Combined inhaled anticholinergics and short-acting beta2-agonists for initial treatment of acute asthma in children

Cochrane Database of Systematic Reviews

Volumn 2013, Issue 8, 2013, Pages

  Griffiths, Benedict ^a   Ducharme, Francine M ^b,c  

^a ST THOMAS HOSPITAL   (United Kingdom)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c UNIVERSITY OF MONTREAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BRONCHODILATING AGENT; CHOLINERGIC RECEPTOR BLOCKING AGENT; CORTICOSTEROID; IPRATROPIUM BROMIDE; SHORT ACTING DRUG; ATROPINE;

ACUTE DISEASE; ASTHMA; CHILD; CLINICAL OUTCOME; CLINICAL PROTOCOL; COMPARATIVE STUDY; DISEASE EXACERBATION; DISEASE SEVERITY; DRUG EFFICACY; DRUG SAFETY; DRUG USE; EMERGENCY WARD; EVIDENCE BASED MEDICINE; FORCED EXPIRATORY VOLUME; HEALTH CARE NEED; HOSPITAL ADMISSION; HOSPITAL DISCHARGE; HUMAN; HYPERTENSION; INCIDENCE; LUNG FUNCTION; LUNG RESISTANCE; MONOTHERAPY; NAUSEA; OUTCOME ASSESSMENT; OXYGEN SATURATION; PARALLEL DESIGN; PREDICTION; PRIORITY JOURNAL; RETREATMENT; REVIEW; RISK REDUCTION; SCORING SYSTEM; SINGLE DRUG DOSE; SYSTEMATIC REVIEW; TACHYCARDIA; TREMOR; VOMITING; ADOLESCENT; DISEASE COURSE; DRUG COMBINATION; HOSPITALIZATION; INFANT; INHALATIONAL DRUG ADMINISTRATION; META ANALYSIS; PRESCHOOL CHILD; PROCEDURES; RANDOMIZED CONTROLLED TRIAL (TOPIC); STATISTICS AND NUMERICAL DATA; METHODOLOGY; STATISTICS;

ADMINISTRATION, INHALATION; ADOLESCENT; ADRENERGIC BETA-2 RECEPTOR AGONISTS; ASTHMA; ATROPINE; CHILD; CHILD, PRESCHOOL; CHOLINERGIC ANTAGONISTS; DISEASE PROGRESSION; DRUG THERAPY, COMBINATION; HOSPITALIZATION; HUMANS; INFANT; IPRATROPIUM; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 84893345022     PISSN: None     EISSN: 1469493X     Source Type: Journal    
DOI: 10.1002/14651858.CD000060.pub2     Document Type: Review

References (86)

1. Beck R. Use of ipratropium bromide by inhalation in the treatment of acute asthma in children. Clinical experience [in French] [Utilisation du bromure d'ipratropium par voie inhalée pour le traitement de l'asthme aigu chez l'enfant]. Archives de Pediatrie 1995;2 Suppl(2):145-8.
2. Beck R, Robertson C, Galdes-Sebaldt M, Levison H. Combined salbutamol and ipratropium bromide by inhalation in the treatment of severe acute asthma. Journal of Pediatrics 1985;107:605-8.
3. Benito Fernandez J, Mintegui Raso S, Sanchez Echaniz J, Vazquez Ronco MA, Pijoan Zubizarreta JI. Efficacy of early administration of nebulized ipratropium bromide in children with asthmatic crisis [in Spanish]. Anales Espanoles de Pediatria 2000;53(3):217-22.
4. Boehringer Ingelheim Pharmaceuticals. A comparison of Combivent UDV (ipratropium 500mcg and salbutamol 2.5mg) and salbutamol UDV alone (2.5mg). Personal communication from Boehringer Ingelheim 2009.
5. Calvo GM, Calvo AM, Marin HF, Moya GJ. Is it useful to add an anticholinergic treatment to beta2-adrenergic medication in acute asthma attack. Journal of Investigative Allergology Clinical Immunology 1998;8(1):30-4.
6. Chakraborti A, Lodha R, Pandey RM, Kabra SK. Randomized controlled trial of ipratropium bromide and salbutamol versus salbutamol alone in children with acute exacerbation of asthma. Indian Journal of Pediatrics. 2006;73(11):979-83.
