Obstructive sleep apnea in children is associated with severity-dependent deterioration in overnight endothelial function.

Sleep medicine

Volumn 14, Issue 6, 2013, Pages 526-531

  Kheirandish Gozal, Leila ^a   Etzioni, Tamar ^b   Bhattacharjee, Rakesh ^b   Tan, Hui Leng ^b   Samiei, Arash ^b   Molero Ramirez, Helena ^b   Abu Eta, Busool ^b   Pillar, Giora ^b  

^a UNIVERSITY OF CHICAGO   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ANOXIA; CHILD; FEMALE; HUMAN; MALE; OBESITY; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; POLYSOMNOGRAPHY; PRESCHOOL CHILD; SEVERITY OF ILLNESS INDEX; SLEEP DEPRIVATION; SLEEP DISORDERED BREATHING; SLEEP STAGE; SNORING; VASCULAR ENDOTHELIUM;

ADOLESCENT; ANOXIA; CHILD; CHILD, PRESCHOOL; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; MALE; OBESITY; POLYSOMNOGRAPHY; SEVERITY OF ILLNESS INDEX; SLEEP APNEA, OBSTRUCTIVE; SLEEP DEPRIVATION; SLEEP STAGES; SNORING;

EID: 84893406802     PISSN: None     EISSN: 18785506     Source Type: Journal    
DOI: 10.1016/j.sleep.2013.02.010     Document Type: Article

References (46)

