Vitamin C supplementation in pregnancy-Does it decrease rates of preterm birth? A systematic review

American Journal of Perinatology

Volumn 31, Issue 2, 2014, Pages 91-98

  Swaney, Paul ^a   Thorp, John ^a   Allen, Ian ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

ascorbic acid; preterm birth; prevention; vitamin C

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; IRON;

BIRTH WEIGHT; DIETARY INTAKE; GESTATIONAL AGE; HIGH RISK POPULATION; HUMAN; LOW RISK POPULATION; PREECLAMPSIA; PREGNANCY; PREGNANCY OUTCOME; PREMATURE FETUS MEMBRANE RUPTURE; PREMATURE LABOR; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SYSTEMATIC REVIEW; VITAMIN SUPPLEMENTATION;

ANTIOXIDANTS; ASCORBIC ACID; DIETARY SUPPLEMENTS; DRUG THERAPY, COMBINATION; FEMALE; FETAL MEMBRANES, PREMATURE RUPTURE; HUMANS; PREGNANCY; PREMATURE BIRTH; RANDOMIZED CONTROLLED TRIALS AS TOPIC; VITAMIN E;

EID: 84893644789     PISSN: 07351631     EISSN: 10988785     Source Type: Journal    
DOI: 10.1055/s-0033-1338171     Document Type: Review

References (31)

