Evidence for crossing the blood barrier of adult rat brain by human adipose-derived mesenchymal stromal cells during a 6-month period of post-transplantation

Cytotherapy

Volumn 15, Issue 8, 2013, Pages 951-960

  Haddad Mashadrizeh, Aliakbar ^a   Bahrami, Ahmad Reza ^a   Matin, Maryam M ^a   Edalatmanesh, Mohammad Amin ^b   Zomorodipour, Alireza ^c   Fallah, Ali ^d   Gardaneh, Mossa ^c   Ahmadian Kia, Naghmeh ^e   Sanjarmoosavi, Naser ^f  

^a FERDOWSI UNIVERSITY OF MASHHAD   (Iran)

^b ISLAMIC AZAD UNIVERSITY   (Iran)

^c NATIONAL INSTITUTE OF GENETIC ENGINEERING AND BIOTECHNOLOGY   (Iran)

^d SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^e SHAHROUD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^f MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Cell migration; Cell survival; Immune privilege; Mesenchymal stromal cells; Stem cell therapy; Xenotransplantation

Indexed keywords

GREEN FLUORESCENT PROTEIN;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BLOOD BRAIN BARRIER; CELL DIFFERENTIATION; CELL EXPANSION; CELL ISOLATION; CELL METABOLISM; CELL MIGRATION; CELL POPULATION; CELL SURVIVAL; CELL TRACKING; CELL TRANSPLANTATION; CONTROLLED STUDY; HUMAN; HUMAN ADIPOSE DERIVED MESENCHYMAL STROMAL CELL; HUMAN CELL; MESENCHYMAL STROMA CELL; NONHUMAN; RAT; SPLEEN; SURVIVAL RATE; ADIPOSE TISSUE; ANIMAL; BIOLOGICAL THERAPY; CELL CULTURE; CELL MOTION; CELL PROLIFERATION; CYTOLOGY; GENETICS; GRAFT SURVIVAL; IMMUNE PRIVILEGE; MESENCHYMAL STEM CELL TRANSPLANTATION; METHODOLOGY; STEM CELL TRANSPLANTATION; WISTAR RAT; XENOTRANSPLANTATION; PROCEDURES;

RATTUS;

CELL MIGRATION; CELL SURVIVAL; IMMUNE PRIVILEGE; MESENCHYMAL STROMAL CELLS; STEM CELL THERAPY; XENOTRANSPLANTATION;

ADIPOSE TISSUE; ANIMALS; BLOOD-BRAIN BARRIER; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; CELL- AND TISSUE-BASED THERAPY; CELLS, CULTURED; GRAFT SURVIVAL; GREEN FLUORESCENT PROTEINS; HUMANS; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; RATS; RATS, WISTAR;

EID: 84893499299     PISSN: 14653249     EISSN: 14772566     Source Type: Journal    
DOI: 10.1016/j.jcyt.2013.03.003     Document Type: Article

References (50)