1. R. Bhattacharjee L. Kheirandish-Gozal G. Pillar D. Gozal Cardiovascular complications of obstructive sleep apnea syndrome: evidence from children Prog Cardiovasc Dis 51 2009 416 433
2. D. Gozal O.S. Capdevila L. Kheirandish-Gozal Metabolic alterations and systemic inflammation in obstructive sleep apnea among nonobese and obese prepubertal children Am J Respir Crit Care Med 177 2008 1142 1149
3. A.G. Kaditis E.I. Alexopoulos F. Hatzi I. Karadonta K. Chaidas K. Gourgoulianis Adiposity in relation to age as predictor of severity of sleep apnea in children with snoring Sleep Breath 12 2008 25 31
4. R. Tauman D. Gozal Obesity and obstructive sleep apnea in children Paediatr Respir Rev 7 2006 247 259
5. S.L. Verhulst N. Schrauwen D. Haentjens B. Suys R.P. Rooman L. Van Gaal Sleep-disordered breathing in overweight and obese children and adolescents: prevalence, characteristics and the role of fat distribution Arch Dis Child 92 2007 205 208
6. C.E. Ievers-Landis S. Redline Pediatric sleep apnea: implications of the epidemic of childhood overweight Am J Respir Crit Care Med 175 2007 436 441
7. V.K. Somers D.P. White R. Amin W.T. Abraham F. Costa A. Culebras Sleep apnea and cardiovascular disease: an American Heart Association/American College of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council on Cardiovascular Nursing. In collaboration with the National Heart, Lung, and Blood Institute National Center on Sleep Disorders Research (National Institutes of Health) Circulation 118 2008 1080 1111
8. S. Itzhaki L. Lavie G. Pillar G. Tal P. Lavie Endothelial dysfunction in obstructive sleep apnea measured by peripheral arterial tone response in the finger to reactive hyperemia Sleep 28 2005 594 600
9. M. Kato P. Roberts-Thomson B.G. Phillips W.G. Haynes M. Winnicki V. Accurso Impairment of endothelium-dependent vasodilation of resistance vessels in patients with obstructive sleep apnea Circulation 102 2000 2607 2610
10. H. Oflaz C. Cuhadaroglu B. Pamukcu M. Meric T. Ece E. Kasikcioglu Endothelial function in patients with obstructive sleep apnea syndrome but without hypertension Respiration 73 2006 751 756
11. D. Gozal L. Kheirandish-Gozal L.D. Serpero O. Sans Capdevila E. Dayyat Obstructive sleep apnea and endothelial function in school-aged nonobese children: effect of adenotonsillectomy Circulation 116 2007 2307 2314
12. J. Kim R. Bhattacharjee L. Kheirandish-Gozal K. Spruyt D. Gozal Circulating microparticles in children with sleep-disordered breathing Chest 140 2011 408 417
13. R. Bhattacharjee J. Kim W.H. Alotaibi L. Kheirandish-Gozal O.S. Capdevila D. Gozal Endothelial dysfunction in non-hypertensive children: potential contributions of obesity and obstructive sleep apnea Chest 141 2011 682 691
14. R. Bhattacharjee W.H. Alotaibi L. Kheirandish-Gozal O.S. Capdevila D. Gozal Endothelial dysfunction in obese non-hypertensive children without evidence of sleep disordered breathing BMC Pediatr 10 2010 8
15. L. Kheirandish-Gozal R. Bhattacharjee J. Kim H.B. Clair D. Gozal Endothelial progenitor cells and vascular dysfunction in children with obstructive sleep apnea Am J Respir Crit Care Med 182 2010 92 97
16. S. Itzhaki H. Dorchin G. Clark L. Lavie P. Lavie G. Pillar The effects of 1-year treatment with a herbst mandibular advancement splint on obstructive sleep apnea, oxidative stress, and endothelial function Chest 131 2007 740 749
17. S. Onkelinx V. Cornelissen K. Goetschalckx T. Thomaes P. Verhamme L. Vanhees Reproducibility of different methods to measure the endothelial function Vasc Med 17 2012 79 84
18. M. Moerland A.J. Kales L. Schrier M.G. van Dongen D. Bradnock J. Burggraaf Evaluation of the EndoPAT as a tool to assess endothelial function Int J Vasc Med 012 2012 904141 [published online ahead of print February 14, 2012]
19. C.E. McCrea A.C. Skulas-Ray M. Chow S.G. West Test-retest reliability of pulse amplitude tonometry measures of vascular endothelial function: implications for clinical trial design Vasc Med 17 2012 29 36
20. R. Rubinshtein J.T. Kuvin M. Soffler R.J. Lennon S. Lavi R.E. Nelson Assessment of endothelial function by non-invasive peripheral arterial tonometry predicts late cardiovascular adverse events Eur Heart J 31 2010 1142 1148
21. M. Lazdam A.J. Lewandowski I. Kylintireas C. Cunnington J. Diesch J. Francis Impaired endothelial responses in apparently healthy young people associated with subclinical variation in blood pressure and cardiovascular phenotype Am J Hypertens 25 2012 46 53
