Family-Based Association Analysis of Alcohol Dependence Criteria and Severity

Alcoholism: Clinical and Experimental Research

Volumn 38, Issue 2, 2014, Pages 354-366

  Wetherill, Leah ^a   Kapoor, Manav ^b   Agrawal, Arpana ^b   Bucholz, Kathleen ^b   Koller, Daniel ^a   Bertelsen, Sarah E ^b   Le, Nhung ^b   Wang, Jen Chyong ^b   Almasy, Laura ^c   Hesselbrock, Victor ^d   Kramer, John ^e   Nurnberger, John I ^a   Schuckit, Marc ^f   Tischfield, Jay A ^g   Xuei, Xiaoling ^a   Porjesz, Bernice ^h   Edenberg, Howard J ^a   Goate, Alison M ^b   Foroud, Tatiana ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

^d UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^e UNIVERSITY OF IOWA   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g The State University of New Jersey   (United States)

^h SUNY DOWNSTATE MEDICAL CENTER   (United States)

Author keywords

Alcohol Dependence Criteria; Family Based Association; GWAS; Latent Class Analysis

Indexed keywords

ALCOHOL CONSUMPTION; ALCOHOLISM; ARTICLE; CHROMOSOME 11; CHROMOSOME ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; DSM-IV; ENTROPY; EUROPEAN AMERICAN; FAMILY ASSESSMENT; GENE FREQUENCY; GENE REPLICATION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HERITABILITY; HUMAN; MAJOR CLINICAL STUDY; OLFACTORY RECEPTOR; PHENOTYPE; PRIORITY JOURNAL; PROBABILITY; QUALITY CONTROL; SINGLE NUCLEOTIDE POLYMORPHISM;

ALCOHOL DEPENDENCE CRITERIA; FAMILY-BASED ASSOCIATION; GWAS; LATENT CLASS ANALYSIS;

ADULT; ALCOHOL DRINKING; ALCOHOLISM; CLINICAL TRIALS DATA MONITORING COMMITTEES; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FAMILY; FEMALE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; SODIUM CHANNELS; UNITED STATES;

EID: 84893677369     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/acer.12251     Document Type: Article

References (53)