7. Cook JJ, Fergusson DM, Dawson KP. Ipratropium and fenoterol in the treatment of acute asthma. Pharmatherapeutica 1985;4(6):383-6.
8. Ducharme FM, Davis GM. Randomized controlled trial of ipratropium bromide and frequent low doses of salbutamol in the treatment of mild and moderate acute asthma. Journal of Pediatrics 1998;133(4):479-85.
9. Guill MF, Maloney MJ, DuRant RH. Comparison of inhaled metaproterenol, inhaled atropine sulfate and their combination in treatment of children with acute asthma. Annals of Allergy 1987;59:367-71.
10. Iramain R, Lopez-Herce J, Coronel J, Spitters C, Guggiari J, Bogado N. inhaled salbutamol plus ipratropium in moderate and severe asthma crises in children. Journal of Asthma 2011;48:298-303.
11. Peterson R, Wensley D, Mitchell I, Klassen T, Lamarre J, Rivard G, et al.Boehringer Ingelheim Trial No 2442430.3. Boehringer Ingelheim 1994.
12. Phanichyakam P, Kraisarin C, Sasisakulporn C. Comparison of inhaled terbutaline and inhaled terbutaline plus ipratropium bromide in acute asthmatic children. Asian Pacific Journal of Allergy and Immunology 1990;8:45-8.
13. Qureshi FA, Zaritsky A, Lakkis H. Efficacy of nebulized ipratropium in severe asthmatic children. Annals of Emergency Medicine 1997;29:205-11.
14. Qureshi F, Pestian J, Davis P, Zaritsky A. Effect of nebulized ipratropium on the hospitalization rates of children with asthma. New England Journal of Medicine 1998;339(15):1030-5.
15. Qureshi F, Pestian J, Davis P, Zaritsky A. Effect of nebulized ipratropium on the hospitalization rates of children with asthma. New England Journal of Medicine 1998;339(15):1030-5.
16. Qureshi F, Pestian J, Davis P, Zaritsky A. Effect of nebulized ipratropium on the hospitalization rates of children with asthma. New England Journal of Medicine 1998;339(15):1030-35.
17. Reisman J, Galdes-Sebaldt M, Kazim F, Canny G, Levison H. Frequent administration by inhalation of salbutamol and ipratropium bromide in the initial management of severe acute asthma in children. Journal of Allergy & Clinical Immunology 1988;81:16-20.
18. Schuh S, Johnson DW, Callahan S, Canny G, Levison H. Efficacy of frequent nebulized ipratropium added to frequent high-dose albuterol therapy in severe childhood asthma. Journal of Pediatrics 1995;126:639-45.
19. Schuh S, Johnson DW, Callahan S, Canny G, Levison H. Efficacy of frequent nebulized ipratropium added to frequent high-dose albuterol therapy in severe childhood asthma. Journal of Pediatrics 1995;126:639-45.
20. Schuh S, Johnson DW, Callahan S, Canny G, Levison H. Efficacy of frequent nebulized ipratropium added to frequent high-dose albuterol therapy in severe childhood asthma. Journal of Pediatrics 1995;126:639-45.
21. Sharma A, Madaan A. Nebulized salbutamol vs salbutamol and ipratropium combination in asthma. Indian Journal of Pediatrics 2004;71(2):121-4.
22. Sienra Monge JJ, Bermejo Guevara MA, del Rio Navarro BE, Rosas Vargas MA, Reyes Ruiz NI. Degree and duration of bronchodilatation with an agonist beta 2 administered alone versus an agonist beta 2 administered with ipratropium bromide in children with acute asthma. Revista Alergia Mexico 2000;47(1):26-9.
23. Watanasomsiri A, Phipatanakul W. Comparison of nebulized ipratropium bromide with salbutamol versus salbutamol alone in acute asthma exacerbation in children [Abstract]. Chest 2004;126(4 Suppl):761S-b.
24. Watanasomsiri A, Phipatanakul W. Comparison of nebulized ipratropium bromide with salbutamol vs salbutamol alone in acute asthma exacerbation in children. Annals of Allergy, Asthma, & Immunology 2006;96(5):701-6.
25. Watson WTA, Becker AB, Simmons FER. Comparison of ipratropium solution, fenoterol solution and their combination administered by nebulizer and face mask to children with acute asthma. Journal of Allergy & Clinical Immunology 1988;82:1012-8.
