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Volumn 8, Issue 12, 2013, Pages

TP53 and MDM2 gene polymorphisms, gene-gene interaction, and hepatocellular carcinoma risk: Evidence from an updated meta-analysis

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; PROLINE; PROTEIN MDM2; PROTEIN P53; MDM2 PROTEIN, HUMAN;

EID: 84893506200     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0082773     Document Type: Article
Times cited : (24)

References (56)
  • 1
    • 78049485263 scopus 로고    scopus 로고
    • Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
    • Ferlay J, Shin HR, Bray F, Forman D, Mathers C, et al. (2010) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127: 2893-2917.
    • (2010) Int J Cancer , vol.127 , pp. 2893-2917
    • Ferlay, J.1    Shin, H.R.2    Bray, F.3    Forman, D.4    Mathers, C.5
  • 2
    • 84886056830 scopus 로고    scopus 로고
    • Estimation and prediction of incidence, mortality and prevalence on liver cancer, in 2008, China
    • Li Q, Du J, Guan P, Qu CF, Dai M (2012) [Estimation and prediction of incidence, mortality and prevalence on liver cancer, in 2008, China]. Zhonghua Liu Xing Bing Xue Za Zhi 33: 554-557.
    • (2012) Zhonghua Liu Xing Bing Xue Za Zhi , vol.33 , pp. 554-557
    • Li, Q.1    Du, J.2    Guan, P.3    Qu, C.F.4    Dai, M.5
  • 3
    • 7044231396 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Recent trends in the United States
    • El-Serag HB (2004) Hepatocellular carcinoma: recent trends in the United States. Gastroenterology 127: S27-34.
    • (2004) Gastroenterology , vol.127
    • El-Serag, H.B.1
  • 4
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis
    • El-Serag HB, Rudolph KL (2007) Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 132: 2557-2576.
    • (2007) Gastroenterology , vol.132 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 5
    • 75349084543 scopus 로고    scopus 로고
    • Risk of HCC: Genetic heterogeneity and complex genetics
    • Dragani TA (2010) Risk of HCC: genetic heterogeneity and complex genetics. J Hepatol 52: 252-257.
    • (2010) J Hepatol , vol.52 , pp. 252-257
    • Dragani, T.A.1
  • 6
    • 0035012606 scopus 로고    scopus 로고
    • DNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression
    • Tong WM, Hande MP, Lansdorp PM, Wang ZQ (2001) DNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression. Mol Cell Biol 21: 4046-4054.
    • (2001) Mol Cell Biol , vol.21 , pp. 4046-4054
    • Tong, W.M.1    Hande, M.P.2    Lansdorp, P.M.3    Wang, Z.Q.4
  • 7
    • 69349100179 scopus 로고    scopus 로고
    • Suppression of induced pluripotent stem cell generation by the p53-p21 pathway
    • Hong H, Takahashi K, Ichisaka T, Aoi T, Kanagawa O, et al. (2009) Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature 460: 1132-1135.
    • (2009) Nature , vol.460 , pp. 1132-1135
    • Hong, H.1    Takahashi, K.2    Ichisaka, T.3    Aoi, T.4    Kanagawa, O.5
  • 8
    • 0037153150 scopus 로고    scopus 로고
    • Cancer: Super p53
    • Marte B (2002) Cancer: super p53. Nature 420: 279.
    • (2002) Nature , vol.420 , pp. 279
    • Marte, B.1
  • 9
    • 33749118677 scopus 로고    scopus 로고
    • iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53
    • Bergamaschi D, Samuels Y, Sullivan A, Zvelebil M, Breyssens H, et al. (2006) iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53. Nat Genet 38: 1133-1141.