1. Agrawal A, Scherrer JF, Pergadia ML, Lynskey MT, Madden PA, Sartor CE, Grant JD, Duncan AE, Haber JR, Jacob T, Bucholz KK, Xian H (2011) A latent class analysis of DSM-IV and Fagerstrom (FTND) criteria for nicotine dependence. Nicotine Tob Res 13:972-981.
2. Agrawal A, Verweij KJ, Gillespie NA, Heath AC, Lessov-Schlaggar CN, Martin NG, Nelson EC, Slutske WS, Whitfield JB, Lynskey MT (2012) The genetics of addiction-a translational perspective. Transl Psychiatry 2:e140.
3. Almasy L, Blangero J (1998) Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 62:1198-1211.
4. American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders DSM-IV. 4th ed. American Psychiatric Association, Washington, DC.
5. Begleiter H, Reich T, Hesselbrock V, Porjesz B, Li TK, Schuckit M, Edenberg H, Rice JP (1995) The collaborative study on the genetics of alcoholism. Alcohol Health Res World 19:228-236.
6. Beseler CL, Taylor LA, Kraemer DT, Leeman RF (2012) A latent class analysis of DSM-IV alcohol use disorder criteria and binge drinking in undergraduates. Alcohol Clin Exp Res 36:153-161.
7. Bierut L, Agrawal A, Bucholz K, Doheny KF, Laurie C, Pugh EW, Fisher SL, Fox L, Howells W, Bertelsen S, Hinrichs A, Almasy L, Breslau N, Culverhouse R, Dick D, Edenberg H, Foroud T, Grucza R, Hatsukami D, Hesselbrock V, Johnson E, Kramer J, Krueger R, Kuperman S, Lynskey MT, Mann K, Neuman RJ, Nothen MM, Nurnberger J, Porjesz B, Ridinger M, Saccone N, Schuckit M, Tischfield J, Wang J, Rietschel M, Goate A, Rice J (2010) A genome-wide association study of alcohol dependence. Proc Natl Acad Sci USA 107:5082-5087.
8. Bito-Onon JJ, Simms JA, Chatterjee S, Holgate J, Bartlett SE (2011) Varenicline, a partial agonist at neuronal nicotinic acetylcholine receptors, reduces nicotine-induced increases in 20% ethanol operant self-administration in Sprague-Dawley rats. Addict Biol 16:440-449.
9. Bragulat V, Dzemidzic M, Talavage T, Davidson D, O'Connor SJ, Kareken DA (2008) Alcohol sensitizes cerebral responses to the odors of alcoholic drinks: an fMRI study. Alcohol Clin Exp Res 32:1124-1134.
10. Browning BL, Browning SR (2009) A unified approach to genotype imputation and haplotype-phase inference for large data sets of trios and unrelated individuals. Am J Hum Genet 84:210-223.
11. Bucholz KK, Cadoret R, Cloninger CR, Dinwiddie SH, Hesselbrock VM, Nurnberger JI Jr, Reich T, Schmidt I, Schuckit MA (1994) A new, semi-structured psychiatric interview for use in genetic linkage studies: a report on the reliability of the SSAGA. J Stud Alcohol 55:149-158.
12. Bucholz KK, Heath AC, Reich T, Hesselbrock VM, Kramer JR, Nurnberger JI Jr, Schuckit MA (1996) Can we subtype alcoholism? A latent class analysis of data from relatives of alcoholics in a multicenter family study of alcoholism. Alcohol Clin Exp Res 20:1462-1471.
13. Bureau A, Croteau J, Tayeb A, Merette C, Labbe A (2011) Latent class model with familial dependence to address heterogeneity in complex diseases: adapting the approach to family-based association studies. Genet Epidemiol 35:182-189.
14. Chen WM, Manichaikul A, Rich SS (2009) A generalized family-based association test for dichotomous traits. Am J Hum Genet 85:364-376.
15. Covault J, Gelernter J, Jensen K, Anton R, Kranzler HR (2008) Markers in the 5′-region of GABRG1 associate to alcohol dependence and are in linkage disequilibrium with markers in the adjacent GABRA2 gene. Neuropsychopharmacology 33:837-848.
16. Edenberg HJ, Dick DM, Xuei X, Tian H, Almasy L, Bauer LO, Crowe RR, Goate A, Hesselbrock V, Jones K, Kwon J, Li TK, Nurnberger JI Jr, O'Connor SJ, Reich T, Rice J, Schuckit MA, Porjesz B, Foroud T, Begleiter H (2004) Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations. Am J Hum Genet 74:705-714.
17. Edenberg HJ, Foroud T (2006) The genetics of alcoholism: identifying specific genes through family studies. Addict Biol 11:386-396.
18. Edenberg HJ, Koller DL, Xuei X, Wetherill L, McClintick JN, Almasy L, Bierut LJ, Bucholz KK, Goate A, Aliev F, Dick D, Hesselbrock V, Hinrichs A, Kramer J, Kuperman S, Nurnberger JI Jr, Rice JP, Schuckit MA, Taylor R, Todd Webb B, Tischfield JA, Porjesz B, Foroud T (2010) Genome-wide association study of alcohol dependence implicates a region on chromosome 11. Alcohol Clin Exp Res 34:840-852.
