Prophylaxis of venous thromboembolism with low molecular weight heparin in bariatric surgery: A prospective, randomised pilot study evaluating two doses of parnaparin (BAFLUX study)

Obesity Surgery

Volumn 24, Issue 2, 2014, Pages 284-291

  Imberti, Davide ^a   Baldini, Edoardo ^b   Pierfranceschi, Matteo Giorgi ^c   Nicolini, Alberto ^d   Cartelli, Concetto ^d   De Paoli, Marco ^e   Boni, Marcello ^f   Filippucci, Esmeralda ^g   Cariani, Stefano ^h   Bottani, Giorgio ⁱ  

^a Hospital of Piacenza   (Italy)

^b UO Chirurgia Generale   (Italy)

^c GUGLIELMO DA SALICETO HOSPITAL   (Italy)

^d S MARIA NUOVA HOSPITAL   (Italy)

^e GALLIERA HOSPITAL   (Italy)

^f Chirurgia Generale   (Italy)

^g Ospedale San Giovanni Battista   (Italy)

^h UNIVERSITY OF BOLOGNA   (Italy)

ⁱ Ospedale Civile   (Italy)

Author keywords

Bariatric surgery; Obesity; Parnaparin; Prophylaxis; Venous thromboembolism

Indexed keywords

PARNAPARIN;

ADULT; ARTICLE; BARIATRIC SURGERY; BLEEDING TENDENCY; BODY MASS; COMPARATIVE EFFECTIVENESS; CONFIDENCE INTERVAL; CONTROLLED STUDY; DEATH; DEEP VEIN THROMBOSIS; DOPPLER FLOWMETRY; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG SAFETY; EMBOLISM PREVENTION; FEMALE; HUMAN; INCIDENCE; LEG; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OPTIMAL DRUG DOSE; PILOT STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; VENOUS CIRCULATION; VENOUS THROMBOEMBOLISM;

ADULT; ANTICOAGULANTS; BARIATRIC SURGERY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FEMALE; HEPARIN, LOW-MOLECULAR-WEIGHT; HUMANS; MALE; OBESITY, MORBID; PILOT PROJECTS; PREMEDICATION; PROSPECTIVE STUDIES; TREATMENT OUTCOME; VENOUS THROMBOEMBOLISM;

EID: 84893689598     PISSN: 09608923     EISSN: 17080428     Source Type: Journal    
DOI: 10.1007/s11695-013-1105-x     Document Type: Article

References (34)