    • (2006) Nat Genet , vol.38 , pp. 1133-1141
    • Bergamaschi, D.1    Samuels, Y.2    Sullivan, A.3    Zvelebil, M.4    Breyssens, H.5
  • 10
    • 34250355147 scopus 로고    scopus 로고
    • Tumor suppressor p53 Arg72Pro polymorphism and longevity, cancer survival, and risk of cancer in the general population
    • Orsted DD, Bojesen SE, Tybjaerg-Hansen A, Nordestgaard BG (2007) Tumor suppressor p53 Arg72Pro polymorphism and longevity, cancer survival, and risk of cancer in the general population. J Exp Med 204: 1295-1301.
    • (2007) J Exp Med , vol.204 , pp. 1295-1301
    • Orsted, D.D.1    Bojesen, S.E.2    Tybjaerg-Hansen, A.3    Nordestgaard, B.G.4
  • 11
    • 33745116207 scopus 로고    scopus 로고
    • Trp53-dependent DNA-repair is affected by the codon 72 polymorphism
    • Siddique M, Sabapathy K (2006) Trp53-dependent DNA-repair is affected by the codon 72 polymorphism. Oncogene 25: 3489-3500.
    • (2006) Oncogene , vol.25 , pp. 3489-3500
    • Siddique, M.1    Sabapathy, K.2
  • 12
    • 14644437751 scopus 로고    scopus 로고
    • MDM2 is a central node in the p53 pathway: 12 years and counting
    • Bond GL, Hu W, Levine AJ (2005) MDM2 is a central node in the p53 pathway: 12 years and counting. Curr Cancer Drug Targets 5: 3-8.
    • (2005) Curr Cancer Drug Targets , vol.5 , pp. 3-8
    • Bond, G.L.1    Hu, W.2    Levine, A.J.3
  • 13
    • 84874006965 scopus 로고    scopus 로고
    • Association between MDM2 promoter SNP309 T/G polymorphism and liver cancer risk - A meta-analysis
    • Ma HB, Huang T, Han F, Chen WY (2012) Association between MDM2 promoter SNP309 T/G polymorphism and liver cancer risk - a meta-analysis. Asian Pac J Cancer Prev 13: 2841-2846.
    • (2012) Asian Pac J Cancer Prev , vol.13 , pp. 2841-2846
    • Ma, H.B.1    Huang, T.2    Han, F.3    Chen, W.Y.4
  • 14
    • 84863394227 scopus 로고    scopus 로고
    • Genetic risk of hepatocellular carcinoma in patients with hepatitis C virus: A case control study
    • Tomoda T, Nouso K, Sakai A, Ouchida M, Kobayashi S, et al. (2012) Genetic risk of hepatocellular carcinoma in patients with hepatitis C virus: a case control study. J Gastroenterol Hepatol 27: 797-804.
    • (2012) J Gastroenterol Hepatol , vol.27 , pp. 797-804
    • Tomoda, T.1    Nouso, K.2    Sakai, A.3    Ouchida, M.4    Kobayashi, S.5
  • 15
    • 84872314670 scopus 로고    scopus 로고
    • Combined effects of p53 and MDM2 polymorphisms on susceptibility and surgical prognosis in hepatitis B virus-related hepatocellular carcinoma
    • Yang Y, Xia T, Li N, Zhang J, Cong W, et al. (2013) Combined effects of p53 and MDM2 polymorphisms on susceptibility and surgical prognosis in hepatitis B virus-related hepatocellular carcinoma. Protein Cell 4: 71-81.
    • (2013) Protein Cell , vol.4 , pp. 71-81
    • Yang, Y.1    Xia, T.2    Li, N.3    Zhang, J.4    Cong, W.5
  • 17
    • 84878689634 scopus 로고    scopus 로고
    • Association between the p53 codon 72 Arg/Pro polymorphism and hepatocellular carcinoma risk
    • Lv L, Wang P, Zhou X, Sun B (2013) Association between the p53 codon 72 Arg/Pro polymorphism and hepatocellular carcinoma risk. Tumour Biol 34: 1451-1459.