26. Zorc JJ, Pusic MV, Ogborn CJ, Lebet R, Duggan AK. Ipratropium bromide added to asthma treatment in the pediatric emergency department. Pediatrics 1999;103(4):748-52.
27. Zorc JJ, Pusic MV, Ogborn CJ, Lebet R, Duggan AK. Ipratropium bromide added to asthma treatment in the pediatric emergency department. Pediatrics 1999;103(4):748-52.
28. Zorc JJ, Pusic MV, Ogborn CJ, Lebet R, Duggan AK. Ipratropium bromide added to asthma treatment in the pediatric emergency department. Pediatrics 1999;103(4):748-52.
29. Zorc JJ, Pusic, MV, Ogborn CJ, Lebet R, Duggan AK. Ipratropium bromide added to asthma treatment in the pediatric emergency department. Pediatrics 1999;103(4):748-52.
30. Anthracopoulos M, Karatza A, Davlouros PA, Beratis NG. Comparison of salbutamol (SAL) and combined salbutamol and ipratropium bromide (SAL+IB) nebulization therapy in acute asthma exacerbations (AAE) in paediatric patients. European Respiratory Journal 2000;16 Suppl 31:304s.
31. Anthracopoulos MB, Karatza AA, Davlouros PA, Chiladakis JA, Manolis AS, Beratis NG. Effects of two nebulization regimens on heart rate variability during acute asthma exacerbations in children. Journal of Asthma 2005;42(4):273-9.
32. Boner AL, De Stefano G, Niero E, Vallone G, Gaburro D. Salbutamol and ipratropium bromide solution in the treatment of bronchospasm in asthmatic children. Annals of Allergy 1987;58:54-8.
33. Bratteby L-E, Foucard T, Lonnerholm G. Combined treatment with ipratropium bromide and beta-2-adrenoceptor agonists in childhood asthma. American Review of Respiratory Disease 1986;68:239-47.
34. Browne GJ, Trieu L, Van Asperen P. Randomized, double-blind, placebo-controlled trial of intravenous salbutamol and nebulized ipratropium bromide in early management of severe acute asthma in children presenting to an emergency department. Critical Care Medicine 2002;30(2):448-53.
35. Caubet Y. Comparison of the effectiveness and the tolerance of the dosing aerosols of fenoterol/ipratropium against salbutamol in the asthmatic child [in French] [Comparaison de l'efficacite et de la tolerance des aerosols doseurs de l'association fenoterol/ipratropium contre le salbutamol chez le grand enfant asthmatique]. La Revue de Pediatrie 1989;25(2):74-6.
36. Craven D, Kercsmar CM, Myers TR, O'Riordan MA, Golonka G, Moore S. Ipratropium bromide plus nebulized albuterol for the treatment of hospitalized children with acute asthma. Journal of Pediatrics 2001;138(1):51-8.
37. Davis A, Vickerson F, Worsley G, Mindorff C, Kazim F, Levison H. Determination of dose-response relationship for nebulized ipratropium in asthmatic children. Journal of Pediatrics 1984;Dec:1002-5.
38. Delacourt C, de Blic J, Lebourgeois M, Scheinmann P. Value of ipratropium bromide in asthma crisis in children [in French] [Interet du bromure d'ipratropium dans la crise d'asthme de l'enfant]. Archives de Pediatrie 1994;1:87-92.
39. DeStefano G, Bonetti S, Bonizzato C, Valletta EA, Piacentini GL, Boner AL. Additive effect of albuterol and ipratropium bromide in the treatment of bronchospasm in children. Annals of Allergy 1989;65(4):260-2.
40. Ekwo E, Weinberger M. Evaluation of a program for the pharmacologic management of children with asthma. Journal of Allergy & Clinical Immunology 1978;61(4):240-7.
41. Freeman J, Landau LI. The effects of ipratropium bromide and fenoterol nebulizer solutions in children with asthma. Clinical Pediatrics 1989;28(12):556-60.
42. Friberg S, Graff-Lonnevig V. Ipratropium bromide (Atrovent) in childhood asthma: a cumulative dose-response study. Annals of Allergy 1989;62:131-4.
43. Goggin N, Macarthur C, Parkin PC. Randomized trial of the addition of ipratropium bromide to albuterol and corticosteroid therapy in children hospitalized because of an acute asthma exacerbation. Archives of Pediatrics & Adolescent Medicine 2001;155(12):1329-34.
