Corticosteroids inhibit sphingosine 1-phosphate-induced interleukin-6 secretion from human airway smooth muscle via mitogen-activated protein kinase phosphatase 1-mediated repression of mitogen and stress-activated protein kinase 1

American Journal of Respiratory Cell and Molecular Biology

Volumn 50, Issue 2, 2014, Pages 358-368

  Che, Wenchi ^a   Parmentier, Johannes ^a   Seidel, Petra ^a   Manetsch, Melanie ^a   Ramsay, Emma E ^a   Alkhouri, Hatem ^a   Ge, Qi ^a   Armour, Carol L ^a   Ammit, Alaina J ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Asthma; DUSP; Lipid mediators; Mitogen activated protein kinases; Sphingosine 1 phosphate

Indexed keywords

CRE RECOMBINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DEXAMETHASONE; HISTONE H3; INTERLEUKIN 6; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; SPHINGOSINE 1 PHOSPHATE; STRESS ACTIVATED PROTEIN KINASE 1; TRIPTOLIDE;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; BREATHING MUSCLE; CELLULAR DISTRIBUTION; CHROMATIN; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG MECHANISM; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REPRESSION; GENE EXPRESSION; GENETIC TRANSCRIPTION; HISTONE PHOSPHORYLATION; HUMAN; HUMAN CELL; IMMUNOMODULATION; IN VITRO STUDY; INTRACELLULAR SIGNALING; PROMOTER REGION; PROTEIN EXPRESSION; RNA STABILITY; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; UPREGULATION;

ADRENAL CORTEX HORMONES; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DUAL SPECIFICITY PHOSPHATASE 1; HUMANS; INTERLEUKIN-6; LYSOPHOSPHOLIPIDS; MITOGEN-ACTIVATED PROTEIN KINASE PHOSPHATASES; MUSCLE, SMOOTH; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; SIGNAL TRANSDUCTION; SPHINGOSINE;

EID: 84893223779     PISSN: 10441549     EISSN: 15354989     Source Type: Journal    
DOI: None     Document Type: Article

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