Polypill therapy, subclinical atherosclerosis, and cardiovascular events - Implications for the use of preventive pharmacotherapy: MESA (Multi-Ethnic Study of Atherosclerosis)

Journal of the American College of Cardiology

Volumn 63, Issue 5, 2014, Pages 434-443

  Bittencourt, Márcio Sommer ^a   Blaha, Michael J ^b   Blankstein, Ron ^a   Budoff, Matthew ^c   Vargas, Jose D ^d,e   Blumenthal, Roger S ^b   Agatston, Arthur S ^f,g   Nasir, Khurram ^b,f,g,h,i  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE   (United States)

^d JOHNS HOPKINS HOSPITAL   (United States)

^e NATIONAL INSTITUTES OF HEALTH   (United States)

^f Baptist Health South Florida   (United States)

^g FLORIDA INTERNATIONAL UNIVERSITY   (United States)

^h FLORIDA INTERNATIONAL UNIVERSITY   (United States)

ⁱ Baptist Vascular Institute   (United States)

Author keywords

polypill; risk stratification; subclinical atherosclerosis

Indexed keywords

ACETYLSALICYLIC ACID; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

ADULT; AGED; ARTICLE; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; CORONARY ARTERY CALCIUM SCORE; ETHNIC GROUP; EVENT FREE SURVIVAL; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIDETECTOR COMPUTED TOMOGRAPHY; POLYPHARMACY; POLYPILL THERAPY; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; TREATMENT DURATION; VERY ELDERLY; CARDIOVASCULAR RISK; ETHNIC DIFFERENCE; ISCHEMIC HEART DISEASE; MEDICAL DECISION MAKING; PATIENT SELECTION; RISK REDUCTION;

CAC; CARDIOVASCULAR DISEASE; CHD; CORONARY ARTERY CALCIUM; CORONARY HEART DISEASE; CVD; FRAMINGHAM RISK SCORE; FRS; HAZARD RATIO; HR; NNT; NUMBER NEEDED TO TREAT; POLYPILL; RISK STRATIFICATION; SUBCLINICAL ATHEROSCLEROSIS;

ADULT; AGED; AGED, 80 AND OVER; ATHEROSCLEROSIS; CALCINOSIS; CALCIUM; CORONARY ANGIOGRAPHY; CORONARY ARTERY DISEASE; CORONARY VESSELS; DRUG THERAPY, COMBINATION; ETHNIC GROUPS; FEMALE; FOLLOW-UP STUDIES; HUMANS; INCIDENCE; MALE; MIDDLE AGED; PREVALENCE; RISK ASSESSMENT; RISK FACTORS; TIME FACTORS; TOMOGRAPHY, X-RAY COMPUTED; UNITED STATES;

EID: 84893260493     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2013.08.1640     Document Type: Article

References (30)