44. Greenough A, Loftus Bg, Pool J, Price JF. Response to bronchodilators assessed by lung mechanics. Archives of Disease in Childhood 1986;61:1020-3.
45. Greenough A, Yuksel B, Everett L, Price JF. Inhaled ipratropium bromide and terbutaline in asthmatic children. Respiratory Medicine 1993;87:111-4.
46. Groggins RC, Milner AD, Stokes GM. Bronchodilator effects of clemastine, ipratropium bromide, and salbutamol in preschool children with asthma. Archives of Disease in Childhood 1981;56:342-4.
47. Hodges IGC, Groggins RC, Milner AD, Stokes GM. Bronchodilator effect of inhaled ipratropium bromide in wheezy toddlers. Archives of Disease in Childhood 1981;56:729-32.
48. Kumaratne M, Gunawardane G. Addition of ipratropium to nebulized albuterol in children with acute asthma presenting to a pediatric office. Clinical Pediatrics 2003;42(2):127-32.
49. Lenney W, Evans NAP. Nebulized salbutamol and ipratropium bromide in asthmatic children. British Journal of Diseases of the Chest 1986;80:59-65.
50. Mann NP, Hiller EJ. Ipratropium bromide in children with asthma. Thorax 1982;37:72-4.
51. O'Driscoll BR, Taylor RJ, Horsley MG, Chambers DK, Bernstein A. Nebulised salbutamol with and without ipratropium bromide in acute airflow obstruction. Lancet 1989;1(8652):1418-20.
52. Paredes N, Sol M, Del Rio N, Sienra M. Comparative efficacy of salbutamol versus salbutamol with ipratropium bromide in acute asthma in children [Abstract]. XV International Congress of Allergology and Clinical Immunology: Annual Meeting of the European Academy of Allergology and Clinical Immunology. 1994:377.
53. Ralston ME, Euwema MS, Knecht KR, Ziolkowski TJ, Coakley TA, Cline SM. Comparison of levalbuterol and racemic albuterol combined with ipratropium bromide in acute pediatric asthma: a randomized controlled trial. Journal of Emergency Medicine 2005;29(1):29-35.
54. Rayner RJ, Cartlidge PHT, Upton CJ. Salbutamol and ipratropium in acute asthma. Archives of Disease in Childhood 1987;62:840-1.
55. Stokes GM, Milner AD, Hodges IGC, Henry RL. Nebulised ipratropium bromide in wheezy infants and young children. European Journal of Respiratory Diseases 1983;64:494-8.
56. Storr J, Lenney W. Nebulised ipratropium and salbutamol in asthma. Archives of Disease in Childhood 1986;61:602-3.
57. Timsit S, Sannier N, Bocquet N, Cojocaru B, Wille C, Boursiquot C, et al.Benefit of ipratropium bromide for the treatment of childhood asthma in the emergency department. Archives de Pediatrie 2002;9(2):117-24.
58. Vichyanond P, Sladek WA, Sur S, Hill MR, Szefler SJ, Nelson HS. Efficacy of atropine methylnitrate alone and in combination with albuterol in children with asthma. Chest 1990;98:637-42.
59. Ward MJ, Fentem PH, Smith WH, Davies D. Ipratropium bromide in acute asthma. British Medical Journal Clinical Research Ed. 1981;282(6264):598-600.
60. Ward MJ, Macfarlane JT, Davies D. A place for ipratropium bromide in the treatment of severe acute asthma. British Journal of Diseases of the Chest 1985;79(4):374-8.
61. Wilson N, Dixon C, Silverman M. Bronchial responsiveness to hyperventilation in children with asthma: inhibition by ipratropium bromide. Thorax 1984;39:588-93.
62. Arets H, Brackel H, Van der Ent C. Forced expiratory manoeuvres in children: do they meet ATS and ERS criteria for spirometry?. European Respiratory Journal 2001;18:655-60.
63. British Thoracic Society and Scottish intercollegiate Guidelines Network. British guideline on the management of asthma: a national clinical guideline, 2011. www.brit-thoracic.org.uk/guidelines (accessed 8 August 2013).