    • (2013) Tumour Biol , vol.34 , pp. 1451-1459
    • Lv, L.1    Wang, P.2    Zhou, X.3    Sun, B.4
  • 18
    • 84860436204 scopus 로고    scopus 로고
    • TP53 codon 72 polymorphism with hepatocellular carcinoma: A metaanalysis
    • Ding C, Yu H, Qin H (2012) TP53 codon 72 polymorphism with hepatocellular carcinoma: a metaanalysis. J Int Med Res 40: 446-454.
    • (2012) J Int Med Res , vol.40 , pp. 446-454
    • Ding, C.1    Yu, H.2    Qin, H.3
  • 19
    • 0034685429 scopus 로고    scopus 로고
    • Meta-analysis of observational studies in epidemiology: A proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group
    • Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, et al. (2000) Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA 283: 2008-2012.
    • (2000) JAMA , vol.283 , pp. 2008-2012
    • Stroup, D.F.1    Berlin, J.A.2    Morton, S.C.3    Olkin, I.4    Williamson, G.D.5
  • 20
    • 24144436042 scopus 로고    scopus 로고
    • Systematic review and meta-analysis of the association between {beta}2-adrenoceptor polymorphisms and asthma: A HuGE review
    • Thakkinstian A, McEvoy M, Minelli C, Gibson P, Hancox B, et al. (2005) Systematic review and meta-analysis of the association between {beta}2-adrenoceptor polymorphisms and asthma: a HuGE review. Am J Epidemiol 162: 201-211.
    • (2005) Am J Epidemiol , vol.162 , pp. 201-211
    • Thakkinstian, A.1    McEvoy, M.2    Minelli, C.3    Gibson, P.4    Hancox, B.5
  • 21
    • 0037098199 scopus 로고    scopus 로고
    • Quantifying heterogeneity in a meta-analysis
    • Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21: 1539-1558.
    • (2002) Stat Med , vol.21 , pp. 1539-1558
    • Higgins, J.P.1    Thompson, S.G.2
  • 24
    • 84959801619 scopus 로고
    • Statistical aspects of the analysis of data from retrospective studies of disease
    • Mantel N, Haenszel W (1959) Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 22: 719-748.
    • (1959) J Natl Cancer Inst , vol.22 , pp. 719-748
    • Mantel, N.1    Haenszel, W.2
  • 25
    • 0030922816 scopus 로고    scopus 로고
    • Bias in meta-analysis detected by a simple, graphical test
    • Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315: 629-634.
    • (1997) BMJ , vol.315 , pp. 629-634
    • Egger, M.1    Davey Smith, G.2    Schneider, M.3    Minder, C.4
  • 26
    • 24344491812 scopus 로고    scopus 로고
    • A p53 polymorphism modifies the risk of hepatocellular carcinoma among non-carriers but not carriers of chronic hepatitis B virus infection
    • Zhu ZZ, Cong WM, Liu SF, Xian ZH, Wu WQ, et al. (2005) A p53 polymorphism modifies the risk of hepatocellular carcinoma among non-carriers but not carriers of chronic hepatitis B virus infection. Cancer Lett 229: 77-83.
    • (2005) Cancer Lett , vol.229 , pp. 77-83
    • Zhu, Z.Z.1    Cong, W.M.2    Liu, S.F.3    Xian, Z.H.4    Wu, W.Q.5
  • 27
    • 29244482564 scopus 로고    scopus 로고
    • Association of p53 codon 72 polymorphism with genetic susceptibility to hepatocellular carcinoma in Chinese population
    • Zhu ZZ, Cong WM, Zhu GS, Liu SF, Xian ZH, et al. (2005) [Association of p53 codon 72 polymorphism with genetic susceptibility to hepatocellular carcinoma in Chinese population]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 22: 632-635.
    • (2005) Zhonghua Yi Xue Yi Chuan Xue Za Zhi , vol.22 , pp. 632-635
    • Zhu, Z.Z.1    Cong, W.M.2    Zhu, G.S.3    Liu, S.F.4    Xian, Z.H.5
  • 28
    • 34447325879 scopus 로고    scopus 로고
    • The Pro variant of the p53 codon 72 polymorphism is associated with hepatocellular carcinoma in Moroccan population
    • Ezzikouri S, El Feydi AE, Chafik A, Benazzouz M, El Kihal L, et al. (2007) The Pro variant of the p53 codon 72 polymorphism is associated with hepatocellular carcinoma in Moroccan population. Hepatol Res 37: 748-754.
