Helical propensity in an intrinsically disordered protein accelerates ligand binding

Angewandte Chemie - International Edition

Volumn 53, Issue 6, 2014, Pages 1548-1551

  Iešmantavičius, Vytautas ^a   Dogan, Jakob ^b   Jemth, Per ^b   Teilum, Kaare ^a   Kjaergaard, Magnus ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

conformational selection; ligand binding; NMR spectroscopy; proteins; secondary structure

Indexed keywords

CONFORMATIONAL SELECTION; CREB BINDING PROTEINS; INTERMOLECULAR INTERACTIONS; INTRINSICALLY DISORDERED PROTEINS; LIGAND BINDING; SECONDARY STRUCTURES; STOPPED-FLOW KINETICS; TRANSIENT STRUCTURE;

CHEMICAL ACTIVATION; KINETICS; LIGANDS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

PROTEINS;

CREB1 PROTEIN, HUMAN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; INTRINSICALLY DISORDERED PROTEIN; LIGAND; NCOA3 PROTEIN, HUMAN; PROTEIN; STEROID RECEPTOR COACTIVATOR 3;

ARTICLE; CHEMISTRY; CONFORMATIONAL SELECTION; GENETICS; HUMAN; KINETICS; LIGAND BINDING; METABOLISM; MUTATION; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN BINDING; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

CONFORMATIONAL SELECTION; LIGAND BINDING; NMR SPECTROSCOPY; PROTEINS; SECONDARY STRUCTURE;

CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; HUMANS; INTRINSICALLY DISORDERED PROTEINS; KINETICS; LIGANDS; MUTATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; NUCLEAR RECEPTOR COACTIVATOR 3; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY;

EID: 84893454221     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201307712     Document Type: Article

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