ACEMg supplementation ameliorates progressive Connexin 26 hearing loss in a child

International Journal of Pediatric Otorhinolaryngology

Volumn 78, Issue 3, 2014, Pages 564-566

  Thatcher, Aaron ^a   Le Prell, Colleen ^b   Miller, Josef ^a   Green, Glenn ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

Antioxidants; Connexin 26; Genetic hearing loss; Sensorineural hearing loss

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; BETA CAROTENE; CONNEXIN 26; MAGNESIUM;

ARTICLE; AUDIOMETER; AUDIOMETRY; AUDITORY THRESHOLD; CASE REPORT; CHILD; DIET SUPPLEMENTATION; DISEASE COURSE; DISEASE DURATION; FREQUENCY MODULATION; HEARING IMPAIRMENT; HUMAN; MAGNESIUM SUPPLEMENTATION; MALE; OTOSCOPY; PRIORITY JOURNAL; RECOMMENDED DRUG DOSE; SCORING SYSTEM; TREATMENT DURATION; TREATMENT RESPONSE; VITAMIN SUPPLEMENTATION; WORD RECOGNITION;

EID: 84893580434     PISSN: 01655876     EISSN: 18728464     Source Type: Journal    
DOI: 10.1016/j.ijporl.2013.12.030     Document Type: Article

References (11)

1. Nance W.E. The genetics of deafness. Ment. Retard. Dev. Disabil. Res. Rev. 2003, 9(2):109-119.
2. Green G.E., Mueller R.F., Cohn E.S., Avraham K.B., Kanaan M., Smith R.J.H. Audiological manifestations and features of connexin 26 deafness. Audiol. Med. 2003, 1:5-11.
3. Kenna M.A., Feldman H.A., Neault M.W., Frangulov A., Wu B.L., Fligor B., et al. Audiologic phenotype and progression in GJB2 (Connexin 26) hearing loss. Arch. Otolaryngol. Head Neck Surg. 2010, 136(January (1)):81-87.
4. Cohen-Salmon M., Ott T., Michel V., Hardelin J.P., Perfettini I., Eybalin M., et al. Targeted ablation of connexin26 in the inner ear epithelial gap junction network causes hearing impairment and cell death. Curr. Biol. 2002, 12:1106-1111.
5. Nagashima R., Yamaguchi T., Tanaka H., Ogita K. Mechanism underlying the protective effect of tempol and Nω-nitro-l-arginine methyl ester on acoustic injury: possible involvement of c-Jun N-terminal kinase pathway and connexin26 in the cochlear spiral ligament. J. Pharmacol. Sci. 2010, 114(1):50-62.
6. Hutnik C.M., Pocrnich C.E., Liu H., Laird D.W., Shao Q. The protective effect of functional connexin43 channels on a human epithelial cell line exposed to oxidative stress. Invest. Ophthalmol. Vis. Sci. 2008, 49(2):800-806.
7. Le Prell C.G., Yamashita D., Minami S.B., Yamasoba T., Miller J.M. Mechanisms of noise-induced hearing loss indicate multiple methods of prevention. Hear. Res. 2007, 226:22-43.
8. Le Prell C.G., Johnson A.C., Lindblad A.C., Skjönsberg Å., Ulfendahl M., Guire K., et al. Increased vitamin plasma levels in Swedish military personnel treated with nutrients prior to automatic weapon training. Noise Health 2011, 13(55):432.
9. Cryns K., Orzan E., Murgia A., Huygen P.L., Moreno F., del Castillo I., et al. A genotype-phenotype correlation for GJB2 (connexin 26) deafness. J. Med. Genet. 2004, 41:147-154.
10. Hilgert N., Huentelman M.J., Thorburn A.Q., Fransen E., Dieltjens N., Mueller-Malesinska M., et al. Phenotypic variability of patients homozygous for the GJB2 mutation 35delG cannot be explained by the influence of one major modifier gene. Eur. J. Hum. Genet. 2009, 17(April (4)):517-524.
11. Chan D.K., Schrijver I., Chang K.W. Connexin-26-associated deafness: phenotypic variability and progression of hearing loss. Genet. Med. 2010, 12(March (3)):174-181.