    • (2007) Hepatol Res , vol.37 , pp. 748-754
    • Ezzikouri, S.1    El Feydi, A.E.2    Chafik, A.3    Benazzouz, M.4    El Kihal, L.5
  • 29
    • 77955680497 scopus 로고    scopus 로고
    • MDM2 promoter polymorphism is associated with increased susceptibility to hepatocellular carcinoma in Turkish population
    • Akkiz H, Sumbul AT, Bayram S, Bekar A, Akgollu E (2010) MDM2 promoter polymorphism is associated with increased susceptibility to hepatocellular carcinoma in Turkish population. Cancer Epidemiol 34: 448-452.
    • (2010) Cancer Epidemiol , vol.34 , pp. 448-452
    • Akkiz, H.1    Sumbul, A.T.2    Bayram, S.3    Bekar, A.4    Akgollu, E.5
  • 30
    • 74049144962 scopus 로고    scopus 로고
    • Association between MDM2-SNP309 and hepatocellular carcinoma in Taiwanese population
    • Leu JD, Lin IF, Sun YF, Chen SM, Liu CC, et al. (2009) Association between MDM2-SNP309 and hepatocellular carcinoma in Taiwanese population. World J Gastroenterol 15: 5592-5597.
    • (2009) World J Gastroenterol , vol.15 , pp. 5592-5597
    • Leu, J.D.1    Lin, I.F.2    Sun, Y.F.3    Chen, S.M.4    Liu, C.C.5
  • 31
    • 33748344945 scopus 로고    scopus 로고
    • MDM2 promoter SNP309 is associated with the risk of hepatocellular carcinoma in patients with chronic hepatitis C
    • Dharel N, Kato N, Muroyama R, Moriyama M, Shao RX, et al. (2006) MDM2 promoter SNP309 is associated with the risk of hepatocellular carcinoma in patients with chronic hepatitis C. Clin Cancer Res 12: 4867-4871.
    • (2006) Clin Cancer Res , vol.12 , pp. 4867-4871
    • Dharel, N.1    Kato, N.2    Muroyama, R.3    Moriyama, M.4    Shao, R.X.5
  • 32
    • 84555205744 scopus 로고    scopus 로고
    • Impact of TP53 codon 72 and MDM2 promoter 309 allelic dosage in a Moroccan population with hepatocellular carcinoma
    • Ezzikouri S, Essaid El Feydi A, Afifi R, Benazzouz M, Hassar M, et al. (2011) Impact of TP53 codon 72 and MDM2 promoter 309 allelic dosage in a Moroccan population with hepatocellular carcinoma. Int J Biol Markers 26: 229-233.
    • (2011) Int J Biol Markers , vol.26 , pp. 229-233
    • Ezzikouri, S.1    Essaid El Feydi, A.2    Afifi, R.3    Benazzouz, M.4    Hassar, M.5
  • 33
    • 80051592011 scopus 로고    scopus 로고
    • TP53 and MDM2 gene polymorphisms and risk of hepatocellular carcinoma among Italian patients
    • Di Vuolo V, Buonaguro L, Izzo F, Losito S, Botti G, et al. (2011) TP53 and MDM2 gene polymorphisms and risk of hepatocellular carcinoma among Italian patients. Infect Agent Cancer 6: 13.
    • (2011) Infect Agent Cancer , vol.6 , pp. 13
    • Di Vuolo, V.1    Buonaguro, L.2    Izzo, F.3    Losito, S.4    Botti, G.5
  • 34
    • 84863520712 scopus 로고    scopus 로고
    • MDM2 SNP309T>G polymorphism increases susceptibility to hepatitis B virus-related hepatocellular carcinoma in a northeast Han Chinese population
    • Wang X, Zhang X, Qiu B, Tang Y, Sun H, et al. (2012) MDM2 SNP309T>G polymorphism increases susceptibility to hepatitis B virus-related hepatocellular carcinoma in a northeast Han Chinese population. Liver Int 32: 1172-1178.
