Overexpression of muscarinic receptor 3 promotes metastasis and predicts poor prognosis in Non-Small-Cell lung cancer

Journal of Thoracic Oncology

Volumn 9, Issue 2, 2014, Pages 170-178

  Lin, Gengpeng ^a   Sun, Longhua ^a   Wang, Ran ^a   Guo, Yubiao ^a   Xie, Canmao ^a,b  

^a THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

^b Nanchang Hospital of Integrative Traditional Chinese and Western Medicine   (China)

Author keywords

Chronic obstructive pulmonary disease; Invasion; Metastasis; Muscarinic receptor 3; Non small cell lung cancer

Indexed keywords

BETA ACTIN; GELATINASE B; MUSCARINIC M3 RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SMALL INTERFERING RNA;

ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER PATIENT; CANCER PROGNOSIS; CANCER SURVIVAL; CELL INVASION; CELL MIGRATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL FEATURE; CONTROLLED STUDY; ENZYME ACTIVITY; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; GENE OVEREXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG NON SMALL CELL CANCER; METASTASIS; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; SMOKING; WESTERN BLOTTING; ZYMOGRAPHY;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; BLOTTING, WESTERN; CARCINOMA, LARGE CELL; CARCINOMA, NON-SMALL-CELL LUNG; CARCINOMA, SQUAMOUS CELL; CELL ADHESION; CELL MOVEMENT; CELL PROLIFERATION; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMMUNOENZYME TECHNIQUES; LUNG NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; RECEPTOR, MUSCARINIC M3; RNA, MESSENGER; SURVIVAL RATE; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL; WOUND HEALING; YOUNG ADULT;

EID: 84893417722     PISSN: 15560864     EISSN: 15561380     Source Type: Journal    
DOI: 10.1097/JTO.0000000000000066     Document Type: Article

References (31)

1. Ferlay J, Shin HR, Bray F, et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010, 127: 2893-2917.
2. Malvezzi M, Bertuccio P, Levi F, La Vecchia C, Negri E. European cancer mortality predictions for the year 2013. Ann Oncol 2013;24:792-800.
3. Vestbo J, Hurd SS, Agust AG, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 2013;187:347-365.
4. de Torres JP, Marn JM, Casanova C, et al. Lung cancer in patients with chronic obstructive pulmonary disease-incidence and predicting factors. Am J Respir Crit Care Med 2011;184:913-919.
5. Gulln JA, Surez I, Medina A, Rubinos G, Fernndez R, Gonzlez I. Role of emphysema and airway obstruction in prognosis of lung cancer. Lung Cancer 2011;71:182-185.
6. Tammemgi MC, Katki HA, Hocking WG, et al. Selection criteria for lung-cancer screening. N Engl J Med 2013;368:728-736.
7. Wess J. Molecular biology of muscarinic acetylcholine receptors. Crit Rev Neurobiol 1996;10:69-99.
8. Belmonte KE. Cholinergic pathways in the lungs and anticholinergic therapy for chronic obstructive pulmonary disease. Proc Am Thorac Soc 2005, 2: 297-304, 311-312.
9. Roffel AF, Elzinga CR, Zaagsma J. Muscarinic M3 receptors mediate contraction of human central and peripheral airway smooth muscle. Pulm Pharmacol 1990;3:47-51.
10. Rogers DF. Motor control of airway goblet cells and glands. Respir Physiol 2001;125:129-144.
11. Fryer AD, Jacoby DB. Muscarinic receptors and control of airway smooth muscle. Am J Respir Crit Care Med 1998;158(5 Pt 3):S154-S160.
12. Shah N, Khurana S, Cheng K, Raufman JP. Muscarinic receptors and ligands in cancer. Am J Physiol Cell Physiol 2009;296:C221-C232.
13. Xie G, Cheng K, Shant J, Raufman JP. Acetylcholine-induced activation of M3 muscarinic receptors stimulates robust matrix metalloproteinase gene expression in human colon cancer cells. Am J Physiol Gastrointest Liver Physiol 2009;296:G755-G763.
14. Kodaira M, Kajimura M, Takeuchi K, Lin S, Hanai H, Kaneko E. Functional muscarinic m3 receptor expressed in gastric cancer cells stimulates tyrosine phosphorylation and MAP kinase. J Gastroenterol 1999;34:163-171.
15. Fiszman GL, Middonno MC, de la Torre E, Farina M, Espaol AJ, Sales ME. Activation of muscarinic cholinergic receptors induces MCF-7 cells proliferation and angiogenesis by stimulating nitric oxide synthase activity. Cancer Biol Ther 2007;6:1106-1113.
16. Song P, Sekhon HS, Lu A, et al. M3 muscarinic receptor antagonists inhibit small cell lung carcinoma growth and mitogen-Activated protein kinase phosphorylation induced by acetylcholine secretion. Cancer Res 2007;67:3936-3944.
17. Quigley RL, Shafer SH, Williams CL. Regulation of integrin-mediated adhesion by muscarinic acetylcholine receptors and protein kinase C in small cell lung carcinoma. Chest 1998;114:839-846.
18. Zhang S, Togo S, Minakata K, et al. Distinct roles of cholinergic receptors in small cell lung cancer cells. Anticancer Res 2010;30:97-106.
19. Jacques J, Hill DP, Shier KJ, Jindani A, Miller AB. Appraisal of the World Health Organization classification of lung tumours. Can Med Assoc J 1980;122:897-901.
20. Detterbeck FC, Boffa DJ, Tanoue LT. The new lung cancer staging system. Chest 2009;136:260-271.
21. Rabe KF, Hurd S, Anzueto A, et al.; Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 2007;176:532-555.
22. Sato E, Koyama S, Okubo Y, Kubo K, Sekiguchi M. Acetylcholine stimulates alveolar macrophages to release inflammatory cell chemotactic activity. Am J Physiol 1998;274(6 Pt 1):L970-L979.
23. Hanna JM, Onaitis MW. Cell of origin of lung cancer. J Carcinog 2013;12:6.
24. Adcock IM, Caramori G, Barnes PJ. Chronic obstructive pulmonary disease and lung cancer: new molecular insights. Respiration 2011;81:265-284.
25. Karoor V, Le M, Merrick D, Fagan KA, Dempsey EC, Miller YE. Alveolar hypoxia promotes murine lung tumor growth through a VEGFR-2/EGFRdependent mechanism. Cancer Prev Res (Phila) 2012;5:1061-1071.
26. Profita M, Bonanno A, Montalbano AM, et al. Cigarette smoke extract activates human bronchial epithelial cells affecting non-neuronal cholinergic system signalling in vitro. Life Sci 2011;89:36-43.
27. Garcia-Rio F, Miravitlles M, Soriano JB, et al.; EPI-SCAN Steering Committee. Systemic inflammation in chronic obstructive pulmonary disease: a population-based study. Respir Res 2010;11:63.
28. Xu ZP, Devillier P, Xu GN, et al. TNF-?-induced CXCL8 production by A549 cells: involvement of the non-neuronal cholinergic system. Pharmacol Res 2013;68:16-23.
29. Williams CL, Hayes VY, Hummel AM, Tarara JE, Halsey TJ. Regulation of E-cadherin-mediated adhesion by muscarinic acetylcholine receptors in small cell lung carcinoma. J Cell Biol 1993;121:643-654.
30. Larue L, Bellacosa A. Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3 kinase/AKT pathways. Oncogene 2005;24:7443-7454.
31. Zhang D, Brodt P. Type 1 insulin-like growth factor regulates MT1-MMP synthesis and tumor invasion via PI 3-kinase/Akt signaling. Oncogene 2003;22:974-982.