Association between agent orange exposure and nonmelanotic invasive skin cancer: A pilot study

Plastic and Reconstructive Surgery

Volumn 133, Issue 2, 2014, Pages 432-437

  Clemens, Mark W ^a   Kochuba, Andrew L ^a   Carter, Mary Ella ^a   Han, Kevin ^a   Liu, Jun ^a   Evans, Karen ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 2,4 DICHLOROPHENOXYACETIC ACID; 2,4,5 TRICHLOROPHENOXYACETIC ACID;

AGED; ARTICLE; CASE REPORT; CHEMICALLY INDUCED DISORDER; HUMAN; INCIDENCE; MALE; MIDDLE AGED; PILOT STUDY; RETROSPECTIVE STUDY; SKIN TUMOR; VERY ELDERLY;

2,4,5-TRICHLOROPHENOXYACETIC ACID; 2,4-DICHLOROPHENOXYACETIC ACID; AGED; AGED, 80 AND OVER; HUMANS; INCIDENCE; MALE; MIDDLE AGED; PILOT PROJECTS; RETROSPECTIVE STUDIES; SKIN NEOPLASMS; TETRACHLORODIBENZODIOXIN;

EID: 84893539817     PISSN: 00321052     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.prs.0000436859.40151.cf     Document Type: Article

References (31)

1. Pavuk M, Michalek JE, Schecter A. Did TCDD exposure or service in Southeast Asia increase the risk of cancer in Air Force Vietnam veterans who did not spray Agent Orange? J Occup Environ Med. 2005;47:335-342.
2. Poland A, Palen D, Glover E. Tumour promotion by TCDD in skin of HRS/J hairless mice. Nature 1982;300:271-273.
3. Office of Public Health and Environmental Hazards. Agent Orange: Diseases associated with Agent Orange exposure. Available at: http://www.va.gov/ agentorange/. Accessed February 24, 2012.
4. Schuck PH. Agent Orange on Trial: Mass Toxic Disasters in the Courts. Cambridge, Mass: Belknap Press; 1987
5. Department of Veterans Affairs. Agent Orange review: Information for veterans who served in Vietnam. J Occup Med. 2008;20:1-7.
6. DeStefano F. Effects of Agent Orange exposure. JAMA 1995;273:1494.
7. Frumkin H. Agent Orange and cancer: An overview for clinicians. CA Cancer J Clin. 2003;53:245-255.
8. Hansen ES, Lander F, Lauritsen JM. Time trends in cancer risk and pesticide exposure, a long-term follow-up of Danish gardeners. Scand J Work Environ Health 2007;33:465-469.
9. American Cancer Society. Cancer facts & fgures 2010. Available at: http://www.cancer.org/research/cancerfacts-figures/cancerfactsfigures/ cancer-facts-and-figures-2010. Accessed June 10, 2011.
10. Hussain SK, Sundquist J, Hemminki K. Incidence trends of squamous cell and rare skin cancers in the Swedish national cancer registry point to calendar year and age-dependent increases. J Invest Dermatol. 2010;130:1323-1328.
11. Stern RS. Prevalence of a history of skin cancer in 2007: Results of an incidence-based model. Arch Dermatol. 2010;146:279-282.
12. Dunson DB, Haseman JK, van Birgelen AP, Stasiewicz S, Tennant RW. Statistical analysis of skin tumor data from Tg.AC mouse bioassays. Toxicol Sci. 2000;55:293-302.
13. Institute of Medicine. Veterans and Agent Orange: Update 2006. Washington, DC: National Academies Press; 2007.
14. Institute of Medicine. Veterans and Agent Orange: Update 2008. Washington, DC: National Academies Press; 2009.
15. Wyde ME, Braen AP, Hejtmancik M, et al. Oral and dermal exposure to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) induces cutaneous papillomas and squamous cell carcinomas in female hemizygous Tg.AC transgenic mice. Toxicol Sci. 2004;82:34-45.
16. Rogers HW, Weinstock MA, Harris AR, et al. Incidence estimate of nonmelanoma skin cancer in the United States, 2006. Arch Dermatol. 2010;146:283-287.
17. Altekruse SF, Kosary CL, Krapcho M. SEER Cancer Statistics Review, 1975-2007. Available at: http://seer.cancer.gov/csr/1975-2007/. Accessed May 24, 2011.
18. Demers AA, Nugent Z, Mihalcioiu C, Wiseman MC, Kliewer EV. Trends of nonmelanoma skin cancer from 1960 through 2000 in a Canadian population. J Am Acad Dermatol. 2005;53:320-328.
19. Flohil SC, de Vries E, Neumann M. Incidence, prevalence and future trends of primary basal cell carcinoma in the Netherlands. Acta Derm Venereol. 2011;91:24-30.
20. American Cancer Society. 2009 Cancer Facts and Figures. Available at: http://www.cancer.org/research/cancerfacts-figures/cancerfactsfigures/ cancer-facts-and-figures-2009. Accessed June 10, 2011.
21. Linos E, Swetter SM, Cockburn MG, Colditz GA, Clarke CA. Increasing burden of melanoma in the United States. J Invest Dermatol. 2009;129:1666-1674.
22. Panteleyev AA, Bickers DR. Dioxin-induced chloracne: Reconstructing the cellular and molecular mechanisms of a classic environmental disease. Exp Dermatol. 2006;15:705-730.
23. Ramot Y, Nyska A, Lieuallen W, et al. Infammatory and chloracne-like skin lesions in B6C3F1 mice exposed to 3, 3', 4, 4'-tetrachloroazobenzene for 2 years. Toxicology 2009;265:1-9.
24. Rao MS, Subbarao V, Prasad JD, Scarpelli DG. Carcinogenicity of 2, 3, 7, 8-tetrachloridibenzo-p-dioxin in the Syrian golden hamster. Carcinogenesis 1988;9:1677-1679.
25. Moses M, Lilis R, Crow KD, et al. Health status of workers with past exposure to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in the manufacture of 2, 4, 5-trichlorophenoxyacetic acid: Comparison of fndings with and without chloracne. Am J Ind Med. 1984;5:161-182.
26. Institute of Medicine. Veterans and Agent Orange. Washington, DC: National Academies Press; 1994.
27. Stephenson J. New IOM report links agent orange exposure to risk of birth defect in Vietnam vets' children. JAMA 1996;275:1066-1067.
28. Kuehn BM. Agent Orange effects. JAMA 2010;303:722.
29. Suskind RR, Hertzberg VS. Human health effects of 2, 4, 5-T and its toxic contaminants. JAMA 1984;251:2372-2380.
30. Novack B, Fisher J. Agent Orange exposure. Plast Reconstr Surg. 1984;74:577.
31. Gallagher RP, Macarthur AC, Lee TK, et al. Plasma levels of poly-chlorinated biphenyls and risk of cutaneous malignant melanoma: A preliminary study. Int J Cancer 2011;128:1872-1880.