22. Y. Shachor-Meyouhas G. Pillar N. Shehadeh Uncontrolled type 1 diabetes mellitus and endothelial dysfunction in adolescents Isr Med Assoc J 9 2007 637 640
23. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents Pediatrics 114 2004 555 576
24. Rechstschaffen A, Kales A. A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects. Brain Information Services/Brain Research Institute, University of California, Los Angeles. 1968.
25. Standards and indications for cardiopulmonary sleep studies in children. American Thoracic Society Am J Respir Crit Care Med 153 1996 866 878
26. H.E. Montgomery-Downs L.M. O’Brien T.E. Gulliver D. Gozal Polysomnographic characteristics in normal preschool and early school-aged children Pediatrics 117 2006 741 753
27. C. Iber S. Ancoli-Israel A.L. Chesson Jr. S.F. Quan The AASM manual for the scoring of sleep and associated events 2007 American Academy of Sleep Medicine
28. J.T. Kuvin A.R. Patel K.A. Sliney N.G. Pandian J. Sheffy R.P. Schnall Assessment of peripheral vascular endothelial function with finger arterial pulse wave amplitude Am Heart J 146 2003 168 174
29. D. Gozal L. Kheirandish-Gozal R. Bhattacharjee K. Spruyt Neurocognitive and endothelial dysfunction in children with obstructive sleep apnea Pediatrics 126 2010 e1161 e1167
30. A.K. Faizi D.W. Kornmo S. Agewall Evaluation of endothelial function using finger plethysmography Clin Physiol Funct Imaging 29 2009 372 375
31. D. Gozal L. Kheirandish-Gozal Cardiovascular morbidity in obstructive sleep apnea: oxidative stress, inflammation, and much more Am J Respir Crit Care Med 177 2008 369 375
32. L. Kheirandish-Gozal The endothelium as a target in pediatric OSA Front Neurol 3 2012 1 6
33. Y. Aggoun N.J. Farpour-Lambert L.M. Marchand E. Golay A.B. Maggio M. Beghetti Impaired endothelial and smooth muscle functions and arterial stiffness appear before puberty in obese children and are associated with elevated ambulatory blood pressure Eur Heart J 29 2008 792 799
34. A. Bhangoo S. Sinha M. Rosenbaum S. Shelov S. Ten Endothelial function as measured by peripheral arterial tonometry increases during pubertal advancement Horm Res Paediatr 76 2011 226 233
35. T. Radtke K. Khattab P. Eser S. Kriemler H. Saner M. Wilhelm Puberty and microvascular function in healthy children and adolescents J Pediatr 161 5 2012 887 891
36. R.B. Schnabel A. Schulz P.S. Wild C.R. Sinning S. Wilde M. Eleftheriadis Noninvasive vascular function measurement in the community: cross-sectional relations and comparison of methods Circ Cardiovasc Imaging 4 2011 371 380
37. M.S. Ip H.F. Tse B. Lam K.W. Tsang W.K. Lam Endothelial function in obstructive sleep apnea and response to treatment Am J Respir Crit Care Med 169 2004 348 353
38. H. Kraiczi K. Caidahl A. Samuelsson Y. Peker J. Hedner Impairment of vascular endothelial function and left ventricular filling: association with the severity of apnea-induced hypoxemia during sleep Chest 119 2001 1085 1091
39. F.J. Nieto D.M. Herrington S. Redline E.J. Benjamin J.A. Robbins Sleep apnea and markers of vascular endothelial function in a large community sample of older adults Am J Respir Crit Care Med 169 2004 354 360
40. L.M. O’Brien L.D. Serpero R. Tauman D. Gozal Plasma adhesion molecules in children with sleep-disordered breathing Chest 129 2006 947 953
41. D. Gozal L.D. Serpero O. Sans Capdevila L. Kheirandish-Gozal Systemic inflammation in non-obese children with obstructive sleep apnea Sleep Med 9 2008 254 259
42. L. Kheirandish-Gozal O.S. Capdevila R. Tauman D. Gozal Plasma C-reactive protein in nonobese children with obstructive sleep apnea before and after adenotonsillectomy J Clin Sleep Med 2 2006 301 304
43. R. Tauman L.M. O’Brien D. Gozal Hypoxemia and obesity modulate plasma C-reactive protein and interleukin-6 levels in sleep-disordered breathing Sleep Breath 11 2007 77 84
44. J. Kim R. Bhattacharjee A.B. Snow O.S. Capdevila L. Kheirandish-Gozal D. Gozal Myeloid related protein 8/14 levels in children with obstructive sleep apnoea Eur Respir J 35 4 2010 843 850
45. A. Kaditis E. Alexopoulos G. Ntamagka K. Chaidas A. Karathanasi S. Gougoura Serum nitrite and nitrate levels in children with obstructive sleep-disordered breathing Sleep Med 11 3 2010 258 262
46. L. Kheirandish-Gozal A. Khalyfa D. Gozal R. Bhattacharjee Y. Wang Endothelial dysfunction in children with obstructive sleep apnea is associated with epigenetic changes in the eNOS gene Chest 2013 10.1378/chest.12-2026 [published online ahead of print January 17, 2013]