Impact of liver cirrhosis on liver enhancement at Gd-EOB-DTPA enhanced MRI at 3 tesla

European Journal of Radiology

Volumn 82, Issue 10, 2013, Pages 1710-1715

  Verloh, N ^a   Haimerl, M ^a   Rennert, J ^a   Muller Wille R ^a   Niessen C ^a   Kirchner, G ^a   Scherer, M N ^a   Schreyer, A G ^a   Stroszczynski, C ^a   Fellner, C ^a   Wiggermann, P ^a  

^a UNIVERSITY HOSPITAL REGENSBURG   (Germany)

Author keywords

3 tesla; Gd EOB DTPA; Liver cirrhosis; Liver function; Magnetic resonance imaging (MRI)

Indexed keywords

FAT; GADOXETIC ACID;

ADULT; ARTERIAL PHASE; ARTICLE; BREATH HOLDING; CHILD PUGH SCORE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HEPATOBILIARY PHASE; HUMAN; LATE ARTERIAL PHASE; LIVER CIRRHOSIS; LIVER FUNCTION; LIVER PARENCHYMA; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; PORTAL VENOUS PHASE; PRIORITY JOURNAL; PROSPECTIVE STUDY;

3TESLA; GD-EOB-DTPA; LIVER CIRRHOSIS; LIVER FUNCTION; MAGNETIC RESONANCE IMAGING (MRI);

ALGORITHMS; CONTRAST MEDIA; FEMALE; GADOLINIUM DTPA; HUMANS; IMAGE ENHANCEMENT; LIVER; LIVER CIRRHOSIS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 84893661511     PISSN: 0720048X     EISSN: 18727727     Source Type: Journal    
DOI: 10.1016/j.ejrad.2013.05.033     Document Type: Article

References (33)