19. Edenberg HJ, Xuei X, Chen HJ, Tian H, Wetherill LF, Dick DM, Almasy L, Bierut L, Bucholz KK, Goate A, Hesselbrock V, Kuperman S, Nurnberger J, Porjesz B, Rice J, Schuckit M, Tischfield J, Begleiter H, Foroud T (2006) Association of alcohol dehydrogenase genes with alcohol dependence: a comprehensive analysis. Hum Mol Genet 15:1539-1549.
20. Enoch MA (2008) The role of GABA(A) receptors in the development of alcoholism. Pharmacol Biochem Behav 90:95-104.
21. Enoch MA, Hodgkinson CA, Yuan Q, Albaugh B, Virkkunen M, Goldman D (2009) GABRG1 and GABRA2 as independent predictors for alcoholism in two populations. Neuropsychopharmacology 34:1245-1254.
22. Feduccia AA, Chatterjee S, Bartlett SE (2012) Neuronal nicotinic acetylcholine receptors: neuroplastic changes underlying alcohol and nicotine addictions. Front Mol Neurosci 5:83.
23. Foroud T, Edenberg HJ, Goate A, Rice J, Flury L, Koller DL, Bierut LJ, Conneally PM, Nurnberger JI, Bucholz KK, Li TK, Hesselbrock V, Crowe R, Schuckit M, Porjesz B, Begleiter H, Reich T (2000) Alcoholism susceptibility loci: confirmation studies in a replicate sample and further mapping. Alcohol Clin Exp Res 24:933-945.
24. Goodwin DW, Schulsinger F, Moller N, Hermansen L, Winokur G, Guze SB (1974) Drinking problems in adopted and nonadopted sons of alcoholics. Arch Gen Psychiatry 31:164-169.
25. Grucza RA, Bucholz KK, Rice JP, Bierut LJ (2008) Secular trends in the lifetime prevalence of alcohol dependence in the United States: a re-evaluation. Alcohol Clin Exp Res 32:763-770.
26. Harari O, Wang JC, Bucholz K, Edenberg HJ, Heath A, Martin NG, Pergadia ML, Montgomery G, Schrage A, Bierut LJ, Madden PF, Goate AM (2012) Pathway analysis of smoking quantity in multiple GWAS identifies cholinergic and sensory pathways. PLoS One 7:e50913.
27. Hasin DS, Stinson FS, Ogburn E, Grant BF (2007) Prevalence, correlates, disability, and comorbidity of DSM-IV alcohol abuse and dependence in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Arch Gen Psychiatry 64:830-842.
28. Heath AC, Bucholz KK, Madden PA, Dinwiddie SH, Slutske WS, Bierut LJ, Statham DJ, Dunne MP, Whitfield JB, Martin NG (1997) Genetic and environmental contributions to alcohol dependence risk in a national twin sample: consistency of findings in women and men. Psychol Med 27:1381-1396.
29. Hesselbrock M, Easton C, Bucholz KK, Schuckit M, Hesselbrock V (1999) A validity study of the SSAGA-a comparison with the SCAN. Addiction 94:1361-1370.
30. Kang SJ, Rangaswamy M, Manz N, Wang JC, Wetherill L, Hinrichs T, Almasy L, Brooks A, Chorlian DB, Dick D, Hesselbrock V, Kramer J, Kuperman S, Nurnberger J Jr, Rice J, Schuckit M, Tischfield J, Bierut LJ, Edenberg HJ, Goate A, Foroud T, Porjesz B (2012) Family-based genome-wide association study of frontal theta oscillations identifies potassium channel gene KCNJ6. Genes Brain Behav 11:712-719.
31. Kareken DA, Bragulat V, Dzemidzic M, Cox C, Talavage T, Davidson D, O'Connor SJ (2010) Family history of alcoholism mediates the frontal response to alcoholic drink odors and alcohol in at-risk drinkers. Neuroimage 50:267-276.
32. Kareken DA, Claus ED, Sabri M, Dzemidzic M, Kosobud AE, Radnovich AJ, Hector D, Ramchandani VA, O'Connor SJ, Lowe M, Li TK (2004) Alcohol-related olfactory cues activate the nucleus accumbens and ventral tegmental area in high-risk drinkers: preliminary findings. Alcohol Clin Exp Res 28:550-557.
33. Kessler DA (2005) Alcohol marketing and youth: the challenge for public health. J Public Health Policy 26:292-295.
34. Ko JY, Martins SS, Kuramoto SJ, Chilcoat HD (2010) Patterns of alcohol-dependence symptoms using a latent empirical approach: associations with treatment usage and other correlates. J Stud Alcohol Drugs 71:870-878.
35. Kuo PH, Aggen SH, Prescott CA, Kendler KS, Neale MC (2008) Using a factor mixture modeling approach in alcohol dependence in a general population sample. Drug Alcohol Depend 98:105-114.
36. Li TK, Hewitt BG, Grant BF (2007) The Alcohol Dependence Syndrome, 30 years later: a commentary. The 2006 H. David Archibald lecture. Addiction 102:1522-1530.