64. Chalut DS, Ducharme FM, Davis GM. The Preschool Respiratory Assessment Measure (PRAM): a responsive index of acute asthma severity. Journal of Pediatrics 2000;137(6):762-8.
65. Chapman K. An international perspective on anticholinergic therapy. American Journal of Medicine 1996;100:2-4S.
66. DerSimonian R, Laird N. Meta-analysis in clinical trials. Controlled Clinical Trials 1986;7(3):177-88.
67. Ducharme FM, Chalut D, Plotnick L, Savadie C, Kudrika D, Zhang Xun, et al.The Pediatric Respiratory Assessment Measure: a valid clinical score for assessing acute asthma severity from toddlers to teenagers. Journal of Pediatrics 2008;152(4):476-80.
68. Global INitiative for Asthma. Global strategy for asthma management and prevention, 2011. www.ginasthma.org (accessed 8 August 2013).
69. Greenland S, Robins JM. Estimation of a common effect parameter from sparse follow-up data. Biometrics 1985;41:55-68.
70. Gross NJ. Ipratropium bromide. New England Journal of Medicine 1988;8:486-94.
71. Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions. Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
72. Homer CJ, Szilagyi P, Rodewald L, Bloom SR, Greenspan P, Yazdgerdi S, et al.Does quality of care affect rates of hospitalization for childhood asthma?. Pediatrics 1996;98:18-23.
73. Khan KS, Daya S, Jahad AR. The importance of quality of primary studies in producing unbiased systematic reviews. Archives of Internal Medicine 1996;156:661-6.
74. Lougheed MD, Lemiere C, Ducharme FM, Licskai C, Dell SD, Rowe BH, et al.Canadian Thoracic Society 2012 guideline update: diagnosis and management of asthma in preschoolers, children and adults. Canadian Respiratory Journal 2012; Vol. 19, issue 2:127-64. [1916-7245: (Electronic)]
75. Payne SM, Donahue C, Rappo P, McNamara JJ, Bass J, First L, et al.Variations in pediatric pneumonia and bronchitis/asthma admission rates. Is appropriateness a factor?. Archives of Pediatric and Adolescent Medicine 1995;149:162-9.
76. The Nordic Cochrane Centre: The Cochrane Collaboration. Review Manager (RevMan). 5.1. Copenhagen: The Nordic Cochrane Centre: The Cochrane Collaboration, 2011.
77. Rodrigo G, Castro-Rodriguez J. Anticholinergics in the treatment of children and adults with acute asthma: a systematic review with meta analysis. Thorax 2005;60:740-6.
78. Rowe BH, Spooner C, Ducharme F, Bretziaff J, Bota G. Early emergency department treatment of acute asthma with systemic corticosteroids. Cochrane Database of Systematic Reviews 2001, Issue 1. [DOI: 10.1002/14651858.CD002178]
79. Rubin BK, Fink JB. The delivery of inhaled medication to the young child. Pediatric Clinics of North America 2003; Vol. 50, issue 3:717-31. [0031-3955: (Print)]
80. Saxena S, George J, Barber J, Fitzpatrick J, Majeed A. Association of population and practice factors with potentially avoidable admissions rates for chronic diseases in London: cross sectional analysis. Journal of the Royal Society of Medicine 2006;99(2):81-9.
81. Sears MR. Clinical application of beta-agonists. Practical Allergy and Immunology 1992;7:98-100.
82. Silverman M. The role of anticholinergic antimuscarinic bronchodilator therapy in children. Lung 1990;168:304-9.
83. Silverman RA, Flaster E, Enright PL, Simonson SG. FEV1 performance among patients with acute asthma: results from a multicenter clinical trial. Chest 2007;131(1):164-71.
84. Svedmyr N. A beta2-adrenergic agonist for use in asthma pharmacology, pharmacokinetics, clinical efficacy and adverse effects. Pharmacotherapy 1985;5:109-26.
85. Teoh L, Cates C, Hurwitz M, Acworth JP, Van Asperen P, Chang AB. Anticholinergic therapy for acute asthma in children. Cochrane Database of Systematic Reviews 2012, Issue 4. [DOI: 10.1002/14651858.CD003797.pub2]
86. Plotnick L, Ducharme F. Combined inhaled anticholinergics and beta2-agonists for initial treatment of acute asthma in children. Cochrane Database of Systematic Reviews 2000, Issue 3. [DOI: 10.1002/14651858.CD000060]