1. Moloney T.C., Dockery P., Windebank A.J., Barry F.P., Howard L., Dowd E. Survival and immunogenicity of mesenchymal stem cells from the green fluorescent protein transgenic rat in the adult rat brain. Neurorehabil Neural Repair 2010, 24:645-656.
2. Kordower J.H., Freeman T.B., Snow B.J., Vingerhoets F.J., Mufson E.J., Sanberg P.R., et al. Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease. NEngl J Med 1995, 332:1118-1124.
3. Hauser R.A., Freeman T.B., Snow B.J., Nauert M., Gauger L., Kordower J.H., et al. Long-term evaluation of bilateral fetal nigral transplantation in Parkinson disease. Arch Neurol 1999, 56:179-187.
4. Binello E., Germano I.M. Stem cells as therapeutic vehicles for thetreatment of high-grade gliomas. Neuro Oncol 2012, 14:256-265.
5. Choi S.A., Lee J.Y., Wang K.C., Phi J.H., Song S.H., Song J., et al. Human adipose tissue-derived mesenchymal stem cells: characteristics and therapeutic potential as cellular vehicles forprodrug gene therapy against brainstem gliomas. Eur JCancer 2012, 48:129-137.
6. Strem B.M., Hicok K.C., Zhu M., Wulur I., Alfonso Z., Schreiber R.E., et al. Multipotential differentiation of adipose tissue-derived stem cells. Keio J Med 2005, 54:132-141.
7. Gimble J.M., Katz A.J., Bunnell B.A. Adipose-derived stem cells for regenerative medicine. Circ Res 2007, 100:1249-1260.
8. Keilhoff G., Stang F., Goihl A., Wolf G., Fansa H. Transdifferentiated mesenchymal stem cells as alternative therapy in supporting nerve regeneration and myelination. Cell Mol Neurobiol 2006, 26:1235-1252.
9. Lin W., Chen X., Wang X., Liu J., Gu X. Adult rat bone marrow stromal cells differentiate into Schwann cell-like cells in vitro. In Vitro Cell Dev Biol Anim 2008, 44:31-40.
10. Malgieri A., Kantzari E., Patrizi M.P., Gambardella S. Bone marrow and umbilical cord blood human mesenchymal stem cells: state of the art. Int J Clin Exp Med 2010, 3:248-269.
11. Baer P.C., Geiger H. Adipose-derived mesenchymal stromal/stem cells: tissue localization, characterization, and heterogeneity. Stem Cells Int 2012, 2012:812693.
12. Zuk P.A., Zhu M., Ashjian P., De Ugarte D.A., Huang J.I., Mizuno H., et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 2002, 13:4279-4295.
13. Rodriguez A.M., Elabd C., Amri E.Z., Ailhaud G., Dani C. The human adipose tissue is a source of multipotent stem cells. Biochimie 2005, 87:125-128.
14. Vieira N.M., Brandalise V., Zucconi E., Jazedje T., Secco M., Nunes V.A., et al. Human multipotent adipose-derived stem cells restore dystrophin expression of Duchenne skeletal-muscle cells in vitro. Biol Cell 2008, 100:231-241.
15. Sowa Y., Imura T., Numajiri T., Nishino K., Fushiki S. Adipose-derived stem cells produce factors enhancing peripheral nerve regeneration: influence of age and anatomic site of origin. Stem Cells Dev 2012, 21:1852-1862.
16. Taha M.F., Hedayati V. Isolation, identification and multipotential differentiation of mouse adipose tissue-derived stem cells. Tissue Cell 2010, 42:211-216.
17. Levi B., James A.W., Nelson E.R., Vistnes D., Wu B., Lee M., et al. Human adipose derived stromal cells heal critical size mouse calvarial defects. PLoS One 2010, 5:e11177.
18. Gimble J.M., Nuttall M.E. Adipose-derived stromal/stem cells (ASC) in regenerative medicine: pharmaceutical applications. Curr Pharm Des 2011, 17:332-339.
19. De Ugarte D.A., Alfonso Z., Zuk P.A., Elbarbary A., Zhu M., Ashjian P., et al. Differential expression of stem cell mobilization-associated molecules on multi-lineage cells from adipose tissue and bone marrow. Immunol Lett 2003, 89:267-270.
20. Han Z.B., Chen H.X., Deng J.X. [Multipotential differentiation and potential applications of adipose-derived stem cells]. Sheng Wu Gong Cheng Xue Bao 2007, 23:195-200.
21. Mendez I., Vinuela A., Astradsson A., Mukhida K., Hallett P., Robertson H., et al. Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years. Nat Med 2008, 14:507-509.
22. Bobis S., Jarocha D., Majka M. Mesenchymal stem cells: characteristics and clinical applications. Folia Histochem Cytobiol 2006, 44:215-230.
23. Undale A.H., Westendorf J.J., Yaszemski M.J., Khosla S. Mesenchymal stem cells for bone repair and metabolic bone diseases. Mayo Clin Proc 2009, 84:893-902.
24. Edalatmanesh M.A., Bahrami A.R., Hosseini E., Hosseini M., Khatamsaz S. Neuroprotective effects of mesenchymal stem cell transplantation in animal model of cerebellar degeneration. Neurol Res 2011, 33:913-920.
