Therapeutic effects of DZ2002, a reversible SAHH inhibitor, on lupus-prone NZB×NZW F1 mice via interference with TLR-mediated APC response

Acta Pharmacologica Sinica

Volumn 35, Issue 2, 2014, Pages 219-229

  He, Shi Jun ^a   Lin, Ze Min ^b   Wu, Yan Wei ^a   Bai, Bing Xin ^b   Yang, Xiao Qian ^a   He, Pei Lan ^a   Zhu, Feng Hua ^a   Tang, Wei ^a   Zuo, Jian Ping ^a,b  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSYLHOMOCYSTEINASE INHIBITOR; CD40 ANTIGEN; DZ 2002; DZ2002; HLA DR ANTIGEN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G2A ANTIBODY; IMMUNOGLOBULIN G3 ANTIBODY; IMMUNOGLOBULIN M; INTERLEUKIN 12P40; INTERLEUKIN 17; INTERLEUKIN 23P19; INTERLEUKIN 6; STAT3 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR AGONIST; TRANSFORMING GROWTH FACTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ARTICLE; BODY WEIGHT; BONE MARROW CELL; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; DISEASE COURSE; EX VIVO STUDY; FEMALE; GLOMERULONEPHRITIS; HUMAN; HUMAN CELL; IMMUNOGLOBULIN PRODUCTION; IN VITRO STUDY; KIDNEY INJURY; LUPUS ERYTHEMATOSUS; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEINURIA; SIGNAL TRANSDUCTION; SPLEEN CELL; TH17 CELL; TREATMENT DURATION; UPREGULATION;

ADENINE; ANIMALS; ANTIGEN-PRESENTING CELLS; BUTYRATES; DENDRITIC CELLS; FEMALE; GLOMERULONEPHRITIS; HUMANS; LEUKOCYTES, MONONUCLEAR; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED NZB; TOLL-LIKE RECEPTORS;

EID: 84893619348     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2013.167     Document Type: Article

References (0)