Revisiting whitlockite, the second most abundant biomineral in bone: Nanocrystal synthesis in physiologically relevant conditions and biocompatibility evaluation

ACS Nano

Volumn 8, Issue 1, 2014, Pages 634-641

  Jang, Hae Lin ^a   Jin, Kyoungsuk ^a   Lee, Jaehun ^a   Kim, Younghye ^a   Nahm, Seung Hoon ^b   Hong, Kug Sun ^a   Nam, Ki Tae ^a  

^a Seoul National University   (South Korea)

^b Korea Research Institute of Standards and Science   (South Korea)

Author keywords

biomaterial; biomineralization; bone growth; calcium phosphate; inorganic synthesis; nanoparticle; whitlockite

Indexed keywords

BONE GROWTH; HETEROGENEOUS PHASIS; INORGANIC SYNTHESIS; LARGE SCALE SYNTHESIS; NANOCRYSTAL SYNTHESIS; SYNTHESIS CONDITIONS; THERMODYNAMICALLY STABLE; WHITLOCKITE;

BIOCOMPATIBILITY; BIOLOGICAL MATERIALS; BIOMATERIALS; BIOMINERALIZATION; BONE; CALCIUM; CALCIUM PHOSPHATE; NANOPARTICLES; PH; PHYSIOLOGICAL MODELS;

SYNTHESIS (CHEMICAL);

BIOMATERIAL; CALCIUM PHOSPHATE; HYDROXYAPATITE; NANOPARTICLE;

ARTICLE; BONE; CELL CULTURE; CHEMISTRY; HUMAN; METABOLISM; THERMODYNAMICS; TRANSMISSION ELECTRON MICROSCOPY; X RAY DIFFRACTION;

BIOCOMPATIBLE MATERIALS; BONE AND BONES; CALCIUM PHOSPHATES; CELLS, CULTURED; DURAPATITE; HUMANS; MICROSCOPY, ELECTRON, TRANSMISSION; NANOPARTICLES; THERMODYNAMICS; X-RAY DIFFRACTION;

EID: 84893481398     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn405246h     Document Type: Article

References (40)