25. Gimble J., Guilak F. Adipose-derived adult stem cells: isolation, characterization, and differentiation potential. Cytotherapy 2003, 5:362-369.
26. Zufferey R., Dull T., Mandel R.J., Bukovsky A., Quiroz D., Naldini L., et al. Self-inactivating lentivirus vector for safe andefficient in vivo gene delivery. JVirol 1998, 72:9873-9880.
27. Whelan J.A., Russell N.B., Whelan M.A. Amethod for the absolute quantification of cDNA using real-time PCR. JImmunol Methods 2003, 278:261-269.
28. Schmittgen T.D., Livak K.J. Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 2008, 3:1101-1108.
29. Weissman I.L. Stem cells: units of development, units of regeneration, and units in evolution. Cell 2000, 100:157-168.
30. Selkirk S.M. Gene therapy in clinical medicine. Postgrad MedJ 2004, 80:560-570.
31. Singec I., Jandial R., Crain A., Nikkhah G., Snyder E.Y. The leading edge of stem cell therapeutics. Annu Rev Med 2007, 58:313-328.
32. Bexell D., Gunnarsson S., Tormin A., Darabi A., Gisselsson D., Roybon L., et al. Bone marrow multipotent mesenchymal stroma cells act as pericyte-like migratory vehicles in experimental gliomas. Mol Ther 2009, 17:183-190.
33. Cavarretta I.T., Altanerova V., Matuskova M., Kucerova L., Culig Z., Altaner C. Adipose tissue-derived mesenchymal stem cells expressing prodrug-converting enzyme inhibit human prostate tumor growth. Mol Ther 2010, 18:223-231.
34. Altanerova V., Cihova M., Babic M., Rychly B., Ondicova K., Mravec B., et al. Human adipose tissue-derived mesenchymal stem cells expressing yeast cytosinedeaminase::uracil phosphoribosyltransferase inhibit intracerebral rat glioblastoma. Int J Cancer 2012, 130:2455-2463.
35. Zhou H.S., Liu D.P., Liang C.C. Challenges and strategies: the immune responses in gene therapy. Med Res Rev 2004, 24:748-761.
36. Engelhardt B. Molecular mechanisms involved in T cell migration across the blood-brain barrier. JNeural Transm 2006, 113:477-485.
37. Kawakami N., Flugel A. Knocking at the brain's door: intravital two-photon imaging of autoreactive T cell interactions with CNS structures. Semin Immunopathol 2010, 32:275-287.
38. Engelhardt B., Coisne C. Fluids and barriers of the CNS establish immune privilege by confining immune surveillance to a two-walled castle moat surrounding the CNS castle. Fluids Barriers CNS 2011, 8:4.
39. Lin Y., Hogan W.J. Clinical application of mesenchymal stem cells in the treatment and prevention of graft-versus-host disease. Adv Hematol 2011, 2011:427863.
40. Modo M., Mellodew K., Cash D., Fraser S.E., Meade T.J., Price J., et al. Mapping transplanted stem cell migration after a stroke: a serial, in vivo magnetic resonance imaging study. Neuroimage 2004, 21:311-317.
41. Webber D.J., Bradbury E.J., McMahon S.B., Minger S.L. Transplanted neural progenitor cells survive and differentiatebut achieve limited functional recovery in thelesioned adult rat spinal cord. Regen Med 2007, 2:929-945.
42. Dantuma E., Merchant S., Sugaya K. Stem cells for the treatment of neurodegenerative diseases. Stem Cell Res Ther 2010, 1:37.
43. Chu K., Kim M., Park K.I., Jeong S.W., Park H.K., Jung K.H., et al. Human neural stem cells improve sensorimotor deficits in theadult rat brain with experimental focal ischemia. Brain Res 2004, 1016:145-153.
44. Muller F.J., Snyder E.Y., Loring J.F. Gene therapy: can neural stem cells deliver?. Nat Rev Neurosci 2006, 7:75-84.
45. Watson D.J., Walton R.M., Magnitsky S.G., Bulte J.W., Poptani H., Wolfe J.H. Structure-specific patterns of neural stem cell engraftment after transplantation in the adult mouse brain. Hum Gene Ther 2006, 17:693-704.
46. Abbott N.J., Ronnback L., Hansson E. Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci 2006, 7:41-53.
47. Spencer B.J., Verma I.M. Targeted delivery of proteins across the blood-brain barrier. Proc Natl Acad Sci U S A 2007, 104:7594-7599.
48. Neuwelt E., Abbott N.J., Abrey L., Banks W.A., Blakley B., Davis T., et al. Strategies to advance translational research into brain barriers. Lancet Neurol 2008, 7:84-96.
49. Kilroy G.E., Foster S.J., Wu X., Ruiz J., Sherwood S., Heifetz A., et al. Cytokine profile of human adipose-derivedstem cells:expression of angiogenic, hematopoietic, and pro-inflammatory factors. JCell Physiol 2007, 212:702-709.
50. Walter M., Liang S., Ghosh S., Hornsby P.J., Li R. Interleukin 6 secreted from adipose stromal cells promotes migration and invasion of breast cancer cells. Oncogene 2009, 28:2745-2755.