028 (2012). doi: 10.1016/j.cell.2012.06.044; pmid: 22939625
    • (2012) Cell , vol.150 , pp. 1016-1028
    • Haskel-Ittah, M.1
  • 83
    • 46249114829 scopus 로고    scopus 로고
    • Scaling of the BMP activation gradient in Xenopus embryos
    • doi: 10.1038/nature07059; pmid: 18580943
    • D. Ben-Zvi, B. Z. Shilo, A. Fainsod, N. Barkai, Scaling of the BMP activation gradient in Xenopus embryos. Nature 453, 1205-1211 (2008). doi: 10.1038/nature07059; pmid: 18580943
    • (2008) Nature , vol.453 , pp. 1205-1211
    • Ben-Zvi, D.1    Shilo, B.Z.2    Fainsod, A.3    Barkai, N.4
  • 84
    • 0036685473 scopus 로고    scopus 로고
    • Is quorum sensing a side effect of diffusion sensing?
    • doi: 10.1016/S0966-842X(02)02400-9; pmid: 12160634
    • R. J. Redfield, Is quorum sensing a side effect of diffusion sensing? Trends Microbiol. 10, 365-370 (2002). doi: 10.1016/S0966-842X(02)02400-9; pmid: 12160634
    • (2002) Trends Microbiol. , vol.10 , pp. 365-370
    • Redfield, R.J.1
  • 85
    • 78751659611 scopus 로고    scopus 로고
    • Primitive agriculture in a social amoeba
    • doi: 10.1038/nature09668; pmid: 21248849
    • D. A. Brock, T. E. Douglas, D. C. Queller, J. E. Strassmann, Primitive agriculture in a social amoeba. Nature 469, 393-396 (2011). doi: 10.1038/nature09668; pmid: 21248849
    • (2011) Nature , vol.469 , pp. 393-396
    • Brock, D.A.1    Douglas, T.E.2    Queller, D.C.3    Strassmann, J.E.4
  • 86
    • 66149108283 scopus 로고    scopus 로고
    • Snowdrift game dynamics and facultative cheating in yeast
    • doi: 10.1038/nature07921; pmid: 19349960
    • J. Gore, H. Youk, A. van Oudenaarden, Snowdrift game dynamics and facultative cheating in yeast. Nature 459, 253-256 (2009). doi: 10.1038/nature07921; pmid: 19349960
    • (2009) Nature , vol.459 , pp. 253-256
    • Gore, J.1    Youk, H.2    Van Oudenaarden, A.3
  • 87
    • 17844374314 scopus 로고    scopus 로고
    • A synthetic multicellular system for programmed pattern formation
    • doi: 10.1038/nature03461; pmid: 15858574
    • S. Basu, Y. Gerchman, C. H. Collins, F. H. Arnold, R. Weiss, A synthetic multicellular system for programmed pattern formation. Nature 434, 1130-1134 (2005). doi: 10.1038/nature03461; pmid: 15858574
    • (2005) Nature , vol.434 , pp. 1130-1134
    • Basu, S.1    Gerchman, Y.2    Collins, C.H.3    Arnold, F.H.4    Weiss, R.5
  • 88
    • 67549145283 scopus 로고    scopus 로고
    • A synthetic genetic edge detection program
    • doi: 10.1016/j.cell.2009.04.048; pmid: 19563759
    • J. J. Tabor et al., A synthetic genetic edge detection program. Cell 137, 1272-1281 (2009). doi: 10.1016/j.cell.2009.04.048; pmid: 19563759
    • (2009) Cell , vol.137 , pp. 1272-1281
    • Tabor, J.J.1
  • 89
    • 42149089190 scopus 로고    scopus 로고
    • A synthetic Escherichia coli predator-prey ecosystem
    • doi: 10.1038/msb.2008.24; pmid: 18414488
    • F. K. Balagaddé et al., A synthetic Escherichia coli predator-prey ecosystem. Mol. Syst. Biol. 4, 187 (2008). doi: 10.1038/msb.2008.24; pmid: 18414488
    • (2008) Mol. Syst. Biol. , vol.4 , pp. 187
    • Balagaddé, F.K.1
  • 90
    • 78651397316 scopus 로고    scopus 로고
    • Robust multicellular computing using genetically encoded NOR gates and chemical 'wires'
    • doi: 10.1038/nature09565; pmid: 21150903
    • A. Tamsir, J. J. Tabor, C. A. Voigt, Robust multicellular computing using genetically encoded NOR gates and chemical 'wires'. Nature 469, 212-215 (2011). doi: 10.1038/nature09565; pmid: 21150903
    • (2011) Nature , vol.469 , pp. 212-215
    • Tamsir, A.1    Tabor, J.J.2    Voigt, C.A.3
  • 91
    • 78651406505 scopus 로고    scopus 로고
    • Distributed biological computation with multicellular engineered networks
    • doi: 10.1038/nature09679; pmid: 21150900
    • S. Regot et al., Distributed biological computation with multicellular engineered networks. Nature 469, 207-211 (2011). doi: 10.1038/nature09679; pmid: 21150900
