Piromelatine, a novel melatonin receptor agonist, stabilizes metabolic profiles and ameliorates insulin resistance in chronic sleep restricted rats

European Journal of Pharmacology

Volumn 727, Issue 1, 2014, Pages 60-65

  She, Meihua ^a   Hu, Xiaobo ^a   Su, Zehong ^a   Zhang, Chi ^a   Yang, Shenghua ^b   Ding, Lin ^a   Laudon, Moshe ^c   Yin, Weidong ^a  

^a UNIVERSITY OF SOUTH CHINA   (China)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c NEURIM PHARMACEUTICALS LTD   (Israel)

Author keywords

Agonist; Glucose tolerance; Insulin sensitivity; Melatonin; Piromelatine; Sleep restriction

Indexed keywords

BIOLOGICAL MARKER; GLUCOSE BLOOD LEVEL; HYPNOTIC SEDATIVE AGENT; INDOLE DERIVATIVE; INSULIN; LIPID; MELATONIN RECEPTOR; N-(2-(5-METHOXY-INDOL-3-YL)-ETHYL)-4-OXO-4H-PYRAN-2-CARBOXAMIDE; PYRAN DERIVATIVE;

AGONISTS; ANIMAL; BLOOD; BODY WEIGHT; CALORIC INTAKE; CHRONIC DISEASE; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; GLUCOSE BLOOD LEVEL; INSULIN RESISTANCE; MALE; METABOLISM; OXIDATIVE STRESS; SLEEP DEPRIVATION; SPRAGUE DAWLEY RAT; TIME;

ANIMALS; BIOLOGICAL MARKERS; BLOOD GLUCOSE; BODY WEIGHT; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; ENERGY INTAKE; HYPNOTICS AND SEDATIVES; INDOLES; INSULIN; INSULIN RESISTANCE; LIPIDS; MALE; OXIDATIVE STRESS; PYRANS; RATS, SPRAGUE-DAWLEY; RECEPTORS, MELATONIN; SLEEP DEPRIVATION; TIME FACTORS;

EID: 84893649737     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.01.037     Document Type: Article

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