    • (2012) Liver Int , vol.32 , pp. 1172-1178
    • Wang, X.1    Zhang, X.2    Qiu, B.3    Tang, Y.4    Sun, H.5
  • 35
    • 47049091199 scopus 로고    scopus 로고
    • MDM2 and p53 polymorphisms are associated with the development of hepatocellular carcinoma in patients with chronic hepatitis B virus infection
    • Yoon YJ, Chang HY, Ahn SH, Kim JK, Park YK, et al. (2008) MDM2 and p53 polymorphisms are associated with the development of hepatocellular carcinoma in patients with chronic hepatitis B virus infection. Carcinogenesis 29: 1192-1196.
    • (2008) Carcinogenesis , vol.29 , pp. 1192-1196
    • Yoon, Y.J.1    Chang, H.Y.2    Ahn, S.H.3    Kim, J.K.4    Park, Y.K.5
  • 36
    • 84860292713 scopus 로고    scopus 로고
    • p53 codon 72 polymorphism is associated with susceptibility to hepatocellular carcinoma in the Turkish population: A case-control study
    • Sumbul AT, Akkiz H, Bayram S, Bekar A, Akgollu E, et al. (2012) p53 codon 72 polymorphism is associated with susceptibility to hepatocellular carcinoma in the Turkish population: a case-control study. Mol Biol Rep 39: 1639-1647.
    • (2012) Mol Biol Rep , vol.39 , pp. 1639-1647
    • Sumbul, A.T.1    Akkiz, H.2    Bayram, S.3    Bekar, A.4    Akgollu, E.5
  • 37
    • 15344342919 scopus 로고    scopus 로고
    • Codon 72 polymorphism of P53 gene does not affect the risk of cirrhosis and hepatocarcinoma in HCV-infected patients
    • Leveri M, Gritti C, Rossi L, Zavaglia C, Civardi E, et al. (2004) Codon 72 polymorphism of P53 gene does not affect the risk of cirrhosis and hepatocarcinoma in HCV-infected patients. Cancer Lett 208: 75-79.
    • (2004) Cancer Lett , vol.208 , pp. 75-79
    • Leveri, M.1    Gritti, C.2    Rossi, L.3    Zavaglia, C.4    Civardi, E.5
  • 38
    • 0032979681 scopus 로고    scopus 로고
    • A p53 genetic polymorphism as a modulator of hepatocellular carcinoma risk in relation to chronic liver disease, familial tendency, and cigarette smoking in hepatitis B carriers
    • Yu MW, Yang SY, Chiu YH, Chiang YC, Liaw YF, et al. (1999) A p53 genetic polymorphism as a modulator of hepatocellular carcinoma risk in relation to chronic liver disease, familial tendency, and cigarette smoking in hepatitis B carriers. Hepatology 29: 697-702.
    • (1999) Hepatology , vol.29 , pp. 697-702
    • Yu, M.W.1    Yang, S.Y.2    Chiu, Y.H.3    Chiang, Y.C.4    Liaw, Y.F.5
  • 39
    • 0037466368 scopus 로고    scopus 로고
    • Frequent loss of p53 codon 72 Pro variant in hepatitis C virus-positive carriers with hepatocellular carcinoma
    • Anzola M, Cuevas N, Lopez-Martinez M, Saiz A, Burgos JJ, et al. (2003) Frequent loss of p53 codon 72 Pro variant in hepatitis C virus-positive carriers with hepatocellular carcinoma. Cancer Lett 193: 199-205.