    • (2011) Nature , vol.469 , pp. 207-211
    • Regot, S.1
  • 92
    • 84881408628 scopus 로고    scopus 로고
    • Dynamically reshaping signaling networks to program cell fate via genetic controllers
    • doi: 10.1126/science.1235005; pmid: 23950497
    • K. E. Galloway, E. Franco, C. D. Smolke, Dynamically reshaping signaling networks to program cell fate via genetic controllers. Science 341, 1235005 (2013). doi: 10.1126/science.1235005; pmid: 23950497
    • (2013) Science , vol.341 , pp. 1235005
    • Galloway, K.E.1    Franco, E.2    Smolke, C.D.3
  • 93
    • 84877607428 scopus 로고    scopus 로고
    • Amplifying genetic logic gates
    • doi: 10.1126/science.1232758; pmid: 23539178
    • J. Bonnet, P. Yin, M. E. Ortiz, P. Subsoontorn, D. Endy, Amplifying genetic logic gates. Science 340, 599-603 (2013). doi: 10.1126/science.1232758; pmid: 23539178
    • (2013) Science , vol.340 , pp. 599-603
    • Bonnet, J.1    Yin, P.2    Ortiz, M.E.3    Subsoontorn, P.4    Endy, D.5
  • 94
    • 80054124775 scopus 로고    scopus 로고
    • Sequential establishment of stripe patterns in an expanding cell population
    • doi: 10.1126/science.1209042; pmid: 21998392
    • C. Liu et al., Sequential establishment of stripe patterns in an expanding cell population. Science 334, 238-241 (2011). doi: 10.1126/science.1209042; pmid: 21998392
    • (2011) Science , vol.334 , pp. 238-241
    • Liu, C.1
  • 95
    • 78650334784 scopus 로고    scopus 로고
    • Build life to understand it
    • doi: 10.1038/468889a; pmid: 21164460
    • M. B. Elowitz, W. A. Lim, Build life to understand it. Nature 468, 889-890 (2010). doi: 10.1038/468889a; pmid: 21164460
    • (2010) Nature , vol.468 , pp. 889-890
    • Elowitz, M.B.1    Lim, W.A.2
  • 96
    • 84865294751 scopus 로고    scopus 로고
    • Synthetic approaches to understanding biological constraints
    • doi: 10.1016/j.cbpa.2012.05.199; pmid: 22682889
    • A. Velenich, J. Gore, Synthetic approaches to understanding biological constraints. Curr. Opin. Chem. Biol. 16, 323-328 (2012). doi: 10.1016/j.cbpa.2012.05.199; pmid: 22682889
    • (2012) Curr. Opin. Chem. Biol. , vol.16 , pp. 323-328
    • Velenich, A.1    Gore, J.2
  • 97
    • 84880962137 scopus 로고    scopus 로고
    • Building robust functionality in synthetic circuits using engineered feedback regulation
    • doi: 10.1016/j.copbio.2013.02.025; pmid: 23566378
    • S. Chen, P. Harrigan, B. Heineike, J. Stewart-Ornstein, H. El-Samad, Building robust functionality in synthetic circuits using engineered feedback regulation. Curr. Opin. Biotechnol. 24, 790-796 (2013). doi: 10.1016/j.copbio.2013.02.025; pmid: 23566378
    • (2013) Curr. Opin. Biotechnol. , vol.24 , pp. 790-796
    • Chen, S.1    Harrigan, P.2    Heineike, B.3    Stewart-Ornstein, J.4    El-Samad, H.5
  • 98
    • 81955167344 scopus 로고    scopus 로고
    • The era of systems developmental biology
    • doi: 10.1016/j.gde.2011.10.004; pmid: 22079435
    • N. Perrimon, N. Barkai, The era of systems developmental biology. Curr. Opin. Genet. Dev. 21, 681-683 (2011). doi: 10.1016/j.gde.2011.10.004; pmid: 22079435
    • (2011) Curr. Opin. Genet. Dev. , vol.21 , pp. 681-683
    • Perrimon, N.1    Barkai, N.2
  • 100
    • 0030778204 scopus 로고    scopus 로고
    • Effective intercellular communication distances are determined by the relative time constants for cyto/chemokine secretion and diffusion
    • doi: 10.1073/pnas.94.23.12258; pmid: 9356436
    • K. Francis, B. O. Palsson, Effective intercellular communication distances are determined by the relative time constants for cyto/chemokine secretion and diffusion. Proc. Natl. Acad. Sci. U.S.A. 94, 12258-12262 (1997). doi: 10.1073/pnas.94.23.12258; pmid: 9356436
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 12258-12262
    • Francis, K.1    Palsson, B.O.2


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