37. Luo X, Kranzler HR, Zuo L, Wang S, Blumberg HP, Gelernter J (2005) CHRM2 gene predisposes to alcohol dependence, drug dependence and affective disorders: results from an extended case-control structured association study. Hum Mol Genet 14:2421-2434.
38. Moss HB, Chen CM, Yi HY (2008) DSM-IV criteria endorsement patterns in alcohol dependence: relationship to severity. Alcohol Clin Exp Res 32:306-313.
39. Muthén LK, Muthén BO (1998-2011) Mplus User's Guide. 6th ed. Muthén & Muthén, Los Angeles, CA.
40. Prescott CA, Sullivan PF, Kuo PH, Webb BT, Vittum J, Patterson DG, Thiselton DL, Myers JM, Devitt M, Halberstadt LJ, Robinson VP, Neale MC, van den Oord EJ, Walsh D, Riley BP, Kendler KS (2006) Genomewide linkage study in the Irish affected sib pair study of alcohol dependence: evidence for a susceptibility region for symptoms of alcohol dependence on chromosome 4. Mol Psychiatry 11:603-611.
41. Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D (2006) Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 38:904-909.
42. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D, Maller J, Sklar P, de Bakker PI, Daly MJ, Sham PC (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 81:559-575.
43. Schank JR, Ryabinin AE, Giardino WJ, Ciccocioppo R, Heilig M (2012) Stress-related neuropeptides and addictive behaviors: beyond the usual suspects. Neuron 76:192-208.
44. Schuckit MA, Edenberg HJ, Kalmijn J, Flury L, Smith TL, Reich T, Bierut L, Goate A, Foroud T (2001) A genome-wide search for genes that relate to a low level of response to alcohol. Alcohol Clin Exp Res 25:323-329.
45. Shand FL, Slade T, Degenhardt L, Baillie A, Nelson EC (2011) Opioid dependence latent structure: two classes with differing severity? Addiction 106:590-598.
46. Slutske WS, True WR, Scherrer JF, Heath AC, Bucholz KK, Eisen SA, Goldberg J, Lyons MJ, Tsuang MT (1999) The heritability of alcoholism symptoms: "indicators of genetic and environmental influence in alcohol-dependent individuals" revisited. Alcohol Clin Exp Res 23:759-769.
47. Speca DJ, Chihara D, Ashique AM, Bowers MS, Pierce-Shimomura JT, Lee J, Rabbee N, Speed TP, Gularte RJ, Chitwood J, Medrano JF, Liao M, Sonner JM, Eger EI II, Peterson AS, McIntire SL (2010) Conserved role of unc-79 in ethanol responses in lightweight mutant mice. PLoS Genet 6:e1001057.
48. Stormark KM, Laberg JC, Bjerland T, Nordby H, Hugdahl K (1995) Autonomic cued reactivity in alcoholics: the effect of olfactory stimuli. Addict Behav 20:571-584.
49. Tenesa A, Haley CS (2013) The heritability of human disease: estimation, uses and abuses. Nat Rev Genet 14:139-149.
50. Wang JC, Foroud T, Hinrichs AL, Le NXH, Bertelsen S, Budde J, Chou YL, Harari O, Koller DL, Wetherill L, Agrawal A, Almasy L, Brooks A, Bucholz K, Dick D, Hesselbrock V, Kang S, Kapoor M, Kramer J, Kuperman S, Manz N, McClintick JN, Nurnberger JJ, Ragaswamy M, Rice J, Schuckit M, Tischfield JA, Xuei X, Porjesz B, Heath AC, Edenberg HJ, Bierut LJ, Goate AM (in press) A genome wide association study of alcohol dependence symptom counts in extended pedigrees identifies C15orf53. Mol Psychiatry doi: 10.1038/mp.2012.143 [Epub ahead of print].
51. Wang JC, Grucza R, Cruchaga C, Hinrichs AL, Bertelsen S, Budde JP, Fox L, Goldstein E, Reyes O, Saccone N, Saccone S, Xuei X, Bucholz K, Kuperman S, Nurnberger J Jr, Rice JP, Schuckit M, Tischfield J, Hesselbrock V, Porjesz B, Edenberg HJ, Bierut LJ, Goate AM (2009) Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence. Mol Psychiatry 14:501-510.
52. Wang JC, Hinrichs AL, Stock H, Budde J, Allen R, Bertelsen S, Kwon JM, Wu W, Dick DM, Rice J, Jones K, Nurnberger JI Jr, Tischfield J, Porjesz B, Edenberg HJ, Hesselbrock V, Crowe R, Schuckit M, Begleiter H, Reich T, Goate AM, Bierut LJ (2004) Evidence of common and specific genetic effects: association of the muscarinic acetylcholine receptor M2 (CHRM2) gene with alcohol dependence and major depressive syndrome. Hum Mol Genet 13:1903-1911.
53. Wu LT, Blazer DG, Woody GE, Burchett B, Yang C, Pan JJ, Ling W (2012) Alcohol and drug dependence symptom items as brief screeners for substance use disorders: results from the Clinical Trials Network. J Psychiatr Res 46:360-369.