1. DeMaria EJ. Bariatric surgery for morbid obesity. N Engl J Med. 2007;356(21):2176-83. Review. PubMed PMID: 17522401.
2. Gould MK, Garcia DA, Wren SM, et al. Prevention of VTE in nonorthopedic surgical patients: antithrombotic therapy and prevention of thrombosis, 9th edn: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141(2 Suppl):e227S-77S. Erratum in: Chest.2012 May;141(5):1369. PubMed PMID: 22315263; PubMed Central PMCID: PMC3278061.
3. Sjöström L, Lindroos AK, Peltonen M, et al. Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med. 2004;351(26):2683-93.
4. Prystowsky JB, Morasch MD, Eskandari MK, et al. Prospective analysis of the incidence of deep venous thrombosis in bariatric surgery patients. Surgery. 2005;138(4):759-63. discussion 763-5. PubMed PMID: 16269306.
5. Rocha AT, de Vasconcellos AG, da Luz Neto ER, et al. Risk of venous thromboembolism and efficacy of thromboprophylaxis in hospitalized obese medical patients and in obese patients undergoing bariatric surgery. Obes Surg. 2006;16(12):1645-55. Review. PubMed PMID: 17217642.
6. Stroh C, Birk D, Flade-Kuthe R, et al. Evidence of thromboembolism prophylaxis in bariatric surgery - results of a quality assurance trial in bariatric surgery in Germany from 2005 to 2007 and review of the literature. Obes Surg. 2009;19(7):928-36.
7. Gonzalez QH, Tishler DS, Plata-Munoz JJ, et al. Incidence of clinically evident deep venous thrombosis after laparoscopic Roux-en-Y gastric bypass. Surg Endosc. 2004;18(7):1082-4. PubMed PMID: 15156394.
8. Scholten DJ, Hoedema RM, Scholten SE. A comparison of two different prophylactic dose regimens of low molecular weight heparin in bariatric surgery. Obes Surg. 2002;12(1):19-24. PubMed PMID: 11868291.
9. Kalfarentzos F, Stavropoulou F, Yarmenitis S, et al. Prophylaxis of venous thromboembolism using two different doses of low-molecular-weight heparin (nadroparin) in bariatric surgery: a prospective randomized trial. Obes Surg. 2001;11(6):670-6. PubMed PMID: 11775562.
10. Hamad GG, Choban PS. Enoxaparin for thromboprophylaxis in morbidly obese patients undergoing bariatric surgery: findings of the prophylaxis against VTE outcomes in bariatric surgery patients receiving enoxaparin (PROBE) study. Obes Surg. 2005;15(10):1368-74. PubMed PMID: 16354513.
11. Kothari SN, Lambert PJ, Mathiason MA. Best Poster Award. A comparison of thromboembolic and bleeding events following laparoscopic gastric bypass in patients treated with prophylactic regimens of unfractionated heparin or enoxaparin. Am J Surg. 2007;194(6):709-11. PubMed PMID: 18005758.
12. Raftopoulos I, Martindale C, Cronin A, et al. The effect of extended post-discharge chemical thromboprophylaxis on venous thromboembolism rates after bariatric surgery: a prospective comparison trial. Surg Endosc. 2008;22(11):2384-91. PubMed PMID: 18622558.
13. Magee CJ, Barry J, Javed S, et al. Extended thromboprophylaxis reduces incidence of postoperative venous thromboembolism in laparoscopic bariatric surgery. Surg Obes Relat Dis. 2010;6(3):322-5. PubMed PMID: 20510295.
14. Cotter SA, Cantrell W, Fisher B, et al. Efficacy of venous thromboembolism prophylaxis in morbidly obese patients undergoing gastric bypass surgery. Obes Surg. 2005;15(9):1316-20. PubMed PMID: 16259895.
15. Hirsh J, Raschke R. Heparin and low-molecular-weight heparin: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest. 2004;126(3 Suppl):188S-203S. PubMed PMID: 15383472.
16. Geerts WH, Bergqvist D, Pineo GF, et al. Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th edition). Chest. 2008;133(6 Suppl):381S-453S. PubMed PMID: 18574271.
17. Planès A, Samama MM, Lensing AW, et al. Prevention of deep vein thrombosis after hip replacement - comparison between two low-molecular heparins, tinzaparin and enoxaparin. Thromb Haemost. 1999;81(1):22-5. PubMed PMID: 10348714.
18. Borkgren-Okonek MJ, Hart RW, Pantano JE, et al. Enoxaparin thromboprophylaxis in gastric bypass patients: extended duration, dose stratification, and antifactor Xa activity. Surg Obes Relat Dis. 2008;4(5):625-31. PubMed PMID: 18261965.
19. Simoneau MD, Vachon A, Picard F. Effect of prophylactic dalteparin on anti-factor Xa levels in morbidly obese patients after bariatric surgery. Obes Surg. 2010;20(4):487-91. PubMed PMID: 18931882.
20. Lim W. Using low molecular weight heparin in special patient populations. J Thromb Thrombolysis. 2010;29(2):233-40. PubMed PMID: 19902146.
21. Rowan BO, Kuhl DA, Lee MD, et al. Anti-Xa levels in bariatric surgery patients receiving prophylactic enoxaparin. Obes Surg. 2008;18(2):162-6. PubMed PMID: 18165884.
22. Sanderink GJ, Le Liboux A, Jariwala N, et al. The pharmacokinetics and pharmacodynamics of enoxaparin in obese volunteers. Clin Pharmacol Ther. 2002;72(3):308-18. PubMed PMID: 12235452.
23. McKeage K, Keating GM. Parnaparin: a review of its use in the management of venous thromboembolism, chronic venous disease and other vascular disorders. Drugs. 2008;68(1):105-22. PubMed PMID: 18081375.
24. Linkins LA, Dans AL, Moores LK, et al. Treatment and prevention of heparin-induced thrombocytopenia: antithrombotic therapy and prevention of thrombosis, 9th edn: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141(2 Suppl):e495S-530S. doi: 10.1378/chest.11-2303. PubMed PMID: 22315270; PubMed Central PMCID: PMC3278058.
25. Becattini C, Agnelli G, Manina G, et al. Venous thromboembolism after laparoscopic bariatric surgery for morbid obesity: clinical burden and prevention. Surg Obes Relat Dis. 2012;8(1):108-15. PubMed PMID: 22014482.
26. Imberti D, Legnani C, Baldini E, et al. Pharmacodynamics of low molecular weight heparin in patients undergoing bariatric surgery: a prospective, randomised study comparing two doses of parnaparin (BAFLUX study). Thromb Res. 2009;124(6):667-71. PubMed PMID: 19482341.
27. Forestieri P, Quarto G, De Caterina M, et al. Prophylaxis of thromboembolism in bariatric surgery with parnaparin. Obes Surg. 2007;17(12):1558-62. PubMed PMID: 18004632.
28. Simone EP, Madan AK, Tichansky DS, et al. Comparison of two low-molecular-weight heparin dosing regimens for patients undergoing laparoscopic bariatric surgery. Surg Endosc. 2008;22(11):2392-5. PubMed PMID: 18594915.
29. Wilson SJ, Wilbur K, Burton E, et al. Effect of patient weight on the anticoagulant response to adjusted therapeutic dosage of low-molecular-weight heparin for the treatment of venous thromboembolism. Haemostasis. 2001;31(1):42-8. PubMed PMID: 11408748.
30. Heizmann M, Baerlocher GM, Steinmann F, et al. Anti-Xa activity in obese patients after double standard dose of nadroparin for prophylaxis. Thromb Res. 2002;106(4-5):179-81. PubMed PMID: 12297122.
31. Brasileiro AL, Miranda Jr F, Ettinger JE, et al. Incidence of lower limbs deep vein thrombosis after open and laparoscopic gastric bypass: a prospective study. Obes Surg. 2008;18(1):52-7. PubMed PMID: 18080727.
32. Handeland GF, Abildgaard U, Holm HA, et al. Dose adjusted heparin treatment of deep venous thrombosis: a comparison of unfractionated and low molecular weight heparin. Eur J Clin Pharmacol. 1990;39(2):107-12. PubMed PMID: 2174783.
33. Kearon C, Julian JA, Newman TE, et al. Noninvasive diagnosis of deep venous thrombosis. McMaster Diagnostic Imaging Practice Guidelines Initiative. Ann Intern Med. 1998;128(8):663-77. Erratum in: Ann Intern Med 1998 Sep 1;129(5):425. PubMed PMID: 9537941.
34. Kearon C. Noninvasive diagnosis of deep vein thrombosis in postoperative patients. Semin Thromb Hemost. 2001;27(1):3-8. PubMed PMID: 11288945.