The supralinear dose-response for environmental toxicants: A statistical artifact?

Clinical Toxicology

Volumn 52, Issue 2, 2014, Pages 88-90

  Hornung, R W ^a   Lanphear, B P ^b  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b SIMON FRASER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ENVIRONMENTAL CHEMICAL; TOXIC SUBSTANCE;

ARTIFACT; DOSE RESPONSE; ENVIRONMENTAL EXPOSURE; HUMAN; NOTE; SIMULATION; STATISTICAL ANALYSIS;

HUMANS; INTELLIGENCE; LEAD;

EID: 84893513488     PISSN: 15563650     EISSN: 15569519     Source Type: Journal    
DOI: 10.3109/15563650.2013.878946     Document Type: Note

References (26)

1. H ornung R W, M einhardt T . Q uantitative risk assessment of lung cancer in US uranium miners. Health Phys 1987; 52: 417- 430
2. Hertz-Picciotto I, Smith AH . Observations on the dose-response curve for arsenic exposure and lung cancer . Scand J Work Environ Health 1993 ; 19 : 217-226
3. Lanphear BP, Dietrich KN, Auinger P, Cox C . Cognitive defi cits associated with blood lead levels - 10 μg/dL in US children . Public Health Reports 2000 ; 115 : 521-529
4. England LJ, Kendrick JS, Gargiullo PM, Zahniser SC, Hannon WH .Measures of maternal tobacco exposure and infant birth weight at term . Am J Epidemiol 2001 ; 153 : 954-960
5. Canfi eld RL, Henderson CR, Cory-Slechta DA, Cox C, Jusko TA, Lanphear BP . Intellectual impairment in children with blood lead concentrations below 10 micrograms per deciliter . New Engl J Med 2003 ; 348 : 1517-1526
6. Lanphear BP, Hornung R, Khoury J, Yolton K, Baghurst P, Bellinger DC, et al . Low-level environmental lead exposure and children' s intellectual function: An international pooled analysis . Environ Health Perspect 2005 ; 113 : 894-899
7. Y olton K, A uinger P, D ietrich K N, L anphear B P, H ornung R . E xposure to environmental tobacco smoke and cognitive abilities among US children and adolescents. Environ Health Persp 2005: 113: 98- 103
8. Kordas K, Canfi eld RL, L ó pez P, Rosado JL, Vargas GG, Cebri á n ME, et al . Defi cits in cognitive function and achievement in Mexican fi rst-graders with low blood lead concentrations . Environ Res 2006 ; 100 : 371-386
9. T ellez-Rojo M, B ellinger D C, A rroyo-Quiroz C, L amadrid-Figueroa H, Mercado-García A, Schnaas-Arrieta L, et al . Longitudinal associations between blood lead concentrations lower than 10 μg/dL and neurobehavioral development in environmentally exposed children in Mexico City . Pediatrics 2006; 118: E323- 330
10. Surkan PJ, Zhang A, Trachtenberg F, Daniel DB, McKinaly S, Bellinger DC . Neuropsychological function in children with blood lead levels - 10 μg/dL . Neurotoxicology 2007 ; 28 : 1170-1177
11. Pope CA, Burnett RT, Krewski D, Daniel DB, McKinlay S, Bellinger DC . Cardiovascular mortality and exposure to airborne fi ne particulate matter and cigarette smoke: Shape of the exposureresponse relationship . Circulation 2009 ; 120 : 941-948
12. Crouse DL, Peters PA, Van Donkelaar A, Goldberg MS, Villeneuve PJ, Brion O, et al . Risk of nonaccidental and cardiovascular mortality in relation to long-term exposure to low concentrations of fi ne particulate matter: A Canadian national-level cohort study . Environ Health Perspect 2012 ; 120 : 708-714
13. Vlaanderen J, Portengen L, Rothman N, Lan Q, Kromhout H, Vermeulen R . Flexible Meta-regression to assess the shape of the benzene-leukemia exposure-response curve . Environ Health Perspect 2010 ; 118 : 526-532
14. Stayner L, Steenland K, Dosemeci M, Hertz-Picciotto I . Attenuation of exposure-response curves in occupational cohort studies at high exposure levels . Scand J Work Environ Health 2003 ; 29 : 317-324
15. Lanphear BP, Hornung RW, Khoury J, Dietrich KN, Cory-Slechta DA, Canfi eld RL . The conundrum of unmeasured confounding . Sci Total Environ 2008 ; 396 : 196-200
16. Bergdahl IA . Response to: What is the meaning of non-linear doseresponse relationships between blood lead concentrations and IQ .Neurotoxicology 2006; 27 : 1125
17. Jusko TA, Lockhart DW, Sampson PD, Henderson CR, Canfi eld RL .Response to: What is the meaning of non-linear dose-response relationships between blood lead concentrations and IQ . Neurotoxicology 2006 ; 27 : 1123-1125
18. Bowers TS, Beck BD . What is the meaning of non-linear doseresponse relationships between blood lead concentrations and IQ? Neurotoxicology 2006 ; 27 : 520-524
19. Hornung R, Lanphear B, Dietrich K . Response to: What is the meaning of non-linear dose-response relationships between blood lead concentration and IQ? Neurotoxicology 2006; 27 : 635
20. Gulson B . Can some of the detrimental neurodevelopmental effects attributed to lead be due to pesticides? Sci Total Environ 2008 ; 396: 197- 199
21. Banner W, Kahn CM . Low blood lead level effects on intelligence: Can a dose-response curve be determined from the epidemiological data? Clin Toxicol 2014; 52: 113- 117
22. Bellinger DC . A strategy for comparing the contributions of environmental chemicals and other risk factors to neurodevelopment of children. Environ Health Perspect 2012 ; 120 : 501-507
23. Trasande L, Liu Y . Reducing the staggering costs of environmental disease in children, estimated at $ 76.6 billion in 2008 . Health Affairs 2011; 30 : 1-8
24. Hornung RW, Reed LD . Estimation of average concentration in the presence of nondetectable values . App Occup Environ Hyg 1990 ; 5 : 46-51
25. Centers for Disease Control and Prevention. L ow-level lead exposure harms children: A renewed call for primary prevention. Report of the Advisory Committee on Lead Poisoning Prevention; 2012
26. National Toxicology Program . Monograph on health effects of lowlevel lead . National Institute of Environmental Health Sciences, US Department of Health and Human Services; 2012