Shrna-mediated XRCC2 gene knockdown efficiently sensitizes colon tumor cells to X-ray irradiation in vitro and in vivo

International Journal of Molecular Sciences

Volumn 15, Issue 2, 2014, Pages 2157-2171

  Wang, Qin ^a   Wang, Yan ^a   Du, Liqing ^a   Xu, Chang ^a   Sun, Yuanming ^a   Yang, Bing ^b   Sun, Zhijuan ^a   Fu, Yue ^a   Cai, Lu ^c   Fan, Saijun ^a   Fan, Feiyue ^a   Liu, Qiang ^a  

^a INSTITUTE OF RADIATION MEDICINE   (China)

^b TIANJIN MEDICAL UNIVERSITY   (China)

^c University of Louisville School of Medicine   (United States)

Author keywords

Colon cancer; Ionizing radiation; Radiosensitivity; RNA interference; XRCC2

Indexed keywords

NUCLEAR PROTEIN; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; XRCC2 PROTEIN; DNA BINDING PROTEIN; SMALL INTERFERING RNA; XRCC2 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CARCINOGENICITY; CELL CULTURE; CELL GROWTH; CELL PROLIFERATION; COLON TUMOR; CONTROLLED STUDY; DNA DAMAGE; FLOW CYTOMETRY; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IONIZING RADIATION; MOUSE; MTT ASSAY; NONHUMAN; PROTEIN EXPRESSION; RADIOSENSITIZATION; REAL TIME POLYMERASE CHAIN REACTION; TUMOR CELL; WESTERN BLOTTING; X IRRADIATION; ANIMAL; CELL CYCLE; CELL TRANSFORMATION; DISEASE MODEL; GENETICS; MALE; PATHOLOGY; RADIATION DOSE; RADIATION RESPONSE; TUMOR CELL LINE; TUMOR VOLUME; X RAY; XENOGRAFT;

ANIMALS; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; COLONIC NEOPLASMS; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; GENE EXPRESSION; GENE KNOCKDOWN TECHNIQUES; HETEROGRAFTS; HUMANS; MALE; MICE; RADIATION TOLERANCE; RNA, SMALL INTERFERING; TUMOR BURDEN; X-RAYS;

EID: 84893199593     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms15022157     Document Type: Article

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