1. Mathews T. J., MacDorman M. F. Infant mortality statistics from the 2005 period linked birth/infant death data set. Natl Vital Stat Rep: 2008; 57 1 32
2. Swamy G. K., Ostbye T., Skjaerven R. Association of preterm birth with long-term survival, reproduction, and next-generation preterm birth. JAMA: 2008; 299 1429 1436
3. Kochanek K. D., Kirmeyer S. E., Martin J. A., Strobino D. M., Guyer B. Annual summary of vital statistics: 2009. Pediatrics: 2012; 129 338 348
4. Beck S., Wojdyla D., Say L., et al. The worldwide incidence of preterm birth: a systematic review of maternal mortality and morbidity. Bull World Health Organ: 2010; 88 31 38
5. Lykke J. A., Paidas M. J., Langhoff-Roos J. Recurring complications in second pregnancy. Obstet Gynecol: 2009; 113 1217 1224
6. Edlow A. G., Srinivas S. K., Elovitz M. A. Second-trimester loss and subsequent pregnancy outcomes: what is the real risk? Am J Obstet Gynecol: 2007; 197 1 581
7. Goldenberg R. L., Mayberry S. K., Copper R. L., Dubard M. B., Hauth J. C. Pregnancy outcome following a second-trimester loss. Obstet Gynecol: 1993; 81 444 446
8. Wikstrom A. K., Stephansson O., Cnattingius S. Previous preeclampsia and risks of adverse outcomes in subsequent nonpreeclamptic pregnancies. Am J Obstet Gynecol: 2011; 204 1 148
9. Chang J. J., Muglia L. J., Macones G. A. Association of early-onset pre-eclampsia in first pregnancy with normotensive second pregnancy outcomes: a population-based study. BJOG: 2010; 117 946 953
10. Kyrklund-Blomberg N. B., Cnattingius S. Preterm birth and maternal smoking: risks related to gestational age and onset of delivery. Am J Obstet Gynecol: 1998; 179 1051 1055
11. Sibai B. M., Caritis S. N., Hauth J. C., et al. Preterm delivery in women with pregestational diabetes mellitus or chronic hypertension relative to women with uncomplicated pregnancies. The National institute of Child health and Human Development Maternal- Fetal Medicine Units Network. Am J Obstet Gynecol: 2000; 183 1520 1524
12. Slattery M. M., Morrison J. J. Preterm delivery. Lancet: 2002; 360 1489 1497
13. Woods J. R. Jr, Plessinger M. A., Miller R. K. Vitamins C and E: missing links in preventing preterm premature rupture of membranes? Am J Obstet Gynecol: 2001; 185 5 10
14. Myatt L., Cui X. Oxidative stress in the placenta. Histochem Cell Biol: 2004; 122 369 382
15. Davidge S. T. Oxidative stress and altered endothelial cell function in preeclampsia. Semin Reprod Endocrinol: 1998; 16 65 73
16. Roberts J. M., Hubel C. A. Is oxidative stress the link in the two-stage model of pre-eclampsia? Lancet: 1999; 354 788 789
17. Otten J. J., Hellwig J. P., Meyers L. D., eds. Dietary reference intakes: the essential guide to nutrient requirements. In: The National Academies Press; 2006:202-210. Available at: http://www.nap.edu/openbook.php?record-id=11537. Accessibility verified February 3, 2012.
18. Armitage P., Berry G. Statistical Methods in Medical Research. 3rd ed. Blackwell, Oxford, UK,: 1994
19. U.S. Preventive Services Task Force Procedure Manual AHRQ publication no. 08-05118-EF. Updated 2011. Available at: http://www. uspreventiveservicestaskforce.org/uspstf08/methods/procmanual.htm. Accessibility verified April 15, 2012.
20. Casanueva E., Ripoll C., Tolentino M., et al. Vitamin C supplementation to prevent premature rupture of the chorioamniotic membranes: a randomized trial. Am J Clin Nutr: 2005; 81 859 863
21. Xu H., Perez-Cuevas R., Xiong X., et al. An international trial of antioxidants in the prevention of preeclampsia (INTAPP). Am J Obstet Gynecol: 2010; 202 1 239
22. Roberts J. M., Myatt L., Spong C. Y., et al. Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network Vitamins C and E to prevent complications of pregnancy-associated hypertension. N Engl J Med: 2010; 362 1282 1291
23. Rumbold A. R., Crowther C. A., Haslam R. R., Dekker G. A., Robinson J. S. ACTS Study Group Vitamins C and E and the risks of preeclampsia and perinatal complications. N Engl J Med: 2006; 354 1796 1806
24. McCance D. R., Holmes V. A., Maresh M. J., et al. Diabetes and Pre-eclampsia Intervention Trial (DAPIT) Study Group Vitamins C and E for prevention of pre-eclampsia in women with type 1 diabetes (DAPIT): a randomised placebo-controlled trial. Lancet: 2010; 376 259 266
25. Poston L., Briley A. L., Seed P. T., Kelly F. J., Shennan A. H. Vitamins in Pre-eclampsia (VIP) Trial Consortium Vitamin C and vitamin E in pregnant women at risk for pre-eclampsia (VIP trial): randomised placebo-controlled trial. Lancet: 2006; 367 1145 1154
26. Beazley D., Ahokas R., Livingston J., Griggs M., Sibai B. M. Vitamin C and E supplementation in women at high risk for preeclampsia: a double-blind, placebo-controlled trial. Am J Obstet Gynecol: 2005; 192 520 521
27. Chappell L. C., Seed P. T., Briley A. L., et al. Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial. Lancet: 1999; 354 810 816
28. Steyn P. S., Odendaal H. J., Schoeman J., Stander C., Fanie N., Grové D. A randomised, double-blind placebo-controlled trial of ascorbic acid supplementation for the prevention of preterm labour. J Obstet Gynaecol: 2003; 23 150 155
29. Spinnato J. A. II, Freire S., Pinto e Silva J. L., et al. Antioxidant supplementation and premature rupture of the membranes: a planned secondary analysis. Am J Obstet Gynecol: 2008; 199 1 433
30. Villar J., Purwar M., Merialdi M., et al. WHO Vitamin C and Vitamin E trial group World Health Organisation multicentre randomised trial of supplementation with vitamins C and E among pregnant women at high risk for pre-eclampsia in populations of low nutritional status from developing countries. BJOG: 2009; 116 780 788
31. Luke B. The evidence linking maternal nutrition and prematurity. J Perinat Med: 2005; 33 500 505