    • (2003) Cancer Lett , vol.193 , pp. 199-205
    • Anzola, M.1    Cuevas, N.2    Lopez-Martinez, M.3    Saiz, A.4    Burgos, J.J.5
  • 40
    • 78649593548 scopus 로고    scopus 로고
    • A potentially functional polymorphism in the promoter region of miR-34b/c is associated with an increased risk for primary hepatocellular carcinoma
    • Xu Y, Liu L, Liu J, Zhang Y, Zhu J, et al. (2011) A potentially functional polymorphism in the promoter region of miR-34b/c is associated with an increased risk for primary hepatocellular carcinoma. Int J Cancer 128: 412-417.
    • (2011) Int J Cancer , vol.128 , pp. 412-417
    • Xu, Y.1    Liu, L.2    Liu, J.3    Zhang, Y.4    Zhu, J.5
  • 41
    • 84878646211 scopus 로고    scopus 로고
    • Promoter polymorphisms of pri-miR-34b/c are associated with hepatocellular carcinoma
    • Son MS, Jang MJ, Jeon YJ, Kim WH, Kwon CI, et al. (2013) Promoter polymorphisms of pri-miR-34b/c are associated with hepatocellular carcinoma. Gene 524: 156-160.
    • (2013) Gene , vol.524 , pp. 156-160
    • Son, M.S.1    Jang, M.J.2    Jeon, Y.J.3    Kim, W.H.4    Kwon, C.I.5
  • 44
    • 70349438994 scopus 로고    scopus 로고
    • Tumour suppression by p53: A role for the DNA damage response?
    • Meek DW (2009) Tumour suppression by p53: a role for the DNA damage response? Nat Rev Cancer 9: 714-723.
    • (2009) Nat Rev Cancer , vol.9 , pp. 714-723
    • Meek, D.W.1
  • 45
    • 22844432020 scopus 로고    scopus 로고
    • A chromatin-associated and transcriptionally inactive p53-Mdm2 complex occurs in mdm2 SNP309 homozygous cells
    • Arva NC, Gopen TR, Talbott KE, Campbell LE, Chicas A, et al. (2005) A chromatin-associated and transcriptionally inactive p53-Mdm2 complex occurs in mdm2 SNP309 homozygous cells. J Biol Chem 280: 26776-26787.
    • (2005) J Biol Chem , vol.280 , pp. 26776-26787
    • Arva, N.C.1    Gopen, T.R.2    Talbott, K.E.3    Campbell, L.E.4    Chicas, A.5
  • 46
    • 0027459198 scopus 로고
    • mdm2 expression is induced by wild type p53 activity
    • Barak Y, Juven T, Haffner R, Oren M (1993) mdm2 expression is induced by wild type p53 activity. EMBO J 12: 461-468.
    • (1993) EMBO J , vol.12 , pp. 461-468
    • Barak, Y.1    Juven, T.2    Haffner, R.3    Oren, M.4
  • 47
    • 21344470650 scopus 로고    scopus 로고
    • A single nucleotide polymorphism in the MDM2 gene: From a molecular and cellular explanation to clinical effect
    • Bond GL, Hu W, Levine A (2005) A single nucleotide polymorphism in the MDM2 gene: from a molecular and cellular explanation to clinical effect. Cancer Res 65: 5481-5484.
    • (2005) Cancer Res , vol.65 , pp. 5481-5484
    • Bond, G.L.1    Hu, W.2    Levine, A.3
  • 48
    • 8844278362 scopus 로고    scopus 로고
    • A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans
    • Bond GL, Hu W, Bond EE, Robins H, Lutzker SG, et al. (2004) A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans. Cell 119: 591-602.
    • (2004) Cell , vol.119 , pp. 591-602
    • Bond, G.L.1    Hu, W.2    Bond, E.E.3    Robins, H.4    Lutzker, S.G.5
  • 49
    • 27144529920 scopus 로고    scopus 로고
    • The role of P53 and MDM2 polymorphisms in the risk of esophageal squamous cell carcinoma
    • Hong Y, Miao X, Zhang X, Ding F, Luo A, et al. (2005) The role of P53 and MDM2 polymorphisms in the risk of esophageal squamous cell carcinoma. Cancer Res 65: 9582-9587.