1. Elliott, J. C. Structure and Chemistry of the Apatites and Other Calcium Orthophosphates; Elsevier Science & Technology: Amsterdam, 1994.
2. Driessens, F. C. M.; Verbeeck, R. M. H. Biominerals; CRC Press: Boca Raton, FL, 1990.
3. Lagier, R.; Baud, C. A. Magnesium Whitlockite, a Calcium Phosphate Crystal of Special Interest in Pathology Pathol. Res. Pract. 2003, 199, 329-335
4. Scotchford, C. A.; Vickers, M.; Ali, S. Y. The Isolation and Characterization of Magnesium Whitlockite Crystals from Human Articular-Cartilage Osteoarthr. Cartil. 1995, 3, 79-94
5. Hayashi, Y. High-Resolution Electron Microscopy of Mineral Deposits on a Thin Layer of Pellicle Adhering to Intact Enamel Surface Electron Microsc. 1996, 45, 501-504
6. Palamara, J.; Phakey, P. P.; Rachinger, W. A.; Orams, H. J. Electron Microscopy of Surface Enamel of Human Unerupted and Erupted Teeth Arch. Oral. Biol. 1980, 25, 715-725
7. Cashman, K. D.; Flynn, A. Optimal Nutrition: Calcium, Magnesium and Phosphorus Proc. Nutr. Soc. 1999, 58, 477-487
8. Hannig, M.; Hannig, C. Nanomaterials in Preventive Dentistry Nat. Nanotechnol. 2010, 5, 565-569
9. Colfen, H. Biomineralization: A Crystal-Clear View Nat. Mater. 2010, 9, 960-961
10. Jackson, S. F.; Randall, J. T. The Fine Structure of Bone Nature 1956, 178, 798-798
11. Terpstra, R.; Driessens, F. Magnesium in Tooth Enamel and Synthetic Apatites Calcif. Tissue Int. 1986, 39, 348-354
12. Meinke, D. K.; Skinner, H. C. W.; Thomson, K. S. X-Ray Diffraction of the Calcified Tissues in Polypterus Calcif. Tissue Int. 1979, 28, 37-42
13. Quint, P.; Althoff, J.; Hohling, H. J.; Boyde, A.; Laabs, W. A. Characteristic Molar Ratios of Magnesium, Carbon-Dioxide, Calcium and Phosphorus in the Mineralizing Fracture Callus and Predentine Calcif. Tissue Int. 1980, 32, 257-261
14. Koutsoukos, P.; Amjad, Z.; Tomson, M. B.; Nancollas, G. H. Crystallization of Calcium Phosphates. A Constant Composition Study J. Am. Chem. Soc. 1980, 102, 1553-1557
15. LeGeros, R.; Daculsi, G.; Kijkowska, R.; Kerebel, B. Magnesium in Health and Disease; John Libbey: New York, 1989.
16. Rowles, S. The Precipitation of Whitlockite from Aqueous Solutions Bull. Soc. Chim. Fr. 1968, 1797-1802
17. 14 J. Therm. Anal. Calorim. 2004, 77, 863-871
18. Okazaki, M.; Takahashi, J.; Kimura, H. Unstable Behavior of Magnesium Containing Hydroxyapatites Caries Res. 1986, 20, 324-331
19. Ryan, L. M.; Cheung, H. S.; LeGeros, R. Z.; Kurup, I. V.; Toth, J.; Westfall, P. R.; McCarthy, G. M. Cellular Responses to Whitlockite Calcif. Tissue Int. 1999, 65, 374-377
20. Rothwell, W. P.; Waugh, J. S.; Yesinowski, J. P. High-Resolution Variable-Temperature Phosphorus-31 NMR of Solid Calcium Phosphates J. Am. Chem. Soc. 1980, 102, 2637-2643
21. 2 Bull. Soc. Chim. Belg. 1986, 95, 455-476
22. Martens, C. S.; Harriss, R. C. Inhibition of Apatite Precipitation in the Marine Environment by Magnesium Ions Geochim. Cosmochim. Acta 1970, 34, 621-625
23. Nancollas, G.; Tomazic, B.; Tomson, M. The Precipitation of Calcium Phosphates in the Presence of Magnesium Croat. Chem. Acta 1976, 48, 431-438
24. LeGeros, R.; Shirra, W.; Miravite, M.; LeGeros, J. Amorphous Calcium Phosphates: Synthetic and Biological Coll. Int. CNRS 1975, 230, 105-115
25. Trautz, O. R.; Zapantal, R.; Legeros, J. P. Effect of Magnesium on Various Calcium Phosphates J. Dent. Res. 1964, 43, 751-754
26. 2 Nat. Phys. Sci. 1972, 237, 30-32
27. 14 Can. J. Chem. 1974, 52, 1155-1164
28. Calvo, C.; Gopal, R. Crystal-Structure of Whitlockite from Palermo Quarry Am. Mineral. 1975, 60, 120-133
29. Gee, A.; Deitz, V. R. Pyrophosphate Formation upon Ignition of Precipitated Basic Calcium Phosphates J. Am. Chem. Soc. 1955, 77, 2961-2965
30. Walser, M. Ion Association. VI. Interactions between Calcium, Magnesium, Inorganic Phosphate, Citrate and Protein in Normal Human Plasma J. Clin. Invest. 1961, 40, 723-730
31. Ferron, M.; Wei, J.; Yoshizawa, T.; Del Fattore, A.; DePinho, R. A.; Teti, A.; Ducy, P.; Karsenty, G. Insulin Signaling in Osteoblasts Integrates Bone Remodeling and Energy Metabolism Cell 2010, 142, 296-308
32. Teitelbaum, S. L. Bone Resorption by Osteoclasts Science 2000, 289, 1504-1508
33. Silver, I. A.; Murrills, R. J.; Etherington, D. J. Microelectrode Studies on the Acid Microenvironment beneath Adherent Macrophages and Osteoclasts Exp. Cell. Res. 1988, 175, 266-276
34. Jalota, S.; Bhaduri, S. B.; Tas, A. C. In Vitro Testing of Calcium Phosphate (HA, TCP, and Biphasic HA-TCP) Whiskers J. Biomed. Mater. Res. Part A 2006, 78A, 481-490
35. Sader, M. S.; LeGeros, R. Z.; Soares, G. A. Human Osteoblasts Adhesion and Proliferation on Magnesium-Substituted Tricalcium Phosphate Dense Tablets J. Mater. Sci. Mater. Med. 2009, 20, 521-527
36. Webster, T. J.; Ergun, C.; Doremus, R. H.; Bizios, R. Hydroxylapatite with Substituted Magnesium, Zinc, Cadmium, and Yttrium. II. Mechanisms of Osteoblast Adhesion J. Biomed. Mater. Res. 2002, 59, 312-317
37. 2+ on the Chemico-Physical and in Vitro Biological Properties of Calcium Phosphate Biomimetic Coatings J. Inorg. Biochem. 2009, 103, 1666-1674
38. Webster, T. J.; Massa-Schlueter, E. A.; Smith, J. L.; Slamovich, E. B. Osteoblast Response to Hydroxyapatite Doped with Divalent and Trivalent Cations Biomaterials 2004, 25, 2111-2121
39. 2: A Host to Accommodate Large Lithophile Elements in the Earth's Mantle Phys. Chem. Miner. 1987, 15, 125-130
40. 2 J. Solid State Chem. 1977, 22, 253-262