Deferoxamine attenuates white matter injury in a piglet intracerebral hemorrhage model

Stroke

Volumn 45, Issue 1, 2014, Pages 290-292

  Xie, Qing ^a   Gu, Yuxiang ^a   Hua, Ya ^a   Liu, Wenquan ^a   Keep, Richard F ^a   Xi, Guohua ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Brain edema; Cerebral hemorrhage; Deferoxamine; Receptor interacting protein serine threonine kinase 1; Tumor necrosis factor alpha

Indexed keywords

DEFEROXAMINE; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN EDEMA; BRAIN HEMORRHAGE; BRAIN TISSUE; BRAIN WATER; CONTROLLED STUDY; DRUG EFFECT; FRONTAL LOBE; NONHUMAN; PIGLET; PRIORITY JOURNAL; SYSTEMIC THERAPY; WHITE MATTER INJURY;

EID: 84893660366     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Keep RF, Hua Y, Xi G. Intracerebral haemorrhage: mechanisms of injury and therapeutic targets. Lancet Neurol. 2012;11:720-731.
2. Ropper AH. Lateral displacement of the brain and level of consciousness in patients with an acute hemispheral mass. N Engl J Med. 1986;314:953-958.
3. Degterev A, Huang Z, Boyce M, Li Y, Jagtap P, Mizushima N, et al. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol. 2005;1:112-119.
4. Zhu X, Tao L, Tejima-Mandeville E, Qiu J, Park J, Garber K, et al. Plasmalemma permeability and necrotic cell death phenotypes after intracerebral hemorrhage in mice. Stroke. 2012;43:524-531.
5. Gu Y, Hua Y, Keep RF, Morgenstern LB, Xi G. Deferoxamine reduces intracerebral hematoma-induced iron accumulation and neuronal death in piglets. Stroke. 2009;40:2241-2243.
6. Wagner KR, Xi G, Hua Y, Kleinholz M, de Courten-Myers GM, Myers RE. Early metabolic alterations in edematous perihematomal brain regions following experimental intracerebral hemorrhage. J Neurosurg. 1998;88:1058-1065.
7. Hua Y, Wu J, Keep R, Nakamura T, Hoff J, Xi G. Tumor necrosis factor-alpha increases in the brain following intracerebral hemorrhage and thrombin stimulation. Neurosurgery. 2006;58:542-550
8. Nakamura T, Keep RF, Hua Y, Schallert T, Hoff JT, Xi G. Deferoxamineinduced attenuation of brain edema and neurological deficits in a rat model of intracerebral hemorrhage. J Neurosurg. 2004;100:672-678.
9. Okauchi M, Hua Y, Keep RF, Morgenstern LB, Xi G. Effects of deferoxamine on intracerebral hemorrhage-induced brain injury in aged rats. Stroke. 2009;40:1858-1863.
10. Mehdiratta M, Kumar S, Hackney D, Schlaug G, Selim M. Association between serum ferritin level and perihematoma edema volume in patients with spontaneous intracerebral hemorrhage. Stroke. 2008;39:1165-1170.