To B or not to B? Glucocorticoid impact on B lymphocyte fate and function

Endocrinology

Volumn 155, Issue 2, 2014, Pages 339-341

  Kovacs, William J ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID; HYDROCORTISONE; PREDNISONE;

ANTIBODY PRODUCTION; APOPTOSIS; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; BONE MARROW; CELL FATE; CELL FUNCTION; HUMAN; HUMORAL IMMUNITY; IMMUNOGLOBULIN PRODUCING CELL; LYMPHOID ORGAN; NOTE; PRE B LYMPHOCYTE; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; APOPTOSIS; B-LYMPHOCYTES; DEXAMETHASONE; MALE; RECEPTORS, GLUCOCORTICOID;

EID: 84893204673     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2013-2085     Document Type: Note

References (33)

1. Ingle DJ. Problems relating to the adrenal cortex. Endocrinology. 1942; 419-438.
2. Bartlett D, Morita Y, Munck A. Rapid inhibition by cortisol of incorporation of glucose in vivo into the thymus of the rat. Nature. 1962;196: 897-898.
3. Munck A. Metabolic site and time course of cortisol action on glucose uptake, lactic acid output, and glucose 6-phosphate levels of rat thymus cells in vitro. J Biol Chem. 1968;243: 1039-1042.
4. Munck A, Brinck-Johnsen T. Specific and nonspecific physicochemical interactions of glucocorticoids and related steroids with rat thymus cells in vitro. J Biol Chem. 1968;243: 5556-5565.
5. Wira C, Munck A. Specific glucocorticoid receptors in thymus cells. Localization in the nucleus and extraction of the cortisol-receptor complex. J Biol Chem. 1970;245: 3436-3438.
6. Baxter JD, Harris AW, Tomkins GM, Cohn M. Glucocorticoid receptors in lymphoma cells in culture: relationship to glucocorticoid killing activity. Science. 1971;171: 189-191.
7. Sibley CH, Tomkins GM. Isolation of lymphoma cell variants resistant to killing by glucocorticoids. Cell. 1974;2: 213-220.
8. Sibley CH, Tomkins GM. Mechanisms of steroid resistance. Cell. 1974;2: 221-227.
9. Gehring U, Tomkins GM. A new mechanism for steroid unresponsiveness: loss of nuclear binding activity of a steroid hormone receptor. Cell. 1974;3: 301-306.
10. Ward E, Slocumb CH, Polley HF, Kendall EC, Hench PS. Clinical effects of cortisone administered orally to 100 patients with rheumatoid arthritis. Ann Rheum Dis. 1951;10: 477-484.
11. Flammer JR, Rogatsky I. Minireview: glucocorticoids in autoimmunity: unexpected targets and mechanisms. Mol Endocrinol. 2011;25: 1075-1086.
12. Gruver-Yates AL, Quinn MA, Cidlowski JA. Analysis of glucocorticoid receptors and their apoptotic response to dexamethasone in male murine B cells during development. Endocrinology. 2014;155: 463-474.
13. Fauci AS, Dale DC. The effect of in vivo hydrocortisone on subpopulations of human lymphocytes. J Clin Invest. 1974;53: 240-246.
14. Saxon A, Stevens RH, Ramer SJ, Clements PJ, Yu DTY. Glucocorticoids administered in vivo inhibit human suppressorTlymphocyte function and diminish B lymphocyte responsiveness in in vitro immunoglobulin synthesis. J Clin Invest. 1978;61: 922-930.
15. Claman HN, Moorhead JW, Benner WH. Corticosteroids and lymphoid cells in vitro. I. Hydrocortisone lysis of human, guinea pig, and mouse thymus cells. J Lab Clin Med. 1971;78: 499-507.
16. Fauci AS, Pratt KR, Whalen G. Activation of human B lymphocytes. IV. Regulatory effects of corticosteroids on the triggering signal in the plaque-forming cell response of human peripheral blood B lymphocytes to polyclonal activation. J Immunol. 1977;119: 598-603.
17. Grayson J, Dooley NJ, Koski IR, Blaese RM. Immunoglobulin production induced in vitro by glucocorticoid hormones: T cell-dependent stimulation of immunoglobulin production without B cell proliferation in cultures of human peripheral blood lymphocytes. J Clin Invest. 1981;68: 1539-1547.
18. Jabara HH, Ahern DJ, Vercelli D, Geha RS. Hydrocortisone and IL-4 induce IgE isotype switching in human B cells. J Immunol. 1991;147: 1557-1560.
19. Wu CY, Sarfati M, Heusser C, et al. Glucocorticoids increase the synthesis of immunoglobulin E by interleukin 4-stimulated human lymphocytes. J Clin Invest. 1991;87: 870-877.
20. Jabara HH, Brodeur SR, Geha RS. Glucocorticoids upregulate CD40 ligand expression and induce CD40L-dependent immunoglobulin isotype switching. J Clin Invest. 2001;107: 371-378.
21. Wardemann H, Yurasov S, Schaefer A, Young JW, Meffre E, Nussenzweig MC. Predominant autoantibody production by early human B cell precursors. Science. 2003;301: 1374-1377.
22. Goodnow CC, Crosbie J, Adelstein S, et al. Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature. 1988;334: 676-682.
23. Huang H, Kearney JF, Grusby MJ, Benoist C, Mathis D. Induction of tolerance in arthritogenic B cells with receptors of differing affinity for self-antigen. Proc Natl Acad Sci USA. 2006;103: 3734-3739.
24. Tiegs SL, Russell DM, Nemazee D. Receptor editing in self-reactive bone marrow B cells. J Exp Med. 1993;177: 1009-1020.
25. Bynoe MS, Grimaldi CM, Diamond B. Estrogen up-regulates Bcl-2 and blocks tolerance induction of naive B cells. Proc Natl Acad Sci USA. 2000;97: 2703-2708.
26. Grimaldi CM, Cleary J, Dagtas AS, Moussai D, Diamond B. Estrogen alters thresholds for B cell apoptosis and activation. J Clin Invest. 2002;109: 1625-1633.
27. Grimaldi CM, Jeganathan V, Diamond B. Hormonal regulation of B cell development: 17β-estradiol impairs negative selection of highaffinity DNA-reactiveBcells at more than one developmental checkpoint. J Immunol. 2006;176: 2703-2710.
28. Peled JU, Kuang FL, Iglesias-Ussel MD, t al. The biochemistry of somatic hypermutation. Annu Rev Immunol. 2008;26: 481-511.
29. Stavnezer J, Guikema JEJ, Schrader CE. Mechanism and regulation of class switch recombination. Annu Rev Immunol. 2008;26: 261-292.
30. Pauklin S, Sernández IV, Bachmann G, Ramiro AR, Petersen-Mahrt SK. Estrogen directly activates AID transcription and function. J Exp Med. 2009;206: 99-111.
31. Mai T, Zan H, Zhang J, Hawkins JS, Xu Z, Casali P. Estrogen receptors bind to and activate the HOXC4/HoxC4 promoter to potentiate HoxC4-mediated activation-induced cytosine deaminase induction, immunoglobulin class switch DNA recombination, and somatic hypermutation. J Biol Chem. 2010;285: 37797-37810.
32. Pauklin S, Petersen-Mahrt SK. Progesterone inhibits activation-induced deaminase by binding to the promoter. J Immunol. 2009; 183: 1238-1244.
33. Benko AL, Olsen NJ, Kovacs WJ. Glucocorticoid inhibition of activation- induced cytidine deaminase expression in human B lymphocytes. Mol Cell Endocrinol. 2013; 382: 881-887.