1. Zizka J, Klzo L, Ferda J, Mrklovsky M, Bukac J. Dynamic and delayed contrast enhancement in upper abdominal MRI studies: comparison of gadoxetic acid and gadobutrol. European Journal of Radiology 2007;62(2):186-91.
2. Asayama Y, Tajima T, Nishie A, et al. Uptake of Gd-EOB-DTPA by hepatocellular carcinoma: radiologic-pathologic correlation with special reference to bile production. European Journal of Radiology 2011;80(3):243-8.
3. Kobayashi S, Matsui O, Gabata T, et al. Relationship between signal intensity on hepatobiliary phase of gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced MR imaging and prognosis of borderline lesions of hepatocellular carcinoma. European Journal of Radiology 2012;81(11):3002-9.
4. Akai H, Matsuda I, Kiryu S, et al. Fate of hypointense lesions on Gd-EOBDTPA- enhanced magnetic resonance imaging. European Journal of Radiology 2012;81(11):2973-7.
5. Cho SH, Kang UR, Kim JD, Han YS, Choi DL. The value of gadoxetate disodiumenhanced MR imaging for predicting posthepatectomy liver failure after major hepatic resection: A preliminary study. European Journal of Radiology 2011;80(2):195-200.
6. van Montfoort, JE, Stieger B, Meijer DK, et al. Hepatic uptake of the magnetic resonance imaging contrast agent gadoxetate by the organic anion transporting polypeptide Oatp1. Journal of Pharmacology and Experimental Therapeutics 1999;290(1):153-7.
7. Weinmann HJ, Bauer H, Frenzel T, Muhler A, Ebert W. Mechanism of hepatic uptake of gadoxetate disodium. Academic Radiology 1996;3(Suppl. 2): 232-4.
8. Van Beers, BE, Pastor CM, Hussain HK. Primovist, eovist: what to expect? Journal of Hepatology 2012;57(2):421-9.
9. Hamm B, Staks T, Muhler A, et al. Phase I clinical evaluation of Gd-EOB-DTPA as a hepatobiliary MR contrast agent: safety, pharmacokinetics, and MR imaging. Radiology 1995;195(3):785-92.
10. Muhler A, Heinzelmann I, Weinmann HJ. Elimination of gadoliniumethoxybenzyl- DTPA in a rat model of severely impaired liver and kidney excretory function. An experimental study in rats. Investigative Radiology 1994;29(2):213-6.
11. Tamada T, Ito K, Sone T, et al. Gd-EOB-DTPA enhanced MR imaging: evaluation of biliary and renal excretion in normal and cirrhotic livers. European Journal of Radiology 2011;80(3):207-11.
12. Annet L, Materne R, Danse E, et al. Hepatic flow parameters measured with MR imaging and Doppler US: correlations with degree of cirrhosis and portal hypertension. Radiology 2003;229(2):409-14.
13. Fischer MA, Donati OF, Reiner CS, et al. Feasibility of semiquantitative liver perfusion assessment by ferucarbotran bolus injection in doublecontrast hepatic MRI. Journal of Magnetic Resonance Imaging 2012;36(1): 168-76.
14. Hagiwara M, Rusinek H, Lee VS, et al. Advanced liver fibrosis: diagnosis with 3D whole-liver perfusion MR imaging-initial experience. Radiology 2008;246(3):926-34.
15. Tajima T, Takao H, Akai H, et al. Relationship between liver function and liver signal intensity in hepatobiliary phase of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging. Journal of Computer Assisted Tomography 2010;34(3):362-6.
16. Motosugi U, Ichikawa T, Sou H, et al. Liver parenchymal enhancement of hepatocyte-phase images in Gd-EOB-DTPA-enhanced MR imaging: which biological markers of the liver function affect the enhancement? Journal of Magnetic Resonance Imaging 2009;30(5):1042-6.
17. Tamada T, Ito K, Higaki A, et al. Gd-EOB-DTPA-enhanced MR imaging: evaluation of hepatic enhancement effects in normal and cirrhotic livers. European Journal of Radiology 2011;80(3):311-6.
18. Katsube T, Okada M, Kumano S, et al. Estimation of liver function using T1 mapping on Gd-EOB-DTPA-enhanced magnetic resonance imaging. Investigative Radiology 2011;46(4):277-83.
19. Popper H. Pathologic aspects of cirrhosis. A review. American Journal of Pathology 1977;87(1):228-64.
20. Pascolo L, Cupelli F, Anelli PL, et al. Molecular mechanisms for the hepatic uptake of magnetic resonance imaging contrast agents. Biochemical and Biophysical Research Communications 1999;257(3):746-52.
21. Reimer P, Rummeny EJ, Daldrup HE, et al. Enhancement characteristics of liver metastases, hepatocellular carcinomas, and hemangiomas with Gd-EOBDTPA: preliminary results with dynamic MR imaging. European Radiology 1997;7(2):275-80.
22. Reimer P, Rummeny EJ, Shamsi K, et al. Phase II clinical evaluation of Gd-EOB-DTPA: dose, safety aspects, and pulse sequence. Radiology 1996;199(1):177-83.
23. Nishie A, Asayama Y, Ishigami K, et al. MR prediction of liver fibrosis using a liver-specific contrast agent: superparamagnetic iron oxide versus Gd-EOBDTPA. Journal of Magnetic Resonance Imaging 2012;36(3):664-71.
24. Ryeom HK, Kim SH, Kim JY, et al. Quantitative evaluation of liver function with MRI Using Gd-EOB-DTPA. Korean Journal of Radiology 2004;5(4):231-9.
25. Tsuda N, Okada M, Murakami T. Potential of gadolinium- ethoxybenzyldiethylenetriamine pentaacetic acid (Gd-EOB-DTPA) for differential diagnosis of nonalcoholic steatohepatitis and fatty liver in rats using magnetic resonance imaging. Investigative Radiology 2007;42(4):242-7.
26. Nilsson H, Blomqvist L, Douglas L, Nordell A, Jonas E. Assessment of liver function in primary biliary cirrhosis using Gd-EOB-DTPA-enhanced liver MRI. HPB (Oxford) 2010;12(8):567-76.
27. Chernyak V, Kim J, Rozenblit AM, Mazzoriol F, Ricci Z. Hepatic enhancement during the hepatobiliary phase after gadoxetate disodium administration in patients with chronic liver disease: The role of laboratory factors. Journal of Magnetic Resonance Imaging 2011;34(2):301-9.
28. de Bazelaire, CM, Duhamel GD, Rofsky NM, Alsop DC. MR imaging relaxation times of abdominal and pelvic tissues measured in vivo at 3.0 T: preliminary results. Radiology 2004;230(3):652-9.
29. Tamada T, Ito K, Sone T, et al. Dynamic contrast-enhanced magnetic resonance imaging of abdominal solid organ and major vessel: comparison of enhancement effect between Gd-EOB-DTPA and Gd-DTPA. Journal of Magnetic Resonance Imaging 2009;29(3):636-40.
30. Planchamp C, Montet X, Frossard JL, et al. Magnetic resonance imaging with hepatospecific contrast agents in cirrhotic rat livers. Investigative Radiology 2005;40(4):187-94.
31. Geier A, Dietrich CG, Voigt S, et al. Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis. Hepatology 2003;38(2):345-54.
32. Geier A, Kim SK, Gerloff T, et al. Hepatobiliary organic anion transporters are differentially regulated in acute toxic liver injury induced by carbon tetrachloride. Journal of Hepatology 2002;37(2):198-205.
33. Maharaj B, Maharaj RJ, Leary WP, et al. Sampling variability and its influence on the diagnostic yield of percutaneous needle biopsy of the liver. Lancet 1986;1(8480):523-5.