1. S. Yusuf Two decades of progress in preventing vascular disease Lancet 360 2002 2 3
2. N.J. Wald, and M.R. Law A strategy to reduce cardiovascular disease by more than 80% BMJ 326 2003 1419
3. K.M. Narayan, G.A. Mensah, and S. Sorensen et al. Combination pharmacotherapy for cardiovascular disease prevention: threat or opportunity for public health? Am J Prev Med 29 2005 134 138
4. J. Wise Polypill holds promise for people with chronic disease Bull World Health Organ 83 2005 885 887
5. M.J. Budoff, S. Achenbach, and R.S. Blumenthal et al. Assessment of coronary artery disease by cardiac computed tomography: a scientific statement from the American Heart Association Committee on Cardiovascular Imaging and Intervention, Council on Cardiovascular Radiology and Intervention, and Committee on Cardiac Imaging, Council on Clinical Cardiology Circulation 114 2006 1761 1791
6. R. Detrano, A.D. Guerci, and J.J. Carr et al. Coronary calcium as a predictor of coronary events in four racial or ethnic groups N Engl J Med 358 2008 1336 1345
7. S. Mohlenkamp, N. Lehmann, and S. Moebus et al. Quantification of coronary atherosclerosis and inflammation to predict coronary events and all-cause mortality J Am Coll Cardiol 57 2011 1455 1464
8. T.S. Polonsky, R.L. McClelland, and N.W. Jorgensen et al. Coronary artery calcium score and risk classification for coronary heart disease prediction JAMA 303 2010 1610 1616
9. M. Blaha, M.J. Budoff, and L.J. Shaw et al. Absence of coronary artery calcification and all-cause mortality J Am Coll Cardiol Img 2 2009 692 700
10. A. Sarwar, L.J. Shaw, and M.D. Shapiro et al. Diagnostic and prognostic value of absence of coronary artery calcification J Am Coll Cardiol Img 2 2009 675 688
11. D.E. Bild, D.A. Bluemke, and G.L. Burke et al. Multi-ethnic study of atherosclerosis: objectives and design Am J Eipdemiol 156 2002 871 881
12. S. Yusuf, P. Pais, and R. Afzal et al. Effects of a polypill (Polycap) on risk factors in middle-aged individuals without cardiovascular disease (TIPS): a phase II, double-blind, randomised trial Lancet 373 2009 1341 1351
13. M. Rastegarpanah, F. Malekzadeh, G.N. Thomas, A. Mohagheghi, K.K. Cheng, and T. Marshall A new horizon in primary prevention of cardiovascular disease, can we prevent heart attack by "heart polypill"? Arch Iranian Med 11 2008 306 313
14. F. Malekzadeh, T. Marshall, and A. Pourshams et al. A pilot double-blind randomised placebo-controlled trial of the effects of fixed-dose combination therapy ('polypill') on cardiovascular risk factors Int J Clin Pract 64 2010 1220 1227
15. A. Rodgers, A. Patel, and O. Berwanger et al. An international randomised placebo-controlled trial of a four-component combination pill ("polypill") in people with raised cardiovascular risk PLoS One 6 2011 e19857
16. J.J. Carr, J.C. Nelson, and N.D. Wong et al. Calcified coronary artery plaque measurement with cardiac CT in population-based studies: standardized protocol of Multi-Ethnic Study of Atherosclerosis (MESA) and Coronary Artery Risk Development in Young Adults (CARDIA) study Radiology 234 2005 35 43
17. D.G. Altman, and P.K. Andersen Calculating the number needed to treat for trials where the outcome is time to an event BMJ 319 1999 1492 1495
18. P. Muntner, D. Mann, R.P. Wildman, D. Shimbo, V. Fuster, and M. Woodward Projected impact of polypill use among US adults: medication use, cardiovascular risk reduction, and side effects Am Heart J 161 2011 719 725
19. R. Jackson Updated New Zealand cardiovascular disease risk-benefit prediction guide BMJ 320 2000 709 710
20. S. Baker, P. Priest, and R. Jackson Using thresholds based on risk of cardiovascular disease to target treatment for hypertension: modelling events averted and number treated BMJ 320 2000 680 685
21. E.B. Colkesen, H.T. Jorstad, and R.J. Peters et al. A comparative analysis of three widely used lipid management guidelines in the EPIC-Norfolk cohort Eur J Prev Cardiol 20 2013 98 106
22. P.M. Ridker, J.G. MacFadyen, and B.G. Nordestgaard et al. Rosuvastatin for primary prevention among individuals with elevated high-sensitivity C-reactive protein and 5% to 10% and 10% to 20% 10-year risk: Implications of the Justification for Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) trial for "intermediate risk" Circ Cardiovasc Qual Outcomes 3 2010 447 452
23. M.J. Blaha, M.J. Budoff, and A.P. DeFilippis et al. Associations between C-reactive protein, coronary artery calcium, and cardiovascular events: implications for the JUPITER population from MESA, a population-based cohort study Lancet 378 2011 684 692
24. K. Nasir, J. Rubin, and M.J. Blaha et al. Interplay of coronary artery calcification and traditional risk factors for the prediction of all-cause mortality in asymptomatic individuals Circ Cardiovasc Imaging 5 2012 467 473
25. A.J. Einstein Effects of radiation exposure from cardiac imaging: how good are the data? J Am Coll Cardiol 59 2012 553 565
26. J.K. Min, F.Y. Lin, and D.S. Gidseg et al. Determinants of coronary calcium conversion among patients with a normal coronary calcium scan: what is the "warranty period" for remaining normal? J Am Coll Cardiol 55 2010 1110 1117
27. V. Raman, E.M. McWilliams, S.M. Holmberg, and K. Miles Economic analysis of the use of coronary calcium scoring as an alternative to stress ECG in the non-invasive diagnosis of coronary artery disease Eur Radiol 22 2012 579 587
28. J.P. Shields, C.H. Mielke Jr., and P. Watson Inter-rater reliability of electron beam computed tomography to detect coronary artery calcification Am J Cardiac Imaging 10 1996 91 96
29. J. Hippisley-Cox, and C. Coupland Unintended effects of statins in men and women in England and Wales: population based cohort study using the QResearch database BMJ 340 2010 c2197
30. G. De Berardis, G. Lucisano, and A. D'Ettorre et al. Association of aspirin use with major bleeding in patients with and without diabetes JAMA 307 2012 2286 2294