    • (2005) Cancer Res , vol.65 , pp. 9582-9587
    • Hong, Y.1    Miao, X.2    Zhang, X.3    Ding, F.4    Luo, A.5
  • 50
    • 33646337650 scopus 로고    scopus 로고
    • Hepatocellular carcinoma and hepatitis B virus
    • Chan HL, Sung JJ (2006) Hepatocellular carcinoma and hepatitis B virus. Semin Liver Dis 26: 153-161.
    • (2006) Semin Liver Dis , vol.26 , pp. 153-161
    • Chan, H.L.1    Sung, J.J.2
  • 51
    • 78049324216 scopus 로고    scopus 로고
    • Targeting the inflammation in HCVassociated hepatocellular carcinoma: A role in the prevention and treatment
    • Castello G, Costantini S, Scala S (2010) Targeting the inflammation in HCVassociated hepatocellular carcinoma: a role in the prevention and treatment. J Transl Med 8: 109.
    • (2010) J Transl Med , vol.8 , pp. 109
    • Castello, G.1    Costantini, S.2    Scala, S.3
  • 52
    • 0029913730 scopus 로고    scopus 로고
    • mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein
    • Chen J, Wu X, Lin J, Levine AJ (1996) mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein. Mol Cell Biol 16: 2445-2452.
    • (1996) Mol Cell Biol , vol.16 , pp. 2445-2452
    • Chen, J.1    Wu, X.2    Lin, J.3    Levine, A.J.4
  • 53
    • 29944441900 scopus 로고    scopus 로고
    • Genetic polymorphisms in cell cycle regulatory genes MDM2 and TP53 are associated with susceptibility to lung cancer
    • Zhang X, Miao X, Guo Y, Tan W, Zhou Y, et al. (2006) Genetic polymorphisms in cell cycle regulatory genes MDM2 and TP53 are associated with susceptibility to lung cancer. Hum Mutat 27: 110-117.
    • (2006) Hum Mutat , vol.27 , pp. 110-117
    • Zhang, X.1    Miao, X.2    Guo, Y.3    Tan, W.4    Zhou, Y.5
  • 54
    • 33845718248 scopus 로고    scopus 로고
    • MDM2 SNP309 T>G alone or in combination with the TP53 R72P polymorphism does not appear to influence disease expression and age of diagnosis of colorectal cancer in HNPCC patients
    • Talseth BA, Meldrum C, Suchy J, Kurzawski G, Lubinski J, et al. (2007) MDM2 SNP309 T>G alone or in combination with the TP53 R72P polymorphism does not appear to influence disease expression and age of diagnosis of colorectal cancer in HNPCC patients. Int J Cancer 120: 563-565.
    • (2007) Int J Cancer , vol.120 , pp. 563-565
    • Talseth, B.A.1    Meldrum, C.2    Suchy, J.3    Kurzawski, G.4    Lubinski, J.5
  • 55
    • 33744918197 scopus 로고    scopus 로고
    • Association of a functional polymorphism in the promoter of the MDM2 gene with risk of nonsmall cell lung cancer
    • Lind H, Zienolddiny S, Ekstrom PO, Skaug V, Haugen A (2006) Association of a functional polymorphism in the promoter of the MDM2 gene with risk of nonsmall cell lung cancer. Int J Cancer 119: 718-721.
    • (2006) Int J Cancer , vol.119 , pp. 718-721
    • Lind, H.1    Zienolddiny, S.2    Ekstrom, P.O.3    Skaug, V.4    Haugen, A.5
  • 56
    • 35948951588 scopus 로고    scopus 로고
    • Uncertainty in heterogeneity estimates in meta-analyses
    • Ioannidis JP, Patsopoulos NA, Evangelou E (2007) Uncertainty in heterogeneity estimates in meta-analyses. BMJ 335: 914-916.
    • (2007) BMJ , vol.335 , pp. 914-916
    • Ioannidis, J.P.1    Patsopoulos, N.A.2    Evangelou, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.